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1. 发明授权

US07026134B2 Haptens, immunogens and antibodies to oxycodone and its metabolites 有权
公开(公告)号：US07026134B2
公开(公告)日：2006-04-11
申请号：US10323850
申请日：2002-12-20
申请人： John Victor Lamont , Robert Ivan McConnell , Stephen Peter Fitzgerald , El Ouard Benchikh , Andrew Philip Lowry
发明人： John Victor Lamont , Robert Ivan McConnell , Stephen Peter Fitzgerald , El Ouard Benchikh , Andrew Philip Lowry
IPC分类号： G01N33/535 , C07K16/44 , C12P21/08 , C07D471/08
CPC分类号： G01N33/9486 , C07D489/02
摘要： Novel haptens, which can be conjugated to form immunogens, are of formula I, II or III wherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional group.

2. 发明授权

US06232090B1 Dried tetramethoxysilane sol-gel containing a leachable reagent 失效
标题翻译：含有可浸出试剂的干燥四甲氧基硅烷溶胶 - 凝胶
公开(公告)号：US06232090B1
公开(公告)日：2001-05-15
申请号：US09192280
申请日：1998-11-16
申请人： Stephen Peter Fitzgerald , John Victor Lamont , Robert Ivan McConnell
发明人： Stephen Peter Fitzgerald , John Victor Lamont , Robert Ivan McConnell
IPC分类号： C12Q100
CPC分类号： G01N33/535 , G01N33/5436 , G01N33/552
摘要： First and second reactants that give a signal when mixed in the presence of an analyte in a liquid sample, are separately contained in sol-gels that release the reactants in the presence of the liquid. For example, when the first and second reactants respectively comprise an oxidant and a reductant, and the reaction provides a detectable signal, the system can be used to detect the presence of contaminants in a water sample. The sol-gel may be obtained by reaction of water with, per part by volume thereof, at least 2 parts of a metal alkoxide, and drying the resultant gel.
摘要翻译：在液体样品中的分析物存在下混合时产生信号的第一和第二反应物分别包含在溶液中，在溶液存在下释放反应物。例如，当第一和第二反应物分别包含氧化剂和还原剂并且反应提供可检测的信号时，该系统可用于检测水样品中污染物的存在。可以通过水与其每体积体积的至少2份金属醇盐反应并干燥所得凝胶来获得溶胶 - 凝胶。

3. 发明授权

US07811824B2 Method and apparatus for monitoring the properties of a biological or chemical sample 有权
标题翻译：用于监测生物或化学样品性质的方法和装置
公开(公告)号：US07811824B2
公开(公告)日：2010-10-12
申请号：US11392808
申请日：2006-03-30
申请人： John Victor Lamont , Robert Ivan McConnell , Stephen Peter Fitzgerald
发明人： John Victor Lamont , Robert Ivan McConnell , Stephen Peter Fitzgerald
IPC分类号： G01N33/48 , G01N33/483
CPC分类号： G06Q50/22 , G06F19/20 , G06F19/28 , Y10T436/115831 , Y10T436/12
摘要： A method of monitoring the properties of a biological or chemical sample. The method includes carrying out a plurality of different tests on the sample to generate corresponding test data; optionally carrying out a preliminary processing of the test data to generate partially processed data; storing the test data and/or partially processed data; causing a processing system to analyze a user-defined selection of the test data or partially processed data to generate result data relating to one or more properties of the sample; and subsequent to the previous step, receiving a second user defined selection of the test data or partially processed data, different from the first selection, and causing the processing system to analyze the second user-defined selection of the test data or partially processed data to generate second result data relating to one or more properties of the sample different from the properties corresponding to the first user-defined selection.
摘要翻译：监测生物或化学样品性质的方法。该方法包括对样本进行多个不同的测试以产生相应的测试数据; 可选地执行测试数据的初步处理以产生部分处理的数据; 存储测试数据和/或部分处理的数据; 使处理系统分析用户定义的测试数据选择或部分处理的数据，以生成与样本的一个或多个属性有关的结果数据; 并且在所述前一步骤之后，接收与所述第一选择不同的所述测试数据或部分处理的数据的第二用户定义的选择，并且使所述处理系统分析所述测试数据或部分处理的数据的所述第二用户定义的选择，产生与不同于与第一用户定义的选择相对应的属性的样本的一个或多个属性相关的第二结果数据。

