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1. 发明申请

US20140085184A1 Interaction Techniques for Flexible Displays 审中-公开
标题翻译：灵活显示器的交互技术
公开(公告)号：US20140085184A1
公开(公告)日：2014-03-27
申请号：US13919046
申请日：2013-06-17
申请人： Roel Vertegaal , David Holman
发明人： Roel Vertegaal , David Holman
IPC分类号： G06F3/01
CPC分类号： G06F3/01 , G06F3/017 , G06F3/0325 , G06F3/0425
摘要： The invention relates to a set of interaction techniques for obtaining input to a computer system based on methods and apparatus for detecting properties of the shape, location and orientation of flexible display surfaces, as determined through manual or gestural interactions of a user with said display surfaces. Such input may be used to alter graphical content and functionality displayed on said surfaces or some other display or computing system.
摘要翻译：本发明涉及用于基于用于检测柔性显示表面的形状，位置和取向的属性的方法和装置来获得对计算机系统的输入的一组交互技术，这通过用户与所述显示表面的手动或姿态交互来确定。这种输入可以用于改变显示在所述表面上或其他显示器或计算系统上的图形内容和功能。

2. 发明申请

US20120112994A1 Interaction Techniques for Flexible Displays 有权
标题翻译：灵活显示器的交互技术
公开(公告)号：US20120112994A1
公开(公告)日：2012-05-10
申请号：US13228681
申请日：2011-09-09
申请人： Roel Vertegaal , David Holman
发明人： Roel Vertegaal , David Holman
IPC分类号： G09G5/00
CPC分类号： G06F3/01 , G06F3/017 , G06F3/0325 , G06F3/0425
摘要： The invention relates to a set of interaction techniques for obtaining input to a computer system based on methods and apparatus for detecting properties of the shape, location and orientation of flexible display surfaces, as determined through manual or gestural interactions of a user with said display surfaces. Such input may be used to alter graphical content and functionality displayed on said surfaces or some other display or computing system.
摘要翻译：本发明涉及用于基于用于检测柔性显示表面的形状，位置和取向的属性的方法和装置来获得对计算机系统的输入的一组交互技术，这通过用户与所述显示表面的手动或姿态交互来确定。这种输入可以用于改变显示在所述表面上或其他显示器或计算系统上的图形内容和功能。

3. 发明授权

US08466873B2 Interaction techniques for flexible displays 有权
标题翻译：柔性显示器的交互技术
公开(公告)号：US08466873B2
公开(公告)日：2013-06-18
申请号：US13228681
申请日：2011-09-09
申请人： Roel Vertegaal , David Holman
发明人： Roel Vertegaal , David Holman
IPC分类号： G09G5/00
CPC分类号： G06F3/01 , G06F3/017 , G06F3/0325 , G06F3/0425
摘要： The invention relates to a set of interaction techniques for obtaining input to a computer system based on methods and apparatus for detecting properties of the shape, location and orientation of flexible display surfaces, as determined through manual or gestural interactions of a user with said display surfaces. Such input may be used to alter graphical content and functionality displayed on said surfaces or some other display or computing system.
摘要翻译：本发明涉及用于基于用于检测柔性显示表面的形状，位置和取向的属性的方法和装置来获得对计算机系统的输入的一组交互技术，这通过用户与所述显示表面的手动或姿态交互来确定。这种输入可以用于改变显示在所述表面上或其他显示器或计算系统上的图形内容和功能。

4. 发明申请

US20070247422A1 Interaction techniques for flexible displays 审中-公开
标题翻译：柔性显示器的交互技术
公开(公告)号：US20070247422A1
公开(公告)日：2007-10-25
申请号：US11731447
申请日：2007-03-30
申请人： Roel Vertegaal , David Holman
发明人： Roel Vertegaal , David Holman
IPC分类号： G09G5/00
CPC分类号： G06F3/01 , G06F3/017 , G06F3/0325 , G06F3/0425
摘要： The invention relates to a set of interaction techniques for obtaining input to a computer system based on methods and apparatus for detecting properties of the shape, location and orientation of flexible display surfaces, as determined through manual or gestural interactions of a user with said display surfaces. Such input may be used to alter graphical content and functionality displayed on said surfaces or some other display or computing system.
摘要翻译：本发明涉及用于基于用于检测柔性显示表面的形状，位置和取向的属性的方法和装置来获得对计算机系统的输入的一组交互技术，这通过用户与所述显示表面的手动或姿态交互来确定。这种输入可以用于改变显示在所述表面上或其他显示器或计算系统上的图形内容和功能。

