专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1242080A4 DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE 审中-公开
标题翻译：抑制剂及其用途DOPAMINETRANSPORT
公开(公告)号：EP1242080A4
公开(公告)日：2003-01-22
申请号：EP00968417
申请日：2000-09-27
申请人： UNIV GEORGETOWN
发明人： WANG SHAOMENG , KOZIKOWSKI ALAN , SAKAMURI SUKUMAR , ENYEDY ISTIVAN , JOHNSON KEN
IPC分类号： C07D211/52 , C07D491/04 , A61K31/436 , A61K31/451 , A61P25/16 , A61P25/24 , A61P25/30 , C07D491/056
CPC分类号： C07D491/04 , C07D211/52

2. 发明公开

EP1082310A4 METHODS OF IDENTIFYING AND USING HLA BINDING COMPOUNDS AS HLA-AGONISTS AND ANTAGONISTS 审中-公开
标题翻译：方法识别并使用HLA结合的化合物AS HLA-激动剂和拮抗剂
公开(公告)号：EP1082310A4
公开(公告)日：2001-09-12
申请号：EP99918878
申请日：1999-04-29
申请人： UNIV GEORGETOWN
发明人： RICHERT JOHN R , WANG SHAOMENG , KOHLER NIKLAS , LIU MING , WU XIONG-WU , YIN DAXU
IPC分类号： A61K31/18 , A61K31/196 , A61K31/435 , A61K31/47 , A61K31/495 , A61K31/517 , A61P25/00 , A61P37/00 , C07B61/00 , C07D215/38 , C07D239/92 , C07D401/14 , C07D417/14 , G06F17/30 , G06F17/50 , G06F19/00
CPC分类号： C07D401/14 , A61K31/18 , A61K31/435 , A61K31/495 , C07D239/92 , C07D417/14

3. 发明公开

EP1161266A4 MATRIPTASE, A SERINE PROTEASE AND ITS APPLICATIONS 审中-公开
标题翻译：蛋白裂解酶，丝氨酸蛋白酶，及其用途
公开(公告)号：EP1161266A4
公开(公告)日：2007-09-19
申请号：EP00914875
申请日：2000-03-10
申请人： UNIV GEORGETOWN
发明人： DICKSON ROBERT B , LIN CHEN-YONG , JOHNSON MICHAEL , WANG SHAOMENG , ENYEDY ISTVAN
IPC分类号： C12Q1/37 , G01N33/53 , A61K36/48 , A61K38/00 , A61K38/56 , A61K45/00 , A61K49/00 , A61K51/00 , A61K51/08 , A61K51/10 , A61P1/00 , A61P17/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/09 , C12P21/08 , G01N33/573 , G01N33/577
CPC分类号： A61K49/0039 , A61K38/00 , A61K49/0056 , A61K49/0058 , A61K51/10 , C12Q1/37 , G01N33/573 , G01N2333/96433 , G01N2500/20
摘要： The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directed to a method of treating malignancies, which have the phenotype of matriptase production by administering a tumor formation inhibiting effective amount of a concentrate of Bowman-Birk inhibitor (BBIC), or other matriptase inhibitor. The invention also is directed to nucleic acids encoding a matriptase protein or fragments thereof, and their use for structure elucidation and modeling to identify other inhibitors of matriptase, as well as to methods of identifying matriptase modulating agents, including activators and inhibitors.

4. 发明申请

WO0197794A2 STRUCTURE BASED DISCOVERY OF INHIBITORS OF MATRIPTASE FOR THE TREATMENT OF CANCER AND OTHER CONDITIONS 审中-公开
标题翻译：基质结构抑制剂治疗癌症及其他病症的研究
公开(公告)号：WO0197794A2
公开(公告)日：2001-12-27
申请号：PCT/US0118773
申请日：2001-06-12
申请人： UNIV GEORGETOWN , LIN CHEN YONG , DICKSON ROBERT B , WANG SHAOMENG , ENYEDY ISTVAN , LEE SHEAU LING
发明人： LIN CHEN-YONG , DICKSON ROBERT B , WANG SHAOMENG , ENYEDY ISTVAN , LEE SHEAU-LING
IPC分类号： A61K31/155 , A61K31/341 , A61K31/404 , A61K31/505 , A61K31/655 , A61K49/00 , G01N33/574 , A61K31/00
CPC分类号： A61K31/655 , A61K31/155 , A61K31/341 , A61K31/404 , A61K31/505 , A61K49/0002 , G01N33/574 , G01N2333/96486
摘要： The present invention relates to a method of inhibiting carcinoma progression wherein matriptase plays a role in a subject in need of such inhibition including administering to a subject an effective amount of a compound comprising two positively charged groups, which are the same or different. The groups are linked by a chemical group having a length of between 5 and 30 A, and preferably between 15 and 24 A. Diagnostic methods based on matriptase action and therapeutic methods involving inhibition of matriptase activity are provided.
摘要翻译：本发明涉及一种抑制癌症进展的方法，其中底物酶在需要这种抑制的受试者中起作用，包括向受试者施用有效量的包含相同或不同的两个带正电荷的基团的化合物。这些基团通过长度为5至30A，优选15至24A的化学基团连接。提供了基于片段酶作用的诊断方法和涉及抑制matriptase活性的治疗方法。

