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1. 发明申请

WO2021003084A1 P2X7R ANTAGONISTS 审中-公开
公开(公告)号：WO2021003084A1
公开(公告)日：2021-01-07
申请号：PCT/US2020/040076
申请日：2020-06-29
申请人： QIAN, Ligang , ZHANG, Chunbo
发明人： QIAN, Ligang , ZHANG, Chunbo
IPC分类号： A61K31/445 , C07C311/15 , C07D401/12
摘要： A compound has Formula I: (I). R 1 is hydrogen, hydroxy, halogen, nitro, amino, alkyl, alkoxy, alkylamino, cycloalkyl, cycloalkyamino, heterocyclyl, aryl, heteroaryl, -NR 7 R 8 , -CO-R 10 , or -NH-CO-R 10 ; L is a bond, a heterocyclic bivalent group, a heteroaromatic bivalent group, or an aromatic bivalent group; M is a bond, alkyl, aryl, heterocyclic bivalent group, heteroaromatic bivalent group, or aromatic bivalent group; X is a bond, -O-, -S-, -SO 2 -, -CO-, -NR 9 -, -(CH 2 ) m -, or heterocyclic bivalent group, m is 1, 2, 3, 4, 5, or 6; Y is a bond, -NH-, heterocyclic bivalent group, heteroaromatic bivalent group, bivalent benzyl group, or aromatic bivalent group; and Z is hydrogen, halogen, alkyl, aryl, heterocyclyl, heteroaryl, -NR 7 R 8 , -CO-R 10 , or -NH-CO-R 10 ; R 7 , R 8 , and R 9 are independently hydrogen, hydroxy, halogen, nitro, amino, alkyl, alkoxy, alkylamino, cycloalkyl, cycloalkyamino, heterocyclyl, or heteroaryl; and R 10 is -O-tert-butyl, -CH 2 CH 2 -phenyl, hydrogen, hydroxy, halogen, nitro, amino, alkyl, alkoxy, alkylamino, cycloalkyl, cycloalkyamino, heterocyclyl, or heteroaryl.

2. 发明申请

WO2004009542A2 PROCESS FOR PREPARING CERTAIN PYRROLOTRIAZINE COMPOUNDS 审中-公开
标题翻译：制备某些吡咯烷酮化合物的方法
公开(公告)号：WO2004009542A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/022755
申请日：2003-07-21
申请人： BRISTOL-MYERS SQUIBB COMPANY , BHIDE, Rajeev , FAN, Junying , PARLANTI, Luca , BARBOSA, Stephanie , QIAN, Ligang , CAI, Zhen-Wei , GIBSON, Francis, S.
发明人： BHIDE, Rajeev , FAN, Junying , PARLANTI, Luca , BARBOSA, Stephanie , QIAN, Ligang , CAI, Zhen-Wei , GIBSON, Francis, S.
IPC分类号： C07D
CPC分类号： C07D487/04 , A61K31/53 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a process for preparing certain pyrrolotriazine compounds of the formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译：本发明涉及一种制备式（I）的吡咯并三嗪化合物及其药学上可接受的盐的方法。式（I）化合物抑制生长因子受体如VEGFR-2和FGFR-1的酪氨酸激酶活性，从而使其用作抗癌剂。式I化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。

3. 发明申请

WO2006007378A2 PYRROLOTRIAZINE KINASE INHIBITORS 审中-公开
标题翻译：吡咯啉激酶抑制剂
公开(公告)号：WO2006007378A2
公开(公告)日：2006-01-19
申请号：PCT/US2005/021187
申请日：2005-06-15
申请人： BRISTOL-MYERS SQUIBB COMPANY , CAI, Zhen-wei , LOMBARDO, Louis J. , BHIDE, Rajeev S. , QIAN, Ligang , WEI, Donna D. , BARBOSA, Stephanie
发明人： CAI, Zhen-wei , LOMBARDO, Louis J. , BHIDE, Rajeev S. , QIAN, Ligang , WEI, Donna D. , BARBOSA, Stephanie
IPC分类号： A61K31/53 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译：本发明提供式I化合物及其药学上可接受的盐。式I化合物抑制生长因子受体如VEGFR-2和FGFR-1的酪氨酸激酶活性，从而使其成为抗癌剂。式I化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。

4. 发明申请

WO2004009784A2 NOVEL INHIBITORS OF KINASES 审中-公开
标题翻译：新鲜的抑制剂
公开(公告)号：WO2004009784A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/022826
申请日：2003-07-18
申请人： BRISTOL-MYERS SQUIBB COMPANY , BHIDE, Rajeev , CAI, Zhen-Wei , QIAN, Ligang , BARBOSA, Stephanie
发明人： BHIDE, Rajeev , CAI, Zhen-Wei , QIAN, Ligang , BARBOSA, Stephanie
IPC分类号： C12N
CPC分类号： C07D487/04 , A61K31/53 , A61K45/06 , A61K2300/00
摘要： The present invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐。式（I）化合物抑制生长因子受体如VEGFR-2和FGFR-1的酪氨酸激酶活性，从而使其用作抗癌剂。式（I）化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。

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