4. 发明授权

US06881572B2 Assay device incubator 有权
标题翻译：测定装置孵化器
公开(公告)号：US06881572B2
公开(公告)日：2005-04-19
申请号：US10406224
申请日：2003-04-04
申请人： Stephen Peter Fitzgerald , John Victor Lamont , Robert Ivan McConnell
发明人： Stephen Peter Fitzgerald , John Victor Lamont , Robert Ivan McConnell
IPC分类号： B01F11/00 , B01L7/00 , C12M1/00 , G01N35/00 , G01N35/02 , C12M1/02
CPC分类号： G01N35/028 , B01F11/0022 , B01L7/00 , G01N2035/00356 , G01N2035/00524 , Y10S435/809
摘要： An assay device incubator comprises a housing (46) defining a region within which at least one assay device is located in use, the housing defining laterally opposed sidewalls (48, 50) of at least one bay (33) in which an assay device can be located. The housing (46) includes one or more guides (49, 51) for supporting the assay device and enabling the assay device to undergo to and fro movement therealong. A vibration system (40, 60) is coupled to the at least one tray in use for vibrating the tray to and fro along the or each guide. A heating system (70) heats the region within the housing.
摘要翻译：测定装置培养箱包括限定其中至少一个测定装置位于使用中的区域的壳体（46），所述壳体限定至少一个隔间（33）的横向相对的侧壁（48,50），其中测定装置可以位于。壳体（46）包括用于支撑测定装置的一个或多个引导件（49,51），并且使测定装置能够沿着其移动。振动系统（40,60）在使用中联接到所述至少一个托盘，用于沿着或每个引导件来回振动托盘。加热系统（70）加热壳体内的区域。

5. 发明授权

US07846713B2 Calibrating microarrays 有权
标题翻译：校准微阵列
公开(公告)号：US07846713B2
公开(公告)日：2010-12-07
申请号：US10491811
申请日：2002-10-10
申请人： John Victor Lamont , Robert Ivan McConnell , Stephen Peter Fitzgerald , Maria Luz Rodriguez
发明人： John Victor Lamont , Robert Ivan McConnell , Stephen Peter Fitzgerald , Maria Luz Rodriguez
IPC分类号： C12M1/00
CPC分类号： G01N33/54386 , G01N33/54306 , Y10S436/807 , Y10S436/809
摘要： An assay for measuring the amount of a first analyte in a sample, comprises the steps of: (i) contacting the sample with a device that comprises one or more first reaction sites which comprise a first ligand having affinity for the first analyte, and a series of second reaction sites each comprising different known concentrations of an immobilized second analyte; (ii) removing any unbound first analyte; (iii) contacting the device with a second ligand that is detectably labelled and which has affinity for the first analyte, and a third ligand that is detectably labelled and which has affinity for the second analyte; (iv) removing any unbound second and third ligands; and (v) measuring the amount of second and third ligands, wherein measurement of the third ligand is used to establish a calibration curve, used to determine the amount of first analyte present in sample.
摘要翻译：用于测量样品中第一分析物的量的测定包括以下步骤：（i）使样品与包含一个或多个包含对第一分析物具有亲和力的第一配体的第一反应位点的装置接触，以及一系列第二反应位点各自包含不同已知浓度的固定化第二分析物; （ii）去除任何未结合的第一分析物; （iii）使该装置与可检测标记并对第一分析物具有亲和力的第二配体和可检测地标记并对第二分析物具有亲和力的第三配体; （iv）除去任何未结合的第二和第三配体; 和（v）测量第二和第三配体的量，其中第三配体的测量用于建立校准曲线，用于确定样品中存在的第一分析物的量。

