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1. 发明公开

EP3634145A1 POLYPEPTIDE, USE AND METHOD FOR HYDROLYSING PROTEIN 审中-公开
公开(公告)号：EP3634145A1
公开(公告)日：2020-04-15
申请号：EP18813701.2
申请日：2018-06-08
申请人： Novozymes A/S
发明人： LIU, Cui , HENDRIKSEN, Hanne, Vang , LYNGLEV, Gitte, Budolfsen , FRISNER, Henrik , LIU, Ye , DELLA PIA, Eduardo, Antonio , HELDT-HANSEN, Hans, Peter , JENSEN, Kenneth , PENG, Wei , LI, Ming
IPC分类号： A23J1/00 , C07K14/37 , C12N9/58 , C12N15/57 , C12N15/63

2. 发明公开

EP3411477A1 POLYPEPTIDES HAVING PROTEASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
公开(公告)号：EP3411477A1
公开(公告)日：2018-12-12
申请号：EP17747010.1
申请日：2017-02-04
申请人： Novozymes A/S
发明人： LIU, Ye , JIANG, Xianzhi , HAN, Bucong , TANG, Lan , BENIE, Astrid , FRISNER, Henrik
IPC分类号： C12N9/58
CPC分类号： C12N9/58
摘要： Disclosed are isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. Nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides are also disclosed.

3. 发明公开

EP1751295A2 A PROCESS OF PRODUCING A FERMENTATION PRODUCT 审中-公开
标题翻译：法生产发酵产物
公开(公告)号：EP1751295A2
公开(公告)日：2007-02-14
申请号：EP05754334.0
申请日：2005-05-11
申请人： Novozymes North America, Inc. , Novozymes A/S
发明人： BHARGAVA, Swapnil , FRISNER, Henrik , BISGARD-FRANTZEN, Henrik , TAMS, Jeppe Wegener
IPC分类号： C12P7/06
CPC分类号： C12P7/10 , C12P19/14 , Y02E50/16 , Y02E50/17
摘要： The invention relates to a process of producing a fermentation product, such as ethanol, from starch-containing material, including i) subjecting starch-containing material to an alpha-amylase, ii) subjecting the material obtained in step i) to an alpha-glucosidase and/or a maltose-generating enzyme, and iii) fermenting the material in the presence of a fermenting organism, such as yeast. Alternatively the invention relates to a process of producing a fermentation product from starch-containing material, preferably granular starch, which process comprises: a) subjecting starch-containing material to an alpha-glucosidase and optionally a glucose-generating and/or maltose-generating enzyme, and b) fermenting the material in the presence of a fermenting organism.

4. 发明申请

WO2017050291A1 USE OF SERINE PROTEASES FOR IMPROVING ETHANOL YIELD 审中-公开
标题翻译：使用丝氨酸蛋白酶改善乙醇含量
公开(公告)号：WO2017050291A1
公开(公告)日：2017-03-30
申请号：PCT/CN2016/100090
申请日：2016-09-26
申请人： NOVOZYMES A/S , GUO, Xinyan
发明人： GUO, Xinyan , KREEL, Nathaniel Edward , JUMP, Joseph , HOOSS, Melissa C. , ROBERTS, Madison , VIDAL, Bernardo, Jr. , JENSEN, Kenneth , FRISNER, Henrik , HOFF, Tine , LIU, Ye , TANG, Lan
IPC分类号： C12N9/54 , C12P1/00 , C12P7/06 , C12N9/30 , C12N9/34 , C12N9/40 , C12N15/63 , C12N9/48 , C12N9/58 , C12N9/50
CPC分类号： C12N9/48 , C12N9/50 , C12N9/54 , C12N9/58 , C12N15/63 , C12P7/06 , C12P2203/00 , C12Y302/01001 , C12Y304/14 , C12Y304/21 , Y02E50/17
摘要： S53 proteases and the use of S53 protease in processes for converting starch to ethanol are provided.
摘要翻译：提供S53蛋白酶和在淀粉转化为乙醇的方法中使用S53蛋白酶。

