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1. 发明申请

US20120020944A1 USE OF A PROBIOTIC TO REGULATE BODY WEIGHT 审中-公开
标题翻译：使用生物来调节体重
公开(公告)号：US20120020944A1
公开(公告)日：2012-01-26
申请号：US13256818
申请日：2010-03-24
申请人： Thomas Dyrmann Leser , Thomas Gunnarsson , Jens Kildsgaard , Janni Wandahl Pedersen , Bénédicte Flambard
发明人： Thomas Dyrmann Leser , Thomas Gunnarsson , Jens Kildsgaard , Janni Wandahl Pedersen , Bénédicte Flambard
IPC分类号： A61K35/74 , A61P3/04 , A61P1/00 , A61P1/14 , C12N1/20 , A61P3/10
CPC分类号： A61K35/742 , A61K8/99 , A61K31/702 , A61K35/747 , A61K45/06 , A61Q19/06 , C12R1/225
摘要： The use of probiotic bacteria that modulate expression of a number of satiety markers in the intestine and reduces fat deposition to promote an optimal body weight of a mammal is described. The invention further relates to a composition comprising such a probiotic strain of bacteria and/or a fraction of said strain and/or metabolite of said strain for the preparation of a composition for administration to a mammal for promoting an optimal body weight of a mammal.
摘要翻译：描述了使用调节许多饱腹感标记物在肠中的表达并减少脂肪沉积以促进哺乳动物的最佳体重的益生菌。本发明还涉及一种组合物，其包含这样的益生菌菌株和/或所述菌株的所述菌株和/或代谢物的级分，用于制备用于给哺乳动物施用哺乳动物的最佳体重的组合物。

2. 发明申请

US20120027737A1 USE OF PROBIOTICS TO AMELIORATE DIET-INDUCED INSULIN RESISTANCE 审中-公开
标题翻译：使用益生菌来改善胰岛素诱导的胰岛素抵抗
公开(公告)号：US20120027737A1
公开(公告)日：2012-02-02
申请号：US13256852
申请日：2010-03-19
申请人： Thomas Dyrmann Leser , Thomas Gunnarsson , Jens Kildsgaard , Janni Wandahl Pedersen , Bénédicte Flambard
发明人： Thomas Dyrmann Leser , Thomas Gunnarsson , Jens Kildsgaard , Janni Wandahl Pedersen , Bénédicte Flambard
IPC分类号： A61K35/74 , A61P1/14 , A61P1/00 , C12N1/20 , A61P3/04
CPC分类号： A61K35/747 , A23L33/135 , A23V2002/00 , A23V2200/3204 , A23V2200/328
摘要： The invention relates to the use of a composition comprising probiotic bacteria that regulate expression of key components involved in diet-induced insulin resistance for ameliorating or preventing diet-induced insulin resistance. The use of the probiotic strain and/or a fraction of said strain and/or metabolite of said strain for the manufacture of a medicament or a food or feed product to ameliorate diet-induced insulin resistance and help to obtain optimal body weight of a mammal is disclosed. Preferably, the composition comprises at least one probiotic Lactobacillus acidophilus strain and/or a fraction of said strain and/or metabolite of said strain for ameliorating or preventing diet-induced insulin resistance, said composition characterized by up-regulating expression of the ANGPTL4 gene encoding for FIAF in the intestine, down-regulating expression of the Elovl6 gene in the intestine as well as down-regulating expression of the SCD1 gene in skeletal muscles of a mammal, and wherein the probiotic strain is selected from the group of strains consisting of Lactobacillus acidophilus strain LA-5 (DSM13241).
摘要翻译：本发明涉及包含调节饮食诱导的胰岛素抵抗的关键成分的表达以改善或预防饮食诱导的胰岛素抵抗的益生菌的组合物的用途。益生菌菌株和/或所述菌株和/或所述菌株的代谢物的一部分用于制造药物或食品或饲料产品以改善饮食诱导的胰岛素抵抗并有助于获得哺乳动物的最佳体重被披露。优选地，组合物包含至少一种益生菌嗜酸乳杆菌菌株和/或所述菌株和/或所述菌株的代谢物的级分，用于改善或预防饮食诱导的胰岛素抵抗，所述组合物的特征在于上调编码的ANGPTL4基因的表达用于肠内的FIAF，下调Elovl6基因在肠中的表达，以及下调哺乳动物骨骼肌中SCD1基因的表达，其中益生菌菌株选自乳杆菌属嗜酸菌菌株LA-5（DSM13241）。

