专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007092417A1 TOUGHENED POLYLACTIC ACID POLYMERS AND COPOLYMERS 审中-公开
标题翻译：增韧聚酰胺聚合物和共聚物
公开(公告)号：WO2007092417A1
公开(公告)日：2007-08-16
申请号：PCT/US2007/003100
申请日：2007-02-06
申请人： TEPHA, INC. , RIZK, Said , MARTIN, David, P. , HO, Kicherl , GANATRA, Amit , WILLIAMS, Simon, F.
发明人： RIZK, Said , MARTIN, David, P. , HO, Kicherl , GANATRA, Amit , WILLIAMS, Simon, F.
IPC分类号： A61L15/22 , A61L17/12 , A61L27/26 , A61L29/04 , A61L31/04 , C08L67/04
CPC分类号： C08L67/04 , A61K47/34 , A61L15/26 , A61L17/105 , A61L17/12 , A61L27/18 , A61L27/26 , A61L29/049 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/18 , C08G63/06 , C08K3/014 , C08K5/0016 , C08K5/005 , C08K5/0083 , C08L2666/18
摘要： Toughened compositions of PLA and PLA copolymers are disclosed, which also have low tensile modulus values and greater elongation to break. These toughened compositions are prepared by blending PLA and PLA copolymers with poly-4-hydroxybutyrate, and copolymers thereof. Blending of ρoly-4-hydroxybutyrate with PLA and its copolymers has been found to impart advantageous properties to the resulting blend. These compositions, and objects formed from these compositions, have improved toughness and lower stiffness than polylactic acid polymers or copolymers alone.
摘要翻译：公开了PLA和PLA共聚物的增韧组合物，其也具有低拉伸模量值和较大的断裂伸长率。这些增韧的组合物通过将PLA和PLA共聚物与聚-4-羟基丁酸酯及其共聚物共混来制备。已经发现丙烯酸4-羟基丁酸酯与PLA及其共聚物的混合赋予所得共混物有利的性质。这些组合物和由这些组合物形成的物体比单独的聚乳酸聚合物或共聚物具有改善的韧性和较低的刚度。

2. 发明申请

WO2015167807A1 THREE-DIMENSIONAL RESORBABLE IMPLANTS FOR TISSUE REINFORCEMENT AND HERNIA REPAIR 审中-公开
标题翻译：用于组织加固和HERNIA修复的三维可折叠植入物
公开(公告)号：WO2015167807A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/026005
申请日：2015-04-15
申请人： TEPHA, INC.
发明人： RIZK, Said , FOSCO, Antonio , GANATRA, Amit , MARTIN, David, P. , WILLIAMS, Simon, F.
IPC分类号： A61F2/00
CPC分类号： A61F2/0063 , A61F2230/0093 , A61F2240/004
摘要： Resorbable three-dimensional implants that can be temporarily deformed, implanted by minimally invasive means, and resume their original shape in vivo, have been developed. These implants are particularly suitable for use in minimally invasive procedures for tissue reinforcement, repair of hernias, and applications where it is desirable for the implant to contour in vivo to an anatomical shape, such as the inguinofemoral region. In the preferred embodiment, the implants are made from meshes of poly -4- hydroxybutyrate monofilament that have reinforced outlying borders that allow the meshes to form three-dimensional shapes that can be temporarily deformed. These implants can resume three-dimensional shapes after being temporarily deformed that contour to the host's tissue or an anatomical shape, for example, in the repair of a hernia, and particularly a hernia in the inguinofemoral region. The implants can contour to the host's tissue for example, of the inguinofemoral region, without the implants wrinkling, bunching or folding.
摘要翻译：已经开发了可以暂时变形，通过微创手段植入并在体内恢复其原始形状的可再吸收的三维植入物。这些植入物特别适用于用于组织加强，疝修补的微创手术，以及其中期望植入物在体内轮廓到解剖学形状（例如腹股沟区域）的应用。在优选实施例中，植入物由聚-4-羟基丁酸酯单丝的网格制成，其具有增强的外围边界，允许网格形成可暂时变形的三维形状。这些植入物可以在将轮廓暂时变形成主体的组织或解剖形状之后恢复三维形状，例如修复疝气，特别是在腹股沟区域中的疝。植入物可以轮廓到宿主的组织，例如，腹股沟区域，而没有植入物起皱，聚束或折叠。

