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1. 发明申请

WO2008115399A1 SOFT BODY CATHETER WITH LOW FRICTION LUMEN 审中-公开
标题翻译：柔软的身体导管与低摩擦的温度
公开(公告)号：WO2008115399A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/003364
申请日：2008-03-14
申请人： SENORX, INC. , JONES, Michael, L. , LOUW, Frank, R.
发明人： JONES, Michael, L. , LOUW, Frank, R.
IPC分类号： A61N5/10 , A61M36/00 , A61L29/14 , A61L29/08 , A61M25/10
CPC分类号： A61N5/1015 , A61L29/085 , A61M2025/0047
摘要： The disclosure is directed to radiation catheter devices, methods for controlled application of irradiation to tissue at a body site, such as a cavity formed after removal of tissue, e.g. cancer, using such radiation catheter devices, solutions for forming a more lubricious luminal surface and method for lining lumens of such devices to improve the frictional characteristics thereof. The catheter device includes a flexible elongated shaft which is formed of low durometer polymeric material, which can be readily folded or coiled for securing the shaft to or under the skin of the patient and a radiation lumen lined with high durometer polymeric material to improve the frictional characteristics. The elongated shaft has at least one inner lumen for receiving a radiation source which has a layer of high durometer polymeric material that provides lower surface friction to facilitate advancement of a radiation source therein.
摘要翻译：本公开涉及辐射导管装置，用于受控地应用照射到身体部位的组织的方法，例如在去除组织后形成的空腔，例如，癌症，使用这种辐射导管装置，用于形成更加光滑的腔表面的解决方案和用于衬里这些装置的流明以提高其摩擦特性的方法。导管装置包括柔性细长轴，其由低硬度聚合物材料形成，其可以容易地折叠或卷绕以将轴固定到患者的皮肤上或皮下，以及衬有高硬度聚合物材料的辐射腔，以改善摩擦特点。细长轴具有用于接收辐射源的至少一个内腔，辐射源具有提供较低表面摩擦以便促进其中的辐射源的高硬度聚合材料层。

2. 发明申请

WO2004105803A1 MARKER OR FILLER FORMING FLUID FOR USE IN BIOPSY PROCEDURES 审中-公开
标题翻译：标记或填充液生产流程用于生物过程
公开(公告)号：WO2004105803A1
公开(公告)日：2004-12-09
申请号：PCT/US2004/014731
申请日：2004-05-12
申请人： SENORX, INC.
发明人： BURBANK, Fred, H. , JONES, Michael, L. , LOUW, Frank , LUBOCK, Paul
IPC分类号： A61K49/22
CPC分类号： A61B90/39 , A61B2090/3908 , A61B2090/3925 , A61B2090/3933 , A61B2090/3987 , A61K49/226
摘要： A solution for forming a marker or filler mass for an intracorporeal site. The solution contains a polar, water soluble non-aqueous solvent such as dimethyl sulfoxide and a bioabsorbable, essentially water insoluble polymer such as polylactic acid, or copolymers of lactic acid and glycolic acid. The solution may be delivered to the biopsy site by a suitable syringe and delivery tube. The delivery tube is preferably provided with a releasable radiopaque element on the distal tip which can be released within the polymeric marker mass formed in the biopsy cavity.
摘要翻译：用于形成体内部位的标记物或填充剂块的溶液。该溶液含有极性的水溶性非水溶剂如二甲基亚砜和生物可吸收的，基本上不溶于水的聚合物如聚乳酸，或乳酸和乙醇酸的共聚物。溶液可以通过合适的注射器和输送管递送到活检部位。输送管优选地设置在远端上的可释放的不透射线元件，其可以在形成于活检腔内的聚合物标记块内释放。

3. 发明申请

WO2003089012A3 CAVITY FILLING BIOPSY SITE MARKER 审中-公开
公开(公告)号：WO2003089012A3
公开(公告)日：2003-10-30
申请号：PCT/US2003/011767
申请日：2003-04-16
申请人： SENORX, INC.
发明人： BURBANK, Fred, H. , LUBOCK, Paul , JONES, Michael, L.
IPC分类号： A61K49/04
摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome ® or SenoCor 360™ cannula.

4. 发明申请

WO2003089012A2 CAVITY FILLING BIOPSY SITE MARKER 审中-公开
公开(公告)号：WO2003089012A2
公开(公告)日：2003-10-30
申请号：PCT/US2003/011767
申请日：2003-04-16
申请人： SENORX, INC.
发明人： BURBANK, Fred, H. , LUBOCK, Paul , JONES, Michael, L.
IPC分类号： A61K49/04
CPC分类号： A61B8/481 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/395 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61K49/222 , A61M37/0069
摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome ® or SenoCor 360™ cannula.
摘要翻译：本发明提供用于在有限时间内标记活检部位的材料，装置和方法。活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。系统可以包括含有粉末的管和含有无菌盐水的注射器。管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

