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1. 发明申请

WO2018211359A1 LASER PROBE WITH LENSED FIBERS FOR PANRETINAL PHOTOCOAGULATION 审中-公开
公开(公告)号：WO2018211359A1
公开(公告)日：2018-11-22
申请号：PCT/IB2018/053209
申请日：2018-05-08
申请人： NOVARTIS AG
发明人： DIAO, Chenguang , FARLEY, Mark Harrison , MIRSEPASSI, Alireza , PARTO, Kambiz , RICHARDSON, Dean , SMITH, Ronald
IPC分类号： A61F9/008
摘要： An example laser probe comprises one or more fibers extending from a proximal end of the laser probe to at least near a distal end of the laser probe, where the proximal end of the laser probe is configured to be coupled to a laser source via an adapter interface, and a cannula having a distal end and surrounding the one or more fibers along at least a portion of the laser probe at or near the distal end of the laser probe. The laser probe further comprises one or more lens elements, where each lens element is fused to or formed directly on the distal end of a corresponding one of the one or more fibers. In some embodiments, the laser probe is a multi-fiber, multi-spot laser probe, e.g., comprising four or more fibers and four or more corresponding lens elements.

2. 发明申请

WO2015100134A1 FORWARD SCANNING OPTICAL PROBES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS 审中-公开
标题翻译：前向扫描光学探测器及相关设备，系统和方法
公开(公告)号：WO2015100134A1
公开(公告)日：2015-07-02
申请号：PCT/US2014/071188
申请日：2014-12-18
申请人： NOVARTIS AG , YU, Lingfeng , PARTO, Kambiz
发明人： YU, Lingfeng , PARTO, Kambiz
IPC分类号： A61B1/05
CPC分类号： A61B3/102 , A61B1/00172 , A61B3/0008 , A61B5/0066 , A61B5/0084 , A61B5/6821
摘要： Devices, systems, and methods that utilize a technique of changing a position of the set of optical fibers of the fiber bundle in cooperation with the scanning of the imaging light across a proximal surface of the fiber bundle to improve the resolution of the scanned image. In particular, a bundle actuator can be provided to change a position of the set of optical fibers of the fiber bundle in cooperation with a scanning of the imaging light across the proximal surface of the fiber bundle to cover the areas of the gaps between the optical fibers and to increase a resolution of the scanned image.
摘要翻译：与通过光纤束的近端表面的成像光的扫描配合来改变纤维束组的光纤的位置的技术的装置，系统和方法，以提高扫描图像的分辨率。特别地，可以提供束致动器，以便与穿过光纤束的近侧表面的成像光的扫描协同改变光纤束组的光纤的位置，以覆盖光学纤维束之间的间隙的区域并增加扫描图像的分辨率。

3. 发明申请

WO2015038202A1 OCT PROBE WITH PIVOTING FIBER 审中-公开
标题翻译： OCT探针与出售纤维
公开(公告)号：WO2015038202A1
公开(公告)日：2015-03-19
申请号：PCT/US2014/040742
申请日：2014-06-03
申请人： NOVARTIS AG , WHEATLEY, Barry Lynn , PARTO, Kambiz
发明人： WHEATLEY, Barry Lynn , PARTO, Kambiz
IPC分类号： A61B6/00
CPC分类号： A61B5/0084 , A61B1/0016 , A61B1/00172 , A61B1/07 , A61B3/102 , A61B5/0066
摘要： An OCT probe for imaging patient tissue may include an actuation system arranged to displace an optical fiber within a cannula. The actuation system may include a driver actuatable to displace a portion of the optical fiber, with the driver acting in an angled direction relative to the axis of the cannula. The actuation system also may include a pivot feature operably engaged with the optical fiber in a manner permitting the optical fiber to pivot on the pivot feature when the driver actuates to displace the portion of the optical fiber.
摘要翻译：用于成像患者组织的OCT探针可以包括布置成置换套管内的光纤的致动系统。致动系统可以包括可致动以驱动光纤的一部分的驱动器，其中驱动器相对于套管的轴线成角度方向。所述致动系统还可以包括枢轴特征，所述枢转特征可以以当所述驱动器致动以使所述光纤的所述部分移位时允许所述光纤在所述枢轴特征上枢转的方式与所述光纤可操作地接合。

