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1. 发明申请

WO2022128881A1 PREDICTIVE BIOMARKERS FOR RISK OF BLADDER CANCER IN DIABETES PATIENTS 审中-公开
公开(公告)号：WO2022128881A1
公开(公告)日：2022-06-23
申请号：PCT/EP2021/085424
申请日：2021-12-13
申请人： RANDOX LABORATORIES LTD
发明人： WATSON, Chris , FITZGERALD, Stephen Peter , LAMONT, John , RUDDOCK, Mark
IPC分类号： G01N33/574
摘要： Herein we have identified a protein signature that is easily measured in blood and urine and highly predictive of bladder cancer (BC) risk in Type 2 Diabetes Mellitus (T2DM) patients. This biomarker model could be applied to screen T2DM patients presenting with haematuria for BC in diabetes clinics. Earlier urology referral of T2DM patients will improve outcomes for these patients.

2. 发明申请

WO2020099895A1 DETECTION OF BLADDER CANCER 审中-公开
公开(公告)号：WO2020099895A1
公开(公告)日：2020-05-22
申请号：PCT/GB2019/053253
申请日：2019-11-15
申请人： RANDOX LABORATORIES LTD
发明人： RUDDOCK, Mark , LAMONT, John , FITZGERALD, Stephen , WILLIAMSON, Kathleen
IPC分类号： G01N33/574
摘要： The present invention provides a method for detecting the presence or risk of bladder cancer in a female patient comprising the steps of detecting the presence of a panel of biomarkers in a sample isolated from a female patient, said panel of biomarkers comprising IL-13 and IL-12p70 and one or more biomarkers selected from BTA, Midkine, PAI-1/t PA, 8OHdG, CEA, CK18, Clusterin, Creatinine, CXCL16, Cystatin B, Cystatin C, d-Dimer, EGF, FAS, HAD, IL-1a, IL-1b, IL-4, IL-6, IL-7, IL-8, MCP-1, Microalbumin, MMP9NGAL, MMP9TIMP1, NGAL, NSE, Progranulin, TUP, TGFB1, Thrombomodulin, sTNFR1, TPA, VEGF and Triglycerides and/or the concentration of albumin/microalbumin/protein and creatinine expressed as an albumin:creatinine ratio in a sample i s o l a t e d f r o m a female patient; and assessing the results and comparing them to a normal control wherein an elevated presence of the biomarker compared to a normal control indicates the presence or risk of cancer in the patient from whom the sample is isolated.

3. 发明申请

WO2016097711A1 IMPROVEMENTS RELATING TO BIOCHIP STORAGE WELLS 审中-公开
标题翻译：关于生物储存井的改进
公开(公告)号：WO2016097711A1
公开(公告)日：2016-06-23
申请号：PCT/GB2015/053983
申请日：2015-12-14
申请人： RANDOX LABORATORIES LTD
发明人： JACKSON, Stuart , MCCONNELL, Ivan , LAMONT, John , FITZGERALD, Peter , WHARRY, Marc
IPC分类号： B01L3/00 , C12M1/00
CPC分类号： B01L9/52 , B01L3/508 , B01L2200/0689 , B01L2200/142 , B01L2300/042 , B01L2300/044 , B01L2300/045 , B01L2300/047 , B01L2300/0636 , B01L2300/0832 , B01L2300/161 , B65B7/2871 , C12M23/38
摘要： The present invention is directed to a cap for a biochip storage well. The cap comprises a resilient sealant layer capable, under the application of pressure, of forming a vapour-proof seal with a line contact interface formation extending around the perimeter of a biochip storage well. An assay assembly comprising the cap of the invention and a biochip storage is disclosed. Methods of sealing a biochip storage well using a cap of the invention are also disclosed.
摘要翻译：本发明涉及一种用于生物芯片存储井的盖。所述盖包括弹性密封剂层，所述弹性密封剂层能够在施加压力的情况下与围绕生物芯片存储井的周边延伸的线接触界面形成形成防蒸气密封。公开了一种包括本发明的盖和生物芯片存储器的测定组件。还公开了使用本发明的盖密封生物芯片储存井的方法。

