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1. 发明申请

WO2004065450A3 BIODEGRADABLE POLYURETHANES AND USE THEREOF 审中-公开
标题翻译：生物可降解聚氨酯及其用途
公开(公告)号：WO2004065450A3
公开(公告)日：2004-12-16
申请号：PCT/US2004001200
申请日：2004-01-16
申请人： UNIV CARNEGIE MELLON , UNIV PITTSBURGH
发明人： BECKMAN ERIC J , DOLL BRUCE A , GUELCHER SCOTT A , HOLLINGER JEFFREY O , ZHANG JIANYING
IPC分类号： C08G18/12 , C08G18/32 , C08G18/34 , C08G18/38 , C08G18/48 , C08G18/64 , C08G18/66 , C08G18/77
CPC分类号： A61L27/18 , A61L27/3821 , A61L27/54 , A61L27/58 , A61L2300/43 , A61L2430/02 , C08G18/12 , C08G18/3206 , C08G18/348 , C08G18/3885 , C08G18/4833 , C08G18/6446 , C08G18/6659 , C08G18/6692 , C08G18/771 , C08G2101/00 , C08G2101/0083 , C08G2230/00 , C12N5/0654 , C12N2533/40 , C08G18/305
摘要： A biodegradable and biocompatible polyurethane composition synthesized by reacting isocyanate groups of at least one multifunctional isocyanate compound with at least one bioactive agent having at least one reactive group -X which is a hydroxyl group (-OH) or an amine group (-NH2). The polyurethane composition is biodegradable within a living organism to biocompatible degradation products including the bioactive agent. Preferably, the released bioactive agent affects at least one of biological activity or chemical activity in the host organism. A biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is preferably derived from a diurea diol or a diester diol and is preferably biodegradable into biomolecule degradation products or into biomolecule degradation products and a biocompatible diol. Another biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is derived from a diurethane diol and is biodegradable into biomolecule degradation products.
摘要翻译：通过使至少一种多官能异氰酸酯化合物的异氰酸酯基团与至少一种具有至少一个为羟基（-OH）或胺基（-NH 2）的反应性基团-X的生物活性剂反应而合成的生物可降解且生物相容的聚氨酯组合物。聚氨酯组合物在生物体内可生物降解为生物相容性降解产物，包括生物活性剂。优选地，释放的生物活性剂影响宿主生物体中的生物活性或化学活性中的至少一种。生物可降解聚氨酯组合物包含硬链段和软链段。每个硬链段优选衍生自二脲二醇或二酯二醇，并且优选可生物降解成生物分子降解产物或生物分子降解产物和生物相容性二醇。另一种可生物降解的聚氨酯组合物包含硬链段和软链段。每个硬链段都衍生自二氨基二醇，并可生物降解成生物分子降解产物。

2. 发明申请

WO2007005792A8 WOUND HEALING POLYMERIC NETWORKS 审中-公开
标题翻译：创伤治疗聚合物网络
公开(公告)号：WO2007005792A8
公开(公告)日：2008-03-27
申请号：PCT/US2006025915
申请日：2006-07-01
申请人： UNIV PITTSBURGH
发明人： BECKMAN ERIC J , BADYLAK STEPHEN F , WELLS ALAN H , ZHANG JIANYING , FREYTES DONALD
IPC分类号： A61L26/00 , A61L15/26 , A61L15/44
CPC分类号： C08G18/3821 , A61K31/28 , A61K38/39 , A61K45/06 , A61K47/59 , A61K47/60 , A61L26/0019 , A61L26/0066 , A61L26/008 , A61L2300/104 , A61L2300/214 , A61L2300/252 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/418 , C08G18/10 , C08G18/3206 , C08G18/3218 , C08G18/4833 , C08G18/771 , C08G18/8022 , C08G2230/00
摘要： A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing molecule retains the ability to undergo free radical polymerization after attachment of the bioactive agent thereto. The first polymerizing molecule is preferably biocompatible. The polymerizing molecule can, for example, be dihydroxyphenyl-L-alanine (DOPA) or tyrosine. The composition can also include a second component synthesized by reacting at least one core molecule having a plurality of reactive hydrogen groups with at least one multi-isocyanate functional molecule to create a conjugate including terminal isocyanate groups. The conjugate molecule is reacted with a second polymerizing molecule that is adapted to undergo a free radical polymerization. The second polymerizing molecule includes a reactive hydrogen to react with the isocyanate groups of the conjugate. The second polymerizing molecule retains the ability to undergo the free radical polymerization after reaction with the conjugate. In several embodiments, the first polymerizing molecule and the second polymerizing molecule are the same and dihydroxyphenyl-L-alanine (DOPA) or tyrosine.
摘要翻译：组合物包含共价连接到适于进行自由基聚合的第一聚合分子的至少一种生物活性剂。第一聚合分子保留在生物活性剂附着后进行自由基聚合的能力。第一聚合分子优选是生物相容的。聚合分子可以是例如二羟基苯基-L-丙氨酸（DOPA）或酪氨酸。组合物还可以包括通过使具有多个反应性氢基团的至少一个核心分子与至少一个多异氰酸酯官能分子反应以产生包含末端异氰酸酯基团的缀合物而合成的第二组分。共轭分子与适于进行自由基聚合的第二聚合分子反应。第二聚合分子包括与偶联物的异氰酸酯基反应的反应性氢。第二聚合分子保留在与缀合物反应后进行自由基聚合的能力。在几个实施方案中，第一聚合分子和第二聚合分子是相同的，并且是二羟基苯基-L-丙氨酸（DOPA）或酪氨酸。

