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1. 发明申请

WO2013051159A1 NOP RECEPTOR ANTAGONIST 审中-公开
标题翻译： NOP受体拮抗剂
公开(公告)号：WO2013051159A1
公开(公告)日：2013-04-11
申请号：PCT/JP2011/073464
申请日：2011-10-05
申请人： NIPPON SHINYAKU CO., LTD. , OKANO, Masahiko , OYAMA, Tatsuya
发明人： OKANO, Masahiko , OYAMA, Tatsuya
IPC分类号： C07D239/94 , A61K31/517 , A61P3/04 , A61P9/12 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00
CPC分类号： C07D239/94
摘要： A novel excellent non-opioid branch of the opioid peptide family of receptors antagonist is provided, which exhibit an analgesic effect on a varuous pains. The present invention is directed to a non-opioid branch of the opioid peptide family of receptors antagonist represented by the general formula [1] or a pharmaceutically acceptable salt thereof. In the general formula [1], R 1 represents hydrogen or the like, R 2 represents hydrogen or the like, R 3 and R 4 are the same or different and represent hydrogen, alkyl, alkoxy or halogen, R 5 is combined with R 6 to represent alkylene or represents hydrogen, hydroxy, alkyl, phenyl or alkoxy, R 6 represents (1) alkyl, (2) cycloalkyl, (3) phenyl, (4) a 5- to 10-membered aromatic heterocyclic group containing 1 to 3 heteroatoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, or (5) -N(R 61 )(R 62 ).
摘要翻译：提供了阿片类肽受体拮抗剂家族的优异的非阿片样物质分支，其对变性疼痛具有镇痛作用。本发明涉及由通式[1]表示的受体拮抗剂阿片样肽家族的非阿片样物质分支或其药学上可接受的盐。在通式[1]中，R 1表示氢等，R 2表示氢等，R 3和R 4相同或不同，表示氢，烷基，烷氧基或卤素，R 5与R 6一起表示亚烷基或代表氢，羟基，烷基，苯基或烷氧基，R6表示（1）烷基，（2）环烷基，（3）苯基，（4）含有1至3个选自以下的杂原子的5至10元芳族杂环基：的氮原子，氧原子和硫原子，或（5）-N（R61）（R62）。

2. 发明授权

EP1944298B1 QUINAZOLINE DERIVATIVE AND PHARMACEUTICAL 有权转让
标题翻译：喹唑啉衍生物和制药
公开(公告)号：EP1944298B1
公开(公告)日：2013-01-09
申请号：EP06811143.4
申请日：2006-10-03
申请人： Nippon Shinyaku Co., Ltd.
发明人： OKANO, Masahiko , OYAMA, Tatsuya
IPC分类号： C07D239/94 , A61K31/517 , A61P1/16 , A61P3/00 , A61P3/10 , A61P5/00 , A61P5/16 , A61P7/00 , A61P13/12 , A61P17/04 , A61P25/00 , A61P25/08 , A61P25/18
CPC分类号： C07D239/94 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14

3. 发明公开

EP1944298A1 QUINAZOLINE DERIVATIVE AND PHARMACEUTICAL 有权转让
标题翻译： CHINAZOLINDERIVAT UND PHARMAZEUTIKUM
公开(公告)号：EP1944298A1
公开(公告)日：2008-07-16
申请号：EP06811143.4
申请日：2006-10-03
申请人： Nippon Shinyaku Co., Ltd.
发明人： OKANO, Masahiko , OYAMA, Tatsuya
IPC分类号： C07D239/94 , A61K31/517 , A61P1/16 , A61P3/00 , A61P3/10 , A61P5/00 , A61P5/16 , A61P7/00 , A61P13/12 , A61P17/04 , A61P25/00 , A61P25/08 , A61P25/18
CPC分类号： C07D239/94 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14
摘要： It is intended to provide a novel quinazoline derivative with less skin irritation and an excellent action of strongly suppressing scratching behavior and a pharmaceutical composition containing the quinazoline derivative as an active ingredient. The present invention is directed to the quinazoline derivative represented by the general formula [1] or a pharmaceutically acceptable salt thereof. In the general formula [1], R 1 represents hydrogen or the like, R 2 represents hydrogen or the like, R 3 and R 4 are the same or different and represent hydrogen, alkyl, alkoxy or halogen, R 5 is combined with R 6 to represent alkylene or represents hydrogen, hydroxy, alkyl, phenyl or alkoxy, R 6 represents (1) alkyl, (2) cycloalkyl, (3) phenyl, (4) a 5- to 10-membered aromatic heterocyclic group containing one to three heteroatoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, or (5) -N(R 61 ) (R 62 ).
摘要翻译：本发明提供一种新颖的喹唑啉衍生物，其具有较少的皮肤刺激性和强烈抑制刮擦行为的优异作用，以及含有喹唑啉衍生物作为活性成分的药物组合物。本发明涉及由通式[1]表示的喹唑啉衍生物或其药学上可接受的盐。在通式[1]中，R 1表示氢等，R 2表示氢等，R 3和R 4相同或不同，表示氢，烷基，烷氧基或卤素，R 5与R 6表示亚烷基或代表氢，羟基，烷基，苯基或烷氧基，R 6表示（1）烷基，（2）环烷基，（3）苯基，（4）5至10元芳族杂环基，三个选自氮原子，氧原子和硫原子的杂原子，或（5）-N（R 61）（R 62）。

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