5. 发明申请

WO2002072876A2 SCREENING METHOD COMPRISING COMBINATION OF DISCRETE DIMENSION ASSAY TESTING OF ACTIVES, GENE MUTATION AND APPLICATION ASSAY TESTING OF SELECTED ACTIVES 审中-公开
标题翻译：包括活性离子尺寸测定，基因突变和所选活性应用测定试验组合的筛选方法
公开(公告)号：WO2002072876A2
公开(公告)日：2002-09-19
申请号：PCT/DK2002/000160
申请日：2002-03-12
申请人： NOVOZYMES A/S , KJÆRULF, Søren , LAMSA, Michael , THISTED, Thomas , HANSEN, Peter, Kamp , PEDERSEN, Henrik , FRISNER, Henrik
发明人： KJÆRULF, Søren , LAMSA, Michael , THISTED, Thomas , HANSEN, Peter, Kamp , PEDERSEN, Henrik , FRISNER, Henrik
IPC分类号： C12Q1/68
CPC分类号： C12N15/1058
摘要： Screening method comprising combination of discrete dimension assay testing of actives, gene mutation and application assay testing of selected actives. The present invention relates to a screening method for identifying actives with improved performance comprising: (1) screening a library of actives encoded by nucleotide sequences in at least two different discrete dimension assays employing selected parameters and selecting the actives exhibiting improved properties in the discrete dimension assays, (2) collecting nucleotide sequences encoding the selected actives, (3) mutating collected nucleotide sequences, (4) screening actives encoded by the mutated nucleotide sequences in an application assay and selecting actives, which exhibit improved performance.
摘要翻译：本发明涉及用于鉴定具有改进性能的活性物质（肽或蛋白质）的筛选方法，其包括：（1）使用选择的参数在至少两个不同离散维度测定中筛选由核苷酸序列编码的活性物质文库，并选择显示改进的活性物质离子维度测定中的性质，（2）收集编码所选活性物质的核苷酸序列，（3）突变收集的核苷酸序列，（4）在应用测定中筛选由突变的核苷酸序列编码的活性物，并选择表现出改善的性能的活性物质。

6. 发明申请

WO2006028897A3 LIQUEFACTION AND SACCHARIFACTION PROCESSES 审中-公开
公开(公告)号：WO2006028897A3
公开(公告)日：2006-03-16
申请号：PCT/US2005/031101
申请日：2005-08-30
申请人： NOVOZYMES NORTH AMERICA, INC. , NOVOZYMES A/S , BHARGAVA, Swapnil , JOHAL, Malcolm , FRISNER, Henrik
发明人： BHARGAVA, Swapnil , JOHAL, Malcolm , FRISNER, Henrik
IPC分类号： A61K38/43 , A61K38/46 , C12P7/06 , C12P7/08 , C12P1/04 , C12N9/00 , C12N9/14 , C12N9/28 , C12N9/30 , C12N9/54 , C12N9/62
摘要： The present invention relates to a process for liquefying starch-containing material, comprising treating the starch-containing material with a bacterial alpha-amylase at a temperature between 70-90 °C for 10-120 minutes and a pullulanase at a temperature in the range from 40-60 °C for between 20 and 90 minutes. The invention also relates to a saccharification process for saccharifying liquefied starch-containing material, comprising saccharifying a liquefied starch-containing material in the presence of a carbohydrate-source generating enzyme and a pullulanase. Finally, the invention also relates to a process of producing a fermentation product, such as ethanol, comprising a liquefaction step and/or saccharification step carried out in accordance with the present invention.

7. 发明申请

WO2005033325A1 METHOD OF PRODUCING A RECOMBINANT POLYPEPTIDE FREE OF O-LINKED MANNOSE RESIDUES 审中-公开
标题翻译：生产不含O型连接的棉花残留物的重组多肽的方法
公开(公告)号：WO2005033325A1
公开(公告)日：2005-04-14
申请号：PCT/DK2004/000687
申请日：2004-10-08
申请人： NOVOZYMES A/S , NOVO NORDISK A/S , DIERS, Ivan , FRISNER, Henrik , SHAW, Allan, Christian
发明人： DIERS, Ivan , FRISNER, Henrik , SHAW, Allan, Christian
IPC分类号： C12P21/02
CPC分类号： C07K14/605 , A61K38/26 , A61K38/28 , C07K14/62 , C12P21/02
摘要： The present invention relates to removal of the small fraction of O-mannosylated recombinant proteins produced in a fungal host. The main aspect of the invention thus relates to a method for producing a therapeutic recombinant polypeptide free of O-linked mannose residues, comprising the steps of a) providing the polypeptide from a fungal host, and b) demannosylating the polypeptide, where in step (b) O-linked mannose residues on the polypeptide are completely removed by enzymatic treatment of the polypeptide with a glycosidase having mannosidase activity.
摘要翻译：本发明涉及去除在真菌宿主中产生的小部分O-甘露糖基化的重组蛋白质。因此，本发明的主要方面涉及一种用于产生不含O-连接的甘露糖残基的治疗性重组多肽的方法，其包括以下步骤：a）从真菌宿主提供多肽，和b）对多肽进行去葡萄糖化，其中在步骤 b）通过用具有甘露糖苷酶活性的糖苷酶对多肽进行酶处理，完全除去多肽上的O-连接的甘露糖残基。

