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1. 发明申请

WO2020072593A1 COMBINATION THERAPY USING ANTI-SSEA-4 ANTIBODY IN COMBINATION WITH THERAPEUTIC ONCOLOGY AGENTS 审中-公开
公开(公告)号：WO2020072593A1
公开(公告)日：2020-04-09
申请号：PCT/US2019/054221
申请日：2019-10-02
申请人： OBI PHARMA, INC. , YU, Cheng-Der, Tony
发明人： YU, Cheng-Der, Tony , LAI, Jiann-Shiun , TSAI, Yi-Chien
IPC分类号： A61K39/395 , A61K45/00 , A61K47/68 , A61P35/00 , C07K16/18 , C07K16/28 , C07K16/30 , G01N33/574
摘要： The present disclosure is generally directed to treatment methods and compositions comprising administering anti-SSEA-4 antibodies; alone or in additive and/or synergistic combination with other therapeutic agents in oncology to enhance therapeutic efficacy whereby the interaction alters the epitope binding of Siglec-9 protein; including human Siglec-9 or a mammalian Siglec-9; wherein the use of such anti-SSEA-4 compositions are efficacious in preventing, reducing risk, or treating an individual with cancer.

2. 发明申请

WO2018023121A1 HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS 审中-公开
标题翻译：人类抗体，药物组合物和方法
公开(公告)号：WO2018023121A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/044713
申请日：2017-07-31
申请人： OBI PHARMA, INC. , YU, Cheng-Der Tony
发明人： YU, Cheng-Der Tony , CHAN, Woan Eng , LEE, Shu-Yu , LAI, Jiann-Shiun , CHEN, I-Ju
IPC分类号： C07K16/44 , A61K49/16 , G01N33/574 , A61K39/00
摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to Globo H, stage-specific embryonic antigen 3 (SSEA-3) and stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as sarcoma, skin cancer, leukemia, lymphoma, brain cancer, glioblastoma, lung cancer, breast cancer, oral cancer, head-and-neck cancer, nasopharyngeal cancer, esophagus cancer, stomach cancer, liver cancer, bile duct cancer, gallbladder cancer, bladder cancer, pancreatic cancer, intestinal cancer, colorectal cancer, kidney cancer, cervix cancer, endometrial cancer, ovarian cancer, testical cancer, buccal cancer, oropharyngeal cancer, laryngeal cancer and prostate cancer.
摘要翻译：本文公开了包含结合Globo H，阶段特异性胚胎抗原3（SSEA-3）和阶段特异性胚胎抗原4（SSEA-4）的抗体或其抗原结合片段的药物组合物，以及其使用方法。使用方法包括但不限于癌症治疗和诊断。本公开的抗体可以结合某些癌细胞表面。本文公开的抗体的示例性靶标可以包括癌，例如肉瘤，皮肤癌，白血病，淋巴瘤，脑癌，成胶质细胞瘤，肺癌，乳腺癌，口腔癌，头颈癌，鼻咽癌，食道癌，胃癌癌症，肝癌，胆管癌，胆囊癌，膀胱癌，胰腺癌，肠癌，结直肠癌，肾癌，宫颈癌，子宫内膜癌，卵巢癌，睾丸癌，口腔癌，口咽癌，喉癌和前列腺癌

3. 发明申请

WO2015157629A3 ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2015157629A3
公开(公告)日：2015-10-15
申请号：PCT/US2015/025305
申请日：2015-04-10
申请人： YU, Cheng-Der, Tony , OBI PHARMA INC.
发明人： YU, Cheng-Der, Tony , LAI, Jiann-Shiun , CHEN, I-ju , WANG, Cheng-Chi , TSAI, Yi-Chien
IPC分类号： A61K39/00 , A61K31/7105
摘要： The present invention provides antibodies or the antigen-binding portion thereof, that bind to one or more carbohydrate antigens. Also disclosed herein are pharmaceutical pharmaceutical compositions and methods for the inhibition of cancer cells in a subject in need thereof. The pharmaceutical compositions comprise an antibody or an antigen- binding portion thereof and at least one pharmaceutically acceptable carrier.

