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1. 发明申请

US20070299483A1 Implantable pulse generator for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue 审中-公开
公开(公告)号：US20070299483A1
公开(公告)日：2007-12-27
申请号：US11824931
申请日：2007-07-03
申请人： Robert Strother , Joseph Mrva , Geoffrey Thrope
发明人： Robert Strother , Joseph Mrva , Geoffrey Thrope
IPC分类号： A61N1/05
CPC分类号： A61N1/37276 , A61N1/36003 , A61N1/36071 , A61N1/37223
摘要： Improved assemblies, systems, and methods provide an implantable pulse generator for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The implantable pulse generator is sized and configured to be implanted subcutaneous a tissue region. The implantable pulse generator includes an electrically conductive case of a laser welded titanium material. Control circuitry is located within the case, the control circuitry including a rechargeable power source, a receive coil for receiving an RF magnetic field to recharge the power source, and a microcontroller for control of the implantable pulse generator. Improved assemblies, systems, and methods also provide a stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The stimulation system provides at least one electrically conductive surface, a lead connected to the electrically conductive surface, and an implantable pulse generator electrically connected to the lead.

2. 发明申请

US20070191915A1 Systems and methods for intra-operative stimulation 有权
标题翻译：术中刺激的系统和方法
公开(公告)号：US20070191915A1
公开(公告)日：2007-08-16
申请号：US11651165
申请日：2007-01-09
申请人： Robert Strother , Geoffrey Thrope , Joseph Mrva , Steven Galecki , Danny Pack , Christopher Thierfelder , James Coburn
发明人： Robert Strother , Geoffrey Thrope , Joseph Mrva , Steven Galecki , Danny Pack , Christopher Thierfelder , James Coburn
IPC分类号： A61N1/00
CPC分类号： A61B5/04001 , A61B5/4893 , A61B17/1626 , A61B17/8875 , A61B18/1402 , A61B90/04 , A61B2017/00022 , A61B2017/00154 , A61N1/36014
摘要： Improved assemblies, systems, and methods provide safeguarding against tissue injury during surgical procedures and/or identify nerve damage occurring prior to surgery and/or verify range of motion or attributes of muscle contraction during reconstructive surgery. A stimulation control device may incorporate a range of low and high intensity stimulation to provide a stimulation and evaluation of both nerves and muscles. A stimulation control device is removably coupled to a surgical device or is imbedded within the medical device to provide a stimulation and treatment medical device. A disposable hand held stimulation system includes an operative element extending from the housing, the housing includes an operative element adjustment portion and a visual indication to provide feedback or status to the user.
摘要翻译：改进的组件，系统和方法提供了在手术过程中的组织损伤的保护和/或识别在手术之前发生的神经损伤和/或验证重建手术期间肌肉收缩的运动范围或属性。刺激控制装置可以包括一系列低和高强度刺激，以提供对神经和肌肉的刺激和评估。刺激控制装置可拆卸地联接到手术装置或嵌入在医疗装置内以提供刺激和治疗医疗装置。一次性手持刺激系统包括从壳体延伸的操作元件，壳体包括操作元件调节部分和用于向使用者提供反馈或状态的视觉指示。

