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1. 发明公开

EP1711455A4 FACIALLY AMPHIPHILIC POLYARYL AND POLYARYLALKYNYL POLYMERS AND OLIGOMERS AND USES THEREOF 审中-公开
标题翻译：表面两亲性聚芳基和POLYARYLALKINYLPOLYMERE和低聚物及其应用
公开(公告)号：EP1711455A4
公开(公告)日：2007-11-07
申请号：EP05711747
申请日：2005-01-21
申请人： UNIV PENNSYLVANIA , DEGRADO WILLIAM F , LIU DAHUI , TEW GREGORY N , KLEIN MICHAEL L
发明人： DEGRADO WILLIAM F , LIU DAHUI , TEW GREGORY N , KLEIN MICHAEL L
IPC分类号： C07C211/00 , A61K31/74 , C07C211/27 , C07C217/58 , C07C233/78 , C07C279/12
CPC分类号： C07C279/12 , A61K31/74 , C07C211/27 , C07C217/58 , C07C233/78

2. 发明申请

WO02100295A3 FACIALLY AMPHIPHILIC POLYMERS AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译：作为抗感染剂的全氟化聚合物
公开(公告)号：WO02100295A3
公开(公告)日：2003-05-01
申请号：PCT/US0222043
申请日：2002-03-07
申请人： UNIV PENNSYLVANIA , DEGRADO WILLIAM F , TEW GREGORY N , KLEIN MICHAEL L , LIU DAHUI , YUAN JING
发明人： DEGRADO WILLIAM F , TEW GREGORY N , KLEIN MICHAEL L , LIU DAHUI , YUAN JING
IPC分类号： A61L29/00 , A01N25/10 , A01N37/24 , A01N61/00 , A61K31/74 , A61L15/44 , A61L27/54 , A61L29/16 , A61L31/16 , C07C323/36 , C08G18/28 , C08G18/32 , C08G61/00 , C08G61/02 , C08G61/10 , C08G61/12 , C08G69/02 , C08G69/26 , C08G73/00 , C08G73/02 , C08G73/22 , C08G85/00 , D06M15/37 , G02C7/04 , C08G18/00 , A61B19/00 , A61K9/00 , A61K9/70 , A61L9/00 , A61L12/00 , A61L12/08 , A61L31/00 , B29B9/00 , B29B15/00 , C08G63/00 , C08G69/00 , C08G71/02 , C08G71/04 , C08G75/00 , B29B5/00 , B29B27/04
CPC分类号： A61L15/44 , A01N25/10 , A01N37/18 , A01N37/22 , A01N37/24 , A01N37/28 , A01N37/30 , A01N37/42 , A01N47/22 , A01N47/30 , A01N47/44 , A61K31/74 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/20 , A61L2300/216 , A61L2300/404 , C08G18/2865 , C08G18/3225 , C08G61/02 , C08G61/10 , C08G61/122 , C08G69/26 , C08G73/028 , C08G73/22 , C08G2261/312 , Y10T428/193 , Y10T428/24207 , Y10T428/24446 , Y10T428/24455 , Y10T428/29 , Y10T428/31 , Y10T428/31504 , Y10T428/31678 , Y10T428/31725 , Y10T428/8305
摘要： Facially amphiphilic polymers and articles made therefrom having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a method to identify and optimize the facial amphiphilicity of polyamide, polyester, polyurea, polyurethane, polycarbonate and polyphenylene polymers. Utility as a contact disinfectant is disclosed.
摘要翻译：公开了两性聚合物和由其制成的制品具有杀生物面。聚合物可以抑制与表面或邻近所述杀生物表面的区域接触的微生物的生长。还公开了一种鉴定和优化聚酰胺，聚酯，聚脲，聚氨酯，聚碳酸酯和聚亚苯基聚合物的面部两亲性的方法。公开了作为接触消毒剂的效用。

