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1. 发明申请

US20150209576A1 DURABLE SMALL GAUGE WIRE ELECTRICAL CONDUCTOR SUITABLE FOR DELIVERY OF HIGH INTENSITY ENERGY PULSES 审中-公开
标题翻译：适用于输送高强度能量脉冲的耐用小尺寸电导体
公开(公告)号：US20150209576A1
公开(公告)日：2015-07-30
申请号：US14165559
申请日：2014-01-27
申请人： Robert G. Walsh , Jin Shimada , Scott Engle
发明人： Robert G. Walsh , Jin Shimada , Scott Engle
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0563
摘要： Implantable medical devices intended for electrostimulation and sensing devices typically incorporate one or more electrical conductors as leads for electrical stimulation to, or retrieval of localized sensing data from, discrete points in the body, such as the heart. Certain applications require delivery of high intensity electrical pulses, i.e. CRTs, or defibrillators. As described herein a CRT delivers high energy pulses via a durable fine wire lead formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating. A unipolar electrical conductor can have an outer diameter of about 150 microns or even smaller. The buffered fibers support conduction of high intensity electrical pulses as required for internal or external defibrillators, or other biomedical applications, as well as non-medical applications. Defibrillation pulses can be transmitted through less cross-sectional area of metal in the subject fine wire conductor than would be the case with conventional solid core metal wires. Multiple such coated fibers can act as a single conductor. An outer protective sheath of a flexible polymer material can be included.
摘要翻译：旨在用于电刺激和感测装置的可植入医疗设备通常将一个或多个电导体作为引线用于电刺激或从身体中的离散点（例如心脏）检索局部感测数据。某些应用需要输送高强度电脉冲，即CRT或除颤器。如本文所述，CRT通过由具有金属涂层的玻璃，二氧化硅，蓝宝石或结晶石英纤维芯形成的耐用细线引脚提供高能量脉冲。单极电导体可以具有约150微米或甚至更小的外径。缓冲的纤维支持内部或外部除颤器或其他生物医学应用以及非医疗应用所需的高强度电脉冲的传导。除了传统的固体芯金属线材外，除颤脉冲可以通过较小的细线导体中金属的横截面积传递。多个这样的涂覆纤维可以用作单个导体。可以包括柔性聚合物材料的外护套。

2. 发明授权

US08692117B2 Durable fine wire electrical conductor suitable for extreme environment applications 有权
标题翻译：耐用的细线电导体适用于极端环境的应用
公开(公告)号：US08692117B2
公开(公告)日：2014-04-08
申请号：US12804271
申请日：2010-07-16
申请人： Robert G. Walsh , Jin Shimada , Scott Engle
发明人： Robert G. Walsh , Jin Shimada , Scott Engle
IPC分类号： H01B11/00 , H01B7/04 , A61N1/05
CPC分类号： H01B9/005 , A61N1/05 , A61N1/0551 , A61N1/056 , H01B1/14 , H01B1/18 , H01B7/04 , H01B7/048
摘要： Durable fine wire electrical conductors are robust, durable, small in profile, and light weight, yet capable of operating under extreme environmental conditions. Formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating and one or more polymer layers, a unipolar electrical conductor can have an outer diameter as small as about 300 microns or even smaller. The metal buffer coating may be deposited directly on the glass/silica fiber, or upon an intermediate layer between the glass/silica fiber and metal, consisting of carbon and/or polymer. The resulting metallized glass/silica fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar electrical conductors can include several insulated metallized glass/silica fibers residing side by side, or can be coaxial with two or more insulated metal conductive paths. An outer protective sheath of a flexible polymer material can be included.
摘要翻译：耐用的细线电导体坚固耐用，外形小巧，重量轻，但能够在极端环境条件下工作。由具有金属涂层和一个或多个聚合物层的玻璃，二氧化硅，蓝宝石或结晶石英纤维芯形成，单极电导体可以具有小至约300微米甚至更小的外径。金属缓冲涂层可以直接沉积在玻璃/二氧化硅纤维上，或者在由碳和/或聚合物组成的玻璃/二氧化硅纤维和金属之间的中间层上。所得到的金属化玻璃/二氧化硅纤维非常耐用，可以通过小的半径弯曲，并且即使从数百万次的弯曲迭代也不会疲劳。双极电导体可以包括并排存在的几个绝缘的金属化玻璃/二氧化硅纤维，或者可以与两个或更多个绝缘的金属导电路径同轴。可以包括柔性聚合物材料的外护套。

