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1. 发明申请

WO2011098520A1 AGONIST DR5 BINDING POLYPEPTIDES 审中-公开
标题翻译： AGONIST DR5结合聚合物
公开(公告)号：WO2011098520A1
公开(公告)日：2011-08-18
申请号：PCT/EP2011/051958
申请日：2011-02-10
申请人： NOVARTIS AG , ABLYNX NV , CROMIE, Karen , DOMBRECHT, Bruno , ETTENBERG, Seth , KOLKMAN, Joost , LI, Jing , MEERSCHAERT, Kris , STOVER, David Raymond , ZHANG, Jingxin
发明人： CROMIE, Karen , DOMBRECHT, Bruno , ETTENBERG, Seth , KOLKMAN, Joost , LI, Jing , MEERSCHAERT, Kris , STOVER, David Raymond , ZHANG, Jingxin
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2316/95 , C07K2317/22 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present invention relates to amino acid sequences that are directed against TRAIL cell surface receptor 2 (herein also "DR5"), as well as to compounds or constructs thereof, and in particular proteins and polypeptides and nucleotides that encode them (referred to herein in their entirety as "NB agents") and fragments thereof, and pharmaceutically effective variants thereof, and their use in the diagnosis and treatment of DR5 associated diseases and disorders.
摘要翻译：本发明涉及针对TRAIL细胞表面受体2（本文还称为“DR5”）的氨基酸序列，以及编码它们的化合物或其构建体，特别是编码它们的蛋白质和多肽和核苷酸（在本文中称为其整体作为“NB剂”）及其片段及其药学上有效的变体，以及它们在诊断和治疗DR5相关疾病和病症中的用途。

2. 发明申请

WO2008151380A1 METHOD OF PARALLEL MAGNETIC RESONANCE IMAGE PROCESSING 审中-公开
标题翻译：平行磁共振图像处理方法
公开(公告)号：WO2008151380A1
公开(公告)日：2008-12-18
申请号：PCT/AU2008/000852
申请日：2008-06-13
申请人： MONASH UNIVERSITY , ZHANG, Jingxin , CHEN, Zhaolin
发明人： ZHANG, Jingxin , CHEN, Zhaolin
IPC分类号： G01R33/20 , G01R33/3415 , G01R33/48
CPC分类号： G01R33/5611
摘要： A method, an apparatus, and a computer-implemented system are provided for performing reconstruction of an image of a subject within a magnetic resonance imaging (MRI) machine having a plurality of receiver coils. In particular, parallel magnetic resonance imaging (pMRI) reconstruction is performed by receiving pMRI signal data comprising digitised samples acquired from the receiver coils of the MRI machine. A dynamic input-output system of a pMRI detection process of the MRI machine is constructed, wherein the model embodies a plurality of estimated spatial sensitivity functions corresponding with each of the plurality of receiver coils. An inverse model is determined, which corresponds with the system model, using an optimisation method which is adapted to minimise a measure of reconstruction error. More particularly, the measure of reconstruction error accounts for accuracy of image reconstruction by the inverse model in the absence of additive noise and estimation error, in combination with amplification by the inverse model of additive noise and estimation error. An image of the subject is reconstructed by applying the inverse model to the pMRI signal data. A reconstructed image output may then be provided to a user.
摘要翻译：提供了一种方法，装置和计算机实现的系统，用于在具有多个接收器线圈的磁共振成像（MRI）机器内执行对象的图像重建。特别地，并行磁共振成像（pMRI）重建通过接收包括从MRI机的接收器线圈获取的数字化样本的pMRI信号数据来执行。构造MRI机器的pMRI检测处理的动态输入输出系统，其中，该模型体现与多个接收线圈中的每一个对应的多个估计的空间灵敏度函数。使用适于最小化重建误差的度量的优化方法来确定对应于系统模型的逆模型。更具体地，重建误差的量度考虑到在没有加性噪声和估计误差的情况下通过逆模型的图像重建的精度，以及通过加法噪声和估计误差的逆模型的放大。通过将逆模型应用于pMRI信号数据来重建对象的图像。然后可以向用户提供重建的图像输出。