5. 发明申请

US20060096903A1 Method and apparatus for packed column separations and purifications 审中-公开
公开(公告)号：US20060096903A1
公开(公告)日：2006-05-11
申请号：US11294713
申请日：2005-12-05
申请人： David Holman , Cynthia Bruckner-Lea , Fred Brockman , Darrell Chandler
发明人： David Holman , Cynthia Bruckner-Lea , Fred Brockman , Darrell Chandler
IPC分类号： B01D15/00
CPC分类号： G01N30/56 , B01L2200/0668 , B01L2300/0877 , G01N30/6004 , G01N35/0098 , G01N35/085 , G01N2030/565
摘要： In one aspect, the invention encompasses a method of packing and unpacking a column chamber. A mixture of a fluid and a matrix material are introduced through a column chamber inlet so that the matrix material is packed within a column chamber to form a packed column. After the packing, the matrix material is unpacked from the column chamber without moving the column chamber. More specifically, the column chamber having the column chamber inlet or first port for receiving the mixture further has an outlet port and an actuator port. The outlet port is partially closed for capturing the matrix material and permitting the fluid to flow therepast by rotating relative one to the other of a rod placed in the actuator port. Further rotation relative one to the other of the rod and the column chamber opens the outlet and permits the matrix material and the fluid to flow therethrough thereby unpacking the matrix material from the column chamber. In another aspect, the invention encompasses a method of purifying a component of a sample. A column chamber having an inlet end, an outlet end and an actuator end is provided. Flow of matrix material is obstructed by a rod with a binary end inserted in the actuator end. A suspension of the first fluid and the matrix material is flowed into the column chamber to form a packed column of the matrix material within the column chamber. The matrix material is configured to selectively retain a component of the sample. The sample is flowed through the packed column and past the rod to separate the component from the rest of the sample. The rod or the column chamber is rotated with respect to the other to open the outlet end and to remove the matrix material from the column chamber. In yet another aspect, the invention encompasses a system for column-based separations. The system comprises a fluid passageway containing a column chamber and a flow path in fluid communication with the column chamber. The flow path is partially obstructed by a rod. The flow path extends through the column chamber and through the outlet end. The flow path is configured to form a packed column within the column chamber when a suspension of the fluid and the column matrix material is flowed along the flow path.

6. 发明申请

US20080007020A1 TRAY FOR USE ON A WALKER 审中-公开
标题翻译：托盘使用在WALKER
公开(公告)号：US20080007020A1
公开(公告)日：2008-01-10
申请号：US11481811
申请日：2006-07-06
申请人： David Holman
发明人： David Holman
IPC分类号： B60R7/00
CPC分类号： A61H3/00 , A61H2003/004
摘要： A tray is mounted on the arms of a walker and which includes cup holders, and a compartment that can be closed by a lid that can then serve as a work surface. The lid of the compartment also includes a mirror and a light is mounted on the lid adjacent to the mirror.
摘要翻译：托盘安装在步行器的臂上，其包括杯架，以及可以由盖子封闭的隔间，该盖子然后可以用作工作表面。隔间的盖子还包括一个反射镜，并且在靠近反射镜的盖子上安装一个光。

7. 发明授权

US4478175A Rearing unit 失效
标题翻译：饲养单位
公开(公告)号：US4478175A
公开(公告)日：1984-10-23
申请号：US550982
申请日：1983-11-10
申请人： John Fisher , David Holman
发明人： John Fisher , David Holman
IPC分类号： A01K1/02
CPC分类号： A01K1/0227
摘要： A rearing unit, suitable for piglets, has a heated nest box with openable roof, a pen in communication with the nest box having a perforated floor, a liquid feeding device in the pen having one or more artificial nipples and a solids feed device.The nest box temperature may be thermostatically controlled by a sensor below a perforated floor of the nest box.The unit may be constructed from a slotted framework and boards, the boards being sealed in the slots by an adhesive or inert water-repellant sealant.The unit may house very young piglets up to a weight of from 5 to 8 kg. At that weight, they may then be transferred to a similar unit with a larger nest box until they weigh from 10 to 15 kg.
摘要翻译：适合于仔猪的饲养单元具有可开启屋顶的加热巢箱，与具有穿孔地板的巢箱连通的笔，笔中的液体供给装置具有一个或多个人造奶嘴和固体饲料装置。巢箱温度可以由巢箱的穿孔地板下面的传感器恒温控制。该单元可以由开槽框架和板构成，板通过粘合剂或惰性防水密封剂密封在槽中。该单位可容纳5至8公斤重的幼仔。然后以这种重量将它们转移到具有较大巢箱的类似单元中，直到它们重量为10至15kg。

