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1. 发明申请

WO2014144937A2 PROSTHETIC HEART VALVE DEVICES, PROSTHETIC MITRAL VALVES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：前置心脏瓣膜装置，预防性阀门及相关系统及方法
公开(公告)号：WO2014144937A2
公开(公告)日：2014-09-18
申请号：PCT/US2014029549
申请日：2014-03-14
申请人： TWELVE INC
发明人： MORRISS JOHN , MCLEAN MATT , BENSING MAUREEN , DUERI JEAN-PIERRE , GIFFORD HANSON , MIYASHIRO KATIE , SCOTT DAVID JERRY , TRASK DAVID , VALLEY KIRSTEN
CPC分类号： A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2230/0067 , A61F2250/006 , A61F2250/0069
摘要： Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having an upstream portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a mechanically isolated valve support coupled to the anchoring member and configured to support a prosthetic valve. The device can further include an atrial extension member extending radially outward from the upstream portion of the anchoring member and which is deformable without substantially deforming the anchoring member. In some embodiments, the upstream portion of the anchoring member and the extension member may be deformed while the valve support remains sufficiently stable.
摘要翻译：本文公开了用于经皮置换天然心脏瓣膜和相关系统的假体心脏瓣膜装置和方法。根据本技术的特定实施例构造的假体心脏瓣膜装置可以包括锚定构件，其具有被配置成与天然心脏瓣膜的环空上或其附近的组织接合并且以非圆形变形的上游部分符合组织。该装置还可以包括联接到锚定构件并被构造成支撑人造瓣膜的机械隔离的阀支撑件。该装置还可以包括从锚定构件的上游部分径向向外延伸并且可变形而不使锚固构件基本变形的心房延伸构件。在一些实施例中，锚定构件和延伸构件的上游部分可以在阀支撑件保持足够稳定的同时变形。

2. 发明申请

WO2014121280A3 HYDRAULIC DELIVERY SYSTEMS FOR PROSTHETIC HEART VALVE DEVICES AND ASSOCIATED METHODS 审中-公开
标题翻译：用于前置心脏瓣膜装置和相关方法的液压输送系统
公开(公告)号：WO2014121280A3
公开(公告)日：2014-10-30
申请号：PCT/US2014014704
申请日：2014-02-04
申请人： TWELVE INC
发明人： MORRISS JOHN , MCLEAN MATT , DEEM MARK , GIFFORD HANSON , LUNA MICHAEL
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/962
摘要： Systems, apparatuses, and methods for treating native heart valves are disclosed herein. A system (2000) for delivering a prosthetic device into a heart of a patient includes an elongated catheter body (2014) and a delivery capsule (2012). The delivery capsule can be hydraulically driven to deploy at least a portion of a prosthetic heart valve device. The delivery capsule can release the prosthetic heart valve device at a desired treatment site in a patient.
摘要翻译：本文公开了用于治疗天然心脏瓣膜的系统，装置和方法。用于将假体装置输送到患者的心脏中的系统（2000）包括细长的导管主体（2014）和递送胶囊（2012）。递送囊可被液压驱动以展开假体心脏瓣膜装置的至少一部分。递送胶囊可以在患者的期望的治疗部位释放假体心脏瓣膜装置。

3. 发明专利

AU2019280051B2 Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods 未知
公开(公告)号：AU2019280051B2
公开(公告)日：2021-07-08
申请号：AU2019280051
申请日：2019-12-12
申请人： TWELVE INC
发明人： MORRISS JOHN , MCLEAN MATT , BENSING MAUREEN , DUERI JEAN-PIERRE , GIFFORD HANSON , MIYASHIRO KATIE , SCOTT DAVID JERRY , TRASK DAVID , VALLEY KIRSTEN
IPC分类号： A61F2/24
摘要： Prosthetic heart valve devices for percutaneous replacement ofnative heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having an upstream portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a mechanically isolated valve support coupled to the anchoring member and configured to support a prosthetic valve. The device can further include an atrial extension member extending radially outward from the upstream portion of the anchoring member and which is deformable without substantially deforming the anchoring member. In some embodiments, the upstream portion of the anchoring member and the extension member may be deformed while the valve support remains sufficiently stable. 2130,2132 2120 2112 - }170a 170a 17101 -112 4H/ Ht 170 -10, 150 140a 2109 2100 140b 13 4a113