4. 发明申请

WO2019116287A1 THERMALLY ROBUST LASER PROBE ASSEMBLY 审中-公开
公开(公告)号：WO2019116287A1
公开(公告)日：2019-06-20
申请号：PCT/IB2018/059981
申请日：2018-12-12
申请人： NOVARTIS AG
发明人： COOK, Christopher , DIAO, Chenguang , FARLEY, Mark Harrison , MIRSEPASSI, Alireza , PARTO, Kambiz , SMITH, Ronald T.
IPC分类号： A61F9/008 , A61B18/20 , A61B18/24 , A61B18/22 , G02B6/02
摘要： Certain aspects of the present disclosure provide a thermally robust laser probe assembly comprising a cannula, wherein one or more optical fibers extend at least partially through the cannula for transmitting laser light from a laser source to a target location. The probe assembly further comprises a lens housed in the cannula and a protective component press-fitted to the distal end of the cannula, wherein the lens is positioned between the one or more optical fibers and the protective component.

5. 发明申请

WO2018158652A1 MULTI-FIBER MULTI-SPOT LASER PROBE WITH SIMPLIFIED TIP CONSTRUCTION 审中-公开
公开(公告)号：WO2018158652A1
公开(公告)日：2018-09-07
申请号：PCT/IB2018/051036
申请日：2018-02-20
申请人： NOVARTIS AG
发明人： DIAO, Chenguang , FARLEY, Mark Harrison , MIRSEPASSI, Alireza , PARTO, Kambiz , SMITH, Ronald T.
IPC分类号： A61F9/008 , A61B18/22 , G02B6/04 , G02B6/24
摘要： An example multi-fiber, multi-spot laser probe comprises a plurality of fibers extending from a proximal end of the laser probe to at least near a distal end of the laser probe, where the proximal end of the laser probe is configured to be coupled to a laser source via an adapter interface, and a cannula having a distal end and surrounding the plurality of fibers along at least a portion of the laser probe at or near the distal end of the laser probe, where a distal end of each of the plurality of fibers is angle-polished so that the distal end of each fiber is angled relative to a longitudinal axis of the cannula and relative to a plane perpendicular to the longitudinal axis of the cannula. Additional embodiments employ lensed fibers, a distal window, ball lens, lens array, or faceted wedge.

6. 发明申请

WO2015187325A1 BACK REFLECTION MINIMIZATION FOR OCT PROBES 审中-公开
标题翻译： OCT回波反射最小化
公开(公告)号：WO2015187325A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/030630
申请日：2015-05-13
申请人： NOVARTIS AG , WHEATLEY, Barry Lynn
发明人： WHEATLEY, Barry Lynn , PARTO, Kambiz , SCHMIDTLIN, Edouard
IPC分类号： A61B3/10
CPC分类号： A61B3/102 , A61B1/07 , A61B3/1225 , A61B3/14 , A61B5/0066 , A61B5/0084 , A61B2562/0233 , A61B2562/12 , G01B9/0205 , G01B9/02059 , G01B9/02091 , Y10T29/49828
摘要： An OCT probe for imaging patient tissue includes a probe housing, and includes a cannula extending from the probe housing and arranged to penetrate patient tissue. The cannula may include a main body segment and a distal segment. The main body segment may have a lumen defining a first central axis, and the distal segment may have a lumen defining a second central axis that is angled from the first central axis. A lens is disposed in the distal segment. The lens may have a proximal side and a distal side and an optical axis. The optical axis may be substantially parallel to the second central axis and may be angled relative to the first central axis.
摘要翻译：用于成像患者组织的OCT探针包括探针壳体，并且包括从探针壳体延伸并布置成穿透患者组织的套管。套管可以包括主体段和远端段。主体段可以具有限定第一中心轴线的内腔，并且远端段可以具有限定从第一中心轴线成角度的第二中心轴线的内腔。透镜设置在远侧段中。透镜可以具有近侧和远侧以及光轴。光轴可以基本上平行于第二中心轴线并且可以相对于第一中心轴线成角度。