3. 发明申请

WO2004082634A3 FACIALLY AMPHIPHILIC POLYMERS AND OLIGOMERS AND USES THEREOF 审中-公开
标题翻译：全氟聚合物和低聚物及其用途
公开(公告)号：WO2004082634A3
公开(公告)日：2005-11-10
申请号：PCT/US2004008155
申请日：2004-03-17
申请人： UNIV PENNSYLVANIA , DEGRADO WILLIAM F , LIU DAHUI , TEW GREGORY N , KLEIN MICHAEL L , YUAN JING , CHOI SUNGWOOK
发明人： DEGRADO WILLIAM F , LIU DAHUI , TEW GREGORY N , KLEIN MICHAEL L , YUAN JING , CHOI SUNGWOOK
IPC分类号： A61K20060101 , A61K6/00 , A61K31/00 , A61K31/17 , A61K31/785 , A61K38/00 , A61K38/16 , C08F20/52
CPC分类号： A61K31/17 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/3225 , C08G73/028 , C08L75/02
摘要： The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
摘要翻译：本发明公开了使用表面两亲性聚合物和低聚物的方法，包括聚合物和低聚物作为抗微生物剂的药物用途和与肝素治疗相关的出血并发症的解毒剂。本发明还公开了新颖的表面两亲聚合物和低聚物及其组合物，包括药物组合物。本发明还公开了表面两亲聚合物和低聚物的设计和合成。

4. 发明申请

WO2005072246A3 FACIALLY AMPHIPHILIC POLYARYL AND POLYARYLALKYNYL POLYMERS AND OLIGOMERS AND USES THEREOF 审中-公开
标题翻译：全氟己二醇和聚乙烯醇聚合物及其低聚物及其用途
公开(公告)号：WO2005072246A3
公开(公告)日：2006-06-29
申请号：PCT/US2005001885
申请日：2005-01-21
申请人： UNIV PENNSYLVANIA , DEGRADO WILLIAM F , LIU DAHUI , TEW GREGORY N , KLEIN MICHAEL L
发明人： DEGRADO WILLIAM F , LIU DAHUI , TEW GREGORY N , KLEIN MICHAEL L
IPC分类号： C07C211/00 , A61K31/135 , A61K31/74 , C07C211/27 , C07C217/58 , C07C233/78 , C07C279/12
CPC分类号： C07C279/12 , A61K31/74 , C07C211/27 , C07C217/58 , C07C233/78
摘要： The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.
摘要翻译：本发明公开了使用表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法，包括但不限于聚合物和低聚物作为抗微生物剂的药物用途和用于与肝素治疗相关的出血并发症的解毒剂。本发明还公开了新颖的表面两亲聚芳基和聚芳基炔基聚合物和低聚物，新型聚合物和低聚物的组合物，包括药物组合物，以及设计和合成表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法。

5. 发明申请

WO02072007A3 FACIALLY AMPHIPHILIC POLYMERS AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译：作为抗感染剂的全氟化聚合物
公开(公告)号：WO02072007A3
公开(公告)日：2003-05-22
申请号：PCT/US0206899
申请日：2002-03-07
申请人： UNIV PENNSYLVANIA , DEGRADO WILLIAM F , TEW GREGORY N , KLEIN MICHAEL L
发明人： DEGRADO WILLIAM F , TEW GREGORY N , KLEIN MICHAEL L
IPC分类号： A61L29/00 , A01N25/10 , A01N37/24 , A01N61/00 , A61K31/74 , A61L15/44 , A61L27/54 , A61L29/16 , A61L31/16 , C07C323/36 , C08G18/28 , C08G18/32 , C08G61/00 , C08G61/02 , C08G61/10 , C08G61/12 , C08G69/02 , C08G69/26 , C08G73/00 , C08G73/02 , C08G73/22 , C08G85/00 , D06M15/37 , G02C7/04
CPC分类号： A61L15/44 , A01N25/10 , A01N37/18 , A01N37/22 , A01N37/24 , A01N37/28 , A01N37/30 , A01N37/42 , A01N47/22 , A01N47/30 , A01N47/44 , A61K31/74 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/20 , A61L2300/216 , A61L2300/404 , C08G18/2865 , C08G18/3225 , C08G61/02 , C08G61/10 , C08G61/122 , C08G69/26 , C08G73/028 , C08G73/22 , C08G2261/312 , Y10T428/193 , Y10T428/24207 , Y10T428/24446 , Y10T428/24455 , Y10T428/29 , Y10T428/31 , Y10T428/31504 , Y10T428/31678 , Y10T428/31725 , Y10T428/8305
摘要： Facially amphiphilic polyphenylene and heteroarylene polymers and articles made therform having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a methods to attach facially amphiphilic polmers to a solid support. Utility as a contact disinfectant is disclosed.
摘要翻译：公开了具有杀生物表面的具有两亲性的聚亚苯基和亚杂芳基聚合物和制品。聚合物可以抑制与表面或邻近所述杀生物表面的区域接触的微生物的生长。还公开了将表面两亲性聚合物附着在固体支持物上的方法。公开了作为接触消毒剂的效用。