8. 发明申请

US20060208501A1 Lock arrangement 有权
标题翻译：锁定安排
公开(公告)号：US20060208501A1
公开(公告)日：2006-09-21
申请号：US11377846
申请日：2006-03-16
申请人： John Harvey , David Holman
发明人： John Harvey , David Holman
IPC分类号： E05C3/06
CPC分类号： E05B15/102 , B64C25/26 , E05B15/0086 , E05B51/02 , E05B63/0069 , E05C3/24 , Y10S292/54 , Y10S292/60 , Y10S292/65 , Y10T292/0911 , Y10T292/0937 , Y10T292/0947 , Y10T292/1047 , Y10T292/1082 , Y10T292/1092
摘要： A lock arrangement comprises a first jaw component (28) pivotally moveable about a pivot axis (12), a second jaw component (30) releasably securable to the first jaw component (28) to form a pivotable jaw assembly (10), and an actuator arrangement operable to drive the jaw assembly from a locked position to a released position.
摘要翻译：锁定装置包括可围绕枢转轴线（12）枢转运动的第一钳口部件（28），可释放地固定到第一钳口部件（28）以形成可枢转钳口组件（10）的第二钳口部件（30），以及致动器装置可操作以将卡爪组件从锁定位置驱动到释放位置。

9. 发明申请

US20080045470A1 Ceramides and Apoptosis-Signaling Ligand 有权
标题翻译：神经酰胺和细胞凋亡信号配体
公开(公告)号：US20080045470A1
公开(公告)日：2008-02-21
申请号：US11666519
申请日：2005-10-31
申请人： Alicja Bielawska , Yusuf Hannun , James Norris , Zdzislaw Szulc , Jian-yun Dong , Jacek Bielawski , David Schwartz , David Holman , Ahmed El-Zawahry , John McKillop
发明人： Alicja Bielawska , Yusuf Hannun , James Norris , Zdzislaw Szulc , Jian-yun Dong , Jacek Bielawski , David Schwartz , David Holman , Ahmed El-Zawahry , John McKillop
IPC分类号： A61K31/40 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/497 , A61K31/535 , A61K31/70 , A61P43/00 , C07D207/00 , C07D211/00 , C07D233/00 , C07D241/04 , C07D265/30
CPC分类号： C07D213/56 , C07C215/18 , C07C215/28 , C07C275/24
摘要： The invention provides the compounds of formula ( ): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 3 > 4，A，X，Y，a，b和n如本文所定义。还公开了制备式（I）化合物及其用于治疗或预防与细胞过度增生和功能失调的鞘脂信号转导相关的疾病的方法。本发明还包括与凋亡信号传导配体如Fas配体组合的化合物的用途。优选地，Fas配体以基因治疗剂的形式施用。

10. 发明申请

US20070105163A1 Flow-controlled magnetic particle manipulation 有权
标题翻译：流量控制磁性粒子操纵
公开(公告)号：US20070105163A1
公开(公告)日：2007-05-10
申请号：US11646216
申请日：2006-12-26
申请人： Jay Grate , Cynthia Bruckner-Lea , David Holman
发明人： Jay Grate , Cynthia Bruckner-Lea , David Holman
IPC分类号： G01N33/53 , G01N33/551
CPC分类号： G01N27/745 , B01J2219/005 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B03C1/00 , G01N33/54333 , G01N35/0098 , G01N35/08 , G01N2035/00237 , Y10T436/11 , Y10T436/111666 , Y10T436/112499
摘要： Inventive methods and apparatus are useful for collecting magnetic materials in one or more magnetic fields and resuspending the particles into a dispersion medium, and optionally repeating collection/resuspension one or more times in the same or a different medium, by controlling the direction and rate of fluid flow through a fluid flow path. The methods provide for contacting derivatized particles with test samples and reagents, removal of excess reagent, washing of magnetic material, and resuspension for analysis, among other uses. The methods are applicable to a wide variety of chemical and biological materials that are susceptible to magnetic labeling, including, for example, cells, viruses, oligonucleotides, proteins, hormones, receptor-ligand complexes, environmental contaminants and the like.
摘要翻译：本发明的方法和装置可用于在一个或多个磁场中收集磁性材料并将颗粒重新悬浮于分散介质中，并且可选地通过控制相同或不同介质的方向和速率来重复地在相同或不同介质中的收集/再悬浮一次或多次流体流过流体流动路径。该方法提供了将衍生化的颗粒与测试样品和试剂接触，除去过量试剂，洗涤磁性材料以及再悬浮以用于分析以及其它用途。该方法适用于易受磁标记影响的各种化学和生物材料，包括例如细胞，病毒，寡核苷酸，蛋白质，激素，受体 - 配体复合物，环境污染物等。

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