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1. 发明专利

JP2005110645A Method for evaluating degree of canceration in sample originating from mammal 审中-公开
标题翻译：用于评估来自母体的样品中的癌症程度的方法
公开(公告)号：JP2005110645A
公开(公告)日：2005-04-28
申请号：JP2003364405
申请日：2003-10-24
申请人： National Cancer Center-Japan , Sumitomo Chemical Co Ltd , 住友化学株式会社 , 国立がんセンター総長
发明人： USHIJIMA TOSHIKAZU , HAGIWARA JUNJI
IPC分类号： G01N33/50 , A61K38/46 , A61K45/00 , A61K48/00 , A61P13/12 , A61P35/00 , C12N15/09 , C12Q1/02 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating a degree of canceration in a sample originating from a mammal on the basis of the detection of gene abnormality that is suitable for evaluating a diagnostic method and a therapeutic method, and the like, for early detection of cancer. SOLUTION: This method for evaluating the degree of canceration in the sample originating from a mammal comprises (1) the first step where the methylation frequency of disintegrin and metalloproteinase domain 23 gene contained in the sample originating from the mammal or an index value corelating to the same is measured and (2) the second step where the degree of canceration of the sample is determined by the difference given by comparison between the methylation frequency value or the index value, that has the corelationship therewith and a reference. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种基于适合于评价诊断方法和治疗方法的基因异常的检测来评价源自哺乳动物的样品的癌变程度的方法等，用于早期发现癌症。评价来自哺乳动物的样品中的癌变程度的方法包括：（1）第一步，其中源自哺乳动物的样品中含有的解联蛋白和金属蛋白酶结构域23基因的甲基化频率或指标值测量了与其相同的层压，以及（2）第二步，其中样品的癌症程度由通过与具有关系的甲基化频率值或指标值与参考之间的比较给出的差异来确定。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2005087046A Method for evaluating carcinogenesis degree of specimen originated from mammal 有权
标题翻译：用于评估从母体产生的样本的致癌程度的方法
公开(公告)号：JP2005087046A
公开(公告)日：2005-04-07
申请号：JP2003322822
申请日：2003-09-16
申请人： National Cancer Center-Japan , Sumitomo Chemical Co Ltd , 住友化学株式会社 , 国立がんセンター総長
发明人： USHIJIMA TOSHIKAZU , HAGIWARA JUNJI
IPC分类号： G01N33/50 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/574
CPC分类号： G01N33/57496 , C12Q1/6827 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2523/125
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating the carcinogenesis degree of a specimen originated from a mammal on the basis of the detection of a genetic abnormality, suitable for evaluating a diagnosis method for the early discovery of a cancer, a treating method, or the like. SOLUTION: This method for evaluating the carcinogenesis degree of the specimen originated from the mammal is characterized by having (1) the first process for measuring the methylation frequency of fibrillin 2 gene contained in the specimen originated from the mammal or an index value having a correlation with the methylation frequency, and (2) the second process for judging the carcinogenesis degree of the specimen on the basis of a difference obtained by comparing the measured methylation frequency or correlation with the methylation frequency with a control. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种评估来自哺乳动物的来自哺乳动物的标本的癌发生程度的方法，所述方法基于遗传异常的检测，适用于评价癌症早期发现的诊断方法，处理方法等。解决方案：用于评价来自哺乳动物的标本的致癌程度的方法的特征在于：（1）测定源自哺乳动物的标本中含有的原纤维蛋白2基因的甲基化频率的第一种方法或指标值与甲基化频率相关，以及（2）基于通过将测定的甲基化频率或与甲基化频率的相关性与对照相比较而获得的差异来判断样品的致癌程度的第二过程。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2005087045A Method for evaluating carcinogenesis degree of specimen originated from mammal 有权
标题翻译：用于评估从母体产生的样本的致癌程度的方法
公开(公告)号：JP2005087045A
公开(公告)日：2005-04-07
申请号：JP2003322821
申请日：2003-09-16
申请人： National Cancer Center-Japan , Sumitomo Chemical Co Ltd , 住友化学株式会社 , 国立がんセンター総長
发明人： USHIJIMA TOSHIKAZU , HAGIWARA JUNJI
IPC分类号： G01N33/50 , A61K45/00 , A61P35/00 , A61P43/00 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/574
CPC分类号： G01N33/57496 , C12Q1/6827 , C12Q1/6886 , C12Q2600/154 , C12Q2600/158 , C12Q2523/125