4. 发明专利

AU2018201360B2 Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods 未知
公开(公告)号：AU2018201360B2
公开(公告)日：2019-05-16
申请号：AU2018201360
申请日：2018-02-26
申请人： TWELVE INC
发明人： MORRISS JOHN , GIFFORD III HANSON , FANN JAMES L , DUERI JEAN-PIERRE , MCLEAN MATT , GITTINGS DARRIN , LUNA MICHAEL , DEEM MARK , SUTTON DOUGLAS , GRAINGER JEFFREY J
IPC分类号： A61F2/24
摘要： A prosthetic heart valve (100) includes a flexible anchoring member (110) at least partially surrounding and coupled to an inner valve support (120). The device can further include a prosthetic valve (130) coupled to, mounted within, or otherwise carried by the valve support. The valve support includes a plurality of posts (122) connected circumferentially by a plurality of struts (124), where the posts extend along an axial direction generally parallel to the longitudinal axis (101) and the struts extend circumferentially around and transverse to the longitudinal axis. The posts extend an entire longitudinal height HI of the valve support 120. The device also includes one or more sealing members (140) and tissue engaging elements (170) like spikes. 180 122 124, 127 .-- _ _140

5. 发明专利

AU2016235012B2 System for mitral valve repair and replacement 未知
公开(公告)号：AU2016235012B2
公开(公告)日：2017-12-07
申请号：AU2016235012
申请日：2016-09-30
申请人： TWELVE INC
发明人： GIFFORD III HANSON S , FANN JAMES I , MORRISS JOHN , DEEM MARK , GRAINGER JEFFRY J
IPC分类号： A61F2/24
摘要： Systems for mitral valve repair are disclosed where one or more mitral valve interventional devices may be advanced intravascularly into the heart of a patient and deployed upon or along the mitral valve to stabilize the valve leaflets. The interventional device may also facilitate the placement or anchoring of a prosthetic mitral valve implant. The interventional device may generally comprise a distal set of arms pivotably and/or rotating coupled to a proximal set of arms which are also pivotably and/or rotating coupled. The distal set of arms may be advanced past the catheter opening to a subannular position (e.g., below the mitral valve) and reconfigured from a low-profile delivery configuration to a deployed securement configuration. The proximal arm members may then be deployed such that the distal and proximal arm members may grip the leaflets between the two sets of arms to stabilize the leaflets. 15B L16A, 16B 18A, 118A, 18 12 r34A - 8B 34A, 34BjU 2 0 -B -20A, 20B 22A- -j22B -22A, 22B 3 1 ,6 -24A, 24B 24A i 24B 26A- 26B 1-26A 26B 14 38A 'o' -38B 38A, 38B -2k8A, 28B 30A 30B 30A 30B FIG. 2A FIG. 2B S-32 12 1 7A 1 e l8B 12> 17A 3 17B 20A 20B 18A 16A 16B 18B 25A- 268 1 14' / 26A 38B 0 38A 24A 248 28A 30A 30B 20A T20B 29A- 14 31A A 31B 40

6. 发明专利

AU2012272855B2 Prosthetic heart valve devices and associated systems and methods 未知
公开(公告)号：AU2012272855B2
公开(公告)日：2017-06-15
申请号：AU2012272855
申请日：2012-06-21
申请人： TWELVE INC
发明人： GIFFORD III HANSON , FANN JAMES L , MORRISS JOHN , DEEM MARK , DUERI JEAN-PIERRE , GITTINGS DARRIN , GRAINGER JEFFREY J , LUNA MICHAEL , SUTTON DOUGLAS
IPC分类号： A61F2/24
摘要： Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an expandable support having an outer surface and configured for placement between leaflets of the native valve. The device can also include a plurality of asymmetrically arranged arms coupled to the expandable support and configured to receive the leaflets of the native valve between the arms and the outer surface. In some embodiments, the arms can include tip portions for engaging a subannular surface of the native valve.

