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1. 发明申请

WO2008112223A1 RADIATION CATHETER WITH MULTILAYERED BALLOON 审中-公开
标题翻译：带多层气泡的辐射导管
公开(公告)号：WO2008112223A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/003217
申请日：2008-03-11
申请人： SENORX, INC. , QUICK, Richard, L.
发明人： QUICK, Richard, L.
IPC分类号： A61N5/10
CPC分类号： A61N5/1007 , A61M2025/1075 , A61N5/1015 , A61N2005/1003 , A61N2005/1018
摘要： The disclosure is directed to catheter devices and methods for controlled application of irradiation to tissue adjacent a body site, such as cavity after removal of tissue, e.g. cancer. The catheter device includes an inflatable balloon having at least two layers. The inflatable balloon has an expansion of more than 25% and less than 200% when inflated from the un-inflated condition to a turgid condition, preferably more than 50% and less than 150%. In the turgid condition the polymeric material(s) of the balloon layers are at or near the elastic limit of the balloon layer material. The balloon may contain or be formed of or be coated with radiopaque material to facilitate positional or symmetry verification.
摘要翻译：本公开涉及导管装置和方法，用于控制对身体部位附近的组织照射，例如去除组织后的空腔，例如，癌症。导管装置包括具有至少两层的可膨胀气囊。当从未充气状态膨胀到膨胀状态时，膨胀气球膨胀超过25％且小于200％，优选大于50％且小于150％。在潮气条件下，球囊层的聚合物材料处于或接近球囊层材料的弹性极限。球囊可以包含或由不透射线的材料形成或涂覆，以便于位置或对称性的验证。

2. 发明申请

WO2007019445A1 BIOPSY DEVICE WITH FLUID DELIVERY TO TISSUE SPECIMENS 审中-公开
标题翻译：具有流体输送到组织样本的生物装置
公开(公告)号：WO2007019445A1
公开(公告)日：2007-02-15
申请号：PCT/US2006/030722
申请日：2006-08-04
申请人： SENORX, INC. , QUICK, Richard, L. , SHABAZ, Martin, V. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason, H.
发明人： QUICK, Richard, L. , SHABAZ, Martin, V. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason, H.
IPC分类号： A61B10/02 , A61B17/32 , A61B17/00
CPC分类号： A61B17/32002 , A61B10/0275 , A61B10/0283 , A61B2010/0208 , A61B2010/0225 , A61B2017/00473
摘要： The invention is directed to a system and method for separating and collecting one or more tissue specimens from a target site within a patient and flushing the specimen to remove blood, debris and the like before the specimen is removed from the biopsy device. The flow of flushing fluid to the tissue collector is preferably controlled to coincide with delivery of one or more specimens to the collecting tray or basket of the device or after the receipt of the specimen within the tissue collector to ensure that the fluid (16) is applied to a fresh specimen. The tissue tray or basket within the tissue collector (14) has an open or foraminous portion to facilitate removal of fluid, such as the applied fluid and blood, and other debris from the tissue specimens on the tray. Vacuum (22) is provided within the tissue collector, preferably under the tray to remove fluid and debris from the collector interior.
摘要翻译：本发明涉及一种用于从患者内的目标部位分离和收集一个或多个组织样本的系统和方法，并且在从活检装置移除样本之前冲洗样本以除去血液，碎屑等。冲洗流体到组织收集器的流动优选地被控制以与一个或多个样本递送到装置的收集盘或篮子之间或在组织收集器中收到样本之后确保流体（16）是应用于新鲜的标本。组织收集器（14）内的纸巾托盘或篮子具有开放或有孔的部分，以有助于从托盘上的组织标本中去除流体，例如施加的流体和血液以及其它碎屑。真空（22）设置在组织收集器内，优选在托盘下面，以从收集器内部去除流体和碎屑。

3. 发明申请

WO2005063126A2 BIOPSY DEVICE WITH APERTURE ORIENTATION AND IMPROVED TIP FIELD OF THE INVENTION 审中-公开
标题翻译：具有孔径定向和改进尖端的生物装置发明领域
公开(公告)号：WO2005063126A2
公开(公告)日：2005-07-14
申请号：PCT/US2004/043021
申请日：2004-12-20
申请人： SENORX, INC.
发明人： SHABAZ, Martin, V. , QUICK, Richard, L. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason, H.
IPC分类号： A61B10/00
CPC分类号： A61B10/0275 , A61B10/0283 , A61B17/32002 , A61B17/32053 , A61B17/3417 , A61B90/30 , A61B2010/0208 , A61B2010/0225 , A61B2017/00207 , A61B2017/00473 , A61B2017/2911 , A61B2017/2925 , A61B2017/3405 , A61B2090/3908 , A61B2090/3987
摘要： The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component which is releasably secured to the driver component. The probe component has an elongated tubular section, a penetrating distal tip and a tissue receiving aperture in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The driver has drive members for operating the elements of the probe component. The tissue penetrating distal tip preferably has a triple concave curvature shape with three curved cutting edges leading to a sharp distal point.
摘要翻译：本发明涉及一种用于从患者内的目标部位分离和收集组织标本的系统和装置。该装置包括可释放地固定到驱动器部件的探针部件。探针部件具有细长的管状部分，穿透的远端和在远端顶端的管状部分的远端中的组织接收孔，以及组织切割构件，其可滑动地设置在探针构件内以切割组织样本通过向组织切割构件的内腔施加真空而通过孔被吸入装置的内部。驱动器具有用于操作探头部件的元件的驱动部件。组织穿透远侧末端优选地具有三凹曲面形状，其具有三个弯曲的切割边缘，其导致尖锐的远端点。