5. 发明公开

EP1474121A4 SMALL MOLECULE ANTAGONISTS OF BCL2 FAMILY PROTEINS 有权
标题翻译：小分子拮抗剂蛋白Bcl2家族作者：
公开(公告)号：EP1474121A4
公开(公告)日：2006-05-03
申请号：EP02734614
申请日：2002-05-30
申请人： UNIV MICHIGAN , UNIV GEORGETOWN
发明人： WANG SHAOMENG , YANG DAJUN
IPC分类号： C12Q1/02 , A61K31/11 , A61K31/12 , A61K31/122 , A61K31/135 , A61K31/19 , A61K31/225 , A61K31/335 , A61K45/00 , A61K45/06 , A61P9/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P43/00
CPC分类号： A61K31/11 , A61K45/06 , A61K2300/00

6. 发明申请

WO0053232A9 MATRIPTASE, A SERINE PROTEASE AND ITS APPLICATIONS 审中-公开
标题翻译： MATRIPTASE，丝氨酸蛋白酶及其应用
公开(公告)号：WO0053232A9
公开(公告)日：2001-11-15
申请号：PCT/US0006111
申请日：2000-03-10
申请人： UNIV GEORGETOWN , DICKSON ROBERT B , LIN CHEN YONG , JOHNSON MICHAEL , WANG SHAOMENG , ENYEDY ISTVAN
发明人： DICKSON ROBERT B , LIN CHEN-YONG , JOHNSON MICHAEL , WANG SHAOMENG , ENYEDY ISTVAN
IPC分类号： G01N33/53 , A61K36/48 , A61K38/00 , A61K45/00 , A61K49/00 , A61K51/00 , A61K51/08 , A61K51/10 , A61P1/00 , A61P17/00 , A61P35/00 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/09 , C12P21/08 , C12Q1/37 , G01N33/573 , G01N33/577
CPC分类号： A61K49/0039 , A61K38/00 , A61K49/0056 , A61K49/0058 , A61K51/10 , C12Q1/37 , G01N33/573 , G01N2333/96433 , G01N2500/20
摘要： The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directed to a method of treating malignancies, which have the phenotype of matriptase production by administering a tumor formation inhibiting effective amount of a concentrate of Bowman-Birk inhibitor (BBIC), or other matriptase inhibitor. The invention also is directed to nucleic acids encoding a matriptase protein or fragments thereof, and their use for structure elucidation and modeling to identify other inhibitors of matriptase, as well as to methods of identifying matriptase modulating agents, including activators and inhibitors.
摘要翻译：本发明涉及通过检测组织中单链或双链形式的matriptase的存在来检测乳腺或其他组织或病理状况中的恶性肿瘤或恶性前病变的方法。本发明进一步涉及一种通过施用抑制有效量的Bowman-Birk抑制剂（BBIC）浓缩物或其它片剂酶抑制剂的肿瘤形成来治疗恶性肿瘤的方法，其具有基质酶产生的表型。本发明还涉及编码matriptase蛋白质或其片段的核酸，以及其用于结构阐明和建模以鉴定其它抑制剂的用途，以及鉴定片段酶调节剂（包括活化剂和抑制剂）的方法。

