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1. 发明授权

US10137245B2 Central site photoplethysmography, medication administration, and safety 有权
公开(公告)号：US10137245B2
公开(公告)日：2018-11-27
申请号：US13817156
申请日：2011-08-08
申请人： Richard J. Melker , Donn M. Dennis , Jeremy Melker , Mark Rice , Robert Hurley , Mark Gold , Richard Allen
发明人： Richard J. Melker , Donn M. Dennis , Jeremy Melker , Mark Rice , Robert Hurley , Mark Gold , Richard Allen
IPC分类号： A61M16/01 , A61M16/10 , A61M5/172 , A61M5/142 , A61B5/0205 , A61B5/1455 , A61M16/06 , A61M16/16 , G06F19/00 , A61M5/168 , A61B5/00 , A61B5/024 , A61B5/0402 , A61B5/08 , A61B5/083 , A61M16/00
摘要： A monitoring and control system, apparatus and method for safe administration, reduction or cessation of administration of at least on medication, fluid or both, which includes at least one Central Source Site (CSS) Photoplethysmography (PPG) sensor coupled to means for control of delivery of the at least one medication, fluid or both.

2. 发明申请

US20130296823A1 Intelligent Drug and/or Fluid Delivery System to Optimizing Medical Treatment or Therapy Using Pharmacodynamic and/or Pharamacokinetic Data 有权
标题翻译：使用药效学和/或Pharamac动力学数据优化医疗或治疗的智能药物和/或流体输送系统
公开(公告)号：US20130296823A1
公开(公告)日：2013-11-07
申请号：US13817165
申请日：2011-08-17
申请人： Richard J. Melker , Donn M. Dennis , Jeremy Melker , Mark Rice , Robert Hurley
发明人： Richard J. Melker , Donn M. Dennis , Jeremy Melker , Mark Rice , Robert Hurley
IPC分类号： A61M5/172
CPC分类号： A61M5/1723 , A61B5/0205 , A61B5/02416 , A61B5/0261 , A61B5/036 , A61B5/0408 , A61B5/0816 , A61B5/1455 , A61B5/4839 , A61M5/142 , A61M5/168 , A61M5/16854 , A61M5/172 , A61M5/31511 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H20/17
摘要： A pharmacodynamic (PD), pharmacokinetic (PK), or both and PK guided infusion device, system and method optimizes the safety and efficacy of various forms of treatment or therapy (e.g., drug and/or fluid) in a variety of health-care and other settings.
摘要翻译：药物动力学（PD），药代动力学（PK）或两者和PK引导输注装置，系统和方法优化各种形式的治疗或治疗（例如药物和/或流体）在各种保健中的安全性和有效性和其他设置。

3. 发明授权

US07914460B2 Condensate glucose analyzer 有权
标题翻译：冷凝葡萄糖分析仪
公开(公告)号：US07914460B2
公开(公告)日：2011-03-29
申请号：US11504335
申请日：2006-08-15
申请人： Richard J. Melker , David G. Bjoraker , Donn M. Dennis , Jon D. Stewart , Christopher D. Batich , Matthew M. Booth , John Frederick Horn, Jr. , Ronald E. Youngblood
发明人： Richard J. Melker , David G. Bjoraker , Donn M. Dennis , Jon D. Stewart , Christopher D. Batich , Matthew M. Booth , John Frederick Horn, Jr. , Ronald E. Youngblood
IPC分类号： A61B5/08 , A61B5/00
CPC分类号： A61B5/083 , A61B5/1486 , A61B5/413 , Y10T436/144444
摘要： The present invention provides systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments of the invention, electrochemical- or coulometric-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose.
摘要翻译：本发明提供了用于分析呼出气凝缩物（EBC）中存在的葡萄糖的系统和方法。在本发明的某些实施方案中，使用电化学或基于库仑的感测技术来分析葡萄糖的存在和/或浓度。