5. 发明申请

WO2008063638A2 MRI DETECTABLE OBTURATOR 审中-公开
标题翻译： MRI检测器
公开(公告)号：WO2008063638A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/024255
申请日：2007-11-20
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L. , BROADAWAY, Ethan , LOUW, Frank, R.
发明人： LUBOCK, Paul , JONES, Michael, L. , BROADAWAY, Ethan , LOUW, Frank, R.
IPC分类号： A61B19/00
CPC分类号： A61B17/32 , A61B17/3417 , A61B17/3431 , A61B17/3468 , A61B17/3496 , A61B17/3498 , A61B90/39 , A61B2017/00477 , A61B2017/00911 , A61B2090/062 , A61B2090/3908 , A61B2090/3954 , A61B2090/3987
摘要： An obturator with an elongated shaft, a proximal end, a substantially closed distal end and a MRI detectable distal shaft portion, which does not interfere with magnetic resonance imaging of tissue proximate thereto. Preferably, the distal shaft portion has an effective MRI detectable mass so as to provide a clear, T1-weighted image within an outline of the distal shaft portion upon magnetic resonance imaging.
摘要翻译：具有细长轴，近端，基本上封闭的远端和MRI可检测远端轴部分的闭孔器，其不干扰邻近于其的组织的磁共振成像。优选地，远侧轴部分具有有效的MRI检测质量，以便在磁共振成像时在远侧轴部分的轮廓内提供清晰的T1加权图像。

6. 发明申请

WO2004105626A2 FIBROUS MARKER AND INTRACORPOREAL DELIVERY THEREOF 审中-公开
标题翻译： FIBROUS MARKER和INTRACORPOREAL交付
公开(公告)号：WO2004105626A2
公开(公告)日：2004-12-09
申请号：PCT/US2004/014968
申请日：2004-05-13
申请人： SENORX, INC.
发明人： JONES, Michael, L. , LUBOCK, Paul , MALCHOW, Lloyd, H.
IPC分类号： A61B19/00
CPC分类号： A61B90/39 , A61B17/0057 , A61B2017/00637 , A61B2017/00898 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/3954 , A61B2090/3987
摘要： The invention is directed to an intracorporeal marker, a delivery device and assembly for such marker and the method of delivering one or more of the markers to an intracorporeal location within a patient. The marker is a body formed at least in part of a bioabsorbable fibrous material such as a fibrous mat or fabric. The delivery devices preferably also include one or more bioabsorbable short term markers which are configured to expand within the body cavity due to contacting a body fluid. The fibrous marker has a radiographically detectable member which preferably hold a portion of the fibrous body in a compressed condition. Preferably, the fibrous marker has a fibrous felt core formed of bioabsorbable material with a fabric jacket formed of bioabsorbable material. Therapeutic, diagnostic and binding agents may be incorporated into the fibrous body of the marker.
摘要翻译：本发明涉及一种体内标记物，用于这种标记物的递送装置和组合件，以及将一种或多种标记递送到患者体内的位置的方法。标记物是至少部分地由生物可吸收纤维材料如纤维毡或织物形成的主体。递送装置优选还包括一个或多个生物可吸收的短期标记物，其构造成由于接触体液而在体腔内扩张。纤维标记具有可放射线检测的构件，其优选地将纤维体的一部分保持在压缩状态。优选地，纤维标记具有由生物可吸收材料形成的纤维毡芯，其具有由生物可吸收材料形成的织物护套。治疗性，诊断性和结合剂可以并入标记物的纤维体内。

7. 发明申请

WO2009105177A1 POLYSACCHARIDE MARKERS 审中-公开
标题翻译：多糖标记
公开(公告)号：WO2009105177A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/000945
申请日：2009-02-13
申请人： SENORX, INC. , JONES, Michael, L. , LUBOCK, Paul
发明人： JONES, Michael, L. , LUBOCK, Paul
IPC分类号： A61B19/00
CPC分类号： A61B19/54 , A61B90/39 , A61B2017/00004 , A61B2017/00831 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3962 , A61B2090/3987 , A61K9/0024
摘要： The marker member delivery system described has a plurality of marker members disposed within a delivery tube or cannula which contain a suitable polysaccharide such as starch (e.g. corn starch or potato starch) and a binder such as methylcellulose. These marker members are preferably press-formed from powders. The system has preferably has at least one other marker member formed of bioabsorbable material with a radiopaque element attached to or incorporated therein. The marker with a radiopaque marker element is preferably disposed within the delivery tube between two marker members formed of polysaccharide and is preferably formed of a bioabsorbable material other than a polysaccharide.
摘要翻译：所述的标记物传送系统具有多个标记物，其设置在输送管或套管内，其包含合适的多糖如淀粉（例如玉米淀粉或马铃薯淀粉）和粘合剂如甲基纤维素。这些标记物优选由粉末压制成型。该系统优选地具有由生物可吸收材料形成的至少一个其它标记构件，其中附着或结合在其中的不透射线元件。具有不透射线标记元件的标记物优选设置在由多糖形成的两个标记物之间的输送管内，并且优选由除多糖之外的生物可吸收材料形成。