3. 发明申请

WO2018217574A1 CONTINUOUS FORMATION OF TUBES OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 审中-公开
公开(公告)号：WO2018217574A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/033420
申请日：2018-05-18
申请人： TEPHA, INC.
发明人： GANATRA, Amit , RIZK, Said
IPC分类号： B29C47/88 , B29C47/90 , B29C47/92 , A61M25/10 , B29C55/24 , A61L31/16 , C08L67/04 , B29B13/06
摘要： Methods have been discovered that make it possible to continuously extrude tubes of P4HB and copolymers thereof. These methods allow tubes of P4HB and copolymers thereof to be produced without radial deformation of the tubes despite the slow crystallization of the polymer and copolymers. The methods can produce tubes of P4HB and copolymers thereof with tightly defined outside and inside diameters which are required for medical application. These tubes are produced by radial expansion at temperatures above the melting temperature of P4HB and copolymers thereof, and using low tube cooling temperatures and prolonged cooling times. The tubes made from P4HB and copolymers thereof are flexible, and can be prepared with high elongation to break values.

4. 发明申请

WO2016094669A1 METHODS OF ORIENTING MULTIFILAMENT YARN AND MONOFILAMENTS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 审中-公开
标题翻译：聚-4-羟基丁酸酯及其共聚物的多元纤维和单体的定向方法
公开(公告)号：WO2016094669A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/065015
申请日：2015-12-10
申请人： TEPHA, INC.
发明人： GANATRA, Amit , FELIX, Fabio , SHAH, Bhavin , BERNASCONI, Matthew , RIZK, Said , MARTIN, David, P. , WILLIAMS, Simon, F.
IPC分类号： D01F6/62
CPC分类号： D01F6/625 , A61L17/105 , A61L31/06 , A61L31/148 , B29C55/005 , B29K2073/00 , B29K2673/00 , B29L2031/731 , D01D5/08 , D01F8/14 , D02G3/04 , D10B2331/04 , D10B2331/041 , D10B2401/063 , D10B2509/04 , D10B2509/08
摘要： Resorbable multifilament yams and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yams and fibers are produced by cold drawing the multifilament yams and monofilament fibers before hot drawing the yams and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yams and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yams have tenacities higher than 8.1 grams per denier, and in vivo , retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo . The monofilament fibers have tensile strengths higher than 500 MPa. These yams and fibers may be used to make various medical devices for various applications.
摘要翻译：已经开发了可再吸收的复丝纱线和包括聚-4-羟基丁酸酯的单丝纤维及其具有高强度或高拉伸强度的共聚物。在高于聚合物或共聚物的熔融温度的温度下，在拉伸纱线和纤维的拉伸下，通过冷拉丝复丝纱线和单丝纤维来生产纱线和纤维。这些纱线和纤维在体内具有延长的强度保持性，使得它们适用于需要高强度和强度保持性的软组织修复。复丝纱具有高于8.1克/旦尼尔的强度，并且体内在2周时保持其初始强度的至少65％。单丝纤维在体内4周时保持其初始强度的至少50％。单丝纤维的拉伸强度高于500MPa。这些纱线和纤维可用于制造用于各种应用的各种医疗装置。

