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1. 发明申请

WO2022109601A1 ACTIVE CANCER IMMUNOTHERAPY BY IMMUNE MODULATION VIA GLOBO SERIES ANTIGENS 审中-公开
公开(公告)号：WO2022109601A1
公开(公告)日：2022-05-27
申请号：PCT/US2021/072513
申请日：2021-11-19
申请人： OBI PHARMA, INC. , LAI, Ming-Tain
发明人： YU, Cheng-Der, Tony , CHEN, I-Ju , LEE, Wei-Han , YANG, Chueh-Hao , TSAO, Chun-Yen , HSIEH, Chang-Lin , OU, Chien-Chih , TSAI, Chen-En
IPC分类号： G01N33/574 , A61K39/00 , A61P35/00 , C07K16/30 , C07K16/28 , A61K45/06
摘要： The disclosure provides a method of active immunotherapy for a cancer patient, comprising administering vaccines against Globo series antigens (i.e., Globo H, SSEA-3 and SSEA-4). Specifically, the method comprises administering Globo H-CRM197 (OBI-833/821) in patients with cancer. The disclosure also provides a method of selecting a cancer patient who is suitable as treatment candidate for immunotherapy. Exemplary immune response can be characterized by reduction of the severity of disease, including but not limited to, prevention of disease, delay in onset of disease, decreased severity of symptoms, decreased morbidity and delayed mortality.

2. 发明公开

EP3946630A2 COMPANION DIAGNOSTIC ASSAY FOR GLOBO-H RELATED CANCER THERAPY 审中-实审转让
公开(公告)号：EP3946630A2
公开(公告)日：2022-02-09
申请号：EP20777304.5
申请日：2020-03-27
申请人： OBI Pharma, Inc. , Lai, Ming-Tain
发明人： LAI, Ming-Tain , YU, Cheng-Der Tony , LAI, Ming-Tain , CHEN, I-Ju , CHEN, Yu-Jung , YANG, Ming-Chen
IPC分类号： A61P35/00 , C07K16/30 , C07K16/44 , G01N33/574 , A61K49/16 , A61K39/00 , A61K39/395

3. 发明申请

WO2020198699A2 COMPANION DIAGNOSTIC ASSAY FOR GLOBO-H RELATED CANCER THERAPY 审中-公开
公开(公告)号：WO2020198699A2
公开(公告)日：2020-10-01
申请号：PCT/US2020/025516
申请日：2020-03-27
申请人： OBI PHARMA, INC. , LAI, Ming-Tain
发明人： LAI, Ming-Tain , YU, Cheng-Der Tony , LAI, Ming-Tain , CHEN, I-Ju , CHEN, Yu-Jung , YANG, Ming-Chen
IPC分类号： G01N33/573
摘要： Methods and reagents suitable for in vitro diagnostic assay comprising a qualitative immunohistochemical assay using anti-Globo H antibodies and/or binding fragments thereof are provided. The method comprises the detection of Globo-H expression levels in formalin-fixed, paraffin-embedded (FFPE) cancer tissue using a visualization system. The Globo-H expression can be determined by using tumor scoring showing partial or complete staining at any intensity.

4. 发明申请

WO2018023121A1 HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS 审中-公开
标题翻译：人类抗体，药物组合物和方法
公开(公告)号：WO2018023121A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/044713
申请日：2017-07-31
申请人： OBI PHARMA, INC. , YU, Cheng-Der Tony
发明人： YU, Cheng-Der Tony , CHAN, Woan Eng , LEE, Shu-Yu , LAI, Jiann-Shiun , CHEN, I-Ju
IPC分类号： C07K16/44 , A61K49/16 , G01N33/574 , A61K39/00
摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to Globo H, stage-specific embryonic antigen 3 (SSEA-3) and stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as sarcoma, skin cancer, leukemia, lymphoma, brain cancer, glioblastoma, lung cancer, breast cancer, oral cancer, head-and-neck cancer, nasopharyngeal cancer, esophagus cancer, stomach cancer, liver cancer, bile duct cancer, gallbladder cancer, bladder cancer, pancreatic cancer, intestinal cancer, colorectal cancer, kidney cancer, cervix cancer, endometrial cancer, ovarian cancer, testical cancer, buccal cancer, oropharyngeal cancer, laryngeal cancer and prostate cancer.
摘要翻译：本文公开了包含结合Globo H，阶段特异性胚胎抗原3（SSEA-3）和阶段特异性胚胎抗原4（SSEA-4）的抗体或其抗原结合片段的药物组合物，以及其使用方法。使用方法包括但不限于癌症治疗和诊断。本公开的抗体可以结合某些癌细胞表面。本文公开的抗体的示例性靶标可以包括癌，例如肉瘤，皮肤癌，白血病，淋巴瘤，脑癌，成胶质细胞瘤，肺癌，乳腺癌，口腔癌，头颈癌，鼻咽癌，食道癌，胃癌癌症，肝癌，胆管癌，胆囊癌，膀胱癌，胰腺癌，肠癌，结直肠癌，肾癌，宫颈癌，子宫内膜癌，卵巢癌，睾丸癌，口腔癌，口咽癌，喉癌和前列腺癌

