专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011032179A1 VACCINES AND IMMUNOTHERAPEUTICS COMPRISING IL-15 RECEPTOR ALPHA AND/OR NUCLEIC ACID MOLECULES ENCODING THE SAME, AND METHODS FOR USING THE SAME 审中-公开
标题翻译：包含IL-15受体ALPHA和/或编码其的核酸分子的疫苗和免疫组织及其使用方法
公开(公告)号：WO2011032179A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048827
申请日：2010-09-14
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B. , KRAYNYAK, Kimberly, A. , KUTZLER, Michele
发明人： WEINER, David, B. , KRAYNYAK, Kimberly, A. , KUTZLER, Michele
IPC分类号： A61K45/00 , A61K39/00 , A61K39/02
CPC分类号： A61K39/39 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/55516 , A61K2039/55527 , C07K14/7155 , C12N2740/16234
摘要： Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL- 15Ra or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
摘要翻译：公开了组合物，重组疫苗和活减毒病原体，其包含编码免疫原的一个或多个分离的核酸分子与分离的编码IL-15Ra或其功能片段的核酸分子的组合。公开了使用这种组合物诱导个体对免疫原的免疫应答的方法。

2. 发明申请

WO2004112706A3 VACCINES, IMMUNOTHERAPEUTICS AND METHODS FOR USING THE SAME 审中-公开
公开(公告)号：WO2004112706A3
公开(公告)日：2004-12-29
申请号：PCT/US2004/019028
申请日：2004-06-14
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B. , MUTHUMANI, Karuppiah , KUTZLER, Michele , CHOO, Andrew, K. , CHATTERGOON, Michael, A.
发明人： WEINER, David, B. , MUTHUMANI, Karuppiah , KUTZLER, Michele , CHOO, Andrew, K. , CHATTERGOON, Michael, A.
IPC分类号： A61K31/7084
摘要： Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes an immunomodulator protein selected from the group consisting of: Fos, c-jun, Sp-1, Ap-1, Ap-2, p38, p65Rel, MyD88, IRAK, TRAF6, IkB, Inactive NIK, SAP K, SAP-1, JNK, interferon response genes, NFkB, Bax, TRAIL, TRAILrec, TRAILrecDRC5, TRAIL-R3, TRAIL-R4, RANK, RANK LIGAND, Ox40, Ox40 LIGAND, NKG2D, MICA, MICB, NKG2A, NKG2B, NKG2C, NKG2E, NKG2F, TAPI, TAP2 and functional fragments thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.

3. 发明申请

WO2002100345A2 VACCINES, IMMUNOTHERAPEUTICS AND METHODS OF USING THE SAME 审中-公开
标题翻译：疫苗，免疫疗法及其使用方法
公开(公告)号：WO2002100345A2
公开(公告)日：2002-12-19
申请号：PCT/US2002/018541
申请日：2002-06-11
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B. , SIN, Jeong-Im
发明人： WEINER, David, B. , SIN, Jeong-Im
IPC分类号： A61K
CPC分类号： A61K39/39 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K2039/53 , A61K2039/55522 , A61K2300/00
摘要： Compositions for and methods of enhancing, suppressing or otherwise modulating immune responses are disclosed. Improved vaccines which include a nucleotide sequence that encodes VEGF and an immunomodulating protein, both operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Compositions for and methods of treating individuals with autoimmune diseases are disclosed.
摘要翻译：公开了增强，抑制或以其他方式调节免疫应答的组合物和方法。公开了改进的疫苗，其包括编码VEGF的核苷酸序列和免疫调节蛋白，两者都可操作地连接到调节元件。改进的疫苗包括DNA疫苗，用于递送外源抗原和活减毒疫苗的重组疫苗。公开了免疫个体的方法。公开了治疗患有自身免疫性疾病的个体的组合物和方法。