5. 发明申请

WO2021126638A1 RESORBABLE IMPLANTS FOR RECONSTRUCTION OF BONE DEFECTS 审中-公开
公开(公告)号：WO2021126638A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/064102
申请日：2020-12-09
申请人： TEPHA, INC.
发明人： SARIIBRAHIMOGLU, Kemal , LIMEM, Skander , GANATRA, Amit , RIZK, Said , WILLIAMS, Simon, F.
IPC分类号： A61F2/28 , A61F2/30 , A61L31/06 , A61F2/2875 , A61F2/3094 , A61F2002/30032 , A61F2002/30062 , A61F2002/30113 , A61F2002/30224 , A61F2002/30233 , A61F2002/30235 , A61F2002/30299 , A61F2002/30322 , A61F2002/30354 , A61F2002/30405 , A61F2002/30784 , A61F2002/30892 , A61F2002/30914 , A61F2002/30915 , A61F2002/30971 , A61F2002/30985 , A61F2310/00179 , A61L2430/02 , A61L27/18 , A61L27/58 , A61L31/026 , A61L31/146 , A61L31/148 , C08K3/346
摘要： Devices (200) to repair bone defects prevent the formation of depressions and palpable tissue at bone repair sites. The devices can be used to repair burr holes in the cranium, providing an improved cosmetic result that reduces or eliminates functional handicaps that can result from combing and hairdressing. The devices are secured in bone defects with filament elements (210), by expanding the device inside the bone defect, or by gluing. Tissue in-growth into the device regenerates bone at the defect site, and prevents the formation of depressions or palpable tissue. The devices preferably comprise a ceramic and poly-4-hydroxybutyrate or copolymer thereof, or a ceramic and poly (butylene succinate) or copolymer thereof.

6. 发明申请

WO2021042044A1 MEDICAL DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF 审中-公开
公开(公告)号：WO2021042044A1
公开(公告)日：2021-03-04
申请号：PCT/US2020/048773
申请日：2020-08-31
申请人： TEPHA, INC.
发明人： WILLIAMS, Simon F. , RIZK, Said , MARTIN, David P. , LIMEM, Skander , GUO, Kai , LOPEZ, German Oswaldo Hohl , GANATRA, Amit
IPC分类号： A61L17/00 , A61L17/06 , A61L17/10 , A61L27/18 , A61L27/54 , A61L27/56 , A61L27/58
摘要： Resorbable implants, coverings and receptacles comprising poly(butylene succinate) and copolymers thereof have been developed. The implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing molding, pultrusion or other melt or solvent processing method. The implants, or the fibers preset therein, may be oriented.. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings, receptacles and implants described herein, may be made from meshes, webs, lattices, non-wovens, films, fibers, foams, molded, pultruded, machined and 3D printed forms.

7. 发明申请

WO2020092065A1 METHODS OF MANUFACTURING MESH SUTURES FROM POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 审中-公开
公开(公告)号：WO2020092065A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/057441
申请日：2019-10-22
申请人： TEPHA, INC.
发明人： RIZK, Said , SHAH, Bhavin , GANATRA, Amit , LIMEM, Skander , MARTIN, David P. , WILLIAMS, Simon F.
IPC分类号： A61L17/00 , A61L17/10
摘要： Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo . The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications, including mesh sutures.