7. 发明专利

AU2016235012A1 System for mitral valve repair and replacement 未知
公开(公告)号：AU2016235012A1
公开(公告)日：2016-10-27
申请号：AU2016235012
申请日：2016-09-30
申请人： TWELVE INC
发明人： GIFFORD III HANSON S , FANN JAMES I , MORRISS JOHN , DEEM MARK , GRAINGER JEFFRY J
IPC分类号： A61F2/24
摘要： Systems for mitral valve repair are disclosed where one or more mitral valve interventional devices may be advanced intravascularly into the heart of a patient and deployed upon or along the mitral valve to stabilize the valve leaflets. The interventional device may also facilitate the placement or anchoring of a prosthetic mitral valve implant. The interventional device may generally comprise a distal set of arms pivotably and/or rotating coupled to a proximal set of arms which are also pivotably and/or rotating coupled. The distal set of arms may be advanced past the catheter opening to a subannular position (e.g., below the mitral valve) and reconfigured from a low-profile delivery configuration to a deployed securement configuration. The proximal arm members may then be deployed such that the distal and proximal arm members may grip the leaflets between the two sets of arms to stabilize the leaflets. 15B L16A, 16B 18A, 118A, 18 12 r34A - 8B 34A, 34BjU 2 0 -B -20A, 20B 22A- -j22B -22A, 22B 3 1 ,6 -24A, 24B 24A i 24B 26A- 26B 1-26A 26B 14 38A 'o' -38B 38A, 38B -2k8A, 28B 30A 30B 30A 30B FIG. 2A FIG. 2B S-32 12 1 7A 1 e l8B 12> 17A 3 17B 20A 20B 18A 16A 16B 18B 25A- 268 1 14' / 26A 38B 0 38A 24A 248 28A 30A 30B 20A T20B 29A- 14 31A A 31B 40

8. 发明专利

AU2016200392A1 Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods 未知
公开(公告)号：AU2016200392A1
公开(公告)日：2016-02-11
申请号：AU2016200392
申请日：2016-01-22
申请人： TWELVE INC
发明人： MORRISS JOHN , GIFFORD III HANSON , FANN JAMES L , DUERI JEAN-PIERRE , MCLEAN MATT , GITTINGS DARRIN , LUNA MICHAEL , SUTTON DOUGLAS , GRAINGER JEFFREY J , DEEM MARK
IPC分类号： A61F2/24
摘要： A prosthetic heart valve (100) includes a flexible anchoring member (110) at least partially surrounding and coupled to an inner valve support (120). The device can further include a prosthetic valve (130) coupled to, mounted within, or otherwise carried by the valve support. The valve support includes a plurality of posts (122) connected circumferentially by a plurality of struts (124), where the posts extend along an axial direction generally parallel to the longitudinal axis (101) and the struts extend circumferentially around and transverse to the longitudinal axis. The posts extend an entire longitudinal height HI of the valve support 120. The device also includes one or more sealing members (140) and tissue engaging elements (170) like spikes. 180 122 124, - - 140

9. 发明专利

CA2898991A1 HYDRAULIC DELIVERY SYSTEMS FOR PROSTHETIC HEART VALVE DEVICES AND ASSOCIATED METHODS 未知
公开(公告)号：CA2898991A1
公开(公告)日：2014-08-07
申请号：CA2898991
申请日：2014-02-04
申请人： TWELVE INC
发明人： MORRISS JOHN , MCLEAN MATT , DEEM MARK , GIFFORD HANSON , LUNA MICHAEL
IPC分类号： A61F2/24
摘要： Systems, apparatuses, and methods for treating native heart valves are disclosed herein. A system (2000) for delivering a prosthetic device into a heart of a patient includes an elongated catheter body (2014) and a delivery capsule (2012). The delivery capsule can be hydraulically driven to deploy at least a portion of a prosthetic heart valve device. The delivery capsule can release the prosthetic heart valve device at a desired treatment site in a patient.

10. 发明专利

AU2012325809A1 Devices, systems and methods for heart valve replacement 未知
公开(公告)号：AU2012325809A1
公开(公告)日：2014-04-03
申请号：AU2012325809
申请日：2012-10-19
申请人： TWELVE INC
发明人： MORRISS JOHN , GIFFORD HANSON , FANN JAMES L , DUERI JEAN-PIERRE , GITTINGS DARRIN , LUNA MICHAEL , DEEM MARK , SUTTON DOUGLAS
IPC分类号： A61F2/24
摘要： A prosthetic heart valve device (100) for percutaneous replacement of a native heart valve includes an expandable retainer (110) at least partially surrounding and coupled to an inner valve support (120). The device can further include a prosthetic valve (130) coupled to the valve support. The retainer forms a donut-shaped flange (190) having an arcuate outer surface (142) for engaging tissue and an inner lumen defining a passage for blood to flow through the valve support. The retainer can include a plurality of circumferentially positioned, resiliency deformable and flexible ribs (114) which are coupled at their downstream ends 116 to the valve support 120. The flexible ribs, in one embodiment, can have a general C-shape configuration with the tips (117) of the flexible ribs and an opening (119) of the C-shape configuration oriented toward a longitudinal axis (101) of the device.

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