6. 发明授权

US06308751B1 Liquid dispensing apparatus 有权
标题翻译：液体分配装置
公开(公告)号：US06308751B1
公开(公告)日：2001-10-30
申请号：US09552751
申请日：2000-04-19
申请人： Stephen Peter Fitzgerald , John Victor Lamont , Robert Ivan McConnell , James Rudolf Meyer
发明人： Stephen Peter Fitzgerald , John Victor Lamont , Robert Ivan McConnell , James Rudolf Meyer
IPC分类号： B65B104
CPC分类号： G01N35/1081 , G01N35/1083 , G01N35/109 , G01N2035/0482 , G01N2035/0484 , G01N2035/1086
摘要： Liquid dispensing apparatus comprises a support member which supports a movably mounted dispensing member. The support member is movable between first and second positions. A single drive system causes the dispensing member to move relative to the support member to a number of dispense positions while the support member is in its first position and causes the support member to move to the second position.
摘要翻译：液体分配装置包括支撑可移动地安装的分配构件的支撑构件。支撑构件可在第一和第二位置之间移动。单个驱动系统使得分配构件相对于支撑构件移动到多个分配位置，同时支撑构件处于其第一位置并且使得支撑构件移动到第二位置。

7. 发明授权

US06902897B2 Biochip deposition system and method 有权
标题翻译：生物芯片沉积系统及方法
公开(公告)号：US06902897B2
公开(公告)日：2005-06-07
申请号：US10188796
申请日：2002-07-05
申请人： Mark Tweedie , John Victor Lamont , Robert Ivan McConnell , Stephen Peter Fitzgerald
发明人： Mark Tweedie , John Victor Lamont , Robert Ivan McConnell , Stephen Peter Fitzgerald
IPC分类号： B01J19/00 , B01L3/02 , C40B60/14 , C40B70/00 , G01N35/00 , G01N35/10 , C12Q1/68 , C07H21/02
CPC分类号： G01N35/00603 , B01J19/0046 , B01J2219/00351 , B01J2219/00527 , B01J2219/00529 , B01J2219/0054 , B01J2219/00545 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01L3/0268 , B82Y30/00 , C40B60/14 , C40B70/00 , G01N35/10 , G01N2035/1034
摘要： A biochip deposition system and method. The system comprises a deposit mechanism for depositing organic material in spots on a substrate; and a viewing system for detecting the spots on the substrate during a deposit operation and before the spots have dried, for determining if the spots have been correctly deposited, and if not, for generating a suitable output signal. The viewing system includes an illumination device for illuminating deposited spots at a relatively low angle relative to the substrate.
摘要翻译：一种生物芯片沉积系统及方法。该系统包括用于在基板上的点沉积有机材料的沉积机构; 以及观察系统，用于在沉积操作期间和斑点干燥之前检测基板上的斑点，以确定斑点是否已被正确沉积，如果不是，则用于产生合适的输出信号。观察系统包括用于以相对于衬底相对低的角度照射沉积点的照明装置。