4. 发明申请

WO2010091048A1 APPARATUS AND METHOD FOR ACCESSING A BODY SITE 审中-公开
标题翻译：用于接收身体场所的装置和方法
公开(公告)号：WO2010091048A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/022993
申请日：2010-02-03
申请人： SENORX, INC. , SHABAZ, Martin, V. , QUICK, Richard, L. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason
发明人： SHABAZ, Martin, V. , QUICK, Richard, L. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason
IPC分类号： A61B10/02
CPC分类号： A61B10/0275 , A61B10/0283 , A61B17/32002 , A61B17/32053 , A61B17/3417 , A61B2010/0208 , A61B2010/0225 , A61B2017/00473 , A61B2017/3405
摘要： A device to access a desired tissue site within a patient's body and separate a tissue specimen from the tissue site. The device includes a probe member having a tissue penetrating distal tip having a plurality of concaved surfaces which form curved cutting edges at the intersection of adjacent concave surfaces. The probe member has an inner lumen which when subjected to a vacuum, secures tissue for the specimen to the surface of a distal tubular section of the probe which may be off-set from a central longitudinal axis. A circular tissue-cutting blade is configured to move longitudinally to sever a tissue specimen from tissue secured to the surface of the distal tubular section by the application of a vacuum to the inner lumen of the probe.
摘要翻译：一种用于访问患者体内所需组织部位并从组织部位分离组织标本的装置。该装置包括具有组织穿透远侧末端的探针构件，该组织穿透远侧末端具有多个凹面，其在相邻凹面的交叉处形成弯曲的切割边缘。探针构件具有内腔，当经受真空时，将内窥镜的组织固定在探针的远侧管状部分的表面上，该表面可以从中心纵向轴线偏离。圆形组织切割刀片构造成纵向移动以通过向探针的内腔施加真空而将组织标本从组织固定到远端管状部分的表面。

5. 发明申请

WO2006017400A2 BIOPSY DEVICE WITH SELECTABLE TISSUE RECEIVING APERTURE ORIENTATION AND SITE ILLUMINATION 审中-公开
标题翻译：具有选择性组织的生物装置接收孔径方位和场地照明
公开(公告)号：WO2006017400A2
公开(公告)日：2006-02-16
申请号：PCT/US2005/027071
申请日：2005-07-29
申请人： SENORX, INC. , SHABAZ, Martin, V. , QUICK, Richard, L. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason, H.
发明人： SHABAZ, Martin, V. , QUICK, Richard, L. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason, H.
IPC分类号： A61B10/00
CPC分类号： A61B10/0275 , A61B10/0266 , A61B10/0283 , A61B17/32002 , A61B17/3417 , A61B90/30 , A61B2010/0208 , A61B2010/0225 , A61B2017/00473 , A61B2017/00486 , A61B2017/3405 , A61B2090/3908 , A61B2090/3987
摘要： The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component with an elongated tubular section, a penetrating distal tip and a tissue receiving aperture in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The device also has a driver component to which the probe component is releasably secured. The driver has a drive member for adjusting the orientation of the tubular section and thus the aperture therein and one or more drive members for moving the tissue cutting member within the tubular section to sever a tissue specimen from tissue extending into the interior of the tubular section through the aperture. The motion imparted to the tissue cutter is at least longitudinal and preferably is also oscillation and/or rotational to effectively separate a tissue specimen from tissue extending through the aperture in the tubular section.
摘要翻译：本发明涉及一种用于从患者内的目标部位分离和收集组织标本的系统和装置。该装置包括具有细长管状部分的探针部件，穿透远侧末端和在远端顶端的管状部分的远端中的组织接收孔，以及组织切割构件，其可滑动地设置在探针构件内以切割组织样本通过向组织切割构件的内腔施加真空而通过孔被拉入装置的内部。该装置还具有驱动器部件，探针组件可释放地固定到该部件上。驱动器具有用于调节管状部分的方向并因此调节其中的孔的驱动构件和一个或多个驱动构件，用于移动管状区段内的组织切割构件以将组织样本从延伸到管状部分内部的组织切断通过光圈。赋予组织切割器的运动至少是纵向的，并且优选地也是振动和/或旋转以有效地将组织样本与延伸穿过管状部分中的孔的组织分离。