8. 发明申请

WO2007097956A2 TEMPORARY CATHETER FOR BIOPSY SITE TISSUE FIXATION 审中-公开
标题翻译：用于生物场地组织固定的临时导管
公开(公告)号：WO2007097956A2
公开(公告)日：2007-08-30
申请号：PCT/US2007/003877
申请日：2007-02-14
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L.
发明人： LUBOCK, Paul , JONES, Michael, L.
IPC分类号： A61M25/10 , A61B17/00 , A61B17/22 , A61N5/10
CPC分类号： A61M29/02 , A61B10/0041 , A61B17/0218 , A61B90/02 , A61B2017/00557 , A61B2017/00796 , A61B2090/3908 , A61M25/10 , A61M29/00 , A61M2025/1095 , A61N5/1015
摘要： Devices and methods are provided for temporarily maintaining access to a body cavity in a targeted tissue region within a patient's body. One embodiment of the catheter device includes an elongated shaft having a proximal shaft section which is flexible enough to be folded or coiled into a configuration for deployment within the patient. An alternate embodiment includes a catheter device having one or more detachable proximal shaft sections and having at least one one-way valve to restrict fluid flow of inflation fluid to flow to the balloon. After deployment of the catheter device completely within the patient, the opening through which the catheter device is deployed is closed, e.g. by sutures, adhesives and the like to minimize infection at the site. Within a few days or weeks after the tissue has been evaluated for cancer, the temporary catheter device may be removed from the patient. If cancer or pre-cancer cells are found in the specimen removed from the cavity, then a radiation balloon catheter or other irradiation device can be inserted into the patient to irradiate tissue surrounding the biopsy cavity to ensure that cancer cells within the tissue surrounding the cavity are killed.
摘要翻译：提供了用于暂时维持对患者体内的目标组织区域中的体腔的访问的装置和方法。导管装置的一个实施例包括细长轴，其具有近侧轴部，该近端轴部足够柔性以折叠或卷绕成用于部署在患者体内的构造。替代实施例包括具有一个或多个可分离近侧轴部分并且具有至少一个单向阀以限制充气流体流入气囊的流体流动的导管装置。在将导管装置完全展开在患者体内之后，将导管装置展开的开口关闭，例如，通过缝线，粘合剂等来最小化现场的感染。在组织已经被评估癌症后的几天或几周内，临时导管装置可以从患者身上移除。如果在从腔中取出的样品中发现癌症或癌前细胞，则可以将放射气球导管或其它照射装置插入患者体内以照射活检腔周围的组织，以确保围绕腔的组织内的癌细胞被杀

9. 发明申请

WO2010039184A3 POROUS BIOABSORBABLE IMPLANT 审中-公开
公开(公告)号：WO2010039184A3
公开(公告)日：2010-04-08
申请号：PCT/US2009/005268
申请日：2009-09-22
申请人： SENORX, INC. , GOVIL, Amit , JONES, Michael, L. , LUBOCK, Paul
发明人： GOVIL, Amit , JONES, Michael, L. , LUBOCK, Paul
IPC分类号： A61L27/20 , A61L27/50 , A61L27/56 , A61L27/58
摘要： The bioabsorbable implant described has a porous body formed of bioabsorbable materials that have an in vivo life span of at least 2 weeks, preferably at least three weeks and not greater than 20 weeks, preferably no greater than ten weeks. The implant has a scaffolding structure which facilitates tissue in-growth and ultimately tissue replacement of the scaffolding structure. The implant has a radiopaque imaging agent at least at the exterior margins and an orientation plurality of radiopaque elements in the interior of implant. The implant preferably has three radiopaque elements within the interior that form a plane within the implant interior.

10. 发明申请

WO2009134314A1 ASSEMBLY WITH HEMOSTATIC AND RADIOGRAPHICALLY DETECTABLE PELLETS 审中-公开
标题翻译：装配有HEMOSTATIC和RADIOGRAPHICALLY DETECTABLE PELLETS
公开(公告)号：WO2009134314A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/002297
申请日：2009-04-14
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L.
发明人： LUBOCK, Paul , JONES, Michael, L.
IPC分类号： A61B19/00
CPC分类号： A61M37/0069 , A61B90/39 , A61B2017/00004 , A61B2017/00831 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3962 , A61B2090/3987
摘要： The remotely imageable pellet system (10) described has a plurality of pellets (18) disposed within a delivery tube or cannula (11) that are formed at least in part of a polysaccharide such as starch and at least one radiographically detectable bioabsorbable pellet (18) which preferably has a radiopaque element. The radiographically detectable bioabsorbable pellet has at least one and preferably two pellets proximal and distal thereto which are formed of polysaccharide.
摘要翻译：所描述的可远程成像的颗粒系统（10）具有设置在输送管或插管（11）内的多个颗粒（18），其形成为至少部分多糖如淀粉和至少一个可放射线检测的生物可吸收颗粒（18）），其优选地具有不透射线的元件。可放射线检测的生物可吸收颗粒具有由多糖形成的至少一个且优选两个近端和远端的颗粒。

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