4. 发明申请

US20090005270A1 Systems and Methods for Evaluating Enzyme Competency 审中-公开
标题翻译：评价酶能力的系统和方法
公开(公告)号：US20090005270A1
公开(公告)日：2009-01-01
申请号：US11578323
申请日：2005-09-20
申请人： Richard J. Melker , Timothy E. Morey , Laszlo Prokai , Donn M. Dennis
发明人： Richard J. Melker , Timothy E. Morey , Laszlo Prokai , Donn M. Dennis
IPC分类号： C40B60/12 , C12Q1/00 , C12M1/00
CPC分类号： C12Q1/00 , C12Q1/26
摘要： The present invention provides systems and methods for determining enzymatic competency, which is important in determining whether a patient may suffer an adverse drug reaction, has a disease associated with defects in specific enzymatic function, and/or has an enzyme defect that is likely to cause pathophysiology. As contemplated herein, a parent molecular entity is administered to a patient in whom enzymatic competency is to be determined. A sample of the patient's bodily fluid is exposed to a sensor of the invention to distinguish, detect, and quantify a detectable entity in the bodily fluid. Sensor-acquired data regarding the detectable entity is used to determine enzymatic competency. Preferably, a sample of a patient's exhaled breath is collected and exposed to the sensor of the invention. Types of sensor systems of the invention include, but are not limited to, surface resonance arrays; microelectromechanical sensors (such as microcantilever-based technology); molecularly imprinted polymer sensors; amplifying fluorescent sensor technology; aptamer-based sensor technology; SAW sensors; infrared sensors; fuel cells; chemical reactors; and pH sensitive sensors.
摘要翻译：本发明提供了确定酶活性的系统和方法，其在确定患者是否可能遭受不良药物反应，具有与特定酶功能缺陷相关的疾病和/或具有可能导致的酶缺陷病理生理学。如本文所考虑的，将母体分子实体施用于要测定酶能力的患者。将患者体液的样品暴露于本发明的传感器以区分，检测和定量体液中的可检测实体。关于可检测实体的传感器获取的数据用于确定酶的能力。优选地，将患者呼出的呼吸的样品收集并暴露于本发明的传感器。本发明的传感器系统的类型包括但不限于表面共振阵列; 微机电传感器（如基于微型悬臂梁的技术）; 分子印迹聚合物传感器; 放大荧光传感器技术; 基于适体的传感器技术; SAW传感器; 红外传感器; 燃料电池; 化学反应堆和pH敏感传感器。

5. 发明授权

US07978083B2 Hand washing compliance detection system 有权
标题翻译：手洗一致性检测系统
公开(公告)号：US07978083B2
公开(公告)日：2011-07-12
申请号：US12772583
申请日：2010-05-03
申请人： Richard J. Melker , Nikolaus Gravenstein , Donn M. Dennis , Christopher D. Batich
发明人： Richard J. Melker , Nikolaus Gravenstein , Donn M. Dennis , Christopher D. Batich
IPC分类号： G08B23/00
CPC分类号： G08B21/245
摘要： Systems and methods are provided for monitoring use of hand washing agents to determine compliance with hand hygiene guidelines. A hand washing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's hand washing technique. After the hand washing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the hand washing agent and hand hygiene compliance.
摘要翻译：提供了系统和方法，用于监控洗手剂的使用，以确定是否符合手部卫生指南。手洗剂具有可检测的挥发性化合物，例如气味，然后使用受试者的洗手技术将其摩擦到受试者的手上。洗手后，将受试者的手暴露在检测器（例如徽章）中，该检测器包括能够检测挥发性化合物的传感器，以及传达挥发性化合物检测的指示剂，指示使用洗手液代理和手卫生合规。

6. 发明申请

US20100231385A1 Hand Washing Compliance Detection System 有权
标题翻译：手洗一致性检测系统
公开(公告)号：US20100231385A1
公开(公告)日：2010-09-16
申请号：US12772583
申请日：2010-05-03
申请人： Richard J. Melker , Nikolaus Gravenstein , Donn M. Dennis , Christopher D. Batich
发明人： Richard J. Melker , Nikolaus Gravenstein , Donn M. Dennis , Christopher D. Batich
IPC分类号： G08B21/00
CPC分类号： G08B21/245
摘要： Systems and methods are provided for monitoring use of hand washing agents to determine compliance with hand hygiene guidelines. A hand washing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's hand washing technique. After the hand washing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the hand washing agent and hand hygiene compliance.
摘要翻译：提供了系统和方法，用于监控洗手剂的使用，以确定是否符合手部卫生指南。手洗剂具有可检测的挥发性化合物，例如气味，然后使用受试者的洗手技术将其摩擦到受试者的手上。洗手后，将受试者的手暴露在检测器（例如徽章）中，该检测器包括能够检测挥发性化合物的传感器，以及传达挥发性化合物检测的指示剂，指示使用洗手液代理和手卫生合规。

