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1. 发明申请

WO2020068321A1 STOMA SITE PROTECTION DEVICES AND METHODS 审中-公开
公开(公告)号：WO2020068321A1
公开(公告)日：2020-04-02
申请号：PCT/US2019/047658
申请日：2019-08-22
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： BLUMROSEN, Eric Yudelevich , WILLIAMS, Andrew G. , GAO, Shengqiang
IPC分类号： A61J15/00 , A61M25/02 , A61M25/16 , A61M25/18 , A61M31/00 , A61M39/00
摘要： Stoma site protection devices, kits, assemblies and methods are provided that prevent or minimize leakage from a stoma. A stoma site protection device includes a conformal plug that can adapt to the stoma track. Kits and assemblies include additional components such as flexible external bumpers and bandages that provide multiple sealing of the stoma.

2. 发明申请

WO2016106185A1 APPARATUS AND METHOD FOR ASSISTING WITH WOUND CLOSURE 审中-公开
标题翻译：用于围绕闭合的辅助和方法
公开(公告)号：WO2016106185A1
公开(公告)日：2016-06-30
申请号：PCT/US2015/067027
申请日：2015-12-21
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： YANAVITSKI, Marat , GAO, Shengqiang , JUNG, Eugene , KOLOSI, William
IPC分类号： A61B46/20 , A61F13/02
CPC分类号： A61F13/0236 , A61B2046/205 , A61B2090/3937 , A61B2090/3966 , A61F2013/006
摘要： An apparatus for assisting with wound closure includes oppositely disposed, and oppositely facing, proximal and distal surfaces separated by an apparatus body. The distal surface is configured for selective attachment to a patient tissue surface. At least one of the proximal surface, the distal surface, and the apparatus body is made substantially from an polymeric material. The polymeric material includes a structurally incorporated ability to self-repair damage caused by mechanical usage over time. A method of assisting with wound closure is also provided.
摘要翻译：用于辅助伤口闭合的装置包括由装置主体分离的相对设置的相对面对的近侧和远侧表面。远端表面构造成用于选择性地附接到患者组织表面。近端表面，远端表面和装置主体中的至少一个基本上由聚合物材料制成。聚合物材料包括结构上并入的自我修复由于机械使用而造成的损坏的能力。还提供了一种辅助伤口闭合的方法。

3. 发明申请

WO2012170331A1 CATHETER ASSEMBLY 审中-公开
标题翻译：导管总成
公开(公告)号：WO2012170331A1
公开(公告)日：2012-12-13
申请号：PCT/US2012/040684
申请日：2012-06-04
申请人： THE CLEVELAND CLINIC FOUNDATION , PARKER-HANNIFIN CORPORATION , VOGELBAUM, Michael, A. , CHEN, Ji-feng , GAO, Shengqiang , COLLINSON, Michael , GUTHRIE, Robert, B.
发明人： VOGELBAUM, Michael, A. , CHEN, Ji-feng , GAO, Shengqiang , COLLINSON, Michael , GUTHRIE, Robert, B.
IPC分类号： A61M25/00 , A61M25/01
CPC分类号： A61M25/0102 , A61M25/003 , A61M25/0054 , A61M25/0082 , A61M25/1002 , A61M2025/0024 , A61M2025/0039 , A61M2025/0057 , A61M2025/0096 , A61M2025/0175 , A61M2025/105 , A61M2025/1086 , A61M2025/1093 , A61M2210/0693
摘要： A catheter assembly comprises a first catheter including, a wall with an inner surface at least partially defining a lumen. A second catheter is connected to the wall of the first catheter and is disposed outward of the inner surface of the wall. The second catheter is at least partially covered by a sheath portion of the first catheter. A first portion of the wall of the first catheter is made of a relatively low durometer elastomeric material and is relatively extensible. A second portion of the wall is formed of a relatively high durometer elastomeric material, and is relatively inextensible.
摘要翻译：导管组件包括第一导管，其包括具有至少部分地限定内腔的内表面的壁。第二导管连接到第一导管的壁并设置在壁的内表面的外侧。第二导管至少部分被第一导管的鞘部覆盖。第一导管的壁的第一部分由相对较低硬度的弹性体材料制成并且是相对可延展的。壁的第二部分由相对高的硬度弹性体材料形成，并且是相对不可延展的。

4. 发明申请

WO2018191589A1 TISSUE LIGATION DEVICES AND METHODS FOR LIGATING TISSUE 审中-公开
公开(公告)号：WO2018191589A1
公开(公告)日：2018-10-18
申请号：PCT/US2018/027441
申请日：2018-04-13
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： ZEIN, Nizar , GAO, Shengqiang
IPC分类号： A61B17/12
CPC分类号： A61B17/12013 , A61B17/0467 , A61B2017/0034 , A61B2017/00557 , A61B2017/00566 , A61B2017/00734 , A61B2017/00818 , A61B2017/00862 , A61B2017/00867 , A61B2017/00902 , A61B2017/306
摘要： Tissue ligation devices and methods are provides to mechanically strangulate abnormal or undesirable tissue. Tissue ligation devices include a catheter having an outer diameter smaller than the inner diameter of a standard endoscope channel such that the catheter can be inserted into the endoscope. Tissue ligation devices also include a ligation system with an expandable hood disposed located at the distal end of the catheter. A suture extends through a lumen of the catheter and has a distal loop portion exposed outside of the expandable hood.