3. 发明申请

US20070060955A1 Implantable pulse generator systems and methods for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue 审中-公开
标题翻译：用于提供对肌肉和/或神经和/或中枢神经系统组织的功能和/或治疗刺激的可植入脉冲发生器系统和方法
公开(公告)号：US20070060955A1
公开(公告)日：2007-03-15
申请号：US11517056
申请日：2006-09-07
申请人： Robert Strother , Geoffrey Thrope , Joseph Mrva , Danny Pack
发明人： Robert Strother , Geoffrey Thrope , Joseph Mrva , Danny Pack
IPC分类号： A61N1/00
CPC分类号： A61N1/37252 , A61N1/05 , A61N1/0551 , A61N1/36007 , A61N1/3605 , A61N1/36071 , A61N1/37229 , A61N1/375 , A61N1/3754 , A61N1/3758 , A61N1/3787
摘要： Improved assemblies, systems, and methods provide a stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The stimulation system may include both external and internal components, with an implantable pulse generator sized and configured to be implanted subcutaneously in a tissue region. The implantable pulse generator includes a welded titanium case. Circuitry and hardware adapted for wireless telemetry is located within the case, and includes a primary cell or rechargeable power source, a microcontroller for control of the implantable pulse generator, and a power receiving coil for receiving an RF magnetic field to recharge the rechargeable power source, the power receiving coil having a maximum outside dimension.
摘要翻译：改进的装配，系统和方法提供用于肌肉，神经或中枢神经系统组织或任何组合的假体或治疗刺激的刺激系统。刺激系统可以包括外部和内部组件，其中植入式脉冲发生器的尺寸和构造被植入皮下组织区域。可植入脉冲发生器包括焊接钛壳。适用于无线遥测的电路和硬件位于壳体内，并且包括主电池或可再充电电源，用于控制可植入脉冲发生器的微控制器和用于接收RF磁场以对可再充电电源进行充电的电力接收线圈所述受电线圈具有最大的外部尺寸。

4. 发明申请

US20060200219A1 Systems and methods for differentiating and/or identifying tissue regions innervated by targeted nerves for diagnostic and/or therapeutic purposes 审中-公开
标题翻译：用于鉴别和/或识别用于诊断和/或治疗目的的目标神经支配的组织区域的系统和方法
公开(公告)号：US20060200219A1
公开(公告)日：2006-09-07
申请号：US11337319
申请日：2006-01-23
申请人： Geoffrey Thrope , Joseph Mrva , Robert Strother , Kenneth Rundle
发明人： Geoffrey Thrope , Joseph Mrva , Robert Strother , Kenneth Rundle
IPC分类号： A61B5/04 , A61N1/36 , A61N1/08 , A61N1/18
CPC分类号： A61N1/08 , A61B5/05 , A61B5/4893 , A61B90/04 , A61N1/36014 , A61N1/362 , A61N1/36514
摘要： Systems and methods make possible the differentiation and identification of tissue regions locally innervated by targeted nerves. The systems and methods make it possible to access the nervous system at these localized regions for therapeutic benefit. For example, the systems and methods can be used to access parasympathetic nerves localized in fat pads on the surface of the heart.
摘要翻译：系统和方法使得由目标神经局部保护的组织区域的分化和鉴定成为可能。系统和方法使得可以在这些局部区域进入神经系统以获得治疗益处。例如，这些系统和方法可用于获取位于心脏表面的脂肪垫中的副交感神经。

5. 发明申请

US20070293910A1 Implantable pulse generator for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue 有权
公开(公告)号：US20070293910A1
公开(公告)日：2007-12-20
申请号：US11824892
申请日：2007-07-03
申请人： Robert Strother , Joseph Mrva , Geoffrey Thrope
发明人： Robert Strother , Joseph Mrva , Geoffrey Thrope
IPC分类号： A61N1/00
CPC分类号： A61N1/37276 , A61N1/36003 , A61N1/36071 , A61N1/37223 , Y10S128/903 , Y10S128/904
摘要： Improved assemblies, systems, and methods provide an implantable pulse generator for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The implantable pulse generator is sized and configured to be implanted subcutaneous a tissue region. The implantable pulse generator includes an electrically conductive case of a laser welded titanium material. Control circuitry is located within the case, the control circuitry including a rechargeable power source, a receive coil for receiving an RF magnetic field to recharge the power source, and a microcontroller for control of the implantable pulse generator. Improved assemblies, systems, and methods also provide a stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The stimulation system provides at least one electrically conductive surface, a lead connected to the electrically conductive surface, and an implantable pulse generator electrically connected to the lead.

