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1. 发明授权

US09115186B2 Stabilized trimeric HIV-1 gp41 fusion polypeptides comprising the N-terminal heptad repeat (NHR) and foldon (FD) trimerization motif 有权
标题翻译：包含N-末端七重复重复（NHR）和折叠（FD）三聚体基序的稳定的三聚体HIV-1 gp41融合多肽
公开(公告)号：US09115186B2
公开(公告)日：2015-08-25
申请号：US12702209
申请日：2010-02-08
申请人： Shibo Jiang , Zhi Qi , Xi Chen , Chungen Pan
发明人： Shibo Jiang , Zhi Qi , Xi Chen , Chungen Pan
IPC分类号： C07K14/005 , A61K38/00
CPC分类号： A61K38/162 , A61K38/00 , C07K14/005 , C07K2319/735 , C12N7/00 , C12N2740/16022 , C12N2740/16033 , C12N2740/16111 , C12N2740/16122
摘要： Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.
摘要翻译：本文公开了包含三种单体的三聚体多肽药物组合物，每种单体包含具有人类跨膜糖蛋白的N-末端七肽重复（NHR或HR1）或C-末端七重复重复（CHR或HR2）的氨基酸序列的多肽免疫缺陷病毒（HIV）和三聚体基序。

2. 发明申请

US20100204120A1 TRIMERIC HIV FUSION INHIBITORS FOR TREATING OR PREVENTING HIV INFECTION 有权
标题翻译： TRIMERIC艾滋病毒融合抑制剂治疗或预防艾滋病毒感染
公开(公告)号：US20100204120A1
公开(公告)日：2010-08-12
申请号：US12702209
申请日：2010-02-08
申请人： Shibo Jiang , Zhi Qi , Xi Chen , Chungen Pan
发明人： Shibo Jiang , Zhi Qi , Xi Chen , Chungen Pan
IPC分类号： A61K38/16 , C07K14/00 , A61P31/18
CPC分类号： A61K38/162 , A61K38/00 , C07K14/005 , C07K2319/735 , C12N7/00 , C12N2740/16022 , C12N2740/16033 , C12N2740/16111 , C12N2740/16122
摘要： Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.
摘要翻译：本文公开了包含三种单体的三聚体多肽药物组合物，每种单体包含具有人类跨膜糖蛋白的N-末端七肽重复（NHR或HR1）或C-末端七重复重复（CHR或HR2）的氨基酸序列的多肽免疫缺陷病毒（HIV）和三聚体基序。

3. 发明授权

US09921665B2 Input method editor application platform 有权
公开(公告)号：US09921665B2
公开(公告)日：2018-03-20
申请号：US13586267
申请日：2012-08-15
申请人： Matthew Robert Scott , Huihua Hou , Xi Chen , Weipeng Liu , Rongfeng Lai , Xi Chen , Yonghong Shi
发明人： Matthew Robert Scott , Huihua Hou , Xi Chen , Weipeng Liu , Rongfeng Lai , Xi Chen , Yonghong Shi
IPC分类号： G06F15/177 , G06F3/023 , G06F17/27 , H04L12/58 , G06F17/24 , G06Q50/00 , G06F17/30 , G06Q10/10 , G06F3/0484
CPC分类号： G06F17/276 , G06F3/0237 , G06F3/04842 , G06F17/24 , G06F17/273 , G06F17/2735 , G06F17/30241 , G06F17/30477 , G06F17/30554 , G06F17/3056 , G06F17/3064 , G06F17/3087 , G06Q10/10 , G06Q50/01 , H04L51/10 , H04L51/32
摘要： An input method editor (IME) provides a distributed platform architecture that enables associating multiple applications with the IME to provide extended functionalities. The presentations of the applications, such as skins, may be different from each other and that of the IME. The applications may be represented in a manifest file that is human-readable and editable. The IME collects multiple parameters relating to a user input into a host application including a query input by the user and a scenario of the host application, and selects one or more applications to provide candidates based on a score or ranking of the applications under the collected multiple parameters. Machine-learning may be used to improve the score or ranking. The candidates may include text candidates, rich candidates, and informative candidates.

4. 发明授权

US09959340B2 Semantic lexicon-based input method editor 有权
公开(公告)号：US09959340B2
公开(公告)日：2018-05-01
申请号：US13635274
申请日：2012-06-29
申请人： Chi-Ho Li , Weijiang Xu , Matthew Robert Scott , Weipeng Liu , Xi Chen , Xi Chen
发明人： Chi-Ho Li , Weijiang Xu , Matthew Robert Scott , Weipeng Liu , Xi Chen , Xi Chen
IPC分类号： G06F17/21 , G06F17/30 , G06F17/27 , G06F3/0482
CPC分类号： G06F17/30675 , G06F3/0482 , G06F17/2785
摘要： Some implementations provide techniques and arrangements for semantic lexicon based processing, such as in an input method editor. In some instances, a semantic label may be received that is to be defined for a semantic lexicon and at least a first term may be identified as a positive or negative example of the semantic label. In response, some examples may label at least a second term in the semantic lexicon with the semantic label based at least in part on the identification of the first term as a positive or negative example of the semantic label.