6. 发明申请

WO2006132647A2 ANTIMICROBIAL COPOLYMERS AND USES THEREOF 审中-公开
标题翻译：抗微生物共聚物及其用途
公开(公告)号：WO2006132647A2
公开(公告)日：2006-12-14
申请号：PCT/US2005026188
申请日：2005-07-22
申请人： UNIV PENNSYLVANIA , KURODA KENICHI , DEGRADO WILLIAM F
发明人： KURODA KENICHI , DEGRADO WILLIAM F
IPC分类号： A61K31/765 , C08F226/06
CPC分类号： C08F2/38 , A01N33/12 , A01N37/20 , A61K31/765 , C08F2/40 , C08F2/42 , C08F220/18 , C08F220/36 , Y10T442/2525
摘要： The present invention discloses random copolymers and methods of their use, including use of the copolymers as antimicrobial agents in pharmaceutical and non-pharmaceutical applications. The present invention also discloses compositions of the copolymers, and methods of preparing the copolymers.
摘要翻译：本发明公开了无规共聚物及其使用方法，包括在药物和非药物应用中使用共聚物作为抗微生物剂。本发明还公开了共聚物的组合物，以及制备共聚物的方法。

7. 发明申请

WO2008005470A9 POLYPEPTIDES THAT BIND MEMBRANE PROTEINS 审中-公开
标题翻译：多聚蛋白膜蛋白
公开(公告)号：WO2008005470A9
公开(公告)日：2008-04-03
申请号：PCT/US2007015425
申请日：2007-06-29
申请人： UNIV PENNSYLVANIA , SLUSKY JOANNA S , YIN HANG , DEGRADO WILLIAM F
发明人： SLUSKY JOANNA S , YIN HANG , DEGRADO WILLIAM F
IPC分类号： A01N37/18 , A61K38/00
CPC分类号： C07K14/001 , A61K38/00 , C07K16/2848 , C07K2317/34 , C07K2317/76 , G01N33/6845 , G01N33/6872 , G01N2500/04
摘要： Polypeptides which bind to the helical transmembrane region of membrane proteins are disclosed, as are methods for the design of polypeptides that bind to the transmembrane region of membrane proteins. Also provided are methods for the use of the disclosed polypeptides in various applications, as well as products made through the practice of the instant methods.
摘要翻译：公开了与膜蛋白的螺旋跨膜区结合的多肽，以及设计结合膜蛋白的跨膜区的多肽的方法。还提供了在各种应用中使用所公开的多肽的方法，以及通过本方法的实践制备的产品。

8. 发明申请

WO2008005470A2 POLYPEPTIDES THAT BIND MEMBRANE PROTEINS 审中-公开
标题翻译：结合膜蛋白的多肽
公开(公告)号：WO2008005470A2
公开(公告)日：2008-01-10
申请号：PCT/US2007015425
申请日：2007-06-29
申请人： UNIV PENNSYLVANIA , SLUSKY JOANNA S , YIN HANG , DEGRADO WILLIAM F
发明人： SLUSKY JOANNA S , YIN HANG , DEGRADO WILLIAM F
IPC分类号： A61K38/16
CPC分类号： C07K14/001 , A61K38/00 , C07K16/2848 , C07K2317/34 , C07K2317/76 , G01N33/6845 , G01N33/6872 , G01N2500/04
摘要： Polypeptides which bind to the helical transmembrane region of membrane proteins are disclosed, as are methods for the design of polypeptides that bind to the transmembrane region of membrane proteins. Also provided are methods for the use of the disclosed polypeptides in various applications, as well as products made through the practice of the instant methods.
摘要翻译：公开了与膜蛋白的螺旋跨膜区结合的多肽，以及用于设计与膜蛋白的跨膜区结合的多肽的方法。还提供了在各种应用中使用所公开的多肽的方法，以及通过实施本方法制备的产品。