7. 发明申请

WO0213833A2 SMALL MOLECULE INHIBITORS TARGETED AT Bcl-2 审中-公开
标题翻译：小分子抑制剂定位于Bcl-2
公开(公告)号：WO0213833A2
公开(公告)日：2002-02-21
申请号：PCT/US0125575
申请日：2001-08-16
申请人： UNIV GEORGETOWN MED CENTER , WANG SHAOMENG , YANG DAJUN , ENYEDY ISTVAN J
发明人： WANG SHAOMENG , YANG DAJUN , ENYEDY ISTVAN J
IPC分类号： A61K31/33 , A61K31/655 , A61K31/675 , A61K31/70 , A61K33/24 , A61K45/06 , A61P35/00 , A61P35/04
CPC分类号： A61K31/655 , A61K31/675 , A61K31/70 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： A method for promotion of cell death in tumor cells using tricylo-dibenzo-diazocine-dioxides that bind to a pocket of Bcl-2 and block the Bcl-2 anti-apoptotic function. A method of use of compound of the general structural Formula (I) for use in treatment of cancer: wherein X and Y, and R and R1', and R2, R3, R4 and R5 and A and A1, have any of the values defined in the specification.
摘要翻译：使用结合Bcl-2的口袋并阻断Bcl-2抗凋亡功能的三羟甲基 - 二苯并二氮杂环己烷二氧化物促进肿瘤细胞中细胞死亡的方法。一般结构式（I）的化合物用于治疗癌症的方法：其中X和Y，以及R和R 1'以及R 2，R 3，R 4和R 5以及A和A 1具有任何值在规范中定义。

8. 发明申请

WO0010067A2 SELF-GUIDED MOLECULAR DYNAMICS SIMULATION FOR EFFICIENT CONFORMATIONAL SEARCH 审中-公开
标题翻译：自我指导分子动力学模拟有效的一致性搜索
公开(公告)号：WO0010067A2
公开(公告)日：2000-02-24
申请号：PCT/US9918302
申请日：1999-08-13
申请人： UNIV GEORGETOWN , WU XIONG WU , WANG SHAOMENG
发明人： WU XIONG-WU , WANG SHAOMENG
IPC分类号： G06F17/50 , G06F19/16 , G06F
CPC分类号： G06F19/16
摘要： A method of forming a generated conformation of a molecular system comprising generating a molecular dynamics trajectory of said molecular system, wherein said trajectory is initiated by assigning to each atom in said molecular system a set of initial parameters comprising an initial velocity vector and an initial conformation wherein each atom in said molecular system is disposed in an initial position, and wherein said molecular dynamics trajectory is propagated by a computational procedure comprising: (a) calculating a current force exerted on each atom (i) by calculating a derivative of an energy function describing interactions between said atom (i) and other atoms in said molecule; (b) determining a guiding force gi describing an average along a portion of said trajectory of a force exerted on said atom (i); (c) determining a current position and velocity of said atom (i) by ajusting said previous position and velocity according to the equation miai = fi, wherein mi is the mass of atom (i), ai is an acceleration of atom (i) and fi is a force obtained by adding said current force calculated in (a) and said guiding force determined in (b); (d) replacing said previous position and velocity of said atom (i) with said current position and velocity of said atom (i); (e) repeating steps (a) to (d) for one or more iterations to generate said trajectory; and (f) forming said generated conformation by disposing the atoms of said molecule in respective current positions obtained during a given iteration; and processing said generated conformation to determine a structural, energetic, thermodynamic or kinetic property of said molecular system.
摘要翻译：形成生成的分子系统构象的方法，包括产生所述分子系统的分子动力学轨迹，其中所述轨迹是通过将所述分子系统中的每个原子分配给初始速度矢量和初始构象的一组初始参数来启动的其中所述分子系统中的每个原子被设置在初始位置，并且其中所述分子动力学轨迹通过计算过程传播，包括：（a）通过计算能量函数的导数来计算施加在每个原子（i）上的电流力描述所述原子（i）与所述分子中的其它原子之间的相互作用; （b）确定描述沿着所述原子（i）上施加的力的所述轨迹的一部分的平均值的引导力gi; （c）根据方程miai = fi通过调整所述先前位置和速度来确定所述原子（i）的当前位置和速度，其中mi是原子（i）的质量，a i是原子（i）的加速度，并且fi是通过将在（a）中计算的所述电流力和在（b）中确定的所述引导力相加）而获得的力; （d）用所述原子（i）的当前位置和速度替换所述原子（i）的所述先前位置和速度; （e）重复步骤（a）至（d）以进行一次或多次迭代以产生所述轨迹; 和（f）通过将所述分子的原子设置在给定迭代期间获得的各个当前位置中形成所述产生的构象; 并处理所述产生的构象以确定所述分子系统的结构，能量，热力学或动力学性质。