8. 发明授权

EP1506292B2 PECTATE LYASE VARIANTS 有权
标题翻译： PECTATE LYASE变种
公开(公告)号：EP1506292B2
公开(公告)日：2014-04-09
申请号：EP03720292.6
申请日：2003-05-14
申请人： Novozymes A/S
发明人： GLAD, Sanne, Schröder , ANDERSEN, Carsten , BORCHERT, Torben, Vedel , JOHANSEN, Katja, Salomon , FRISNER, Henrik , BJÖRNVAD, Mads, Eskelund , THISTED, Thomas
IPC分类号： C12N9/88 , C12N15/60 , C12N1/21 , C12N1/15 , C11D3/386 , C12P19/00
CPC分类号： C12N9/88 , C11D3/38636
摘要： The present invention relates to pectate lyase variants exhibiting alterations relative to a parent enzyme exhibiting pectate lyase activity as its major enzymatic activity; to a method of producing such enzymes; and to methods for using such enzymes in the textile, detergent and cellulose fiber processing industries. Compared to the parent enzyme, the pectate lyase variants of the present invention exhibit improved stability in detergents.
摘要翻译：本发明涉及相对于显示出果胶裂解酶活性的亲本酶作为其主要酶活性的改变的果胶酸裂解酶变体; 涉及一种生产这种酶的方法; 以及在纺织，洗涤剂和纤维素纤维加工业中使用这些酶的方法。与亲本酶相比，本发明的果胶酸裂合酶变体在洗涤剂中表现出改进的稳定性。

9. 发明公开

EP1442048A2 HIGH THROUGHPUT ISOLATION OF PROTEINS BY CHARGE INDUCTION CHROMATOGRAPHY 审中-公开
标题翻译： ISOLIERUNG VON蛋白酶MITTELS LADUNGSINDUKTION-CHROMATOGRAPHIE MIT HOHEM DURCHSATZ
公开(公告)号：EP1442048A2
公开(公告)日：2004-08-04
申请号：EP02774472.1
申请日：2002-10-29
申请人： Novozymes A/S
发明人： FRISNER, Henrik , CHRISTENSEN, Lars, Lehmann, Hylling
IPC分类号： C07K1/20 , C12N9/00
CPC分类号： C07K1/20 , C12N9/00
摘要： A method for high throughput micro-purification of a library of tag-free biological compounds is claimed wherein a population of discrete liquid samples comprising the library of tag-free biological compounds is contacted with a solid chromatographic material comprising a functional group selected from ion exchange materials, hydrophobic materials, affinity materials and hydrophobic charge induction materials so as to retain the tag-free biological compounds of the library, isolating the chromatographic material retaining the biological compounds, releasing the biological compounds of the library from the solid chromatographic material and collecting the released biological compounds of the library to produce a population of samples comprising the isolated biological compound.
摘要翻译：要求一种用于无标签生物化合物文库的高通量微量纯化的方法，其中包含无标记生物化合物文库的离散液体样品群与包含选自离子交换的官能团的固体色谱材料接触材料，疏水性材料，亲和材料和疏水电荷诱导材料，以保留文库的无标签生物化合物，分离保留生物化合物的色谱材料，从固体色谱材料中释放文库的生物化合物并收集释放文库的生物化合物以产生包含分离的生物化合物的样品群体。

10. 发明公开

EP1370652A2 SCREENING METHOD COMPRISING COMBINATION OF DISCRETE DIMENSION ASSAY TESTING OF ACTIVES, GENE MUTATION AND APPLICATION ASSAY TESTING OF SELECTED ACTIVES 审中-公开
标题翻译： “按应用测定法全面的筛选程序中有效成分的离散DIMENSION检测，基因突变和选定物质试验测试相结合的”
公开(公告)号：EP1370652A2
公开(公告)日：2003-12-17
申请号：EP02703528.6
申请日：2002-03-12
申请人： Novozymes A/S
发明人： KJAERULF, Soren , LAMSA, Michael , THISTED, Thomas , HANSEN, Peter, Kamp , PEDERSEN, Henrik , FRISNER, Henrik
IPC分类号： C12N15/09
CPC分类号： C12N15/1058
摘要： The present invention relates to a screening method for identifying actives (peptides or proteins) with improved performance comprising: (1) screening a library of actives encoded by nucleotide sequences in at least two different discrete dimension assays employing selected parameters and selecting the actives exhibiting improved properties in the discrete dimension assays, (2) collecting nucleotide sequences encoding the selected actives, (3) mutating collected nucleotide sequences, (4) screening actives encoded by the mutated nucleotide sequences in an application assay and selecting actives, which exhibit improved performance.

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