5. 发明申请

WO2013009614A2 SYSTEM AND METHOD FOR WOUND HEALING 审中-公开
标题翻译：用于治疗的系统和方法
公开(公告)号：WO2013009614A2
公开(公告)日：2013-01-17
申请号：PCT/US2012/045743
申请日：2012-07-06
申请人： THE CLEVELAND CLINIC FOUNDATION , PAPAY, Francis, A. , CHEN, Ji-Feng , GAO, Shengqiang
发明人： PAPAY, Francis, A. , CHEN, Ji-Feng , GAO, Shengqiang
IPC分类号： A61F5/30
CPC分类号： A61N1/0468 , A61F13/00068 , A61F13/0216 , A61M1/0084 , A61M1/0088 , A61M35/00 , A61M2202/0208 , A61M2205/054 , A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/30 , A61N1/303 , A61N1/32 , A61N1/325
摘要： A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between, the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode.
摘要翻译：提供一种用于治愈伤口的系统。该系统包括柔性体，治疗剂递送机构，抽吸机构和电源。柔性体包括具有相对设置的限定隔室的第一和第二表面的覆盖膜。隔室包括第一多孔材料，第二多孔材料和设置在其中的至少一个电极。第二多孔材料设置在第一多孔材料和至少一个电极之间。治疗剂输送机构和吸引机构流体地连接到隔室。电源与至少一个电极电连通。

6. 发明申请

WO2022236021A1 ARTICULATED ENDOSCOPIC INSTRUMENT 审中-公开
公开(公告)号：WO2022236021A1
公开(公告)日：2022-11-10
申请号：PCT/US2022/028027
申请日：2022-05-06
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： ERIM, Tolga , GAO, Shengqiang , ERIM, Tanju
IPC分类号： A61B17/29 , A61B18/14 , A61B17/12 , A61B17/3205 , A61B17/00
摘要： An endoscopic instrument (10) containing a retractable tool (150, 152, 154) at its end that is articulated by engaging an actuator that moves pull wires (190) to angularly move the tip of the instrument along a plane for conducting a procedure at a target site. The tool (150, 152, 154) of instrument is linearly move from an extension position to a retracted position by another actuator. The instrument provide rotational control of the tool (150, 152, 154) and instrument tip portion (70) with a rotational actuator for rotating housings that carry both pull wires (190) and a conducting wire (160) connected to the tool (150, 152, 154).

7. 发明申请

WO2016014464A1 CONVECTION ENHANCED DELIVERY DEVICE AND SYSTEM 审中-公开
标题翻译：对流增强装置和系统
公开(公告)号：WO2016014464A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/041249
申请日：2015-07-21
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： VOGELBAUM, Michael A. , GAO, Shengqiang , KOLOSI, William
IPC分类号： A61M25/00 , A61M37/00 , A61M5/142 , A61M39/02 , A61M39/10
CPC分类号： A61M37/00 , A61M25/00 , A61M2025/0031 , A61M2025/0042 , A61M2025/028 , A61M2205/04 , A61M2210/0693
摘要： A convection enhanced delivery device (10) comprises a support member (12) and an elongated microcatheter (14) carried by the support member. The microcatheter projects lengthwise away from the support member. The microcatheter includes a catheter lumen extending in a first direction. A fluid conduit (16) carried by the support member. The fluid conduit includes a conduit lumen that extends in a second direction different than the first direction. The conduit lumen is in fluid communication with the catheter lumen. An inlet port (18) and a connecting port (20) are also carried by the support member. The inlet port is in fluid communication with the fluid conduit. The connecting port is separate from the inlet port and is in fluid communication with the fluid conduit. The connecting port is configured to engage an end portion of an external fluid conduit such that the external fluid conduit projects away from the connecting port and from the support member.
摘要翻译：对流增强输送装置（10）包括由支撑构件承载的支撑构件（12）和细长的微导管（14）。微导管从支撑构件纵向突出。微导管包括沿第一方向延伸的导管内腔。由支撑构件承载的流体导管（16）。流体导管包括沿与第一方向不同的第二方向延伸的管腔。导管管腔与导管腔流体连通。入口（18）和连接口（20）也由支撑构件承载。入口端口与流体导管流体连通。连接口与入口分离，并与流体导管流体连通。连接端口构造成接合外部流体导管的端部，使得外部流体导管远离连接端口和支撑构件突出。