3. 发明申请

US20110177034A1 PROBIOTIC BIFIDOBACTERIUM LONGUM 审中-公开
标题翻译：生物双歧杆菌LONGUM
公开(公告)号：US20110177034A1
公开(公告)日：2011-07-21
申请号：US13002968
申请日：2009-07-06
申请人： Jens Kildsgaard , Thomas Dyrmann Leser , Thomas Gunnarsson , Mette Weise , Ditte Marie Folkenberg , Thomas Janzen , Benedicte Flambard
发明人： Jens Kildsgaard , Thomas Dyrmann Leser , Thomas Gunnarsson , Mette Weise , Ditte Marie Folkenberg , Thomas Janzen , Benedicte Flambard
IPC分类号： A61K35/74 , C12N1/20 , C08B37/00 , A61P29/00 , A61P1/00
CPC分类号： A61K35/745 , A23L33/135 , C12P19/04 , C12R1/01 , Y02A50/473 , Y02A50/481
摘要： The invention relates to novel, probiotic, anti-inflammatory strains of Bifidobacterium longum, their use for treatment of diseases, and for preparation of human or pet food or pharmaceutical compositions. The strains produce high amounts of exopolysaccharides with a high content of mannose- and glucose residues. Accordingly, the invention also relates to a bacterial polysaccharide composition obtained from the strains, their use for treatment of diseases, and pharmaceutical compositions comprising such polysaccharides.
摘要翻译：本发明涉及长双歧杆菌的新型益生菌抗炎菌株，其用于治疗疾病的用途，以及人或宠物食品或药物组合物的制备。菌株产生大量甘露糖和葡萄糖残留量的胞外多糖。因此，本发明还涉及从菌株获得的细菌多糖组合物，其用于治疗疾病的用途，以及包含这种多糖的药物组合物。

4. 发明申请

US20120003351A1 BILE RESISTANT BACILLUS COMPOSITION SECRETING HIGH LEVELS OF ESSENTIAL AMINO ACIDS 有权
标题翻译：耐药性微生物组合物分泌高水平的基本氨基酸
公开(公告)号：US20120003351A1
公开(公告)日：2012-01-05
申请号：US13139938
申请日：2009-12-16
申请人： Mette Dines Cantor , Patrick Derkx , Inge Knap , Ane Knarreborg , Thomas Dyrmann Leser , Lund Bente
发明人： Mette Dines Cantor , Patrick Derkx , Inge Knap , Ane Knarreborg , Thomas Dyrmann Leser , Lund Bente
IPC分类号： C12N1/20 , A23K1/16 , C40B20/00
CPC分类号： A61K35/742 , A23K10/16 , A23K50/10 , A23K50/30 , A23K50/40 , A23K50/75 , A23K50/80 , A23L33/135 , C12N1/20 , C12N1/36 , C12R1/125 , C12R1/25
摘要： A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by high-level secretion of essential amino acid. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.
摘要翻译：一种芽孢杆菌组合物，其特征在于胆汁盐（模拟肠道环境）的快速发芽和生长以及必需氨基酸的高水平分泌。芽孢杆菌组合物可以用作动物饲料中的补充物，其中它具有益生菌（促进健康）作用并且增加动物饲料中营养物质的消化和可利用性。

5. 发明授权

US08334123B2 Bile resistant Bacillus composition secreting high levels of phytase 有权
标题翻译：耐胆汁性芽孢杆菌组合物分泌高水平的植酸酶
公开(公告)号：US08334123B2
公开(公告)日：2012-12-18
申请号：US12667215
申请日：2008-06-11
申请人： Inge Knap , Ane Knarreborg , Thomas Dyrmann Leser , Bente Lund
发明人： Inge Knap , Ane Knarreborg , Thomas Dyrmann Leser , Bente Lund
IPC分类号： C12P1/04
CPC分类号： C12N1/20 , A23K10/18 , A23K50/30 , A23K50/75 , A23K50/80 , A23L27/203 , C12N15/01 , C12R1/125
摘要： A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by high-level secretion of phytase. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.
摘要翻译：一种芽孢杆菌组合物，其特征在于胆汁盐（模拟肠道环境）的快速发芽和生长以及植酸酶的高水平分泌。芽孢杆菌组合物可以用作动物饲料中的补充物，其中它具有益生菌（促进健康）作用并且增加动物饲料中营养物质的消化和可利用性。