3. 发明申请

US20150262733A1 DURABLE FINE WIRE ELECTRICAL CONDUCTOR SUITABLE FOR EXTREME ENVIRONMENT APPLICATIONS 有权
标题翻译：适用于极端环境应用的耐用精细电线导体
公开(公告)号：US20150262733A1
公开(公告)日：2015-09-17
申请号：US14184580
申请日：2014-02-19
申请人： Robert G. Walsh , Jin Shimada , Scott Engle
发明人： Robert G. Walsh , Jin Shimada , Scott Engle
IPC分类号： H01B9/00 , A61N1/05 , H01B7/04 , H01B1/18 , H01B1/14
CPC分类号： H01B9/005 , A61N1/05 , A61N1/0551 , A61N1/056 , H01B1/14 , H01B1/18 , H01B7/04 , H01B7/048
摘要： Durable fine wire electrical conductors are robust, durable, small in profile, and light weight, yet capable of operating under extreme environmental conditions. Formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating and one or more polymer layers, a unipolar electrical conductor can have an outer diameter as small as about 300 microns or even smaller. The metal buffer coating may be deposited directly on the glass/silica fiber, or upon an intermediate layer between the glass/silica fiber and metal, consisting of carbon and/or polymer. The resulting metallized glass/silica fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar electrical conductors can include several insulated metallized glass/silica fibers residing side by side, or can be coaxial with two or more insulated metal conductive paths. An outer protective sheath of a flexible polymer material can be included.
摘要翻译：耐用的细线电导体坚固耐用，外形小巧，重量轻，但能够在极端环境条件下工作。由具有金属涂层和一个或多个聚合物层的玻璃，二氧化硅，蓝宝石或结晶石英纤维芯形成，单极电导体可以具有小至约300微米甚至更小的外径。金属缓冲涂层可以直接沉积在玻璃/二氧化硅纤维上，或者在由碳和/或聚合物组成的玻璃/二氧化硅纤维和金属之间的中间层上。所得到的金属化玻璃/二氧化硅纤维非常耐用，可以通过小的半径弯曲，并且即使从数百万次的弯曲迭代也不会疲劳。双极电导体可以包括并排存在的几个绝缘的金属化玻璃/二氧化硅纤维，或者可以与两个或更多个绝缘的金属导电路径同轴。可以包括柔性聚合物材料的外护套。

4. 发明申请

US20110301657A1 Durable small gauge wire electrical conductor suitable for delivery of high intensity energy pulses 审中-公开
标题翻译：耐用的小规格导线电导体适用于传递高强度能量脉冲
公开(公告)号：US20110301657A1
公开(公告)日：2011-12-08
申请号：US12806743
申请日：2010-08-18
申请人： Robert G. Walsh , Jin Shimada , Scott Engle
发明人： Robert G. Walsh , Jin Shimada , Scott Engle
IPC分类号： A61N1/39
CPC分类号： A61N1/056
摘要： Implantable medical devices intended for electrostimulation and sensing devices typically incorporate one or more electrical conductors as leads for electrical stimulation to, or retrieval of localized sensing data from, discrete points in the body, such as the heart. Certain applications require delivery of high intensity electrical pulses, i.e. CRTs, or defibrillators. As described herein a CRT delivers high energy pulses via a durable fine wire lead formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating. A unipolar electrical conductor can have an outer diameter of about 150 microns or even smaller. The buffered fibers support conduction of high intensity electrical pulses as required for internal or external defibrillators, or other biomedical applications, as well as non-medical applications. Defibrillation pulses can be transmitted through less cross-sectional area of metal in the subject fine wire conductor than would be the case with conventional solid core metal wires. Multiple such coated fibers can act as a single conductor. An outer protective sheath of a flexible polymer material can be included.
摘要翻译：旨在用于电刺激和感测装置的可植入医疗设备通常将一个或多个电导体作为引线用于电刺激或从身体中的离散点（例如心脏）检索局部感测数据。某些应用需要输送高强度电脉冲，即CRT或除颤器。如本文所述，CRT通过由具有金属涂层的玻璃，二氧化硅，蓝宝石或结晶石英纤维芯形成的耐用细线引脚提供高能量脉冲。单极电导体可以具有约150微米或甚至更小的外径。缓冲的纤维支持内部或外部除颤器或其他生物医学应用以及非医疗应用所需的高强度电脉冲的传导。除了传统的实心芯金属线的情况，除颤脉冲可以通过较小的细线导体中的金属横截面积传递。多个这样的涂覆纤维可以用作单个导体。可以包括柔性聚合物材料的外护套。