7. 发明授权

US07755494B2 Hand washing compliance detection system 有权
标题翻译：手洗一致性检测系统
公开(公告)号：US07755494B2
公开(公告)日：2010-07-13
申请号：US11760100
申请日：2007-06-08
申请人： Richard J. Melker , Nikolaus Gravenstein , Donn M. Dennis , Christopher D. Batich
发明人： Richard J. Melker , Nikolaus Gravenstein , Donn M. Dennis , Christopher D. Batich
IPC分类号： G08B23/00
CPC分类号： G08B21/245
摘要： Systems and methods are provided for monitoring use of hand washing agents to determine compliance with hand hygiene guidelines. A hand washing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's hand washing technique. After the hand washing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the hand washing agent and hand hygiene compliance.
摘要翻译：提供了系统和方法，用于监控洗手剂的使用，以确定是否符合手部卫生指南。手洗剂具有可检测的挥发性化合物，例如气味，然后使用受试者的洗手技术将其摩擦到受试者的手上。洗手后，将受试者的手暴露在检测器（例如徽章）中，该检测器包括能够检测挥发性化合物的传感器，以及传达挥发性化合物检测的指示剂，指示使用洗手液代理和手卫生合规。

8. 发明申请

US20080045825A1 Condensate glucose analyzer 有权
标题翻译：冷凝葡萄糖分析仪
公开(公告)号：US20080045825A1
公开(公告)日：2008-02-21
申请号：US11504335
申请日：2006-08-15
申请人： Richard J. Melker , David G. Bjoraker , Donn M. Dennis , Jon D. Stewart , Christopher D. Batich , Matthew M. Booth , John Frederick Horn , Ronald E. Youngblood
发明人： Richard J. Melker , David G. Bjoraker , Donn M. Dennis , Jon D. Stewart , Christopher D. Batich , Matthew M. Booth , John Frederick Horn , Ronald E. Youngblood
IPC分类号： A61B5/00
CPC分类号： A61B5/083 , A61B5/1486 , A61B5/413 , Y10T436/144444
摘要： The present invention provides systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments of the invention, electrochemical- or coulometric-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose.
摘要翻译：本发明提供了用于分析呼出气凝缩物（EBC）中存在的葡萄糖的系统和方法。在本发明的某些实施方案中，使用电化学或基于库仑的感测技术来分析葡萄糖的存在和/或浓度。

9. 发明授权

US09950112B2 Intelligent drug and/or fluid delivery system to optimizing medical treatment or therapy using pharmacodynamic and/or pharamacokinetic data 有权
公开(公告)号：US09950112B2
公开(公告)日：2018-04-24
申请号：US13817165
申请日：2011-08-17
申请人： Richard J. Melker , Donn M. Dennis , Jeremy Melker , Mark Rice , Robert Hurley
发明人： Richard J. Melker , Donn M. Dennis , Jeremy Melker , Mark Rice , Robert Hurley
IPC分类号： A61M31/00 , A61M5/172 , A61M5/142 , A61M5/168 , A61M5/315 , G06Q50/22 , G06F19/00
CPC分类号： A61M5/1723 , A61B5/0205 , A61B5/02416 , A61B5/0261 , A61B5/036 , A61B5/0408 , A61B5/0816 , A61B5/1455 , A61B5/4839 , A61M5/142 , A61M5/168 , A61M5/16854 , A61M5/172 , A61M5/31511 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H20/17
摘要： A pharmacodynamic (PD), pharmacokinetic (PK), or both and PK guided infusion device, system and method optimizes the safety and efficacy of various forms of treatment or therapy (e.g., drug and/or fluid) in a variety of health-care and other settings.

10. 发明申请

US20140341983A1 SMART™ SOLID ORAL DOSAGE FORMS 审中-公开
标题翻译： SMART™固体口服剂型
公开(公告)号：US20140341983A1
公开(公告)日：2014-11-20
申请号：US14344221
申请日：2012-09-14
申请人： Donn M. Dennis , Richard J. Melker
发明人： Donn M. Dennis , Richard J. Melker
IPC分类号： G01N33/497 , A61K47/14 , A61K47/10 , A61K47/06
CPC分类号： G01N33/497 , A61B5/082 , A61B5/083 , A61B5/4833 , A61B5/4839 , A61K9/0056 , A61K9/006 , A61K9/0095 , A61K9/2013 , A61K9/4858 , A61K47/06 , A61K47/10 , A61K47/14 , A61K49/00 , G01N2033/4975 , Y10T436/13
摘要： Solid Oral Dosage Forms (SODFs) comprising Self Monitoring and Reporting Therapeutics (SMART™) adherence technology are provided which require no or minimal modification of clinical trial materials (CTMs) or marketed drug while providing tamper resistant (literally foolproof) measurement of adherence that is highly accurate and without altering the chemical, manufacturing, and controls (CMC) of the CTM or marketed drug.
摘要翻译：提供了包含自我监测和报告治疗（SMART™）粘附技术的固体口服剂型（SODF），其不需要或仅对临床试验材料（CTM）或市售药物进行最小修改，同时提供耐篡改（字面上的防伪）高度准确，不改变CTM或市售药物的化学，制造和控制（CMC）。

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