4. 发明申请

WO2017172990A1 ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS 审中-公开
标题翻译：抗体，药物组合物和方法
公开(公告)号：WO2017172990A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/024853
申请日：2017-03-29
申请人： OBI PHARMA, INC. , YU, Cheng-Der Tony
发明人： YU, Cheng-Der Tony , LAI, Jiann-Shiun , CHEN, I-Ju , LIN, Chiu-Chun
IPC分类号： C07K16/30 , C07K16/28 , C12N5/16 , G01N33/574 , A61K47/50 , A61K49/00 , A61K39/00
摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as breast cancer, lung cancer, esophageal cancer, rectal cancer, biliary cancer, liver cancer, buccal cancer, gastric cancer, colon cancer, nasopharyngeal cancer, kidney cancer, prostate cancer, ovarian cancer, cervical cancer, endometrial cancer, pancreatic cancer, testicular cancer, bladder cancer, head and neck cancer, oral cancer, neuroendocrine cancer, adrenal cancer, thyroid cancer, bone cancer, skin cancer, basal cell carcinoma, squamous cell carcinoma, melanoma, and/or brain tumor.
摘要翻译：本文公开了包含与阶段特异性胚胎抗原4（SSEA-4）结合的抗体或其抗原结合片段的药物组合物，以及其使用方法。使用方法包括但不限于癌症治疗和诊断。本公开的抗体可以结合某些癌细胞表面。本文公开的抗体的示例性靶标可以包括癌，例如乳腺癌，肺癌，食道癌，直肠癌，胆道癌，肝癌，口腔癌，胃癌，结肠癌，鼻咽癌，肾癌，前列腺癌，卵巢癌宫颈癌，子宫内膜癌，胰腺癌，睾丸癌，膀胱癌，头颈部癌，口腔癌，神经内分泌癌，肾上腺癌，甲状腺癌，骨癌，皮肤癌，基底细胞癌，鳞状细胞癌，黑素瘤，和/或脑瘤。

5. 发明申请

WO2017062792A1 NOVEL CARBOHYDRATE ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：新型碳水化合物抗体，药物组合物及其用途
公开(公告)号：WO2017062792A1
公开(公告)日：2017-04-13
申请号：PCT/US2016/056032
申请日：2016-10-07
申请人： OBI PHARMA, INC. , YU, Cheng-Der, Tony
发明人： YU, Cheng-Der, Tony , LAI, Jiann-Shiun , CHEN, I-Ju
IPC分类号： A61K39/395 , C12Q1/68
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/3092 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies or the antigen-binding portion thereof to a associate carbohydrate antigen. Also disclosed herein are pharmaceutical compositions and methods for the inhibition of cancer cells in a subject in need thereof. The pharmaceutical compositions comprise an antibody or an antigen-binding portion thereof and at least one pharmaceutically acceptable carrier.
摘要翻译：本发明提供抗体或其抗原结合部分与缔合的碳水化合物抗原。本文还公开了用于在有需要的受试者中抑制癌细胞的药物组合物和方法。药物组合物包含抗体或其抗原结合部分和至少一种药学上可接受的载体。

6. 发明申请

WO2022173840A1 NOVEL CARBOHYDRATE ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2022173840A1
公开(公告)日：2022-08-18
申请号：PCT/US2022/015834
申请日：2022-02-09
申请人： OBI PHARMA, INC. , LAI, Ming-Tain
发明人： LAI, Jiann-Shiun , CHANG, Hui-Wen , KUO, Yin-Chieh , HSIA, Chi-Sheng , CHAN, Woan Eng
IPC分类号： C07K16/30 , A61K47/68
摘要： The present invention provides antibody or the antigen-binding portion thereof bind to carbohydrate antigen, such as Globo series antigens (e.g. Globo H, SSEA-4 or SSEA-3). Also disclosed herein are pharmaceutical compositions and methods for the inhibition of cancer cells in a subject in need thereof. The pharmaceutical compositions comprise an antibody or an antigen-binding portion thereof and at least one pharmaceutically acceptable carrier.