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating the carcinogenesis degree of a specimen originated from a mammal on the basis of the detection of a genetic abnormality, suitable for evaluating a diagnosis method for the early discovery of a cancer, a treating method, or the like. SOLUTION: This method for evaluating the carcinogenesis degree of the specimen originated from the mammal is characterized by having (1) the first process for measuring the methylation frequency of p53-responsive gene 2 gene contained in the specimen originated from the mammal or an index value having a correlation with the methylation frequency, and (2) the second process for judging the carcinogenesis degree of the specimen on the basis of a difference obtained by comparing the measured methylation frequency or correlation with the methylation frequency with a control. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种评估来自哺乳动物的来自哺乳动物的标本的癌发生程度的方法，所述方法基于遗传异常的检测，适用于评价癌症早期发现的诊断方法，处理方法等。解决方案：用于评价来自哺乳动物的标本的致癌程度的方法的特征在于：（1）测量源自哺乳动物的标本中所含的p53-应答基因2基因的甲基化频率的第一种方法，或与甲基化频率相关的指标值，以及（2）基于通过将测定的甲基化频率或与甲基化频率的相关性与对照相比较而获得的差异来判定标本的致癌程度的第二过程。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2005087050A Method for evaluating carcinogenesis degree of specimen originating from mammal 审中-公开
标题翻译：用于评估来自母体的样本的致癌程度的方法
公开(公告)号：JP2005087050A
公开(公告)日：2005-04-07
申请号：JP2003322827
申请日：2003-09-16
申请人： National Cancer Center-Japan , Sumitomo Chemical Co Ltd , 住友化学株式会社 , 国立がんセンター総長
发明人： USHIJIMA TOSHIKAZU , HAGIWARA JUNJI
IPC分类号： G01N33/53 , A61K48/00 , A61P35/00 , A61P43/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2523/125 , C12Q2600/154
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating the carcinogenesis degree of a specimen originating from a mammal on the basis of the detection of a genetic abnormality, suitable for evaluating a diagnosis method for the early discovery of a cancer, a treating method, or the like. SOLUTION: The method for evaluating the carcinogenesis degree of the specimen originating from the mammal is characterized by having (1) the first process for measuring the methylation frequency of solute carrier family 6 neurotransmitter transporter noradrenalin member 2 gene contained in the specimen originating from the mammal, and (2) the second process for judging the carcinogenesis degree of the specimen on the basis of a difference obtained by comparing the measured methylation frequency with a control. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：解决问题的方法：提供一种评估来自哺乳动物的来自哺乳动物的标本的发生程度的方法，其基于遗传异常的检测，适用于评估癌症早期发现的诊断方法，处理方法等。解决方案：用于评价源自哺乳动物的标本的致癌程度的方法的特征在于具有（1）测定原始样品中包含的溶质载体家族6神经递质转运蛋白去甲肾上腺素成员2基因的甲基化频率的第一过程来自哺乳动物，以及（2）基于通过比较所测量的甲基化频率与对照而获得的差异来判断样品的致癌程度的第二过程。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2005087049A Method for evaluating carcinogenesis degree of specimen originated from mammal 有权
标题翻译：用于评估从母体产生的样本的致癌程度的方法
公开(公告)号：JP2005087049A
公开(公告)日：2005-04-07
申请号：JP2003322826
申请日：2003-09-16
申请人： National Cancer Center-Japan , Sumitomo Chemical Co Ltd , 住友化学株式会社 , 国立がんセンター総長
发明人： USHIJIMA TOSHIKAZU , HAGIWARA JUNJI
IPC分类号： G01N33/53 , A61P35/00 , A61P43/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/50 , G01N33/566
CPC分类号： G01N33/5011 , C12Q1/6827 , C12Q1/6886 , C12Q2600/154 , C12Q2523/125
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating the carcinogenesis degree of a specimen originated from a mammal on the basis of the detection of a genetic abnormality, suitable for evaluating a diagnosis method for the early discovery of a cancer, a treating method, or the like. SOLUTION: This method for evaluating the carcinogenesis degree of the specimen originated from the mammal is characterized by having (1) the first process for measuring the methylation frequency of G-protein-coupled somatostatin and angiotensin-like peptide receptor gene contained in the specimen originated from the mammal, and (2) the second process for judging the carcinogenesis degree of the specimen on the basis of a difference obtained by comparing the measured methylation frequency with a control. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种评估来自哺乳动物的来自哺乳动物的标本的癌发生程度的方法，所述方法基于遗传异常的检测，适用于评价癌症早期发现的诊断方法，处理方法等。解决方案：用于评估源自哺乳动物的标本的致癌程度的方法的特征在于：（1）测量G蛋白偶联生长抑素和血管紧张素样肽受体基因甲基化频率的第一个方法来自哺乳动物的标本，（2）基于通过比较测定的甲基化频率与对照而获得的差异来判定标本的致癌程度的第二过程。版权所有（C）2005，JPO＆NCIPI