5. 发明申请

US20130346872A1 INPUT METHOD EDITOR APPLICATION PLATFORM 有权
标题翻译：输入法编辑器应用平台
公开(公告)号：US20130346872A1
公开(公告)日：2013-12-26
申请号：US13586267
申请日：2012-08-15
申请人： Matthew Robert Scott , Huihua Hou , Xi Chen , Weipeng Liu , Rongfeng Lai , Xi Chen , Yonghong Shi
发明人： Matthew Robert Scott , Huihua Hou , Xi Chen , Weipeng Liu , Rongfeng Lai , Xi Chen , Yonghong Shi
IPC分类号： G06F3/048 , G06F15/16
CPC分类号： G06F17/276 , G06F3/0237 , G06F3/04842 , G06F17/24 , G06F17/273 , G06F17/2735 , G06F17/30241 , G06F17/30477 , G06F17/30554 , G06F17/3056 , G06F17/3064 , G06F17/3087 , G06Q10/10 , G06Q50/01 , H04L51/10 , H04L51/32
摘要： An input method editor (IME) provides a distributed platform architecture that enables associating multiple applications with the IME to provide extended functionalities. The presentations of the applications, such as skins, may be different from each other and that of the IME. The applications may be represented in a manifest file that is human-readable and editable. The IME collects multiple parameters relating to a user input into a host application including a query input by the user and a scenario of the host application, and selects one or more applications to provide candidates based on a score or ranking of the applications under the collected multiple parameters. Machine-learning may be used to improve the score or ranking. The candidates may include text candidates, rich candidates, and informative candidates.
摘要翻译：输入法编辑器（IME）提供了一种分布式平台架构，可将多个应用程序与IME相关联，以提供扩展功能。应用程序的介绍（如皮肤）可能会彼此不同，也可能与IME的不同。应用程序可以在人类可读和可编辑的清单文件中表示。 IME收集与主机应用中的用户输入有关的多个参数，包括用户输入的查询和主机应用的场景，并且根据所收集的应用程序的得分或排名选择一个或多个应用程序来提供候选者多个参数。机器学习可用于提高得分或排名。候选人可以包括文本候选人，丰富的候选人和资料丰富的候选人。

6. 发明申请

US20150121290A1 Semantic Lexicon-Based Input Method Editor 有权
标题翻译：基于语义词法的输入法编辑器
公开(公告)号：US20150121290A1
公开(公告)日：2015-04-30
申请号：US13635274
申请日：2012-06-29
申请人： Chi-Ho Li , Weijiang Xu , Matthew Robert Scott , Weipeng Liu , Xi Chen , Xi Chen
发明人： Chi-Ho Li , Weijiang Xu , Matthew Robert Scott , Weipeng Liu , Xi Chen , Xi Chen
IPC分类号： G06F17/30 , G06F3/0482
CPC分类号： G06F17/30675 , G06F3/0482 , G06F17/2785
摘要： Some implementations provide techniques and arrangements for semantic lexicon based processing, such as in an input method editor. In some instances, a semantic label may be received that is to be defined for a semantic lexicon and at least a first term may be identified as a positive or negative example of the semantic label. In response, some examples may label at least a second term in the semantic lexicon with the semantic label based at least in part on the identification of the first term as a positive or negative example of the semantic label.
摘要翻译：一些实现提供了基于语义词典的处理的技术和布置，例如在输入法编辑器中。在一些情况下，可以接收将为语义词典定义的语义标签，并且至少第一项可以被识别为语义标签的正或负例子。作为响应，一些示例可以至少部分地基于第一术语的标识作为语义标签的正或负例示，将具有语义标签的语义词典中的至少第二项标记为语义标签。

7. 发明授权

US09824085B2 Personal language model for input method editor 有权
公开(公告)号：US09824085B2
公开(公告)日：2017-11-21
申请号：US14423914
申请日：2012-08-31
申请人： Mu Li , Xi Chen
发明人： Mu Li , Xi Chen
IPC分类号： G06F17/28 , G06F17/22 , G06F17/27
CPC分类号： G06F17/2863 , G06F17/2223 , G06F17/276
摘要： Some examples include generating a personal language model based on linguistic characteristics of one or more files stored at one or more locations in a file system. Further, some implementations include predicting and presenting a non-Latin character string based at least in part on the personal language model, such as in response to receiving a Latin character string via an input method editor interface.

