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1. 发明授权

US5100783A Weighted microsponge for immobilizing bioactive material 失效
标题翻译：用于固定生物活性物质的加权微球
公开(公告)号：US5100783A
公开(公告)日：1992-03-31
申请号：US333831
申请日：1989-04-05
申请人： Robert C. Dean, Jr. , Frederick Cahn , Philip G. Phillips
发明人： Robert C. Dean, Jr. , Frederick Cahn , Philip G. Phillips
IPC分类号： C12N1/00 , C12N5/00 , C12N11/02 , C12P1/00
CPC分类号： C12P1/00 , C12N1/00 , C12N11/02 , C12N5/0075 , C12N2533/54
摘要： Weighted microsponges formed of a porous, biostable matrix of a biocompatible polymer containing an inert weighing material are prepared suitable for use in culturing organisms in motive reactor systems. The matrix has an open to the surface pore structure with an average pore size in the range of from about 1 to about 150 microns and the pores occupy from about 70 to about 98% by volume of the microsponge. The microsponges have an average particle size of from about 100 to about 1000 microns and a specific gravity of above about 1.05. Biocompatible polymers that can be used are polysaccharides, proteins and synthetic polymers and the weighing material can be metals, metal alloys, metal oxides or ceramics.
摘要翻译：制备由包含惰性称重材料的生物相容性聚合物的多孔，生物稳定基质形成的加权微球，适用于在动力反应器系统中培养生物体。该基质具有开放的表面孔结构，平均孔径在约1至约150微米的范围内，孔隙占微球体积的约70至约98体积％。微球的平均粒度为约100至约1000微米，比重高于约1.05。可以使用的生物相容性聚合物是多糖，蛋白质和合成聚合物，称重材料可以是金属，金属合金，金属氧化物或陶瓷。

2. 发明授权

US5629191A Method of making a porous matrix particle 失效
标题翻译：制造多孔基体颗粒的方法
公开(公告)号：US5629191A
公开(公告)日：1997-05-13
申请号：US74922
申请日：1993-06-10
申请人： Frederick Cahn
发明人： Frederick Cahn
IPC分类号： C08J9/28 , C12N5/00 , C12N5/06 , C12P21/02
CPC分类号： C08J9/28 , C12N5/0075 , C08J2389/06 , C12N2533/70
摘要： A porous particle having a generally isopycnic density with liquid growth medium, a sponge-like character and a diameter of less than 2 mm which is formed from a homogenous biologically compatible matrix is described. This particle is useful in various systems for culturing anchorage-dependent and -independent cells, and is adaptable to large scale tissue culture which permits harvesting of cell products. The method of making such a particle includes preparing a solution containing a biologically compatible material, forming droplets from the solution, freezing the droplets, drying the droplets by sublimation to form a particle, and crosslinking the biologically compatible material in the particle.
摘要翻译：描述了由均匀的生物相容性基质形成的与液体生长培养基具有大致等密度密度的多孔颗粒，海绵状特征和小于2mm的直径。该颗粒可用于培养锚定依赖和不依赖细胞的各种系统，并且适用于允许细胞产物收获的大规模组织培养。制备这种颗粒的方法包括制备包含生物相容性材料的溶液，从溶液中形成液滴，冷冻液滴，通过升华干燥液滴以形成颗粒，以及交联颗粒中的生物相容性材料。

3. 发明申请

US20080281421A1 Wound Closure System and Methods 审中-公开
标题翻译：伤口闭合系统及方法
公开(公告)号：US20080281421A1
公开(公告)日：2008-11-13
申请号：US11597398
申请日：2005-05-10
申请人： Frederick Cahn , Moreno White
发明人： Frederick Cahn , Moreno White
IPC分类号： A61F2/10
CPC分类号： A61L27/60 , A61B2017/00637 , A61B2017/348 , A61L27/24 , A61L27/56 , C08L89/02
摘要： Wound closure systems and methods are provided, containing a porous layer comprising a collagen material; a substantially non-porous synthetic layer contacting the porous layer, the porous layer and substantially non-porous layer capable of providing wound closure; and a transcutaneous component contacting the porous layer and the substantially non-porous synthetic layer. In various embodiments, the transcutaneous component is capable of receiving a cannula, glucose sensor, electrode, prosthesis, chest tube, medical instrument or bone, muscle, blood vessels, nerve, organ or combination thereof.
摘要翻译：提供了包含包含胶原材料的多孔层的伤口闭合系统和方法; 与多孔层接触的基本上无孔的合成层，能够提供伤口闭合的多孔层和基本无孔层; 以及与多孔层和基本上无孔的合成层接触的经皮成分。在各种实施例中，经皮组件能够接收套管，葡萄糖传感器，电极，假体，胸管，医疗器械或骨骼，肌肉，血管，神经，器官或其组合。

4. 发明授权

US5008116A Immunostimulatory microsphere 失效
标题翻译：免疫刺激微球
公开(公告)号：US5008116A
公开(公告)日：1991-04-16
申请号：US270276
申请日：1988-11-14
申请人： Frederick Cahn
发明人： Frederick Cahn
IPC分类号： A61K9/00 , A61K9/16 , A61K39/39 , A61K47/48
CPC分类号： A61K39/39 , A61K9/1652 , A61K9/1658 , A61K2039/55555 , A61K2039/55583
摘要： The invention relates to the use of an improved carrier or adjuvant to induce a therapeutic response to a weak antigen.
摘要翻译：本发明涉及改进的载体或佐剂诱导对弱抗原的治疗应答的用途。

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