4. 发明申请

WO2015150834A1 DIAGNOSIS OF UROTHELIAL CANCER 审中-公开
标题翻译：诊断尿路癌
公开(公告)号：WO2015150834A1
公开(公告)日：2015-10-08
申请号：PCT/GB2015/051053
申请日：2015-04-02
申请人： RANDOX LABORATORIES LTD.
发明人： RUDDOCK, Mark , REID, Cherith , LAMONT, John , FITZGERALD, Stephen , DE MATOS SIMOES, Ricardo , WILLIAMSON, Kathleen
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/57407 , G01N33/543 , G01N33/57488 , G01N33/577 , G01N33/6869 , G01N2333/485 , G01N2333/5412 , G01N2333/5421 , G01N2333/545
摘要： The present invention provides a method and a solid state device for identifying the presence of urothelial cancer in a patient comprising assigning the subject to a sub-population according to smoking habits, measuring the level of each biomarker of a panel of biomarkers in one or more samples obtained from the subject; and correlating the measured levels of the panel of biomarkers with the likelihood of the subject having urothelial cancer such that the subject can be classified as having urothelial cancer or as being a control.
摘要翻译：本发明提供一种用于鉴定患者中尿路上皮癌的存在的方法和固态装置，包括根据吸烟习惯将受试者分配给亚群体，测量一个或多个生物标志物组中每个生物标志物的水平从受试者获得的样品; 并将生物标志物组的测量水平与受试者具有尿路上皮癌的可能性相关联，使得受试者可以分类为具有尿路上皮癌或作为对照。

5. 发明申请

WO2021089772A1 Biomarker of Drug Induced Cellular Toxicity and Depression 审中-公开
公开(公告)号：WO2021089772A1
公开(公告)日：2021-05-14
申请号：PCT/EP2020/081273
申请日：2020-11-06
申请人： RANDOX LABORATORIES LTD
发明人： INNOCENZI, Paul , FITZGERALD, Peter , RUDDOCK, Mark , LAMONT, John
IPC分类号： G01N33/50 , G01N33/68 , G01N33/94
摘要： Described is the use of GFAP as a marker of drug-induced cellular toxicity and depression.

6. 发明申请

WO2017072252A1 METHOD FOR PREDICTING CONTRAST INDUCED NEPHROPATHY 审中-公开
标题翻译：预测造影剂引起的肾病的方法
公开(公告)号：WO2017072252A1
公开(公告)日：2017-05-04
申请号：PCT/EP2016/075974
申请日：2016-10-27
申请人： RANDOX LABORATORIES LTD
发明人： MCENEANEY, David , LAMONT, John
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/347
摘要： The use of biomarkers for establishing risk of developing contrast-induced nephropathy (CIN) in patients with pre-existent chronic kidney disease (CKD) is described.
摘要翻译：描述了在存在慢性肾病（CKD）的患者中使用生物标志物建立造影剂诱导的肾病（CIN）的风险。