6. 发明专利

JP2005087048A Method for evaluating carcinogenesis degree of specimen originated from mammal 有权
标题翻译：用于评估从母体产生的样本的致癌程度的方法
公开(公告)号：JP2005087048A
公开(公告)日：2005-04-07
申请号：JP2003322825
申请日：2003-09-16
申请人： National Cancer Center-Japan , Sumitomo Chemical Co Ltd , 住友化学株式会社 , 国立がんセンター総長
发明人： USHIJIMA TOSHIKAZU , HAGIWARA JUNJI
IPC分类号： G01N33/53 , A61K48/00 , A61P35/00 , A61P43/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2523/125 , C12Q2600/154
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating the carcinogenesis degree of a specimen originated from a mammal on the basis of the detection of a genetic abnormality, suitable for evaluating a diagnosis method for the early discovery of a cancer, a treating method, or the like. SOLUTION: This method for evaluating the carcinogenesis degree of the specimen originated from the mammal is characterized by having (1) the first process for measuring the methylation frequency of G protein-coupled receptor 7 gene contained in the specimen originated from the mammal, and (2) the second process for judging the carcinogenesis degree of the specimen on the basis of a difference obtained by comparing the measured methylation frequency with a control. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种评估来自哺乳动物的来自哺乳动物的标本的癌发生程度的方法，所述方法基于遗传异常的检测，适用于评价癌症早期发现的诊断方法，处理方法等。解决方案：用于评估源自哺乳动物的标本的致癌程度的方法的特征在于：（1）测量源自哺乳动物的标本中含有的G蛋白偶联受体7基因的甲基化频率的第一种方法，以及（2）基于通过比较测定的甲基化频率与对照而获得的差异来判断标本的致癌程度的第二过程。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2005087047A Method for evaluating carcinogenesis degree of specimen originating from mammal 有权
标题翻译：用于评估来自母体的样本的致癌程度的方法
公开(公告)号：JP2005087047A
公开(公告)日：2005-04-07
申请号：JP2003322823
申请日：2003-09-16
申请人： National Cancer Center-Japan , Sumitomo Chemical Co Ltd , 住友化学株式会社 , 国立がんセンター総長
发明人： USHIJIMA TOSHIKAZU , HAGIWARA JUNJI
IPC分类号： A61K45/00 , A61P35/00 , A61P43/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50
CPC分类号： G01N33/5011 , C12Q1/6827 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2523/125
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating the carcinogenesis degree of a specimen originating from a mammal on the basis of the detection of a genetic abnormality, suitable for evaluating a diagnosis method for the early discovery of a cancer, a treating method, or the like. SOLUTION: This method for evaluating the carcinogenesis degree of the specimen originating from the mammal is characterized by having (1) the first process for measuring the methylation frequency of neurofilament 3 gene contained in the specimen originating from the mammal or an index value having a correlation with the methylation frequency, and (2) the second process for judging the carcinogenesis degree of the specimen on the basis of a difference obtained by comparing the measured methylation frequency or correlation with the methylation frequency with a control. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：解决问题的方法：提供一种评估来自哺乳动物的来自哺乳动物的标本的发生程度的方法，其基于遗传异常的检测，适用于评估癌症早期发现的诊断方法，处理方法等。解决方案：用于评价来自哺乳动物的标本的致癌程度的方法的特征在于：（1）测定源自哺乳动物的标本中所含的神经丝3基因的甲基化频率的第一种方法或指标值与甲基化频率相关，以及（2）基于通过将测定的甲基化频率或与甲基化频率的相关性与对照相比较而获得的差异来判断样品的致癌程度的第二过程。版权所有（C）2005，JPO＆NCIPI