3. 发明申请

WO2007089628A3 MEDICAL ADHESIVE AND METHODS OF TISSUE ADHESION 审中-公开
标题翻译：医用粘合剂和组织粘合方法
公开(公告)号：WO2007089628A3
公开(公告)日：2008-02-21
申请号：PCT/US2007002245
申请日：2007-01-26
申请人： UNIV PITTSBURGH
发明人： BECKMAN ERIC J , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00
CPC分类号： C09J175/04 , A61L24/0042 , A61L24/04 , A61L24/046 , C08G18/1808 , C08G18/1833 , C08G18/227 , C08G18/246 , C08G18/307 , C08G18/3206 , C08G18/771 , C08G18/8025 , C08L75/04
摘要： A method of adhering biological tissue that includes applying a bio-degradable adhesive to the tissue. The adhesive includes a moisture-curable, isocyanate-functional component prepared by reacting (a) a multi-functional isocyanate component and (b) a multi-functional active hydrogen component that includes at least 30% by weight, based upon the total weight of the multi-functional active hydrogen component, of a multi-functional active hydrogen reactant having an equivalent weight less than 100. The ratio R of active hydrogen groups to isocyanate groups can be less than 1.0.
摘要翻译：一种粘附生物组织的方法，包括将生物可降解粘合剂施用于组织。粘合剂包括可湿气固化的异氰酸酯官能组分，其通过使（a）多官能异氰酸酯组分和（b）多官能活性氢组分反应制备，所述多官能活性氢组分包含至少30重量％具有当量重量小于100的多功能活性氢反应物的多官能活性氢组分。活性氢基团与异氰酸酯基团的比率R可以小于1.0。

4. 发明专利

AU2004320265B2 Medical adhesive and methods of tissue adhesion 未知
公开(公告)号：AU2004320265B2
公开(公告)日：2011-03-03
申请号：AU2004320265
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BUCKLEY MICHAEL , BECKMAN ERIC J , AGARWAL SUDHA , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00 , C08G18/00
摘要： An adhesive including a mixture of isocyanate capped molecules formed by reacting multi-isocyanate functional molecules with multi-functional precursor molecules including terminal functional groups selected from the group consisting of a hydroxyl group, a primary amino group and a secondary amino group. Preferably, the functional groups are hydroxyl groups. The multi-functional precursor compounds are biocompatible. Multiamine functional precursors of the multi-isocyanate functional molecules are also biocompatible. As discussed, above, the mixture of molecules preferably has an average isocyanate functionality of at least 2.1 and, more preferably, has an average isocyanate functionality of at least 2.5. As also described above, the mixture of molecules preferably has a viscosity in the range of approximately 1 to approximately 100 centipoise. The mixture of molecules forms a crosslinked polymer network upon contact with the organic tissue in the presence of water. The crosslinked polymer network is biocompatible and biodegradable. The crosslinked polymer network degrades into degradation products including the precursor molecules and the multi-amine functional precursors.