6. 发明申请

WO2001049184A3 RADIOFREQUENCY APPARATUS AND METHOD FOR ACCESSING A BIOPSY SITE 审中-公开
公开(公告)号：WO2001049184A3
公开(公告)日：2001-07-12
申请号：PCT/US2001/000543
申请日：2001-01-04
申请人： SENORX, INC.
发明人： BURBANK, Fred , HOMET, William, C. , LUBOCK, Paul , QUICK, Richard, L. , SHABAZ, Martin
IPC分类号： A61B18/14
摘要： A system for accessing a desired site within a patient's body includes a cannula defining an inner lumen that opens both forwardly (18) and into a longitudinally extending side aperture formed in the side of the cannula, near its distal end. An electrosurgical stylet slidable fits inside the inner lumen. At the distal end of the stylet is an electrosurgical electrode (28) capable of cutting tissue when at forward opening (18)and permitting advancement of the system into a patient's body. The electrode, in an expanded deployed configuration, can be wider than the maximum transverse dimension of the cannula, but it may be deflected toward the center of the stylet so that the electrode fits within the inner lumen of the cannula, permitting the stylet to be inserted and removed through the cannula. An elongate guide tube having a central axial bore which communicates with an orifice in the side of the guide tube can be inserted into the inner lumen of the cannula such that the guide tube orifice coincides with the longitudinally extending side aperture of the cannula. In use, the stylet with the cannula disposed about it is advanced into the patient's tissue, using electrosurgical cutting, until the side aperture of the cannula is disposed adjacent a desired site within the patient. The stylet can then be withdrawn from the cannula providing access through the inner lumen of the cannula to the tissue at the desired site.

7. 发明申请

WO2008063636A3 MRI IMAGEABLE ASSEMBLY 审中-公开
公开(公告)号：WO2008063636A3
公开(公告)日：2008-05-29
申请号：PCT/US2007/024249
申请日：2007-11-20
申请人： SENORX, INC. , LUBOCK, Paul , QUICK, Richard, L. , BROADAWAY, Ethan
发明人： LUBOCK, Paul , QUICK, Richard, L. , BROADAWAY, Ethan
IPC分类号： A61B17/34 , A61B19/00
摘要： A marker delivery device is described which has an obturator (12) with an elongated shaft (16), an inner lumen (18), a proximal end, and a substantially sealed distal end (22). One or more tissue markers are deployed within the inner lumen of the elongated shaft of the obturator. Preferably, the tissue marker (s) is disposed within an inner lumen of a marker delivery tube (14) which is disposed within the inner lumen of the elongated shaft of the obturator. The marker delivery tube has an opening (42) for discharging the tissue markers into a body (e.g. biopsy) cavity. The distal tip of the marker • delivery tube is configured to penetrate the substantially sealed distal end of the obturator so that tissue markers can be delivered while the obturator is in place within the body. Preferably, the obturator includes a detectable element capable of producing a relatively significant image signature during MRI.

8. 发明申请

WO2006127729A1 TISSUE-CUTTING MEMBER FOR A BIOPSY DEVICE 审中-公开
标题翻译：用于生物装置的组织切割构件
公开(公告)号：WO2006127729A1
公开(公告)日：2006-11-30
申请号：PCT/US2006/019959
申请日：2006-05-23
申请人： SENORX, INC. , LUBOCK, Paul , LOUW, Frank, R. , QUICK, Richard, L.
发明人： LUBOCK, Paul , LOUW, Frank, R. , QUICK, Richard, L.
IPC分类号： A61B10/00 , A61B17/32 , A61B17/34
CPC分类号： A61B10/0275 , A61B10/0283 , A61B17/320016 , A61B17/3417
摘要： The invention is directed to tissue cutting members and biopsy devices with such tissue cutting member for separating a tissue specimen from a patient's body at a target site. The tissue cutting member is slidably disposed within an inner lumen of an elongated probe member of the biopsy device to cut a tissue specimen drawn into the interior of an outer cannula of the biopsy device through a tissue receiving aperture in the probe. The tissue cutting member has a tubular distal portion with a distal tip having an outer tissue cutting edge, an inner tissue receiving aperture, and a longitudinally oriented opening with a closed proximal end and open distal end which opens to the inner tissue receiving aperture to facilitate flaring of the distal tubular portion. The cutting member has at least one opening in a wall of the tubular portion to maintain a vacuum during use.
摘要翻译：本发明涉及具有这种组织切割构件的组织切割构件和活检装置，用于在目标部位处将组织标本与患者的身体分离。组织切割构件可滑动地设置在活检装置的细长探针构件的内腔中，以通过探针中的组织接收孔切割拉入活检装置的外套管内部的组织样本。组织切割构件具有管状远端部分，远侧末端具有外部组织切割边缘，内部组织接收孔和纵向定向的开口，其具有封闭的近端和敞开的远端，该远端通向内部组织接收孔，以便于远端管状部分的扩口。切割构件在管状部分的壁中具有至少一个开口，以在使用期间保持真空。