6. 发明授权

US08741280B2 Bile resistant Bacillus composition secreting high levels of essential amino acids 有权
标题翻译：抗胆汁性芽孢杆菌组合物分泌高水平的必需氨基酸
公开(公告)号：US08741280B2
公开(公告)日：2014-06-03
申请号：US13139938
申请日：2009-12-16
申请人： Mette Dines Cantor , Patrick Derkx , Inge Knap , Ane Knarreborg , Thomas Dyrmann Leser , Lund Bente
发明人： Mette Dines Cantor , Patrick Derkx , Inge Knap , Ane Knarreborg , Thomas Dyrmann Leser , Lund Bente
IPC分类号： C12N1/20 , A61K35/74 , C12R1/25
CPC分类号： A61K35/742 , A23K10/16 , A23K50/10 , A23K50/30 , A23K50/40 , A23K50/75 , A23K50/80 , A23L33/135 , C12N1/20 , C12N1/36 , C12R1/125 , C12R1/25
摘要： A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by high-level secretion of essential amino acid. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.
摘要翻译：一种芽孢杆菌组合物，其特征在于胆汁盐（模拟肠道环境）的快速发芽和生长以及必需氨基酸的高水平分泌。芽孢杆菌组合物可以用作动物饲料中的补充物，其中它具有益生菌（促进健康）作用并且增加动物饲料中营养物质的消化和可利用性。

7. 发明申请

US20100247706A1 BILE RESISTANT BACILLUS COMPOSITION SECRETING HIGH LEVELS OF PHYTASE 有权
标题翻译：耐药性微生物组合物分泌高水平的PHYTASE
公开(公告)号：US20100247706A1
公开(公告)日：2010-09-30
申请号：US12667215
申请日：2008-06-11
申请人： Inge Knap , Ane Knarreborg , Thomas Dyrmann Leser , Bente Lund
发明人： Inge Knap , Ane Knarreborg , Thomas Dyrmann Leser , Bente Lund
IPC分类号： A23K1/18 , C12N1/20 , C40B30/00
CPC分类号： C12N1/20 , A23K10/18 , A23K50/30 , A23K50/75 , A23K50/80 , A23L27/203 , C12N15/01 , C12R1/125
摘要： A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by high-level secretion of phytase. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.
摘要翻译：一种芽孢杆菌组合物，其特征在于胆汁盐（模拟肠道环境）的快速发芽和生长以及植酸酶的高水平分泌。芽孢杆菌组合物可以用作动物饲料中的补充物，其中它具有益生菌（促进健康）作用并且增加动物饲料中营养物质的消化和可利用性。

8. 发明授权

US08802079B2 Bile resistant Bacillus composition 有权
标题翻译：抗胆汁芽孢杆菌成分
公开(公告)号：US08802079B2
公开(公告)日：2014-08-12
申请号：US13139894
申请日：2009-12-16
申请人： Inge Knap , Ane Knarreborg , Thomas Dyrmann Leser , Lund Bente , Mette Dines Cantor , Patrick Derkx
发明人： Inge Knap , Ane Knarreborg , Thomas Dyrmann Leser , Lund Bente , Mette Dines Cantor , Patrick Derkx
IPC分类号： A01N63/00 , C12N1/20 , C12P1/04
CPC分类号： C12R1/125 , A23K10/18 , A23K20/00 , A23L33/135 , A23V2002/00 , C12N1/20 , C12N15/01
摘要： A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by producing a compound of interest. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.
摘要翻译：一种芽孢杆菌组合物，其特征在于在胆汁盐（模拟肠道环境）中快速发芽和生长，并产生感兴趣的化合物。芽孢杆菌组合物可以用作动物饲料中的补充物，其中它具有益生菌（促进健康）作用并且增加动物饲料中营养物质的消化和可利用性。

9. 发明申请

US20110262584A1 BILE RESISTANT BACILLUS COMPOSITION 有权
标题翻译：耐双歧杆菌组合物
公开(公告)号：US20110262584A1
公开(公告)日：2011-10-27
申请号：US13139894
申请日：2009-12-16
申请人： Inge Knap , Ane Knarreborg , Thomas Dyrmann Leser , Lund Bente , Mette Dines Cantor , Patrick Derkx
发明人： Inge Knap , Ane Knarreborg , Thomas Dyrmann Leser , Lund Bente , Mette Dines Cantor , Patrick Derkx
IPC分类号： C12N1/20 , A23K1/18 , A23K1/16 , C12Q1/02
CPC分类号： C12R1/125 , A23K10/18 , A23K20/00 , A23L33/135 , A23V2002/00 , C12N1/20 , C12N15/01
摘要： A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by producing a compound of interest. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.
摘要翻译：一种芽孢杆菌组合物，其特征在于胆汁盐（模拟肠道环境）中快速发芽和生长，并产生感兴趣的化合物。芽孢杆菌组合物可以用作动物饲料中的补充物，其中它具有益生菌（促进健康）作用并且增加动物饲料中营养物质的消化和可利用性。

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