4. 发明申请

WO1993004695A1 T CELL RECEPTOR-BASED THERAPY FOR RHEUMATOID ARTHRITIS 审中-公开
标题翻译：基于T细胞受体的治疗风湿性关节炎
公开(公告)号：WO1993004695A1
公开(公告)日：1993-03-18
申请号：PCT/US1992007289
申请日：1992-08-27
申请人： THE WISTAR INSTITUTE , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： THE WISTAR INSTITUTE , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WILLIAMS, William, V. , WEINER, David, B.
IPC分类号： A61K39/00
CPC分类号： C07K14/7051 , A61K38/00
摘要： There is provided by this invention a novel method of treating rheumatoid arthritis in a mammal. The method comprises the steps of obtaining a sample of synovium from the mammal; identifying in said sample T cell receptor variable regions; and administering to said mammal an effective amount of antibodies to at least one of said T cell receptor variable regions or antigenic fragments thereof. The invention further provides a novel method of treating rheumatoid arthritis in a mammal comprising the steps of administering to said mammal an effective amount of antibodies to mammalian T cell receptor variable regions selected from the group consisting of V alpha 17, V alpha 1, V beta 12, V beta 14, V beta 17 and V beta 7 and antigenic fragments thereof. The invention further comprises a novel method for immunizing a mammal to prevent the occurrence of rheumatoid arthritis or to treat ongoing rheumatoid arthritis. The method comprises the steps of administering to said mammal mammalian T cell receptor variable regions selected from the group consisting of V alpha 17, V alpha 1, V beta 12, V beta 14, V beta 17, V beta 7 and antigenic fragments thereof. Kits comprising mammalian T cell receptor variable regions selected from the group consisting of V alpha 17, V alpha 1, V beta 12, V beta 14, V beta 17 and V beta 7 and antigenic fragments thereof or antibodies to said variable regions are also provided by the invention.
摘要翻译：本发明提供一种治疗哺乳动物类风湿性关节炎的新方法。该方法包括从哺乳动物获得滑膜样品的步骤; 在所述样品T细胞受体可变区中鉴定; 以及向所述哺乳动物给予至少一种所述T细胞受体可变区或其抗原性片段的有效量的抗体。本发明进一步提供一种治疗哺乳动物类风湿性关节炎的新方法，包括以下步骤：向哺乳动物施用有效量的抗体，所述哺乳动物T细胞受体可变区选自Vα17，Vα1，Vβ 12，Vβ14，Vβ17和Vβ7及其抗原片段。本发明还包括用于免疫哺乳动物以预防类风湿性关节炎的发生或治疗持续性类风湿性关节炎的新方法。该方法包括以下步骤：向所述哺乳动物施用哺乳动物T细胞受体，其选自Vα17，Vα1，Vβ12，Vβ14，Vβ17，Vβ7及其抗原性片段。还提供了包含选自Vα17，Vα1，Vβ12，Vβ14，Vβ17和Vβ7的哺乳动物T细胞受体可变区及其抗原片段或对所述可变区的抗体的试剂盒通过本发明。

5. 发明申请

WO2013055326A2 VACCINES FOR HUMAN PAPILLOMA VIRUS AND METHODS FOR USING THE SAME 审中-公开
标题翻译：人类斑马鱼病毒疫苗及其使用方法
公开(公告)号：WO2013055326A2
公开(公告)日：2013-04-18
申请号：PCT/US2011/055932
申请日：2011-10-12
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B. , YAN, Jian
发明人： WEINER, David, B. , YAN, Jian
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/53 , A61K2039/54 , A61K2039/70 , C12N2710/20034
摘要： Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV 6, HPV 11, HPV 33 and HPV58 E6 and E7. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HPV are disclosed.
摘要翻译：公开了改进的编码它们的抗HPV免疫原和核酸分子。公开的免疫原包括具有共同的HPV 6，HPV 11，HPV 33和HPV 58 E 6和E 7的那些。公开了药物组合物，包含减毒活疫苗和减毒活疫苗的重组疫苗，并公开了在个体中针对HPV诱导免疫应答的方法。

6. 发明申请

WO2010050939A1 IMPROVED HCV VACCINES AND METHODS FOR USING THE SAME 审中-公开
标题翻译：改进的HCV疫苗及其使用方法
公开(公告)号：WO2010050939A1
公开(公告)日：2010-05-06
申请号：PCT/US2008/081627
申请日：2008-10-29
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , VGX PHARMACEUTICALS, LLC , WEINER, David, B. , LANG, Krystle, A. , YAN, Jian , DRAGHIA-AKLI, Ruxandra , KHAN, Amir
发明人： WEINER, David, B. , LANG, Krystle, A. , YAN, Jian , DRAGHIA-AKLI, Ruxandra , KHAN, Amir
IPC分类号： C07H21/00 , C07K14/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55 , C12N7/00 , C12N9/506 , C12N15/86 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234
摘要： Improved anti-HCV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HCV genotype l a/l b NS3 and NS4A. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HCV are disclosed.
摘要翻译：公开了改进的抗HCV免疫原和编码它们的核酸分子。所公开的免疫原包括那些具有一致的HCV基因型l a / lb NS3和NS4A的那些。公开了药物组合物，包含减毒活疫苗和减毒活疫苗的重组疫苗，并公开了针对HCV个体诱导免疫应答的方法。

