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1. 发明专利

AU564955B2 STERILIZATION OF ENZYME CONTAMINATED BY BACTERIA USING POLYVALENT ALCOHOL 未知
公开(公告)号：AU564955B2
公开(公告)日：1987-09-03
申请号：AU2604484
申请日：1984-03-23
申请人： SNOW BRAND MILK PROD CO LTD
发明人： IWASAKI TAISUKE , HONDA YOSHIHIKO , NAGAOKA FUMIO , AOKI SADAO , HORIGOME KAZUO , IMADA RUYZO
IPC分类号： A23C9/12 , A61L2/00 , A61L2/18 , C12N9/00 , C12N11/00 , A61L2/16
摘要： An enzyme contaminated by bacteria during preservation or repeated use thereof is sterilized by immersing the enzyme contaminated mass in a polyvalent alcohol. This procedure does not inactivate the enzyme.

2. 发明专利

DE2714103A1 Gelling microscopic cells having enzymatic activity - by mixing cell suspension with crosslinking reagent, freezing and thawing 未知
公开(公告)号：DE2714103A1
公开(公告)日：1977-10-20
申请号：DE2714103
申请日：1977-03-30
申请人： SNOW BRAND MILK PROD CO LTD
发明人： IWASAKI TAISUKE , KIKUCHI TOSHIHIKO
IPC分类号： C12N11/00 , C12N11/04 , C12N11/16 , C12P19/24 , C07G7/02
摘要： A suspension of microscopically small cells having intracellular enzymatic activity is admixed with a crosslinking reagent. Mixt. obtd. is frozen. Frozen cells are then thawed in an organic solvent or in water. Alternatively, an organic solvent is added to cell suspension followed by addn. of crosslinking reagent. The cells are then frozen, thawed and, if necessary, dried, pref. under a low temp., e.g. freeze-dried. Intracellular enzymes carried by cells are fixed. The fixed enzymes can be used industrially, in column packing processes for continuous reactions.

3. 发明专利

DE3410436A1 未知
公开(公告)号：DE3410436A1
公开(公告)日：1984-09-27
申请号：DE3410436
申请日：1984-03-22
申请人： SNOW BRAND MILK PROD CO LTD
发明人： IWASAKI TAISUKE , HONDA YOSHIHIKO , NAGAOKA FUMIO , AOKI SADAO , HORIGOME KAZUO , IMADA RUYZO
IPC分类号： A23C9/12 , A61L2/00 , A61L2/18 , C12N9/00 , C12N11/00 , C12N9/38
摘要： An enzyme contaminated by bacteria during preservation or repeated use thereof is sterilized by immersing the enzyme contaminated mass in a polyvalent alcohol. This procedure does not inactivate the enzyme.

4. 发明专利

AU2604484A SING POLYVALENT ALCOHOL 未知
公开(公告)号：AU2604484A
公开(公告)日：1984-09-27
申请号：AU2604484
申请日：1984-03-23
申请人： SNOW BRAND MILK PROD CO LTD
发明人： IWASAKI TAISUKE , HONDA YOSHIHIKO , NAGAOKA FUMIO , AOKI SADAO , HORIGOME KAZUO , IMADA RUYZO
IPC分类号： A23C9/12 , A61L2/00 , A61L2/18 , C12N9/00 , C12N11/00 , A61L2/16
摘要： An enzyme contaminated by bacteria during preservation or repeated use thereof is sterilized by immersing the enzyme contaminated mass in a polyvalent alcohol. This procedure does not inactivate the enzyme.

