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1. 发明授权

US08795348B2 Medical devices and related methods 有权
标题翻译：医疗器械及相关方法
公开(公告)号：US08795348B2
公开(公告)日：2014-08-05
申请号：US11152555
申请日：2005-06-14
申请人： Jan Weber , Thomas J. Holman , Scott Schewe
发明人： Jan Weber , Thomas J. Holman , Scott Schewe
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61F2/95 , A61F2/91 , A61F2/958 , A61F2210/0033 , A61F2220/005 , A61F2220/0058 , A61F2250/0018 , A61F2250/0068 , A61M25/09 , A61M25/1006 , A61M25/10186 , A61M2025/1015 , A61M2025/105 , A61M2025/1056 , A61M2025/1068 , A61M2025/1086 , A61M2025/1093
摘要： A medical system including an elongate member and an elongate element associated with the elongate member so that a shape of the elongate member can be altered upon applying energy to the element.
摘要翻译：一种医疗系统，包括细长构件和与细长构件相关联的细长元件，使得在向元件施加能量时可以改变细长构件的形状。

2. 发明授权

US07491188B2 Reinforced and drug-eluting balloon catheters and methods for making same 有权
标题翻译：加强和药物洗脱球囊导管及其制作方法
公开(公告)号：US07491188B2
公开(公告)日：2009-02-17
申请号：US10963272
申请日：2004-10-12
申请人： Thomas J. Holman , Jan Weber , Scott Schewe
发明人： Thomas J. Holman , Jan Weber , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61M25/1029 , A61M25/10 , A61M25/1002 , A61M25/1034 , A61M25/1038 , A61M2025/0058 , A61M2025/1031 , A61M2025/105 , A61M2025/1084
摘要： The present invention generally relates to the field of intravascular medical devices, and more specifically to the field of balloon catheters and other similar diagnostic or therapeutic catheters within the body for treatment and diagnosis of diseases. In particular, the present invention relates to reinforced balloon catheters and drug-eluting balloon catheters and corresponding methods for producing same.
摘要翻译：本发明一般涉及血管内医疗装置的领域，更具体地涉及用于治疗和诊断疾病的体内气囊导管和其它类似的诊断或治疗导管领域。特别地，本发明涉及增强气囊导管和药物洗脱球囊导管及其相应的制造方法。

3. 发明申请

US20110046539A1 INTERNAL MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH A SOURCE OF ELECTRICAL POWER 有权
标题翻译：用于与电力来源连接的治疗药物的内部医疗装置
公开(公告)号：US20110046539A1
公开(公告)日：2011-02-24
申请号：US12939363
申请日：2010-11-04
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

4. 发明申请

US20080262412A1 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 有权
标题翻译：用于与电力源一起递送治疗剂的内部医疗装置
公开(公告)号：US20080262412A1
公开(公告)日：2008-10-23
申请号：US12077603
申请日：2008-03-20
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30 , A61M25/10
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

5. 发明授权

US08152759B2 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 有权
标题翻译：用于与电力源一起递送治疗剂的内部医疗装置
公开(公告)号：US08152759B2
公开(公告)日：2012-04-10
申请号：US12077603
申请日：2008-03-20
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

6. 发明授权

US08070718B2 Medical devices formed with a sacrificial structure and processes of forming the same 有权
标题翻译：用牺牲结构形成的医疗器械及其形成方法
公开(公告)号：US08070718B2
公开(公告)日：2011-12-06
申请号：US11010810
申请日：2004-12-13
申请人： Jan Weber , Scott Schewe , Thomas J. Holman
发明人： Jan Weber , Scott Schewe , Thomas J. Holman
IPC分类号： A61M29/00 , B29C33/40
CPC分类号： A61M25/1029 , A61M25/0009 , A61M25/0045 , A61M25/1036 , A61M25/104 , A61M2025/1075 , A61M2025/1086
摘要： Medical devices formed using a sacrificial structure, and processes of forming the devices therefrom.
摘要翻译：使用牺牲结构形成的医疗器械，以及由其形成器件的工艺。

7. 发明授权

US07850645B2 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 失效
标题翻译：用于与电力源一起递送治疗剂的内部医疗装置
公开(公告)号：US07850645B2
公开(公告)日：2010-12-14
申请号：US11055930
申请日：2005-02-11
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

8. 发明授权

US08538515B2 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 有权
标题翻译：用于与电力源一起递送治疗剂的内部医疗装置
公开(公告)号：US08538515B2
公开(公告)日：2013-09-17
申请号：US12939363
申请日：2010-11-04
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

9. 发明授权

US07264458B2 Process and apparatus for forming medical device balloons 有权
标题翻译：用于形成医疗装置气囊的方法和装置
公开(公告)号：US07264458B2
公开(公告)日：2007-09-04
申请号：US10753043
申请日：2004-01-07
申请人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
发明人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
IPC分类号： B29C49/64
CPC分类号： A61M25/1029 , B29C49/6445 , B29L2031/7542
摘要： Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.
摘要翻译：医疗装置气囊由管状型坯通过工艺或装置形成，该方法或装置在径向膨胀开始的型坯上建立受控的位置（起始区）。在起始区域内的起始是通过将该位置的型坯加热到比型坯的其余部分高的至少一部分吹制时间的温度来实现的。提供了各种装置配置，其中一些允许容易重新配置启动区域的大小和位置。气球也可以改装，后吹，使用加热装置和方法描述。

10. 发明申请

US20090096134A1 Process and Apparatus for Forming Medical Device Balloons 有权
标题翻译：用于形成医疗器械气球的过程和装置
公开(公告)号：US20090096134A1
公开(公告)日：2009-04-16
申请号：US12336073
申请日：2008-12-16
申请人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
发明人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
IPC分类号： B29C44/02
CPC分类号： A61M25/1029 , B29C49/6445 , B29L2031/7542
摘要： Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.
摘要翻译：医疗装置气囊由管状型坯通过工艺或装置形成，该方法或装置在径向膨胀开始的型坯上建立受控的位置（起始区）。在起始区域内的起始是通过将该位置的型坯加热到比型坯的其余部分高的至少一部分吹制时间的温度来实现的。提供了各种装置配置，其中一些允许容易重新配置启动区域的大小和位置。气球也可以改装，后吹，使用加热装置和方法描述。

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