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1. 发明授权

US6106642A Process for the improved ductility of nitinol 失效
标题翻译：镍钛诺改善延展性的工艺
公开(公告)号：US6106642A
公开(公告)日：2000-08-22
申请号：US088684
申请日：1998-06-02
申请人： Paul DiCarlo , Steven E. Walak
发明人： Paul DiCarlo , Steven E. Walak
IPC分类号： C22F1/10 , C22C19/03 , C22F1/00 , C22F1/18 , C22K1/00
CPC分类号： C22F1/006
摘要： A process for treating nitinol so that desired mechanical properties are achieved. In one embodiment, the process comprises the steps of exposing the nitinol to a primary annealing temperature within the range of approximately 475.degree. C. to 525.degree. C. for a first time period, and thereafter exposing the nitinol to a secondary annealing temperature within the range of approximately 550.degree. C. to 800.degree. C. for a second time period. The invention also includes nitinol articles made by the process of the invention.
摘要翻译：一种处理镍钛诺以达到期望的机械性能的方法。在一个实施方案中，该方法包括以下步骤：将镍钛诺第一次暴露于约475℃至525℃范围内的初级退火温度，然后将镍钛诺暴露于第二退火温度范围为约550℃至800℃，持续第二时间。本发明还包括通过本发明的方法制备的镍诺醇制品。

2. 发明授权

US06997947B2 Multi-property nitinol by heat treatment 失效
公开(公告)号：US06997947B2
公开(公告)日：2006-02-14
申请号：US10304249
申请日：2002-11-26
申请人： Steven E. Walak , Paul DiCarlo
发明人： Steven E. Walak , Paul DiCarlo
IPC分类号： A61F2/06
CPC分类号： A61F2/01 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/016 , A61F2002/91541 , A61F2002/91558 , A61F2230/005 , A61F2230/0069 , A61F2230/008 , A61F2250/0018 , A61F2250/0042 , A61F2250/0048
摘要： Medical devices may be made of shape-memory materials portions of which have been heat treated to exhibit spatial variations in the stiffness of the material. Devices including stents, vena cava filters and guidewires may be constructed from such materials. Devices may also be made from shape-memory materials which have been locally heat treated such that the superelasticity of the treated portion is destroyed while the remainder of the shape-memory material can transition between the martensitic and austenitic states.

3. 发明授权

US06540849B2 Process for the improved ductility of nitinol 失效
公开(公告)号：US06540849B2
公开(公告)日：2003-04-01
申请号：US09507753
申请日：2000-02-22
申请人： Paul DiCarlo , Steven E. Walak
发明人： Paul DiCarlo , Steven E. Walak
IPC分类号： C22C1903
CPC分类号： C22F1/006
摘要： A process for treating nitinol so that desired mechanical properties are achieved. In one embodiment, the process comprises the steps of exposing the nitinol to a primary annealing temperature within the range of approximately 475° C. to 525° C. for a first time period, and thereafter exposing the nitinol to a secondary annealing temperature within the range of approximately 550° C. to 800° C. for a second time period. The invention also includes nitinol articles made by the process of the invention.

4. 发明授权

US06485507B1 Multi-property nitinol by heat treatment 有权
标题翻译：多属性镍钛诺经热处理
公开(公告)号：US06485507B1
公开(公告)日：2002-11-26
申请号：US09362261
申请日：1999-07-28
申请人： Steven E. Walak , Paul DiCarlo
发明人： Steven E. Walak , Paul DiCarlo
IPC分类号： A61F206
CPC分类号： A61F2/01 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/016 , A61F2002/91541 , A61F2002/91558 , A61F2230/005 , A61F2230/0069 , A61F2230/008 , A61F2250/0018 , A61F2250/0042 , A61F2250/0048
摘要： Medical devices may be made of shape-memory materials portions of which have been heat treated to exhibit spatial variations in the stiffness of the material. Devices including stents, vena cava filters and guidewires may be constructed from such materials. Devices may also be made from shape-memory materials which have been locally heat treated such that the superelasticity of the treated portion is destroyed while the remainder of the shape-memory material can transition between the martensitic and austenitic states.
摘要翻译：医疗装置可以由形状记忆材料制成，其部分已被热处理以显示材料刚度的空间变化。包括支架，腔静脉过滤器和导丝的装置可以由这样的材料构成。器件还可以由局部热处理的形状记忆材料制成，使得被处理部分的超弹性被破坏，而其余的形状记忆材料可以在马氏体和奥氏体状态之间转变。