8. 发明申请

WO2015066408A1 PULTRUSION OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 审中-公开
标题翻译：聚-4-羟基丁酸酯及其共聚物的挤出
公开(公告)号：WO2015066408A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/063313
申请日：2014-10-31
申请人： TEPHA, INC.
发明人： GANATRA, Amit , SHAH, Bhavin , RIZK, Said , MARTIN, David, P. , WILLIAMS, Simon, F.
IPC分类号： B29C70/52 , A61L27/14 , A61L27/40 , A61L31/04 , A61L27/18 , A61L31/06 , C08L67/04
CPC分类号： A61L27/18 , A61L27/26 , A61L31/041 , A61L31/06 , B29C70/52 , C08G63/06 , C08L67/04
摘要： Compositions of P4HB (poly-4-hydroxybutyrate) and copolymers thereof, have been developed for pultrusion, as well as processes to produce profiles from these compositions by pultrusion. These pultrusion processes provide profiles without causing structural damage to the surface of the profile. The profiles may be used in medical applications. These compositions include P4HB, and copolymers thereof, having intrinsic viscosities less than 3.2 dl/g but greater than 0.8 dl/g. The profile may be formed using conditions such as: pull rate of 0.1 to 100 mm/min, die temperature of up to 95°C, rod stock temperature up to 95°C, draw ratio of up to 100X, pulling force of greater than 10 MPa, and clamping pressure at least 10 % higher than the pulling force. Preferably, the profile is formed by pulling the rod stock through a series of dies placed at intervals with the hole sizes decreasing in diameter by 0.1 to 10 mm.
摘要翻译： P4HB（聚-4-羟基丁酸酯）及其共聚物的组合物已被开发用于拉挤成型，以及通过拉挤成型由这些组合物生产型材的方法。这些拉挤成型工艺提供轮廓，而不会对轮廓的表面造成结构损坏。型材可用于医疗应用。这些组合物包括特性粘度小于3.2dl / g但大于0.8dl / g的P4HB及其共聚物。型材可以使用以下条件形成：拉伸速度为0.1至100mm / min，模具温度高达95℃，棒料温度高达95℃，拉伸比可达100X，拉力大于 10MPa，夹紧压力比拉力高10％以上。优选地，通过将棒材拉伸通过一系列模具而形成，所述一系列模具以直径减小0.1至10mm的孔尺寸间隔放置。

9. 发明公开

EP3230500A1 METHODS OF ORIENTING MULTIFILAMENT YARN AND MONOFILAMENTS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 审中-公开
标题翻译：聚-4-羟基丁酸酯及其共聚物的多线纱和单丝取向方法及其共聚物
公开(公告)号：EP3230500A1
公开(公告)日：2017-10-18
申请号：EP15825981.2
申请日：2015-12-10
申请人： Tepha, Inc.
发明人： GANATRA, Amit , FELIX, Fabio , SHAH, Bhavin , BERNASCONI, Matthew , RIZK, Said , MARTIN, David, P. , WILLIAMS, Simon, F.
IPC分类号： D01F6/62
CPC分类号： D01F6/625 , A61L17/105 , A61L31/06 , A61L31/148 , B29C55/005 , B29K2073/00 , B29K2673/00 , B29L2031/731 , D01D5/08 , D01F8/14 , D02G3/04 , D10B2331/04 , D10B2331/041 , D10B2401/063 , D10B2509/04 , D10B2509/08
摘要： Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.
摘要翻译：已开发出可吸收的复丝纱线和包括聚-4-羟基丁酸酯的单丝纤维及其高韧性或高拉伸强度的共聚物。纱线和纤维是通过在高于聚合物或共聚物的熔融温度的温度下在张力下热拉伸纱线和纤维之前冷拉多丝纱线和单丝纤维而生产的。这些纱线和纤维在体内具有延长的强度保留，使其适用于需要高强度和强度保持的软组织修复。多丝纱线的韧度高于8.1旦/旦尼尔，并且在体内在2周时保持至少65％的初始强度。单丝纤维在体内4周时保持其初始强度的至少50％。单丝纤维的拉伸强度高于500MPa。这些纱线和纤维可用于制造各种医疗设备以用于各种应用。

10. 发明公开

EP4021518A1 MEDICAL DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF 审中-公开
公开(公告)号：EP4021518A1
公开(公告)日：2022-07-06
申请号：EP20771716.6
申请日：2020-08-31
申请人： Tepha, Inc.
发明人： WILLIAMS, Simon F. , RIZK, Said , MARTIN, David P. , LIMEM, Skander , GUO, Kai , LOPEZ, German Oswaldo Hohl , GANATRA, Amit
IPC分类号： A61L17/00 , A61L17/06 , A61L17/10 , A61L27/18 , A61L27/54 , A61L27/56 , A61L27/58

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式