8. 发明专利

JP2005198533A Method for judging prognosis of mammalian neuroblastoma 有权
标题翻译： MAMMALIAN NEUROBLASTOMA的判定方法
公开(公告)号：JP2005198533A
公开(公告)日：2005-07-28
申请号：JP2004006867
申请日：2004-01-14
申请人： Chiba Prefecture , National Cancer Center-Japan , 千葉県 , 国立がんセンター総長
发明人： USHIJIMA TOSHIKAZU , NAKAGAWARA AKIRA
IPC分类号： C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for accurately predicting the prognosis of mammalian neuroblastoma. SOLUTION: This method for accurately predicting the prognosis of the mammalian neuroblastoma comprises measuring the methylation frequency of the cytosine of CpG island contained in one or more genes selected from the group consisting of a gene encoding a protein belonging to protocadherin β-family, a gene encoding a protein belonging to protocadherin α-family, a protein encoding a hepatocyte growth factor-like protein, DKFZp 451I127 gene, and cytochrome p450 CYP26C1 gene, and then judging the prognosis of the mammalian neuroblastoma on the basis of the methylation frequency. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供准确预测哺乳动物神经母细胞瘤预后的方法。解决方案：用于准确预测哺乳动物神经母细胞瘤的预后的方法包括测定包含在一个或多个选自以下的基因中的CpG岛的甲基化频率：编码属于原癌基因蛋白β家族的蛋白质的基因，编码属于原螯合素α家族的蛋白质，编码肝细胞生长因子样蛋白质的蛋白质，DKFZp 451I127基因和细胞色素p450 CYP26C1基因的基因，然后基于甲基化频率判断哺乳动物神经母细胞瘤的预后。版权所有（C）2005，JPO＆NCIPI

9. 发明专利

JP2004135661A Method for evaluating degree of canceration in sample originating from mammal 有权
公开(公告)号：JP2004135661A
公开(公告)日：2004-05-13
申请号：JP2003325744
申请日：2003-09-18
申请人： National Cancer Center-Japan , Sumitomo Chem Co Ltd , 住友化学工業株式会社 , 国立がんセンター総長
发明人： USHIJIMA TOSHIKAZU , KANEDA ATSUSHI
IPC分类号： G01N33/50 , A61K31/7068 , A61K38/00 , A61K45/00 , A61K48/00 , A61P35/00 , C12N15/09 , C12Q1/02 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating a degree of canceration in a sample originating from a mammal based on detection of gene abnormality useful for evaluating a diagnostic method, a therapeutic method and the like for finding out cancers in an early stage. SOLUTION: The method for evaluating the degree of canceration in the sample originating from the mammal comprises (1) a first process for measuring methylation frequency of HAND1 gene included in the sample originating from the mammal or an index-value relatively relating to the same and (2) a second process for judging the degree of canceration of the sample depending on difference given by comparing the methylation frequency or the index-value relatively relating to the same measured in the process (1) with a control. COPYRIGHT: (C)2004,JPO

10. 发明专利

JP2004113116A Method for rating canceration degree of mammal-derived specimen 审中-公开
公开(公告)号：JP2004113116A
公开(公告)日：2004-04-15
申请号：JP2002280687
申请日：2002-09-26
申请人： National Cancer Center-Japan , Sumitomo Chem Co Ltd , 住友化学工業株式会社 , 国立がんセンター総長
发明人： USHIJIMA TOSHIKAZU , KANEDA ATSUSHI
IPC分类号： G01N33/50 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P35/00 , C07H21/04 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/574
摘要： PROBLEM TO BE SOLVED: To provide a method for rating the canceration degree of a mammal-derived specimen based on detecting gene abnormality, suitable for evaluating diagnostic or therapeutic methods for discovering cancer at early stages. SOLUTION: This method for rating the canceration degree of the mammal-derived specimen comprises (1) the 1st step of assaying the methylation frequency of Thrombomodulin gene contained in the specimen or an index value correlated with the methylation frequency and (2) the 2nd step of determining the canceration degree based on a difference obtained by comparing the above methylation frequency or index value with the corresponding control. COPYRIGHT: (C)2004,JPO

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