9. 发明申请

WO2004075719A2 BIOPSY DEVICE WITH INNER CUTTING MEMBER 审中-公开
标题翻译：具有内切刀的生物装置
公开(公告)号：WO2004075719A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/005023
申请日：2004-02-20
申请人： SENORX, INC.
发明人： QUICK, Richard, L. , LOUW, Frank, R. , LUBOCK, Paul , SHABAZ, Martin, V. , SAFABASH, Jason
IPC分类号： A61B
CPC分类号： A61B10/0275 , A61B17/32002 , A61B17/3417 , A61B2010/0208 , A61B2010/0225 , A61B2017/0046 , A61B2017/00473 , A61B2017/3405 , A61B2017/3454 , A61B2090/0811
摘要： The invention is directed to devices and methods for separating and collecting a tissue specimen from a patient’s target site. The device includes a probe member with a penetrating distal tip and a tissue receiving aperture, and a tissue cutting member which is rotatable disposed within the prove member to cut a tissue specimen drawn into the interior of the device through the aperture. The longitudinal edges of the aperture are preferably sharpened to engage the cutting edges of the tissue cutting member. Vacuum may be provided in the inner lumen of the cutting member to transport tissue therethrough. Rotation, rotational oscillation and/or longitudinal reciprocation of the tissue cutting member is effective to separate a tissue specimen from surrounding tissue. An accessing cannula having an tissue receiving aperture may be concentrically disposed within the probe member and about the tissue cutting member. The tissue cutting edge of the tissue cutting member preferably is longitudinally oriented and may have a cutting angle less than 90° with respect to the longitudinal axis of the tissue cutting member.
摘要翻译：本发明涉及用于从患者的目标部位分离和收集组织标本的装置和方法。该装置包括具有穿透性远侧末端和组织接收孔的探针构件，以及组织切割构件，该组织切割构件可旋转地设置在证明构件内，以通过孔切割被拉入设备内部的组织样本。孔的纵向边缘优选地被锐化以接合组织切割构件的切割边缘。可以在切割构件的内腔中设置真空以将组织输送通过其中。组织切割构件的旋转，旋转振动和/或纵向往复运动有效地将组织标本与周围组织分开。具有组织接收孔的进入套管可以同心地设置在探针构件内并且围绕组织切割构件。组织切割构件的组织切割边缘优选地纵向定向并且可以具有相对于组织切割构件的纵向轴线小于90°的切割角度。

10. 发明申请

WO2002053049A2 SHAPEABLE ELECTROSURGICAL SCALPEL 审中-公开
标题翻译：形状的电外科SCALPEL
公开(公告)号：WO2002053049A2
公开(公告)日：2002-07-11
申请号：PCT/US2001/048233
申请日：2001-12-14
申请人： SENORX, INC.
发明人： QUICK, Richard, L. , LUBOCK, Paul , KUSSMAN, Daniel, P. , SHABAZ, Martin, V.
IPC分类号： A61B18/14
CPC分类号： A61B17/32002 , A61B10/0266 , A61B18/14 , A61B18/1402 , A61B2018/00208 , A61B2018/00601 , A61B2018/1405 , A61B2018/1407 , A61B2018/1861
摘要： The invention is directed to an electrosurgical device having a shapeable elongate cutting electrode having a free distal end with an exposed length of at least 0.5 inch and secured by its proximal end to the distal end of a handle. The electrosurgical device is designed for use with a high frequency electrosurgical generator which as an output at a frequency of between about 1MHz and about 10 MHz, preferably about 3 to about 8 MHz. Preferably, the output has an essentially sinusoidal waveform with little harmonic distortion. The methods provide for the enhanced cutting of a variety of tissue including muscular, connective, glandular and fatty tissue. The device is particularly suitable in performing a breast biopsy.
摘要翻译：本发明涉及具有可成形细长切割电极的电外科装置，所述电动装置具有自由远端，所述自由远端具有至少0.5英寸的暴露长度并通过其近端固定到手柄的远端。电外科手术装置被设计成与高频电外科发生器一起使用，所述高频电外科发生器作为约1MHz至约10MHz，优选约3至约8MHz的频率的输出。优选地，输出具有基本正弦的波形而几乎没有谐波失真。该方法提供了对包括肌肉，结缔组织，腺体和脂肪组织的各种组织的增强切割。该设备特别适合进行乳房活检。

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