7. 发明申请

WO2015198019A1 LIQUID SAMPLE COLLECTION DEVICE 审中-公开
标题翻译：液体样品收集装置
公开(公告)号：WO2015198019A1
公开(公告)日：2015-12-30
申请号：PCT/GB2015/051749
申请日：2015-06-15
申请人： RANDOX LABORATORIES LTD
发明人： JACKSON, Stuart , MCCONNELL, Ivan , LAMONT, John , FITZGERALD, Stephen Peter
IPC分类号： A61B10/00
CPC分类号： A61B10/007 , A61F5/441
摘要： A liquid sample collection device is provided. The liquid sample collection device comprises a housing including a liquid collection chamber, and a liquid supply conduit extending from an inlet port and in use generally downwardly to the collection chamber, wherein the collection chamber includes an air vent port located such that in use liquid supplied to the collection chamber through the liquid supply conduit displaces air through the air vent port, and wherein the liquid supply conduit follows a meandering path including at least one air trap section defined at the junction between portions of the conduit extending with upward and downward components respectively, whereby in use once the air vent port is closed, air is displaced along the liquid supply conduit until it is trapped by the air trap section thereby preventing further liquid flow through the conduit.
摘要翻译：提供液体样品收集装置。所述液体样品收集装置包括壳体，所述壳体包括液体收集室和从入口端口大体向下延伸到所述收集室的液体供应管道，其中所述收集室包括通气口，所述通气口位于使用中的液体供应通过液体供应管道将空气排出到通过排气口的空气，并且其中液体供应导管跟随蜿蜒路径，其包括至少一个限定在导管部分之间的连接部处的空气陷阱部分，分别与上部和下部部件分别延伸一旦通气口关闭，空气就沿着液体供应管道移动，直到被空气捕获部分捕获，从而防止进一步的液体流过管道。

8. 发明申请

WO2006030238A1 ANTIBODY LIBRARIES 审中-公开
标题翻译：抗体图书馆
公开(公告)号：WO2006030238A1
公开(公告)日：2006-03-23
申请号：PCT/GB2005/003601
申请日：2005-09-19
申请人： RANDOX LABORATORIES LTD. , FITZGERALD, Peter , LAMONT, John , DUNLOP, Marshall , SCHON, Shirley
发明人： FITZGERALD, Peter , LAMONT, John , DUNLOP, Marshall , SCHON, Shirley
IPC分类号： C12N15/10
CPC分类号： C12N15/1093 , C07K16/005 , C07K16/18 , C07K2317/622
摘要： The invention relates to a composition comprising a plurality of antibody fragments, each comprising a framework region having a murine VH14 heavy chain and a murine VK2 light chain, or homologues thereof, each antibody fragment further comprising at least one different CDR.
摘要翻译：本发明涉及包含多个抗体片段的组合物，每个抗体片段包含具有鼠VH14重链和鼠VK2轻链的框架区或其同源物，每个抗体片段还包含至少一个不同的CDR。

9. 发明申请

WO2023017072A2 RISK PREDICTION MODEL FOR PROSTATE CANCER 审中-公开
公开(公告)号：WO2023017072A2
公开(公告)日：2023-02-16
申请号：PCT/EP2022/072425
申请日：2022-08-10
申请人： RANDOX LABORATORIES LTD
发明人： FITZGERALD, Stephen Peter , RUDDOCK, Mark , LAMONT, John , MCKENNA, Declan
IPC分类号： G01N33/574
摘要： Single markers lack both sensitivity and specificity to stratify risk of PCa in patients who present with elevated tPSA and abnormal DRE. The novel combination of serum markers identified in this study could be employed to help triage patients into 'low' and 'high' risk categories, allowing general practitioners (GPs) to improve management of patients in primary care settings and potentially reducing the number of referrals for unnecessary, invasive, and costly treatments.

10. 发明申请

WO2022096470A1 IMMUNE CHECKPOINT INHIBITOR 审中-公开
公开(公告)号：WO2022096470A1
公开(公告)日：2022-05-12
申请号：PCT/EP2021/080423
申请日：2021-11-02
申请人： RANDOX LABORATORIES LTD
发明人： DUNLOP, Marshall , SCHON, Shirley , LAMONT, John , FITZGERALD, Peter
IPC分类号： C07K16/28
摘要： The present invention relates to therapeutic antibodies, or antigen-binding portions thereof, for use in the treatment of cancer and infectious disease. Specifically, the present invention relates to therapeutic antibodies, or antigen-binding portions thereof, that target the programmed death-ligand 1 polypeptide. The present invention also relates to pharmaceutical compositions comprising said therapeutic antibody, or antigen-binding portions thereof.

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