8. 发明授权

US06897026B2 Array imaging method 有权
标题翻译：阵列成像方法
公开(公告)号：US06897026B2
公开(公告)日：2005-05-24
申请号：US10046728
申请日：2002-01-17
申请人： John Victor Lamont , Robert Ivan McConnell , Stephen Peter Fitzgerald
发明人： John Victor Lamont , Robert Ivan McConnell , Stephen Peter Fitzgerald
IPC分类号： G01N33/53 , C12M1/34 , C40B40/06 , C40B40/10 , C40B50/08 , G01N21/25 , G01N21/78 , G01N33/566 , G01N37/00 , C12Q1/68 , C07H21/04 , C12M1/36 , G01N21/47
CPC分类号： B82Y30/00 , B01J2219/00274 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00599 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/08 , G01N21/253
摘要： A method for imaging molecules contained in an array of discrete reaction sites on the surface of a solid support comprises: (i) imaging the array and detecting a first molecule located on the solid support at a known position with respect to the array; (ii) by reference to the first molecule, aligning inspection windows in registration with the discrete reaction sites; and (iii) determining the amount of detectable signal in each window. The method is used to locate the reaction sites accurately on the array, and to correct for any misalignments.
摘要翻译：用于对包含在固体支持物表面上的离散反应位点阵列中的分子进行成像的分子的方法包括：（i）对阵列进行成像并检测位于相对于阵列的已知位置的固体支持物上的第一分子; （ii）通过参考第一分子，将检查窗对准离散的反应位点; 和（iii）确定每个窗口中的可检测信号的量。该方法用于在阵列上准确定位反应位点，并纠正任何错位。

9. 发明授权

US06649128B1 Assay device processing instrument 有权
标题翻译：测定装置处理仪器
公开(公告)号：US06649128B1
公开(公告)日：2003-11-18
申请号：US09397735
申请日：1999-09-17
申请人： James Rudolf Meyer , Ahti Kalevi Kansanaho , Stephen Peter Fitzgerald , Robert Ivan McConnell , John Victor Lamont , Bailin Cao
发明人： James Rudolf Meyer , Ahti Kalevi Kansanaho , Stephen Peter Fitzgerald , Robert Ivan McConnell , John Victor Lamont , Bailin Cao
IPC分类号： G01N2100
CPC分类号： G01N35/028 , G01N35/00029 , G01N35/0099 , G01N2035/00158 , G01N2035/00326 , G01N2035/0425 , Y10T436/113332
摘要： An assay device processing instrument comprises a plurality of processing modules. A transport system transports an assay device to each processing module, the transport system being adapted to transfer the assay device from the transport system to the module to enable the transport system to transport another assay device while the first is processed by the processing module. A control system controls operation of the transport system such that each assay device is transferred between the modules in a predetermined sequence, and such that a number of assay devices can be processed in different modules simultaneously.
摘要翻译：测定装置处理装置包括多个处理模块。运输系统将测定装置运送到每个处理模块，所述运输系统适于将测定装置从运输系统传送到模块，以使得运输系统能够在第一个由处理模块处理的同时运送另一个测定装置。控制系统控制运输系统的操作，使得每个测定装置以预定顺序在模块之间转移，并且使得可以同时在不同模块中处理多个测定装置。

10. 发明申请

US20090280499A1 METHOD AND KIT FOR DETECTING, OR DETERMINING 3,4- METHYLENEDIOXYMETHAMPHETAMINE 审中-公开
标题翻译：用于检测或测定3,4-亚甲基二甲基氨基甲烷的方法和试剂盒
公开(公告)号：US20090280499A1
公开(公告)日：2009-11-12
申请号：US11695815
申请日：2007-04-03
申请人： Robert Ivan McConnell , Elouard Benchikh , Stephen Peter Fitzgerald , John Victor Lamont
发明人： Robert Ivan McConnell , Elouard Benchikh , Stephen Peter Fitzgerald , John Victor Lamont
IPC分类号： G01N33/53 , C07D317/48 , C12N9/96 , C07K16/18
CPC分类号： C07K16/44 , G01N33/946 , Y10S435/81 , Y10S435/975 , Y10S436/815 , Y10S530/807 , Y10T436/13
摘要： The invention provides a hapten, an immunogen comprising the hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with MDMA.
摘要翻译：本发明提供了一种半抗原，一种免疫原，其包含与产生抗原性的载体材料偶联的半抗原，包含与标记试剂偶联的半抗原的缀合物，以及针对上述免疫原产生并能够与MDMA结合的抗体。

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