6. 发明申请

US20070239224A1 Systems and methods for bilateral stimulation of left and right branches of the dorsal genital nerves to treat urologic dysfunctions 有权
标题翻译：双侧刺激背部生殖神经左右分支的系统和方法，以治疗泌尿功能障碍
公开(公告)号：US20070239224A1
公开(公告)日：2007-10-11
申请号：US11729333
申请日：2007-03-28
申请人： Maria Bennett , Julie Grill , Tina Lechman , Joseph Mrva , Jonathan Sakai , Robert Strother , Geoffrey Thrope , Therese Zmina
发明人： Maria Bennett , Julie Grill , Tina Lechman , Joseph Mrva , Jonathan Sakai , Robert Strother , Geoffrey Thrope , Therese Zmina
IPC分类号： A61N1/05
CPC分类号： A61N1/36007 , A61N1/0524 , A61N1/0551 , A61N1/0558 , A61N1/36014 , A61N1/36107 , A61N1/37211
摘要： Systems and methods treat urologic dysfunctions by implanting a lead and electrode in a tissue region affecting urologic function, and implanting a pulse generator in an anterior pelvic region remote from the electrode. Bilateral stimulation of the left and/or right branches of the dorsal genital nerves using a single lead implanted in adipose or other tissue in the region at or near the pubic symphysis is able to treat urinary incontinence.
摘要翻译：系统和方法通过将铅和电极植入影响泌尿功能的组织区域中并将脉冲发生器植入远离电极的前盆腔区域来治疗泌尿系统功能障碍。使用植入在耻骨联合处或附近的区域中的脂肪或其他组织中的单个引线对背生殖神经的左侧和/或右侧分支的双侧刺激能够治疗尿失禁。

7. 发明申请

US20070060980A1 Implantable pulse generator systems and methods for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue 有权
标题翻译：用于提供对肌肉和/或神经和/或中枢神经系统组织的功能和/或治疗刺激的可植入脉冲发生器系统和方法
公开(公告)号：US20070060980A1
公开(公告)日：2007-03-15
申请号：US11517213
申请日：2006-09-07
申请人： Robert Strother , Geoffrey Thrope , Danny Pack
发明人： Robert Strother , Geoffrey Thrope , Danny Pack
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/05 , A61N1/0551 , A61N1/36007 , A61N1/3605 , A61N1/36071 , A61N1/37229 , A61N1/37252 , A61N1/375 , A61N1/3754 , A61N1/3758 , G16H40/67
摘要： Improved assemblies, systems, and methods provide a stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The stimulation system includes an implantable pulse generator and a lead sized and configured to be implanted subcutaneously in a tissue region. An external controller includes circuitry adapted for wireless telemetry and a charging coil for generating the radio frequency magnetic field to transcutaneously recharge a rechargeable battery in the pulse generator. Using wireless telemetry, the pulse generator is adapted to transmit status information back to the external controller to allow the external controller to automatically adjust up or down the magnitude of the radio frequency magnetic field and/or to instruct a user to reposition the charging coil, the status information adapted to allow optimal recharging of the pulse generator rechargeable battery.
摘要翻译：改进的装配，系统和方法提供用于肌肉，神经或中枢神经系统组织或任何组合的假体或治疗刺激的刺激系统。刺激系统包括可植入脉冲发生器和尺寸和构造成在组织区域中皮下植入的引线。外部控制器包括适于无线遥测的电路和用于产生射频磁场的充电线圈，用于经常地对脉冲发生器中的可再充电电池进行再充电。使用无线遥测，脉冲发生器适于将状态信息发送回外部控制器，以允许外部控制器自动调节射频磁场的大小和/或指示用户重新定位充电线圈，所述状态信息适于允许脉冲发生器可再充电电池的最佳再充电。

