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    • 7. 发明申请
    • COMPOSITION FOR INCREASING CELLULOSIC PRODUCT STRENGTH AND METHOD OF INCREASING CELLULOSIC PRODUCT STRENGTH
    • 用于增加纤维素产品强度的组合物和增加细胞产物强度的方法
    • WO2005089175A2
    • 2005-09-29
    • PCT/US2005007828
    • 2005-03-11
    • UNIV PITTSBURGH
    • CARROLL WILLIAM EAMONRENDU CHRISTIAN JEHNBECKMAN ERIC J
    • D21H17/54C08L39/00C08L39/02C09D133/14C09D139/02D21H17/06D21H17/24D21H17/36D21H17/56D21H21/18D21H21/20
    • D21H21/18C08L39/00C08L39/02C08L39/04C08L2312/00C09D133/02C09D133/14C09D139/02D21H17/06D21H17/36D21H17/56D21H21/20C08L2666/26
    • A composition includes water; at least one hydrophilic polymer containing at least two groups which are independently the same or different a primary amine group or a secondary amine group and at least one saccharide containing a reducible function as described above. The hydrophilic polymer and the saccharide are mixed to form a reaction mixture and reacted to increase the viscosity of the reaction mixture. The reaction is then substantially terminated by reducing the pH of the composition. A method of increasing the strength of a cellulosic pulp product includes the steps of: contacting wet cellulosic pulp with a composition comprising (i) at least one hydrophilic polymer containing at least two groups which are independently the same or different a primary amine group or a secondary amine group and at least one saccharide containing a reducible function, the hydrophilic polymer and the saccharide of the composition having been reacted in a crosslinking reaction prior to contacting the composition with the cellulosic pulp product to increase the viscosity the composition; and, after contacting the cellulosic pulp with the composition, causing the crosslinking reaction between the hydrophilic polymer and the saccharide of the composition to proceed further.
    • 组合物包括水; 至少一种含有至少两个独立地相同或不同的伯胺基或仲胺基的亲水性聚合物和至少一种含有如上所述的还原性功能的糖。 将亲水性聚合物和糖混合以形成反应混合物并反应以增加反应混合物的粘度。 然后通过降低组合物的pH基本上终止反应。 提高纤维素纸浆产品的强度的方法包括以下步骤:使湿纤维素纸浆与组合物接触,所述组合物包含(i)至少一种亲水性聚合物,所述亲水性聚合物含有至少两个独立地相同或不同的伯胺基或 仲胺基团和至少一种含有可还原功能的糖类,亲水性聚合物和组合物的糖类在使组合物与纤维素纸浆产物接触之前已经在交联反应中反应以增加组合物的粘度; 并且在将纤维素纸浆与组合物接触之后,使亲水性聚合物与组合物的糖类之间的交联反应进一步进行。
    • 8. 发明申请
    • WOUND HEALING POLYMERIC NETWORKS
    • 创伤治疗聚合物网络
    • WO2007005792A8
    • 2008-03-27
    • PCT/US2006025915
    • 2006-07-01
    • UNIV PITTSBURGH
    • BECKMAN ERIC JBADYLAK STEPHEN FWELLS ALAN HZHANG JIANYINGFREYTES DONALD
    • A61L26/00A61L15/26A61L15/44
    • C08G18/3821A61K31/28A61K38/39A61K45/06A61K47/59A61K47/60A61L26/0019A61L26/0066A61L26/008A61L2300/104A61L2300/214A61L2300/252A61L2300/402A61L2300/404A61L2300/414A61L2300/418C08G18/10C08G18/3206C08G18/3218C08G18/4833C08G18/771C08G18/8022C08G2230/00
    • A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing molecule retains the ability to undergo free radical polymerization after attachment of the bioactive agent thereto. The first polymerizing molecule is preferably biocompatible. The polymerizing molecule can, for example, be dihydroxyphenyl-L-alanine (DOPA) or tyrosine. The composition can also include a second component synthesized by reacting at least one core molecule having a plurality of reactive hydrogen groups with at least one multi-isocyanate functional molecule to create a conjugate including terminal isocyanate groups. The conjugate molecule is reacted with a second polymerizing molecule that is adapted to undergo a free radical polymerization. The second polymerizing molecule includes a reactive hydrogen to react with the isocyanate groups of the conjugate. The second polymerizing molecule retains the ability to undergo the free radical polymerization after reaction with the conjugate. In several embodiments, the first polymerizing molecule and the second polymerizing molecule are the same and dihydroxyphenyl-L-alanine (DOPA) or tyrosine.
    • 组合物包含共价连接到适于进行自由基聚合的第一聚合分子的至少一种生物活性剂。 第一聚合分子保留在生物活性剂附着后进行自由基聚合的能力。 第一聚合分子优选是生物相容的。 聚合分子可以是例如二羟基苯基-L-丙氨酸(DOPA)或酪氨酸。 组合物还可以包括通过使具有多个反应性氢基团的至少一个核心分子与至少一个多异氰酸酯官能分子反应以产生包含末端异氰酸酯基团的缀合物而合成的第二组分。 共轭分子与适于进行自由基聚合的第二聚合分子反应。 第二聚合分子包括与偶联物的异氰酸酯基反应的反应性氢。 第二聚合分子保留在与缀合物反应后进行自由基聚合的能力。 在几个实施方案中,第一聚合分子和第二聚合分子是相同的,并且是二羟基苯基-L-丙氨酸(DOPA)或酪氨酸。