9. 发明申请

WO2004065363A3 COMPUTATIONAL DESIGN OF A WATER-SOLUBLE ANALOG OF A PROTEIN, SUCH AS PHOSPHOLAMBAN AND POTASSIUM CHANNEL KCSA 审中-公开
标题翻译：蛋白质，如磷酰胺和钾通道KCSA的水溶性模拟物的计算设计
公开(公告)号：WO2004065363A3
公开(公告)日：2005-05-06
申请号：PCT/US2004001317
申请日：2004-01-21
申请人： UNIV PENNSYLVANIA , SLOVIC AVRAM M , SUMMA CHRISTOPHER M , SAVEN JEFFERY G , DEGRADO WILLIAM F , KONO HIDETOSHI
发明人： SLOVIC AVRAM M , SUMMA CHRISTOPHER M , SAVEN JEFFERY G , DEGRADO WILLIAM F , KONO HIDETOSHI
IPC分类号： C07D20060101 , G01N33/48 , G01N33/50 , G06F17/50 , G06F19/16 , G06F19/18 , G06F19/00
CPC分类号： G06F19/16 , G06F19/18
摘要： Membrane proteins and water-soluble proteins share a similar core. This similarity suggests that it should be possible to water-solubilize membrane proteins by mutating only their lipid-exposed residues. Computational tools and methods are disclosed herein that can be used to design water-soluble variants of helical membrane proteins, using the pentameric phospholamban (PLB) and potassium channel KcsA as models. To water-solublize PLB, the membrane-exposed positions were changed to polar or charged amino acids, while the putative core was left unaltered. We generated water-soluble phospholamban (WSPLB), and compared its properties to its predecessor PLB. As a probe of the correctness of the fold of the water soluble KcsA, the computationally designed proteins contain an agitoxin-2 binding site from a mammalian homologue of the channel. The resulting proteins express in high yield in E. coli and share the intended functional and structural properties with KcsA, including secondary structure, tetrameric quaternary structure, and tight, specific binding to both agitoxin2 and a small molecule channel blocker.
摘要翻译：膜蛋白和水溶性蛋白质共享相似的核心。这种相似性表明，应该可以通过仅突变它们的脂质暴露残留物来水溶性膜蛋白。本文公开了可用于设计螺旋膜蛋白质的水溶性变体的计算工具和方法，其使用五聚磷酸甘油（PLB）和钾通道KcsA作为模型。为了水解PLB，将膜暴露的位置改为极性或带电荷的氨基酸，而假定的核心保持不变。我们产生了水溶性磷脂（WSPLB），并将其性能与其前身PLB进行了比较。作为水溶性KcsA的倍数的正确性的探针，计算设计的蛋白质含有来自哺乳动物同源物的通道的搅动蛋白-2结合位点。所得蛋白质在大肠杆菌中以高产率表达，并且与KcsA共享预期的功能和结构性质，包括二级结构，四聚体四级结构，以及紧密的，特异性结合于moloxin2和小分子通道阻断剂。

10. 发明申请

WO2007027742A3 SMALL MOLECULE INTEGRIN a2ßl/GPIa-IIa ANTAGONISTS 审中-公开
标题翻译：小分子INTEGRINa2ßl/ GPIa-IIa拮抗剂
公开(公告)号：WO2007027742A3
公开(公告)日：2007-12-06
申请号：PCT/US2006033819
申请日：2006-08-29
申请人： UNIV PENNSYLVANIA , CHOI SUNGWOOK , SNYDER SETH E , DEGRADO WILLIAM F , BENNETT JOEL S
发明人： CHOI SUNGWOOK , SNYDER SETH E , DEGRADO WILLIAM F , BENNETT JOEL S
IPC分类号： G01N33/53 , A61K39/00 , A61K39/395
CPC分类号： C07K5/06086 , A61K38/00 , C07K5/06113 , C07K5/06191
摘要： Novel compounds inhibiting the integrin a2ßl /GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic uses. The compounds disclosed are useful, inter alia, as inhibitors of integrin a2ßl/GPIa-IIa-mediated activity.
摘要翻译：公开了抑制整联蛋白α2β1/GPIα-IIa受体的新化合物。还公开了含有这些化合物的药物组合物，以及它们的治疗用途的方法。所公开的化合物尤其可用作整联蛋白α2β1/GPIα-IIα介导的活性的抑制剂。

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