8. 发明申请

US20070032836A1 Percutaneous electrode assemblies, systems, and methods for providing highly selective functional or therapeutic neuromuscular stimulation 审中-公开
标题翻译：用于提供高选择性功能或治疗性神经肌肉刺激的经皮电极组件，系统和方法
公开(公告)号：US20070032836A1
公开(公告)日：2007-02-08
申请号：US11545336
申请日：2006-10-10
申请人： Geoffrey Thrope , Robert Strother , Joseph Mrva
发明人： Geoffrey Thrope , Robert Strother , Joseph Mrva
IPC分类号： A61N1/18
CPC分类号： A61N1/32 , A61N1/0551 , Y10S128/907
摘要： Percutaneous electrode assemblies, systems, and methods make possible the providing of short-term therapy or diagnostic testing by providing electrical connections between muscles or nerves inside the body and stimulus generators or recording instruments carried outside the body. The percutaneous electrodes include a flexible body having an electrically conductive region, a tissue penetrating region, and a percutaneous lead electrically coupled to the electrically conductive region. An anchoring element is positioned on the flexible body to resist movement of the electrically conductive region within tissue. An introducer is sized and configured to receive the flexible body and shield the anchoring element from contact with tissue while the electrically conductive region is placed to a desired position within tissue, and accommodates advancement of the anchoring element beyond the interior lumen for contact with tissue to resist movement of the electrically conductive region placed in the desired position.
摘要翻译：经皮电极组件，系统和方法可以通过在体内的肌肉或神经之间提供短期治疗或诊断测试，以及在体外携带的刺激发生器或记录仪器。经皮电极包括具有导电区域，组织穿透区域和电耦合到导电区域的经皮引线的柔性体。锚定元件定位在柔性体上以抵抗组织内导电区域的移动。导引器的尺寸和构造被设计成接收柔性体并且屏蔽锚固元件免受与组织的接触，同时将导电区域放置在组织内的期望位置，并且容纳锚定元件超出内腔以与组织接触阻止放置在所需位置的导电区域的移动。

9. 发明申请

US20060004421A1 Systems and methods for bilateral stimulation of left and right branches of the dorsal genital nerves to treat dysfunctions, such as urinary incontinence 失效
公开(公告)号：US20060004421A1
公开(公告)日：2006-01-05
申请号：US11149654
申请日：2005-06-10
申请人： Maria Bennett , Robert Strother , Julie Grill , Joseph Mrya , Therese Zmina , Geoffrey Thrope
发明人： Maria Bennett , Robert Strother , Julie Grill , Joseph Mrya , Therese Zmina , Geoffrey Thrope
IPC分类号： A61N1/08
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/08 , A61N1/36017 , A61N1/36107 , A61N1/37229 , A61N1/37252 , A61N1/375 , A61N1/3754 , A61N1/3787
摘要： Systems and methods treat urinary incontinence by the bilateral stimulation of the left and/or right branches of the dorsal genital nerves using a single lead implanted in adipose or other tissue in the region at or near the pubic symphysis.

10. 发明申请

US20050182457A1 Portable assemblies, systems and methods for providing functional or therapeutic neuromuscular stimulation 有权
标题翻译：用于提供功能或治疗性神经肌肉刺激的便携式组件，系统和方法
公开(公告)号：US20050182457A1
公开(公告)日：2005-08-18
申请号：US11056591
申请日：2005-02-11
申请人： Geoffrey Thrope , Robert Strother , Joseph Mrva
发明人： Geoffrey Thrope , Robert Strother , Joseph Mrva
IPC分类号： A61N1/18
CPC分类号： A61N1/36017 , A61N1/0558 , A61N1/36003 , A61N1/36021 , A61N1/37211
摘要： Neuromuscular stimulation assemblies, systems, and methods make possible the providing of short-term therapy or diagnostic testing by providing electrical connections between muscles or nerves inside the body and stimulus generators or recording instruments mounted on the surface of the skin outside the body. Neuromuscular stimulation assemblies, systems, and methods may include a steerable introducer that defines an interior lumen sized and configured to shield a percutaneous electrode from contact with tissue during advancement to a desired position within tissue.
摘要翻译：神经肌肉刺激组件，系统和方法可以通过提供身体内肌肉或神经之间的电连接以及安装在身体外部皮肤表面上的刺激发生器或记录仪器来提供短期治疗或诊断测试。神经肌肉刺激组件，系统和方法可以包括可导向的导引器，其限定内腔，其尺寸设计成在经推进到组织内的期望位置时屏蔽经皮电极与组织的接触。

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