5. 发明专利

IT7968768D0 未知
公开(公告)号：IT7968768D0
公开(公告)日：1979-09-05
申请号：IT6876879
申请日：1979-09-05
申请人： SNOW BRAND MILK PROD CO LTD
发明人： HONDA YOSHIHITO , KOUTAKE MASANOBU , KANAZAWA HIDEGE , IWASAKI TAISUKE , OHBA SHOZO , HASHIBA HONOH , KAWANISHI GOSEI
IPC分类号： A23C9/12 , C12M1/40 , C12P19/14 , C12P21/06

6. 发明专利

JPH10245316A AGENT FOR PREVENTING AND AMELIORATING AGING OF SKIN 失效
公开(公告)号：JPH10245316A
公开(公告)日：1998-09-14
申请号：JP6531997
申请日：1997-03-04
申请人： SNOW BRAND MILK PROD CO LTD
发明人： ITAGAKI KOJI , OBA TETSUO , TANIMOTO MORIMASA , OTA YOSHIYUKI , KLAUS DOESBURG , JAN SIKKEMA , IWASAKI TAISUKE
IPC分类号： A61K8/72 , A61K8/00 , A61K8/73 , A61Q19/00 , A61Q19/08 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain the subject new cosmetic by compounding a phosphorylated polysaccharide having humectant action and collagen-producing performance as an active component. SOLUTION: This cosmetic contains a compound of the formula (Glc is glucose residue; Gal is galactose residue; Rha is rhamnose residue; (m) is 0-3; (n) is 1,000-5,000) as an active component. The component of the formula can be produced by hydrolyzing actinase E of defatted milk, treating the defatted milk with ultrafiltration membrane, sterilizing the filtrate to obtain a culture medium, aseptically pipetting the sterilized medium into a jar fermenter, inoculating a precultured liquid, culturing at 20 deg.C and pH5.5 using NH3 water as a neutralizing agent, subjecting the cultured product to centrifugal separation after culture to recover the supernatant, adding an equal amount of CH3 OH, recovering the produced precipitate, dissolving the precipitate in 0.2N saline water, repeating the precipitation operation with CH3 OH, subjecting the treated precipitate to electrophoresis, recovering the component impregnated into the gel and purifying the recovered fraction by ion-exchange chromatography to obtain purified polysaccharide. It is necessary to compound a cosmetic with >=0.001wt.% of the compound of the formula.

7. 发明专利

JPH0622644A COMPOSITION FOR ARTIFICIAL CULTURE OF MUSHROOM 失效
公开(公告)号：JPH0622644A
公开(公告)日：1994-02-01
申请号：JP31007091
申请日：1991-10-30
申请人： SNOW BRAND MILK PROD CO LTD
发明人： HATAMOTO HITOSHI , MIYAMOTO MARI , IWASAKI TAISUKE
IPC分类号： A01G1/04
摘要： PURPOSE:To provide the composition satisfying mushroom growing conditions, safe in view of food sanitation, using chitosan as an inexpensive alternative to sawdust getting hard to obtain, containing a composite made up of bean-curd refuse and chitosan. CONSTITUTION:A composition comprising (A) 100 pts.wt. of bean-curd refuse, (B) 8 pts.wt. of chitosan (deacetylation degree: 75%), (C) 8 pts.wt. of lactic acid, and (D) 484 pts.wt. of water is agitated for 5 min. using a blender. Then, 4.5 pts.wt. of sodium bicarbonate is added to the composition followed by agitation to adjust the pH value of the blend at 6.2, and the resulting blend is cast into a stainless steel vat and frozen at -20 deg.C and then lyophilized. The resultant blend is treated in acetic anhydride to prepare a porous composite, which is then made into granules, thus obtaining the objective composition having the above-mentioned advantages and useful as a solid medium for artificial culture of mushroom such as Fomes japonicus, Flammulina velutipes, or shiitake.