5. 发明专利

BRPI0418804A 未知
公开(公告)号：BRPI0418804A
公开(公告)日：2007-10-16
申请号：BRPI0418804
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BECKMAN ERIC J , BUCKLEY MICHAEL , AGARWAL SUDHA , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00 , C08G18/00

6. 发明专利

CA2576223C A MOISTURE CURABLE, ISOCYANATE-FUNCTIONAL MEDICAL ADHESIVE AND METHODS OF TISSUE ADHESION 未知
公开(公告)号：CA2576223C
公开(公告)日：2013-10-08
申请号：CA2576223
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BECKMAN ERIC J , BUCKLEY MICHAEL , AGARWAL SUDHA , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00 , C08G18/00
摘要： An adhesive including a mixture of isocyanate capped molecules formed by reacting multi-isocyanate functional molecules with multi-functional precursor molecules including terminal functional groups selected from the group consisting of a hydroxyl group, a primary amino group and a secondary amino group. Preferably, the functional groups are hydroxyl groups. The multi-functional precursor compounds are biocompatible. Multiamine functional precursors of the multi-isocyanate functional molecules are also biocompatible. As discussed, above, the mixture of molecules preferably has an average isocyanate functionality of at least 2.1 and, more preferably, has an average isocyanate functionality of at least 2.5. As also described above, the mixture of molecules preferably has a viscosity in the range of approximately 1 to approximately 100 centipoise. The mixture of molecules forms a crosslinked polymer network upon contact with the organic tissue in the presence of water. The crosslinked polymer network is biocompatible and biodegradable. The crosslinked polymer network degrades into degradation products including the precursor molecules and the multi-amine functional precursors.

7. 发明专利

NZ570477A Medical adhesive and methods of tissue adhesion 未知
公开(公告)号：NZ570477A
公开(公告)日：2011-07-29
申请号：NZ57047707
申请日：2007-01-26
申请人： UNIV PITTSBURGH
发明人： BECKMAN ERIC J , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00
摘要： Disclosed is the use of a biodegradable, moisture-curable isocyanate-functional composition in the manufacture of an adhesive for adhering biological tissue, the isocyanate functional composition comprising the reaction product of: (a) a multi-functional isocyanate component having an average functionality of h, wherein h is at least 2; and (b) a multi-functional active hydrogen component comprising at least 30 percent by weight, based upon the total weight of the multi-functional active hydrogen component, of a multi-functional active hydrogen reactant having an equivalent weight (equivalent weight divided by hydroxyl functionality) less than 100, wherein a ratio R of active hydrogen groups to isocyanate groups is selected such that l/h

8. 发明专利

CA2576223A1 MEDICAL ADHESIVE AND METHODS OF TISSUE ADHESION 未知
公开(公告)号：CA2576223A1
公开(公告)日：2005-12-15
申请号：CA2576223
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BECKMAN ERIC J , AGARWAL SUDHA , BUCKLEY MICHAEL , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00 , C08G18/00

9. 发明专利

AU2004320265A1 Medical adhesive and methods of tissue adhesion 未知
公开(公告)号：AU2004320265A1
公开(公告)日：2005-12-15
申请号：AU2004320265
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BUCKLEY MICHAEL , BECKMAN ERIC J , AGARWAL SUDHA , ZHANG JIANYING
IPC分类号： A61L24/04 , A61L24/00 , C08G18/00

10. 发明专利

NZ550970A Medical adhesive and methods of tissue adhesion 未知
公开(公告)号：NZ550970A
公开(公告)日：2010-01-29
申请号：NZ55097004
申请日：2004-05-27
申请人： UNIV PITTSBURGH
发明人： BECKMAN ERIC J , BUCKLEY MICHAEL , AGARWAL SUDHA , ZHANG JIANYING
IPC分类号： C08G18/00 , A61L24/00 , A61L24/04
摘要： Disclosed is the use of a moisture-curable, isocyanate-functional composition in the manufacture of an adhesive for adhering tissue, the isocyanate-functional composition comprising the reaction product of a reaction mixture consisting essentially of: (a) a stoichiometric excess of multi-isocyanate functional molecules derived from multi-functional amino acid precursors; and (b) a multi-functional reactant selected from the group consisting of a saccharide, a polysaccharide, a steroid, glycerol, ascorbic acid, an amino acid, and combinations thereof, the multi-functional reactant having at least two isocyanate-reactive functional groups, wherein the reaction product has an average isocyanate functionality of at least 2.1.

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