3. 发明申请

WO2005013403A2 ELECTROCHEMICAL PREFERENTIAL OXIDATION OF CARBON MONOXIDE FROM REFORMATE 审中-公开
标题翻译：一氧化碳从改性剂中的电化学优选氧化
公开(公告)号：WO2005013403A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/023889
申请日：2004-07-23
申请人： WORCESTER POLYTECHNIC INSTITUTE , DATTA, Ravindra , ZHANG, Jingxin
发明人： DATTA, Ravindra , ZHANG, Jingxin
IPC分类号： H01M8/06
CPC分类号： H01M8/0668 , B01D53/326 , C01B3/50 , C01B3/583 , C01B2203/04 , C01B2203/044 , C01B2203/047 , C01B2203/066 , H01M4/90 , H01M4/9016 , H01M4/923 , H01M8/04223 , H01M8/04225 , H01M8/04798 , H01M8/04888 , H01M8/04917 , H01M8/0612 , H01M8/0656 , H01M8/0681 , H01M8/1007 , H01M16/006 , Y02C20/30
摘要： An electrochemical device comprises an electrochemical reactor that includes a single or multiple electrochemical cells and a galvanostat, a gas source and a fuel cell system. Each of the electrochemical cells includes an anode compartment and a cathode compartment. The gas source is in fluid communication with the anode or cathode compai ment of each of the electrochemical cells, including at least two components that are selectively reactive relative to each other. The selectivity of the two components of the gas source is dependent upon an electrical potential between an anode of the anode compartment and a cathode of the cathode compartment, whereby a constant current between the anode and cathode causes the electrical potential to oscillate autonomously while the gas components are directed through the anode or cathode compartment. The oscillation in potential causes autonomous oscillation of selective reaction of the gas components.
摘要翻译：电化学装置包括电化学反应器，其包括单个或多个电化学电池和恒电除垢器，气体源和燃料电池系统。每个电化学电池包括阳极室和阴极室。气源与每个电化学电池的阳极或阴极混合物流体连通，包括至少两个相对于彼此选择性反应的组分。气源的两个组分的选择性取决于阳极室的阳极和阴极室的阴极之间的电位，由此在阳极和阴极之间的恒定电流导致电势自主振荡，而气体组件被引导通过阳极或阴极室。潜在的振荡导致气体组分的选择性反应的自发振荡。

4. 发明公开

EP2534176A1 AGONIST DR5 BINDING POLYPEPTIDES 审中-公开
标题翻译： AGONISTISCHE DR5-BINDENDE POLYPEPTIDE
公开(公告)号：EP2534176A1
公开(公告)日：2012-12-19
申请号：EP11702650.0
申请日：2011-02-10
申请人： Novartis AG , Ablynx N.V.
发明人： CROMIE, Karen , DOMBRECHT, Bruno , ETTENBERG, Seth , KOLKMAN, Joost , LI, Jing , MEERSCHAERT, Kris , STOVER, David Raymond , ZHANG, Jingxin
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2316/95 , C07K2317/22 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present invention relates to amino acid sequences that are directed against TRAIL cell surface receptor 2 (herein also “DR5”), as well as to compounds or constructs thereof, and in particular proteins and polypeptides and nucleotides that encode them (referred to herein in their entirety as “NB agents”) and fragments thereof, and pharmaceutically effective variants thereof, and their use in the diagnosis and treatment of DR5 associated diseases and disorders.
摘要翻译：本发明涉及针对TRAIL细胞表面受体2（本文还称为“DR5”）以及编码它们的化合物或构建体，特别是编码它们的蛋白质和多肽和核苷酸的氨基酸序列（本文中称为“ 其整体为“NB剂”）及其片段及其药学上有效的变体，以及它们在诊断和治疗DR5相关疾病和病症中的用途。

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