5. 发明申请

WO2015159118A2 COMPOSITIONS OF A CARBOHYDRATE VACCINE FOR INDUCING IMMUNE RESPONSES AND USES THEREOF IN CANCER TREATMENT 审中-公开
标题翻译：用于诱导免疫应答的碳水化合物的组合物及其在癌症治疗中的用途
公开(公告)号：WO2015159118A2
公开(公告)日：2015-10-22
申请号：PCT/IB2014/002744
申请日：2014-09-15
申请人： OBI PHARMA, INC.
发明人： YU, Cheng-Der, Tony , WANG, Cheng-Chi, Irene , LEE, Wei-Han , LIN, Yu-Chen , LIN, Yu-Hsin, Tom , CHEN, I-Ju
IPC分类号： A61K39/00 , A61K47/48
CPC分类号： A61K39/0011 , A61K47/643 , A61K47/646 , A61K2039/55577 , A61K2039/6081 , A61K2039/627 , A61K2039/64 , G01N21/64
摘要： The invention encompasses therapeutic compositions including Globo H-KLH conjugates and/or therapeutic antibodies as well as methods of making and using the same to treat proliferative diseases such as cancer. The therapeutic conjugates include an antigen linked to a carrier. In particular the therapeutic conjugates include a Globo H moiety and a KLH moiety and/or a derivatized KLH moiety subunit optionally linked via a linker. The therapeutic compositions are in part envisaged to act as cancer vaccines for boosting the body's natural ability to protect itself, through the immune system from dangers posed by damaged or abnormal cells such as cancer cells. An effective immune response is one that reduces the severity of disease, including but not limited to, prevention of disease, delay in onset of disease, decreased severity of symptoms, decreased morbidity and delayed mortality.
摘要翻译：本发明包括包括Globo H-KLH缀合物和/或治疗性抗体的治疗组合物，以及制备和使用其来治疗增殖性疾病如癌症的方法。治疗性缀合物包括与载体连接的抗原。特别地，治疗性缀合物包括Globo H部分和KLH部分和/或任选通过连接体连接的衍生的KLH部分亚基。部分设想治疗组合物作为癌症疫苗，以通过免疫系统增强身体的自然保护能力，避免受损或异常细胞如癌细胞引起的危险。有效的免疫应答是降低疾病严重性的因素，包括但不限于预防疾病，疾病发作延迟，症状严重程度降低，发病率下降和延迟死亡。

6. 发明公开

EP3491026A1 HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：EP3491026A1
公开(公告)日：2019-06-05
申请号：EP17835421.3
申请日：2017-07-31
申请人： OBI Pharma, Inc.
发明人： YU, Cheng-Der Tony , CHAN, Woan Eng , LEE, Shu-Yu , LAI, Jiann-Shiun , CHEN, I-Ju
IPC分类号： C07K16/44 , A61K49/16 , G01N33/574 , A61K39/00

7. 发明申请

WO2018094414A1 CONJUGATED BIOLOGICAL MOLECULES, PHARMACEUTICAL COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO2018094414A1
公开(公告)日：2018-05-24
申请号：PCT/US2017/062886
申请日：2017-11-21
申请人： OBI PHARMA, INC. , CHANG, Michael
发明人： CHANG, Michael , LAI, Jiann-Shuin , LI, Wan-Fen , CHEN, I-Ju , TSAI, Yi-Chien , CHEN, Kai-Chuan
IPC分类号： A61K39/00 , A61K47/68 , A61K49/16
摘要： Antibody drug conjugates (ADC's) comprising a drug conjugated to antibody or antigen binding fragments thereof that bind to Globo series antigen disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as sarcoma, skin cancer, leukemia, lymphoma, brain cancer, glioblastoma, lung cancer, breast cancer, oral cancer, head-and-neck cancer, nasopharyngeal cancer, esophagus cancer, stomach cancer, liver cancer, bile duct cancer, gallbladder cancer, bladder cancer, pancreatic cancer, intestinal cancer, colorectal cancer, kidney cancer, cervix cancer, endometrial cancer, ovarian cancer, testical cancer, buccal cancer, oropharyngeal cancer, laryngeal cancer and prostate cancer.