5. 发明授权

US08445022B2 Embolization 有权
标题翻译：栓塞
公开(公告)号：US08445022B2
公开(公告)日：2013-05-21
申请号：US13491915
申请日：2012-06-08
申请人： Paul DiCarlo , Thomas V. Casey, II , Stephan P. Mangin
发明人： Paul DiCarlo , Thomas V. Casey, II , Stephan P. Mangin
IPC分类号： A61K9/14
CPC分类号： A61L31/04 , A61B17/12022 , A61B17/12031 , A61B17/12036 , A61B17/12186 , A61B17/42 , A61B2017/1205 , A61K9/0019 , A61K9/167 , A61L24/0015 , A61L24/0036 , A61L24/046 , A61L31/14 , A61L2300/62 , A61L2430/36 , Y10T428/2982 , Y10T428/2998
摘要： Embolization, as well as related particles, compositions, and methods, are disclosed.
摘要翻译：公开了栓塞，以及相关的颗粒，组合物和方法。

6. 发明授权

US08157850B2 Device and method for loading a luminal graft for endoluminal delivery 失效
标题翻译：用于装载腔内移植物用于腔内递送的装置和方法
公开(公告)号：US08157850B2
公开(公告)日：2012-04-17
申请号：US10629077
申请日：2003-07-29
申请人： Nancy Usiak , Paul DiCarlo , Robert F. Rioux , Kristian DiMatteo , James Weldon , Shubhang Mishra
发明人： Nancy Usiak , Paul DiCarlo , Robert F. Rioux , Kristian DiMatteo , James Weldon , Shubhang Mishra
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2002/9522
摘要： An endoluminal graft is wrapped axially upon itself to form a low profile, which facilitates endoluminal delivery. Apparatus and systems for making and using such grafts are also disclosed.
摘要翻译：腔内移植物在其自身上轴向包裹以形成低轮廓，其有助于腔内递送。还公开了用于制造和使用这种移植物的装置和系统。

7. 发明申请

US20110313368A1 Pressure Activated Valve with High Flow Slit 有权
标题翻译：高流量狭缝压力活化阀
公开(公告)号：US20110313368A1
公开(公告)日：2011-12-22
申请号：US13222277
申请日：2011-08-31
申请人： Karla Weaver , Paul DiCarlo
发明人： Karla Weaver , Paul DiCarlo
IPC分类号： A61M25/14
CPC分类号： A61M39/24 , A61M25/0097 , A61M25/0606 , A61M25/0637 , A61M39/22 , A61M2039/242 , A61M2039/2426
摘要： A pressure actuated valve for controlling the flow of fluid through a medical device, the valve comprises a housing including a lumen extending therethrough and a flow control membrane extending across the lumen to control the flow of fluid through the lumen. The membrane includes a plurality of slits extending therethrough so that, when the membrane is acted upon by a pressure of at least a threshold magnitude, the slits open to permit flow through the lumen and, when not acted upon by a pressure of at least the predetermined magnitude, the slits are maintained closed by a biasing force applied thereto by the membrane to prevent flow through the lumen. Each of the slits extends between end portions thereof along a curve wherein a distance between a first end portion of a first one of the slits and a first end portion of a second one of the slits is a minimum distance between the first and second slits.
摘要翻译：一种用于控制通过医疗装置的流体流动的压力致动阀，所述阀包括壳体，所述壳体包括延伸穿过其中的内腔和延伸穿过所述内腔的流动控制膜，以控制通过所述内腔的流体流动。膜包括延伸穿过其中的多个狭缝，使得当膜以至少阈值大小的压力作用时，狭缝开放以允许流过内腔，并且当不受至少通过由膜施加到其上的偏压力来保持狭缝保持关闭，以防止流过管腔。每个狭缝沿其曲线在其端部之间延伸，其中第一个狭缝中的第一个端部与第二个狭缝的第一端部之间的距离是第一和第二狭缝之间的最小距离。