5. 发明申请

US20110272192A1 Durable fine wire electrical conductor suitable for extreme environment applications 有权
标题翻译：耐用的细线电导体适用于极端环境的应用
公开(公告)号：US20110272192A1
公开(公告)日：2011-11-10
申请号：US12804271
申请日：2010-07-16
申请人： Robert G. Walsh , Jin Shimada , Scott Engle
发明人： Robert G. Walsh , Jin Shimada , Scott Engle
IPC分类号： H02G3/00
CPC分类号： H01B9/005 , A61N1/05 , A61N1/0551 , A61N1/056 , H01B1/14 , H01B1/18 , H01B7/04 , H01B7/048
摘要： Durable fine wire electrical conductors are robust, durable, small in profile, and light weight, yet capable of operating under extreme environmental conditions. Formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating and one or more polymer layers, a unipolar electrical conductor can have an outer diameter as small as about 300 microns or even smaller. The metal buffer coating may be deposited directly on the glass/silica fiber, or upon an intermediate layer between the glass/silica fiber and metal, consisting of carbon and/or polymer. The resulting metallized glass/silica fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar electrical conductors can include several insulated metallized glass/silica fibers residing side by side, or can be coaxial with two or more insulated metal conductive paths. An outer protective sheath of a flexible polymer material can be included.
摘要翻译：耐用的细线电导体坚固耐用，外形小巧，重量轻，但能够在极端环境条件下工作。由具有金属涂层和一个或多个聚合物层的玻璃，二氧化硅，蓝宝石或结晶石英纤维芯形成，单极电导体可以具有小至约300微米甚至更小的外径。金属缓冲涂层可以直接沉积在玻璃/二氧化硅纤维上，或者在由碳和/或聚合物组成的玻璃/二氧化硅纤维和金属之间的中间层上。所得到的金属化玻璃/二氧化硅纤维非常耐用，可以通过小的半径弯曲，并且即使从数百万次的弯曲迭代也不会疲劳。双极电导体可以包括并排存在的几个绝缘的金属化玻璃/二氧化硅纤维，或者可以与两个或更多个绝缘的金属导电路径同轴。可以包括柔性聚合物材料的外护套。

6. 发明申请

US20120009815A1 ADAPTER FOR ELECTRODE AND CONNECTOR ATTACHMENTS FOR A CYLINDRICAL GLASS FIBER FINE WIRE LEAD 审中-公开
标题翻译：适用于圆柱玻璃纤维细线的电极和连接器附件
公开(公告)号：US20120009815A1
公开(公告)日：2012-01-12
申请号：US12892884
申请日：2010-09-28
申请人： Robert G. Walsh , Jin Shimada
发明人： Robert G. Walsh , Jin Shimada
IPC分类号： H01R13/58
CPC分类号： A61N1/056
摘要： A cardiac pacemaker or other CRT device has one or more fine wire leads to the heart. Formed of a glass, silica, sapphire or crystalline quartz fiber with a thin metal coating, a unipolar lead can have an outer diameter as small as about 300 microns or even smaller. The thin metal conductor poses unique challenges for attachment to standardized connectors as well as to stimulation electrodes. This invention describes structures and materials for creating robust and durable electrically conductive connections between the fine wire lead body and a proximal standardized connector and distal ring and tip electrodes by utilization of fine metal coils or mesh and electrically conductive adapters to aid in stabilizing the connections.
摘要翻译：心脏起搏器或其他CRT装置具有一个或多个细导线通向心脏。由具有薄金属涂层的玻璃，二氧化硅，蓝宝石或结晶石英纤维形成，单极铅可以具有小至约300微米甚至更小的外径。薄金属导体对连接到标准化连接器以及刺激电极构成独特的挑战。本发明描述了用于通过利用细金属线圈或网状物和导电适配器来帮助稳定连接而在细线引线主体和近端标准化连接器以及远端环和尖端电极之间形成坚固耐用的导电连接的结构和材料。