8. 发明专利

JPH0614765A COMPOSITION FOR SOLID CULTURE OF MOLD 失效
公开(公告)号：JPH0614765A
公开(公告)日：1994-01-25
申请号：JP31007191
申请日：1991-10-30
申请人： SNOW BRAND MILK PROD CO LTD
发明人： HATAMOTO HITOSHI , MIYAMOTO MARI , IWASAKI TAISUKE
IPC分类号： A23L11/20 , A23L27/50 , C12G3/02 , C12N1/14 , C12R1/80 , A23L1/238
摘要： PURPOSE:To obtain the subject composition, comprising a complex composed of bean- curd refuse and chitosan, having growth conditions for a mold, safe for food sanitation and useful as a culture medium, etc., for producing mold spores, obtaining an enzyme derived from the mold, producing, etc., a mold starter for cheeses, SAKE (Japanese rice wine), MISO (fermented bean paste) or soy sauce. CONSTITUTION:The objective composition for a culture medium for obtaining a mold starter used as a culture medium for producing spores of a mold, obtaining an enzyme capable of producing the mold or as the mold starter for producing cheeses or brewing SAKE, MISO, soy sauce, etc., is obtained by adding 8 pts.wt. chitosan (having 75% deacetylation degree), 8 pts.wt. lactic acid and 484 pts.wt. water to 100 pts.wt. bean- curd refuse which is a by-product in producing bean curd, stirring the resultant mixture with a blender for 5min, then adding 4.5 pts.wt. sodium bicarbonate, further stirring the mixture for 5min, regulating the pH to 6.2, casting the obtained mixture into a vat made of stainless steel, freezing the mixture at -20 deg.C then carrying out the freeze-drying treatment, subsequently treating the freeze-dried mixture in acetic anhydride, preparing a porous complex, then drying and granulating the complex. This composition has growth conditions for the molds and is safe for food sanitation.

9. 发明专利

JPH05123175A PRODUCTION OF (+)-RHODODENDROL 失效
公开(公告)号：JPH05123175A
公开(公告)日：1993-05-21
申请号：JP31166391
申请日：1991-10-30
申请人： SNOW BRAND MILK PROD CO LTD
发明人： FUJITA TAKASHI , HATAMOTO HITOSHI , IWASAKI TAISUKE
IPC分类号： A61K31/05 , A61K36/18 , A61P1/16 , C12P7/22
摘要： PURPOSE:To obtain the subject compound having high optical purity and useful for an analepticum for hepatic diseases in large quantities by adding an enzymatic extraction liquid of Acer nikoense callus to 4-(p-hydroxyphenyl)-2-butanone, subjecting to stereoselective reduction and recovering the reactional product. CONSTITUTION:A young twig of Acer nikoense is cut to a proper size and sterilized by immersing in 70% aqueous solution of ethanol for 3min. After peeling the bark, the twig is cut in round slices of 5mm thick, placed on a medium incorporated with alpha-naphthaleneacetic acid and benzyladenine and cultured in dark place at 25 deg.C to form a callus. The callus is crushed, extracted with 0.1M tris-HC1 buffer solution (pH7.5) and centrifuged. The supernatant liquid is extracted with an enzyme containing an alcohol dehydrogenase and the extract is added to 4-(p-hydroxyphenyl)-2-butanone, which is converted into (+)-4-(p-hydroxyphenyl)-2-butanol [(+)-rhododendrol] by stereoselective reduction reaction.

10. 发明专利

JPH0475587A PRODUCTION OF RHODODENDROL 失效
公开(公告)号：JPH0475587A
公开(公告)日：1992-03-10
申请号：JP18864190
申请日：1990-07-17
申请人： SNOW BRAND MILK PROD CO LTD
发明人： FUJITA TAKASHI , MIYAMOTO MARI , IWASAKI TAISUKE
IPC分类号： C12P7/22 , C12R1/865
摘要： PURPOSE:To produce (+)-rhododendrol having high optical purity on an industrial scale without being influenced by weather, seasons, etc., by treating 4-(p- hydroxyphenyl)-2-butanone with yeast. CONSTITUTION:Yeast is cultured in a medium containing glucose, corn steep liquor and peptone, etc., for about 24-48 hours and mixed with about 0.5g/l-50g/l4-(p-hydroxyphenyl)-2-butanone of a starting substance to start reaction. The reaction time varies with an amount of 4-(p-hydroxyphenyl)-2-butanone added and generally requires 1-7 days. Rhododendrol thus formed is recovered by separating the cell from the medium and extracting the medium and the cell with an organic solvent. The extracted solutions are joined, concentrated under reduced pressure, rhododendrol is purified by silica gel column chromatography and recrystallized to give rhododendrol.

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