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    • 2. 发明申请
    • MATRIX TYPE PATCH FOR TRANSDERMAL ADMINISTRATION OF VITAMIN D ANALOG AND THE USE THEREOF
    • 维生素D类似物的超导管理矩阵类型及其用途
    • WO2004028515A1
    • 2004-04-08
    • PCT/KR2002/001809
    • 2002-09-26
    • CHOI, Young-Kweon
    • CHOI, Young-Kweon
    • A61K9/70
    • A61K9/7061A61K9/7069
    • The present invention relates to a matrix type patch for transdermal administration of vitamin D analog and the use thereof.The preparation of a matrix type patch for transdermal administration is characterized by including adhesive layer, which contains (1) 0.0001 to 10 % by weight of vitamin D analog; and (2) 90 to 99.9999 % by weight of nonpolar adhesive polymer and it maintains effective vitamin D analog concentration of the blood for long period and constant permeation of the drug with reduced skin irritation.The present invention can be used to treat diseases which need vitamin D analog, such as osteoporosis, renal failure and thyroid dysfunction.
    • 本发明涉及用于透皮给药维生素D类似物的基质型贴片及其用途。用于透皮给药的基质型贴剂的制备的特征在于包括粘合剂层,其包含(1)0.0001至10重量% 维生素D类似物 和(2)90〜99.9999重量%的非极性粘合剂聚合物,并且长时间保持有效的维生素D类似物浓度,并且持续地渗透药物,皮肤刺激性降低。本发明可用于治疗需要的疾病 维生素D类似物,如骨质疏松症,肾衰竭和甲状腺功能障碍。