8. 发明申请

US20110276038A1 METHOD AND SYSTEM FOR INTRACAVITARY AND EXTRACAVITARY PROCEDURES 有权
标题翻译：方法和系统的入侵和额外程序
公开(公告)号：US20110276038A1
公开(公告)日：2011-11-10
申请号：US13094736
申请日：2011-04-26
申请人： Jon T. McIntyre , Barry Weitzner , Paul DiCarlo , Paul Smith
发明人： Jon T. McIntyre , Barry Weitzner , Paul DiCarlo , Paul Smith
IPC分类号： A61B17/00
CPC分类号： A61B17/00234 , A61B17/29 , A61B17/320016 , A61B17/42 , A61B18/1492 , A61B2017/00278 , A61B2017/003 , A61B2017/00477 , A61B2017/00876 , A61B2018/143 , A61B2018/1432
摘要： Embodiments include a method of performing a medical procedure in a patient. The method includes inserting a first working instrument and a second working instrument through an opening in the patient, creating an incision in body tissue inside the patient using at least one of the first and second working instruments, and advancing the second working instrument through the incision to position the second working instrument at a work site inside the patient. The method also includes positioning the first working instrument at the work site without advancing the first working instrument through the incision and performing a procedure at the work site inside the patient using the first and second working instruments.
摘要翻译：实施例包括在患者体内执行医疗程序的方法。该方法包括通过患者的开口插入第一工作器械和第二工作器械，使用第一和第二工作器械中的至少一个在身体组织内产生切口，并通过切口推进第二工作器械将第二工作仪器定位在患者体内的工作现场。该方法还包括将第一工作仪器定位在工作现场，而不通过切口推进第一工作仪器，并使用第一和第二工作仪器在病人内的工作现场执行过程。

9. 发明授权

US07828744B2 Method and assembly for breast immobilization 失效
标题翻译：乳房固定方法和装配
公开(公告)号：US07828744B2
公开(公告)日：2010-11-09
申请号：US10422409
申请日：2003-04-23
申请人： Robert Rioux , Paul DiCarlo
发明人： Robert Rioux , Paul DiCarlo
IPC分类号： A61B10/00
CPC分类号： A61B90/17 , A61B18/1477 , A61B90/10 , A61B90/11 , A61B90/14 , A61B2017/008 , A61B2017/3411 , A61B2018/00011 , A61B2018/1425 , A61B2018/143 , A61B2018/1475
摘要： A device, method, and system are provided for immobilizing and stabilizing a breast in preparation for tumor ablation or biopsy while the patient is lying supine. The breast is lifted away from the chest wall of the patient, so that the tissue abnormality to be treated is also lifted away from the chest wall. This reduces the possibility of damage to the neighboring costochondral wall and the surrounding healthy tissue. The device includes a medical device holder that can be used to accurately aim a medical probe, and hold it in place during treating.
摘要翻译：提供了一种装置，方法和系统，用于固定和稳定乳房以准备肿瘤消融或活检，同时患者仰卧。将乳房从患者的胸壁抬起，使待处理的组织异常也从胸壁抬起。这减少了损坏附近的软骨壁和周围的健康组织的可能性。该装置包括可用于精确瞄准医疗探针的医疗装置保持器，并且在治疗期间将其保持在适当位置。

10. 发明授权

US07751869B2 Radiation ablation tracking system and method 失效
标题翻译：辐射消融跟踪系统及方法
公开(公告)号：US07751869B2
公开(公告)日：2010-07-06
申请号：US11298807
申请日：2005-12-09
申请人： Robert F. Rioux , Paul DiCarlo
发明人： Robert F. Rioux , Paul DiCarlo
IPC分类号： A61B5/05
CPC分类号： A61N5/1049 , A61B18/1477 , A61B18/148 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61N5/1065 , A61N2005/1061
摘要： A system and method for treating a target tissue region (e.g., malignant tissue) is provided. A hyperthermic probe is placed into contact with the target tissue region, and the target tissue region is exposed to a therapeutic x-ray radiation beam. The probe is operated to increase the temperature of the target tissue region, thereby facilitating a therapeutic effect of the radiation beam. Image data of the probe containing a fiducial datum is acquired while in contact with the target tissue region, a position of the target tissue region within a treatment coordinate system is determined based on the fiducial datum, and the radiation beam is spatially adjusted relative to the target tissue region based on the determined position of the target tissue region.
摘要翻译：提供了用于治疗靶组织区域（例如，恶性组织）的系统和方法。将高温探针放置成与目标组织区域接触，并且将目标组织区域暴露于治疗性X射线辐射束。操作探针以增加靶组织区域的温度，从而有助于辐射束的治疗效果。在与目标组织区域接触的同时获取包含基准数据的探针的图像数据，基于基准原理确定处理坐标系内的目标组织区域的位置，并且相对于基于所确定的目标组织区域的位置的目标组织区域。

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