9. 发明申请

WO2005069771A3 SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS 审中-公开
标题翻译： BCL-2家族蛋白的小分子拮抗剂
公开(公告)号：WO2005069771A3
公开(公告)日：2006-02-23
申请号：PCT/US2004040553
申请日：2004-12-06
申请人： UNIV MICHIGAN , UNIV GEORGETOWN MED CENTER , WANG SHAOMENG , YANG DAJUN
发明人： WANG SHAOMENG , YANG DAJUN
IPC分类号： C12Q1/02 , A61K31/11 , A61K31/12 , A61K31/122 , A61K31/135 , A61K31/19 , A61K31/225 , A61K31/335 , A61K45/00 , A61K45/06 , A61P9/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P43/00
CPC分类号： A61K31/11 , A61K45/06 , A61K2300/00
摘要： The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of Bcl-2 family proteins. In particular, the present invention provides gossypol compounds (
摘要翻译：本发明涉及Bcl-2家族蛋白质的天然存在和化学合成的小分子拮抗剂。特别地，本发明提供棉酚化合物（<

10. 发明申请

WO0010067A9 SELF-GUIDED MOLECULAR DYNAMICS SIMULATION FOR EFFICIENT CONFORMATIONAL SEARCH 审中-公开
标题翻译：自引导分子动力学模拟有效的一致性搜索
公开(公告)号：WO0010067A9
公开(公告)日：2001-07-12
申请号：PCT/US9918302
申请日：1999-08-13
申请人： UNIV GEORGETOWN , WU XIONG WU , WANG SHAOMENG
发明人： WU XIONG-WU , WANG SHAOMENG
IPC分类号： G06F17/50 , G06F19/16 , G06F19/00
CPC分类号： G06F19/16
摘要： A method of forming a generated conformation of a molecular system comprising generating a molecular dynamics trajectory of said molecular system, wherein said trajectory is initiated by assigning to each atom in said molecular system a set of initial parameters comprising an initial velocity vector and an initial conformation wherein each atom in said molecular system is disposed in an initial position, and wherein said molecular dynamics trajectory is propagated by a computational procedure comprising: (a) calculating a current force exerted on each atom (i) by calculating a derivative of an energy function describing interactions between said atom (i) and other atoms in said molecule; (b) determining a guiding force gi describing an average along a portion of said trajectory of a force exerted on said atom (i); (c) determining a current position and velocity of said atom (i) by ajusting said previous position and velocity according to the equation miai = fi, wherein mi is the mass of atom (i), ai is an acceleration of atom (i) and fi is a force obtained by adding said current force calculated in (a) and said guiding force determined in (b); (d) replacing said previous position and velocity of said atom (i) with said current position and velocity of said atom (i); (e) repeating steps (a) to (d) for one or more iterations to generate said trajectory; and (f) forming said generated conformation by disposing the atoms of said molecule in respective current positions obtained during a given iteration; and processing said generated conformation to determine a structural, energetic, thermodynamic or kinetic property of said molecular system.
摘要翻译：一种形成生成的分子系统构象的方法，包括产生所述分子系统的分子动力学轨迹，其中所述轨迹是通过将所述分子系统中的每个原子分配给初始速度矢量和初始构象的一组初始参数来启动的其中所述分子系统中的每个原子被设置在初始位置，并且其中所述分子动力学轨迹通过计算过程传播，包括：（a）通过计算能量函数的导数来计算施加在每个原子（i）上的电流力描述所述原子（i）与所述分子中的其它原子之间的相互作用; （b）确定描述沿着所述原子（i）上施加的力的所述轨迹的一部分的平均值的引导力gi; （c）通过根据方程miai = fi调整所述先前位置和速度来确定所述原子（i）的当前位置和速度，其中mi是原子（i）的质量，ai是原子（i）的加速度，并且fi是通过将在（a）中计算的所述电流力和在（b）中确定的所述引导力相加）而获得的力; （d）用所述原子（i）的当前位置和速度替换所述原子（i）的所述先前位置和速度; （e）重复步骤（a）至（d）以进行一次或多次迭代以产生所述轨迹; 和（f）通过将所述分子的原子设置在给定迭代期间获得的各个当前位置中形成所述产生的构象; 并处理所述产生的构象以确定所述分子系统的结构，能量，热力学或动力学性质。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式