7. 发明申请

WO2004112706A2 VACCINES, IMMUNOTHERAPEUTICS AND METHODS FOR USING THE SAME 审中-公开
标题翻译：疫苗，免疫球蛋白及其使用方法
公开(公告)号：WO2004112706A2
公开(公告)日：2004-12-29
申请号：PCT/US2004/019028
申请日：2004-06-14
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B. , MUTHUMANI, Karuppiah , KUTZLER, Michele , CHOO, Andrew, K. , CHATTERGOON, Michael, A.
发明人： WEINER, David, B. , MUTHUMANI, Karuppiah , KUTZLER, Michele , CHOO, Andrew, K. , CHATTERGOON, Michael, A.
IPC分类号： A61K
CPC分类号： A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/53 , A61K2039/55516 , A61K2039/575 , A61K2039/6031 , C07K14/005 , C12N2740/16022 , C12N2740/16122 , C12N2740/16134 , Y02A50/394
摘要： Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes an immunomodulator protein selected from the group consisting of: Fos, c-jun, Sp-1, Ap-1, Ap-2, p38, p65Rel, MyD88, IRAK, TRAF6, IkB, Inactive NIK, SAP K, SAP-1, JNK, interferon response genes, NFkB, Bax, TRAIL, TRAILrec, TRAILrecDRC5, TRAIL-R3, TRAIL-R4, RANK, RANK LIGAND, Ox40, Ox40 LIGAND, NKG2D, MICA, MICB, NKG2A, NKG2B, NKG2C, NKG2E, NKG2F, TAPI, TAP2 and functional fragments thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
摘要翻译：组合物，重组疫苗和活减毒病原体，其包含编码免疫原的分离的一个或多个分离的核酸分子，其与编码免疫调节蛋白的分离的核酸分子组合，所述免疫调节蛋白选自：Fos，c-jun，Sp-1， Ap-1，Ap-2，p38，p65Rel，MyD88，IRAK，TRAF6，IkB，非活性NIK，SAPK，SAP-1，JNK，干扰素应答基因，NFkB，Bax，TRAIL，TRAILrec，TRAILrecDRC5，TRAIL-R3，公开了TRAIL-R4，RANK，RANKLIGAND，Ox40，Ox40LIGAND，NKG2D，MICA，MICB，NKG2A，NKG2B，NKG2C，NKG2E，NKG2F，TAPI，TAP2及其功能片段。公开了使用这种组合物诱导个体对免疫原的免疫应答的方法。

8. 发明申请

WO2003030827A2 COMPOSITIONS FOR AND METHODS OF TREATING AND PREVENTING SIRS/SEPSIS 审中-公开
标题翻译：治疗和预防SIRS / SEPSIS的组合物和方法
公开(公告)号：WO2003030827A2
公开(公告)日：2003-04-17
申请号：PCT/US2002/032084
申请日：2002-10-07
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B. , KARUPPIAH, Muthumani
发明人： WEINER, David, B. , KARUPPIAH, Muthumani
IPC分类号： A61K
CPC分类号： A61K45/06 , A61K31/43 , A61K31/522 , A61K31/545 , A61K31/546 , A61K31/7036 , A61K38/162 , A61K48/00 , A61K2300/00
摘要： The present invention relates to methods of inhibiting the immune response underlying sepsis, to methods of preventing sepsis, to methods of treating sepsis and to pharmaceutical compositions useful in such methods.
摘要翻译：本发明涉及抑制脓毒症下的免疫反应的方法，预防败血症的方法，治疗败血症的方法和用于这些方法的药物组合物。

9. 发明申请

WO2002097043A2 WNV CORE PROTEIN/CAPSID INTERACTING PROTEIN AND USES OF THE SAME 审中-公开
标题翻译： WNV核心蛋白/ CAPSID相互作用蛋白质及其用途
公开(公告)号：WO2002097043A2
公开(公告)日：2002-12-05
申请号：PCT/US2002/016692
申请日：2002-05-28
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B. , RAMANATHAN, Mathura, P. , YANG, Joo-Sung
发明人： WEINER, David, B. , RAMANATHAN, Mathura, P. , YANG, Joo-Sung
IPC分类号： C12N
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/393
摘要： Substantially pure WIP-1 and its use in assays to identify PAP-l/WIP-1 interaction inhibitors or WIP-I/WNV Cp interaction inhibitors are disclosed. Compositions comprising antisense sequences to prevent expression of WlP-1 and methods of treating cancer using the same are disclosed.
摘要翻译：公开了基本上纯的WIP-1及其在鉴定PAP-1 / WIP-1相互作用抑制剂或WIP-I / WNV Cp相互作用抑制剂的测定中的用途。公开了包含用于预防WlP-1表达的反义序列的组合物和使用其的治疗癌症的方法。

10. 发明申请

WO2002097042A3 CHIMERIC PROTEINS FOR CELL TARGETING AND APOPTOSIS INDUCTION AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：WO2002097042A3
公开(公告)日：2002-12-05
申请号：PCT/US2002/016680
申请日：2002-05-28
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B.
发明人： WEINER, David, B.
IPC分类号： C07K14/715
摘要： Fusion proteins which comprise an apoptosis inducing protein portion and a cell targeting portion are disclosed. Fusion proteins which comprise a protease portion and a cell targeting portion are disclosed. Compositions for and methods of targeting and inducing the death of cells are disclosed.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式