7. 发明申请

US20110220408A1 Electrode and connector attachments for a cylindrical glass fiber wire lead 审中-公开
标题翻译：用于圆柱形玻璃纤维导线的电极和连接器附件
公开(公告)号：US20110220408A1
公开(公告)日：2011-09-15
申请号：US12660344
申请日：2010-02-23
申请人： Robert G. Walsh , Paul A. Lovoi , Jin Shimada , Kimberly Anderson
发明人： Robert G. Walsh , Paul A. Lovoi , Jin Shimada , Kimberly Anderson
IPC分类号： H02G15/02
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/056 , H01R4/187 , H01R43/0221 , H01R2201/12
摘要： A cardiac pacemaker or other CRT device has one or more fine wire leads to the heart. Formed of a glass, silica, sapphire or crystalline quartz fiber with a metal coating, a unipolar lead can have an outer diameter as small as about 300 microns or even smaller. The metal buffer coating may be deposited directly on the glass/silica fiber, or upon an intermediate layer between the glass/silica fiber and metal, consisting of carbon and/or polymer. The resulting metallized glass/silica fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar fine wire leads can include several insulated metallized glass/silica fibers residing side by side, or can be coaxial with two or more insulated metal conductive paths. An outer protective sheath of a flexible polymer material can be included. The fine wire lead incorporates a thin metal conductor, which poses unique challenges for attachment to standardized connectors, as well as stimulation electrodes. The present invention describes means and materials for creating robust and durable electrically conductive connections between the fine wire lead body and a proximal standardized connector and distal ring and tip electrodes.
摘要翻译：心脏起搏器或其他CRT装置具有一个或多个细导线通向心脏。由具有金属涂层的玻璃，二氧化硅，蓝宝石或结晶石英纤维形成，单极引线可以具有小至约300微米甚至更小的外径。金属缓冲涂层可以直接沉积在玻璃/二氧化硅纤维上，或者在由碳和/或聚合物组成的玻璃/二氧化硅纤维和金属之间的中间层上。所得到的金属化玻璃/二氧化硅纤维非常耐用，可以通过小的半径弯曲，并且即使从数百万次的弯曲迭代也不会疲劳。双极细线引线可以包括并排存在的多个绝缘的金属化玻璃/二氧化硅纤维，或者可以与两个或更多个绝缘金属导电路径同轴。可以包括柔性聚合物材料的外护套。细线引线采用薄金属导体，对连接到标准连接器以及刺激电极构成独特的挑战。本发明描述了用于在细线引线主体和近端标准化连接器以及远端环和尖端电极之间形成坚固耐用的导电连接的装置和材料。

8. 发明申请

US20100331941A1 Implantable fine wire lead for electrostimulation and sensing 审中-公开
标题翻译：用于电刺激和感测的可植入细导线
公开(公告)号：US20100331941A1
公开(公告)日：2010-12-30
申请号：US12584837
申请日：2009-09-10
申请人： Robert G. Walsh , Jin Shimada
发明人： Robert G. Walsh , Jin Shimada
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/056 , A61N1/057 , H01R2201/12
摘要： A cardiac pacemaker or other implantable electrostimulation device has one or more durable fine wire leads to the heart or other electrostimulation site. The lead is formed of a core of silica or glass fiber or similar material, with a protective coating preferably including a metal buffer for conduction. The lead can be unipolar or bipolar (or even with three or more conductors), of small diameter and preferably with an anchoring configuration at the distal end of the lead. The anchor feature can take any of several nonlinear forms such that once implanted in a constrained configuration, the anchor can be released to the expanded, nonlinear configuration. The electrostimulation leads of the invention are extremely durable, can be bent through small radii and can exhibit long life without fatigue failure.
摘要翻译：心脏起搏器或其他可植入电刺激装置具有一个或多个持久的细导线通向心脏或其它电刺激部位。引线由二氧化硅或玻璃纤维或类似材料的芯形成，其中保护性涂层优选包括用于传导的金属缓冲剂。引线可以是小直径的单极或双极（或甚至具有三个或更多个导体），并且优选地具有在引线远端处的锚定构型。锚定特征可以采取几种非线性形式中的任何一种，使得一旦植入在约束构造中，锚可以被释放到扩展的非线性构造。本发明的电刺激是非常耐用的，可以通过小的半径弯曲，并且可以显示长寿命而没有疲劳失效。