7. 发明申请

WO2022173772A1 GLOBO SERIES ANTIGENS-BINDING CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF 审中-公开
公开(公告)号：WO2022173772A1
公开(公告)日：2022-08-18
申请号：PCT/US2022/015720
申请日：2022-02-09
申请人： OBI PHARMA, INC. , LAI, Ming-Tain
发明人： LAI, Jiann-Shiun , JIAN, Shiou-Ling , YU, Jhang-Sian , CHAN, Woan-Eng
IPC分类号： A61K35/17 , C07K16/28 , G01N33/574
摘要： The present disclosure relates to chimeric antigen receptors (CARs), which bind to Globo series antigens (e.g. Globo H, SSEA-3 or SSEA-4), including an antigen-binding fragment (Fab) or a single-chain variable fragment (scFv). Further, the present methods are also provided for administering CARs to a subject in an amount effective to inhibit cancer cells.

8. 发明公开

EP3491026A1 HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：EP3491026A1
公开(公告)日：2019-06-05
申请号：EP17835421.3
申请日：2017-07-31
申请人： OBI Pharma, Inc.
发明人： YU, Cheng-Der Tony , CHAN, Woan Eng , LEE, Shu-Yu , LAI, Jiann-Shiun , CHEN, I-Ju
IPC分类号： C07K16/44 , A61K49/16 , G01N33/574 , A61K39/00

9. 发明公开

EP3129048A2 ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 有权
标题翻译： ANTIKÖRPER，PHARMAZEUTISCHE ZUSAMMENSETZUNGEN UND VERWENDUNGEN DAVON
公开(公告)号：EP3129048A2
公开(公告)日：2017-02-15
申请号：EP15777370.6
申请日：2015-04-10
申请人： OBI Pharma Inc.
发明人： LAI, Jiann-Shiun , CHEN, I-ju , WANG, Cheng-Chi , TSAI, Yi-Chien , TSAI, Yi-Chien , YU, Cheng-der, Tony
IPC分类号： A61K39/00 , A61K31/7105
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/3015 , C07K16/303 , C07K16/44 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/72 , C07K2317/92 , C12N5/163 , G01N33/574 , G01N2400/02 , G01N2440/38
摘要： The present invention provides antibodies or the antigen-binding portion thereof, that bind to one or more carbohydrate antigens. Also disclosed herein are pharmaceutical pharmaceutical compositions and methods for the inhibition of cancer cells in a subject in need thereof. The pharmaceutical compositions comprise an antibody or an antigen-binding portion thereof and at least one pharmaceutically acceptable carrier.
摘要翻译：本发明提供了结合一种或多种碳水化合物抗原的抗体或其抗原结合部分。本文还公开了用于在有需要的受试者中抑制癌细胞的药物组合物和方法。药物组合物包含抗体或其抗原结合部分和至少一种药学上可接受的载体。

10. 发明授权

EP3129048B1 ANTIBODIES BINDING TO TUMOUR ASSOCIATED CARBOHYDRATE ANTIGENS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 有权
公开(公告)号：EP3129048B1
公开(公告)日：2020-01-15
申请号：EP15777370.6
申请日：2015-04-10
申请人： OBI Pharma Inc.
发明人： LAI, Jiann-Shiun , CHEN, I-ju , WANG, Cheng-Chi , TSAI, Yi-Chien , TSAI, Yi-Chien , YU, Cheng-der, Tony
IPC分类号： A61K39/00 , A61K31/7105 , C07K16/30 , C07K16/44 , A61P35/00

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