8. 发明申请

WO2014138513A1 EXCHANGE GUIDEWIRE 审中-公开
标题翻译：交换指南
公开(公告)号：WO2014138513A1
公开(公告)日：2014-09-12
申请号：PCT/US2014/021491
申请日：2014-03-07
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： HUI, Ferdinard , GAO, Shengqiang
IPC分类号： A61M25/09 , A61B17/22
CPC分类号： A61B5/6851 , A61B2017/22047 , A61M25/0169 , A61M25/04 , A61M25/09 , A61M2025/09125 , A61M2025/09191
摘要： A guidewire (10) includes a flexible elongated core (20) having a proximal end (22) and a distal end (24). An anchor wire (10) has a distal end (34) connected to the distal end (24) of the core (20) and a distally located helical portion (50) that encircles the core. The guidewire (10) has an anchoring condition in which the helical portion (50) is expanded radially away from the core (20). The guidewire (10) has an advancing condition in which the helical portion (50) is stretched longitudinally and contracted radially in response to tension on the anchor wire (30).
摘要翻译：导丝（10）包括具有近端（22）和远端（24）的柔性细长芯（20）。锚线（10）具有连接到芯（20）的远端（24）的远端（34）和环绕芯的远侧定位的螺旋部分（50）。导丝（10）具有锚定状态，其中螺旋部分（50）径向地远离芯部（20）延伸。导丝（10）具有前进状态，其中螺旋部分（50）纵向拉伸并响应于锚线（30）上的张力径向收缩。

9. 发明申请

WO2017127487A1 SYSTEM AND APPARATUS FOR ASSISTING WITH SUBMUCOSAL DISSECTIONS 审中-公开
标题翻译：用于辅助透视下剥离的系统和设备
公开(公告)号：WO2017127487A1
公开(公告)日：2017-07-27
申请号：PCT/US2017/014038
申请日：2017-01-19
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： BHATT, Amit , GAO, Shengqiang , KOLOSI, William , VARGO, John
IPC分类号： A61B17/02 , A61B17/00
CPC分类号： A61B17/02 , A61B17/0218 , A61B2017/00269 , A61B2017/00336 , A61B2017/0034 , A61B2017/00862 , A61B2017/00867 , A61B2017/00946 , A61B2017/0225 , A61B2017/0649
摘要： Systems, methods, and apparatuses for assisting with submucosal dissections include a retraction strip body. The retraction strip body is formed at least partially from a deformable material. The retraction strip body is capable of being selectively moved between a first condition and a second condition. In the first condition, the retraction strip body is capable of engaging a target patient tissue. In the second condition, the retraction strip body is capable of retracting the target patient tissue. At least one tissue engagement member is located on the retraction strip body.
摘要翻译：用于辅助粘膜下剥离的系统，方法和设备包括回缩条带体。收缩条带主体至少部分由可变形材料形成。收缩条带体能够在第一状态和第二状态之间选择性地移动。在第一种情况下，缩回带体能够接合目标患者组织。在第二种情况下，收缩条带体能够缩回目标患者组织。至少有一个组织接合构件位于收缩条带体上

10. 发明申请

WO2013134600A1 DEVICES, SYSTEMS, AND METHODS FOR VISUALIZING AND MANIPULATING TISSUE 审中-公开
标题翻译：用于可视化和操纵组织的装置，系统和方法
公开(公告)号：WO2013134600A1
公开(公告)日：2013-09-12
申请号：PCT/US2013/029780
申请日：2013-03-08
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： MIHALJEVIC, Tomislav , GAO, Shengqiang , FUKAMACHI, Kiyotaka , KOBAYASHI, Mariko , JUNG, JR., Eugene
IPC分类号： A61B1/00 , A61B1/005 , A61M25/00
CPC分类号： A61B1/00089 , A61B1/00085 , A61B1/0051 , A61B2017/00243 , A61B2217/007 , A61M25/0074 , A61M25/04
摘要： One aspect of the present disclosure relates to a tissue imaging device that includes a catheter body, a hood, and a visualization assembly. The catheter body includes a distal end portion, a proximal end portion, and at least one lumen extending between the distal and proximal end portions. The catheter body includes at least one drainage port having a first opening and at least one infusion port having a second opening. The first and second openings are located about a lateral aspect of the catheter body. The hood projects distally from the distal end portion and is configured to self-expand into an expanded deployment state that defines an open area therein. The visualization assembly is disposed within the open area and extends distally from the distal end portion of the catheter body.
摘要翻译：本公开的一个方面涉及一种组织成像装置，其包括导管主体，罩和可视化组件。导管主体包括远端部分，近端部分以及在远端部分和近端部分之间延伸的至少一个内腔。导管主体包括至少一个具有第一开口的排出口和至少一个具有第二开口的输注口。第一和第二开口位于导管主体的侧面。罩从远端部分向远侧突出并且被配置成自扩展成在其中限定开放区域的扩展展开状态。可视化组件设置在开放区域内并且从导管主体的远端部分向远端延伸。

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