9. 发明申请

US20130303017A9 ADAPTER FOR ELECTRODE AND CONNECTOR ATTACHMENTS FOR A CYLINDRICAL GLASS FIBER FINE WIRE LEAD 审中-公开
标题翻译：适用于圆柱玻璃纤维细线的电极和连接器附件
公开(公告)号：US20130303017A9
公开(公告)日：2013-11-14
申请号：US12892884
申请日：2010-09-28
申请人： Robert G. Walsh , Jin Shimada
发明人： Robert G. Walsh , Jin Shimada
IPC分类号： H01R13/58
CPC分类号： A61N1/056
摘要： A cardiac pacemaker or other CRT device has one or more fine wire leads to the heart. Formed of a glass, silica, sapphire or crystalline quartz fiber with a thin metal coating, a unipolar lead can have an outer diameter as small as about 300 microns or even smaller. The thin metal conductor poses unique challenges for attachment to standardized connectors as well as to stimulation electrodes. This invention describes structures and materials for creating robust and durable electrically conductive connections between the fine wire lead body and a proximal standardized connector and distal ring and tip electrodes by utilization of fine metal coils or mesh and electrically conductive adapters to aid in stabilizing the connections.
摘要翻译：心脏起搏器或其他CRT装置具有一个或多个细导线通向心脏。由具有薄金属涂层的玻璃，二氧化硅，蓝宝石或结晶石英纤维形成，单极铅可以具有小至约300微米甚至更小的外径。薄金属导体对连接到标准化连接器以及刺激电极构成独特的挑战。本发明描述了用于通过利用细金属线圈或网状物和导电适配器来帮助稳定连接而在细线引线主体和近端标准化连接器以及远端环和尖端电极之间形成坚固耐用的导电连接的结构和材料。

10. 发明授权

US09072868B2 Device for delivery of antimicrobial agent into trans-dermal catheter 有权
标题翻译：用于将抗微生物剂递送至透皮导管的装置
公开(公告)号：US09072868B2
公开(公告)日：2015-07-07
申请号：US12605966
申请日：2009-10-26
申请人： Robert J. Ziebol , William S. Nettekoven , Gregory G. Carlson , Robert G. Walsh , Robert H. Weinmann
发明人： Robert J. Ziebol , William S. Nettekoven , Gregory G. Carlson , Robert G. Walsh , Robert H. Weinmann
IPC分类号： A61M25/01 , A61M39/18 , A61M39/16 , A61M39/20 , A61L2/18 , A61M25/00 , A61M5/00
CPC分类号： A61M25/01 , A61L2/186 , A61L2202/24 , A61M5/001 , A61M25/0017 , A61M25/0105 , A61M25/0111 , A61M39/165 , A61M39/18 , A61M39/20 , A61M2025/0018 , A61M2025/0019 , A61M2025/0056 , A61M2209/10
摘要： A system for delivering an antimicrobial agent into the lumen of a trans-dermal catheter. In an embodiment, the system comprises an elongate member configured for insertion into a lumen of a catheter; an expandable portion of the elongate member, said expandable portion configured to increase in diameter upon exposure to an aqueous fluid; and an antimicrobial composition positioned to be delivered into the catheter. In another embodiment, the system comprises an elongate member configured for insertion into a lumen of a trans-dermal catheter, said elongate member comprising a hydrogel; and an antimicrobial composition positioned to be delivered into the catheter; wherein the elongate member defines a volume of liquid that is at least substantially contained within the lumen of the trans-dermal catheter.
摘要翻译：用于将抗微生物剂递送到经皮导管的内腔中的系统。在一个实施例中，系统包括构造成用于插入导管的内腔中的细长构件; 所述细长构件的可膨胀部分，所述可膨胀部分构造成在暴露于含水流体时直径增加; 以及定位成被输送到导管中的抗微生物组合物。在另一个实施例中，该系统包括构造成用于插入经皮导管内腔的细长构件，所述细长构件包括水凝胶; 以及定位成被输送到导管中的抗微生物组合物; 其中所述细长构件限定至少基本上包含在所述经皮导管的内腔内的一定体积的液体。

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