8. 发明申请

WO2018022933A1 IMMUNOGENIC/THERAPEUTIC GLYCAN COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：免疫原性/治疗性甘草聚糖组合物及其用途
公开(公告)号：WO2018022933A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/044244
申请日：2017-07-27
申请人： OBI PHARMA, INC. , YU, Cheng-Der Tony
发明人： YU, Cheng-Der Tony , YU, Peiwen , LAI, Kuo-Pao , LEE, Wei-Han , CHEN, I-Ju , LIN, Shu-Yi , HSIEH, Yih-Huang
IPC分类号： A61K39/00 , A61K39/39
摘要： The present disclosure encompasses immunogenic/therapeutic compositions including Globo series antigens (SSEA-4, Globo H or SSEA-3) glycoconjugates and therapeutic adjuvants (OBI-821 or OBI-834) as well as methods of making and using the same to treat proliferative diseases such as cancer. The therapeutic conjugates include an antigen linked to a carrier. In particular, the therapeutic conjugates include a SSEA-4, Globo H or SSEA-3 moiety and a KLH moiety subunit linked via a linker. The therapeutic compositions are in part envisaged to act as cancer vaccines (single valnet, bi-valent or tri-valent vaccines) for boosting the body's natural ability to protect itself, through the immune system from dangers posed by damaged or abnormal cells such as cancer cells. Exemplary immune response can be characterized by reduction of the severity of disease, including but not limited to, prevention of disease, delay in onset of disease, decreased severity of symptoms, decreased morbidity and delayed mortality.
摘要翻译：本公开内容涵盖包括Globo系列抗原（SSEA-4，Globo H或SSEA-3）糖缀合物和治疗性佐剂（OBI-821或OBI-834）的免疫原性/治疗性组合物以及制作和使用它来治疗增殖性疾病如癌症。治疗性缀合物包括与载体连接的抗原。特别地，治疗缀合物包括通过接头连接的SSEA-4，Globo H或SSEA-3部分和KLH部分亚基。部分治疗组合物部分设想作为癌症疫苗（单个valnet，二价或三价疫苗）用于通过免疫系统免受由受损或异常细胞如癌症引起的危险而提高机体的自然保护自身能力细胞。示例性免疫应答的特征可在于减轻疾病的严重程度，包括但不限于预防疾病，延迟疾病发作，减轻症状严重程度，降低发病率和延迟死亡率。

9. 发明申请

WO2017172990A1 ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS 审中-公开
标题翻译：抗体，药物组合物和方法
公开(公告)号：WO2017172990A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/024853
申请日：2017-03-29
申请人： OBI PHARMA, INC. , YU, Cheng-Der Tony
发明人： YU, Cheng-Der Tony , LAI, Jiann-Shiun , CHEN, I-Ju , LIN, Chiu-Chun
IPC分类号： C07K16/30 , C07K16/28 , C12N5/16 , G01N33/574 , A61K47/50 , A61K49/00 , A61K39/00
摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as breast cancer, lung cancer, esophageal cancer, rectal cancer, biliary cancer, liver cancer, buccal cancer, gastric cancer, colon cancer, nasopharyngeal cancer, kidney cancer, prostate cancer, ovarian cancer, cervical cancer, endometrial cancer, pancreatic cancer, testicular cancer, bladder cancer, head and neck cancer, oral cancer, neuroendocrine cancer, adrenal cancer, thyroid cancer, bone cancer, skin cancer, basal cell carcinoma, squamous cell carcinoma, melanoma, and/or brain tumor.
摘要翻译：本文公开了包含与阶段特异性胚胎抗原4（SSEA-4）结合的抗体或其抗原结合片段的药物组合物，以及其使用方法。使用方法包括但不限于癌症治疗和诊断。本公开的抗体可以结合某些癌细胞表面。本文公开的抗体的示例性靶标可以包括癌，例如乳腺癌，肺癌，食道癌，直肠癌，胆道癌，肝癌，口腔癌，胃癌，结肠癌，鼻咽癌，肾癌，前列腺癌，卵巢癌宫颈癌，子宫内膜癌，胰腺癌，睾丸癌，膀胱癌，头颈部癌，口腔癌，神经内分泌癌，肾上腺癌，甲状腺癌，骨癌，皮肤癌，基底细胞癌，鳞状细胞癌，黑素瘤，和/或脑瘤。

10. 发明申请

WO2017062792A1 NOVEL CARBOHYDRATE ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：新型碳水化合物抗体，药物组合物及其用途
公开(公告)号：WO2017062792A1
公开(公告)日：2017-04-13
申请号：PCT/US2016/056032
申请日：2016-10-07
申请人： OBI PHARMA, INC. , YU, Cheng-Der, Tony
发明人： YU, Cheng-Der, Tony , LAI, Jiann-Shiun , CHEN, I-Ju
IPC分类号： A61K39/395 , C12Q1/68
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/3092 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies or the antigen-binding portion thereof to a associate carbohydrate antigen. Also disclosed herein are pharmaceutical compositions and methods for the inhibition of cancer cells in a subject in need thereof. The pharmaceutical compositions comprise an antibody or an antigen-binding portion thereof and at least one pharmaceutically acceptable carrier.
摘要翻译：本发明提供抗体或其抗原结合部分与缔合的碳水化合物抗原。本文还公开了用于在有需要的受试者中抑制癌细胞的药物组合物和方法。药物组合物包含抗体或其抗原结合部分和至少一种药学上可接受的载体。

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