8. 发明授权

US09388470B2 Serum or plasma microRNA as biomarkers for non-small cell lung cancer 有权
标题翻译：血清或血浆microRNA作为非小细胞肺癌的生物标志物
公开(公告)号：US09388470B2
公开(公告)日：2016-07-12
申请号：US12996967
申请日：2009-12-14
申请人： Chenyu Zhang , Ke Zeng , Junfeng Zhang , Yi Ba , Xi Chen , Haijin Li
发明人： Chenyu Zhang , Ke Zeng , Junfeng Zhang , Yi Ba , Xi Chen , Haijin Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： The present invention provides non-small cell lung cancer markers and the use thereof in diagnosing and monitoring diseases in vitro. The non-small cell lung cancer markers include at least one of the 26 selected detectable mature microRNAs existing stably in human serum or plasma. The invention also provides probe combinations, a kit and biochip for detecting the non-small cell lung cancer markers. The invention further provides a method for detecting the said lung cancer markers. The method in the present invention enables extensive detection spectrum, high sensitivity, low cost, convenient sample taking and preservation. The method can be applied in the general survey of disease, solves problems of the low specificity and sensitivity encountered with previous single markers, and increases significantly the clinical detection rate of diseases; it forms an effective means for diagnosing diseases at an early stage.
摘要翻译：本发明提供非小细胞肺癌标志物及其在体外诊断和监测疾病中的应用。非小细胞肺癌标志物包括稳定存在于人血清或血浆中的26种选择的可检测的成熟微RNA中的至少一种。本发明还提供探针组合，用于检测非小细胞肺癌标志物的试剂盒和生物芯片。本发明还提供了一种用于检测所述肺癌标志物的方法。本发明的方法能够广泛的检测光谱，高灵敏度，低成本，便于取样和保存。该方法可应用于疾病一般调查，解决了以前单个标记物遇到的低特异性和敏感性问题，大大提高了疾病的临床检出率; 它是早期诊断疾病的有效手段。

9. 发明申请

US20150106702A1 Cross-Lingual Input Method Editor 审中-公开
标题翻译：跨界输入法编辑器
公开(公告)号：US20150106702A1
公开(公告)日：2015-04-16
申请号：US13635219
申请日：2012-06-29
申请人： Matthew Robert Scott , Joseph K. Ngari , Joo-Young Lee , Weipeng Liu , Rongfeng Lai , Xi Chen , Huihua Hou
发明人： Matthew Robert Scott , Joseph K. Ngari , Joo-Young Lee , Weipeng Liu , Rongfeng Lai , Xi Chen , Huihua Hou
IPC分类号： G06F17/24 , G06F17/30
CPC分类号： G06F17/24 , G06F3/0237 , G06F16/338 , G06F17/276 , G06F17/289
摘要： Some implementations provide techniques and arrangements for cross lingual candidate suggestion. For instance, some display a user interface of a host application including a text entry area. An input method editor (IME) receives one or more characters as input. In response, one or more completion candidates are displayed, at least one of the completion candidates being a cross lingual completion candidate in a language different from the one or more characters.
摘要翻译：一些实施提供跨语言候选人建议的技术和安排。例如，一些显示包括文本输入区域的主机应用程序的用户界面。输入法编辑器（IME）接收一个或多个字符作为输入。作为响应，显示一个或多个完成候选，至少一个完成候选是与一个或多个字符不同的语言的跨语言完成候选。

10. 发明申请

US20140302565A1 PMST1 MUTANTS FOR CHEMOENZYMATIC SYNTHESIS OF SIALYL LEWIS X COMPOUNDS 有权
标题翻译：用于SIALYL LEWIS X化合物的化学合成的PMST1突变体
公开(公告)号：US20140302565A1
公开(公告)日：2014-10-09
申请号：US14237334
申请日：2012-08-06
申请人： Xi Chen , Go Sugiarto , Kam Lau
发明人： Xi Chen , Go Sugiarto , Kam Lau
IPC分类号： C12P19/18 , C12N9/10
CPC分类号： C12N9/1081 , C12N9/1077 , C12P19/04 , C12P19/18 , C12Y204/99
摘要： The present invention provides mutants of PmST1 for the preparation of sialyl-Lewisx oligosaccharides, and other sialosides with decreased sialidase activity.
摘要翻译：本发明提供了用于制备唾液酸 - 路易斯寡糖的PmST1突变体和唾液酸酶活性降低的其它唾液酸苷。

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