7. 发明申请

WO2014179191A1 FORWARD SCANNING OPTICAL PROBES 审中-公开
标题翻译：前向扫描光学探测
公开(公告)号：WO2014179191A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/035608
申请日：2014-04-28
申请人： NOVARTIS AG , LIN, Dean
发明人： LIN, Dean , PARTO, Kambiz , SCHMIDTLIN, Edouard , WHEATLEY, Barry
IPC分类号： A61B1/00
CPC分类号： G02B26/103 , A61B1/00172 , A61B5/0062 , A61B5/0066 , A61B5/0084 , A61B18/22 , A61B2018/20357 , A61B2018/20359 , G02B6/262 , G02B26/0875
摘要： In certain embodiments, a scanning system includes optical elements and a movement system. The optical elements include an optical fiber and a gradient-index (GRIN) lens. The optical fiber has a fiber axis that extends to an imaginary fiber axis, and is configured to transmit a light ray. The GRIN lens has a GRIN perimeter and a GRIN lens optical axis, and is configured to refract the light ray. The movement system moves a first optical element relative to a second optical element in a closed path such that the GRIN lens optical axis substantially aligns with the imaginary fiber axis at at least one point of the path and the GRIN perimeter intersects the imaginary fiber axis at at least two points of the path.
摘要翻译：在某些实施例中，扫描系统包括光学元件和移动系统。光学元件包括光纤和梯度折射率（GRIN）透镜。光纤具有延伸到假想纤维轴的光纤轴，并且被配置为透射光线。 GRIN镜头具有GRIN周边和GRIN透镜光轴，并且被配置为折射光线。移动系统在闭合路径中相对于第二光学元件移动第一光学元件，使得GRIN透镜光轴在路径的至少一个点处基本上与假想光纤轴对准，并且GRIN周边与假想光纤轴在至少两点的路径。

8. 发明申请

WO2018109580A1 ILLUMINATED SURGICAL PROBE HAVING A VARIABLE ILLUMINATION NUMERICAL APERTURE 审中-公开
公开(公告)号：WO2018109580A1
公开(公告)日：2018-06-21
申请号：PCT/IB2017/057140
申请日：2017-11-15
申请人： NOVARTIS AG
发明人： MIRSEPASSI, Alireza , PAPAC, Michael J. , PARTO, Kambiz
IPC分类号： A61F9/007 , A61F9/008
摘要： A surgical probe system comprising a surgical probe having a probe needle, an optical fiber incorporated onto the probe needle, wherein a proximal end of the optical fiber is connected to a light source and a distal end of the optical fiber projects illumination light from the light source over a tip of the probe needle; and an adjustment mechanism that varies the illumination light between a first beam having a first numerical aperture that facilitates vitreous visualization and a second beam having a second numerical aperture that facilitates background illumination, wherein the second numerical aperture is larger than the first numerical aperture.

9. 发明申请

WO2018092002A1 MEDICAL INSTRUMENT WITH AN INTEGRATED OPTICAL FIBER 审中-公开
公开(公告)号：WO2018092002A1
公开(公告)日：2018-05-24
申请号：PCT/IB2017/056965
申请日：2017-11-07
申请人： NOVARTIS AG
发明人： MIRSEPASSI, Alireza , WHEATLEY, Barry L. , SMITH, Ronald T. , PAPAC, Michael J. , DIAO, Chenguang , PARTO, Kambiz , MCDONELL, Brian William , FARLEY, Mark Harrison
IPC分类号： A61F9/007 , A61B18/00 , A61B90/30
摘要： Provided herein is an illuminated microsurgical instrument system and an illuminated microsurgical instrument. In one implementation, the system includes a microsurgical instrument having a distally projecting tubular member arranged to perform a medical procedure at an interventional site. The tubular member has a distal tip and an outer surface, the outer surface having a flat surface formed therein. The instrument includes a sheath member surrounding a portion of the tubular member and extending toward the distal tip of the tubular member and an optical fiber extending along a length of the flat surface between the tubular member and the sheath member. The instrument may further include a slack chamber, collar structure, and fiber guard member to support and guide the optical fiber to the distal tip.

10. 发明申请

WO2015094770A2 IMAGING PROBES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS UTILIZING AN ELASTOMERIC OPTICAL ELEMENT 审中-公开
标题翻译：使用弹性光学元件的成像探针和相关设备，系统和方法
公开(公告)号：WO2015094770A2
公开(公告)日：2015-06-25
申请号：PCT/US2014/069101
申请日：2014-12-08
申请人： NOVARTIS AG , WHEATLEY, Barry L. , PARTO, Kambiz
发明人： WHEATLEY, Barry L. , PARTO, Kambiz
IPC分类号： A61B3/10 , A61B5/00
CPC分类号： A61B3/102 , A61B3/12 , A61B5/0084 , G02B3/0087 , G02B26/10
摘要： The imaging probe can comprise a housing, having a proximal region configured to be coupled to an optical cable; a cannula, extending from a distal region of the housing; an optical guide, positioned partially in the housing and partially in the cannula, configured to receive an imaging light from the cable in the proximal region of the housing, and to guide the imaging light towards a distal end of the cannula; an optical focusing element, configured to receive the imaging light from the optical guide, and to emit a focused imaging light; an elastomeric optical element, configured to receive the focused imaging light from the optical focusing element, and to be deformable to redirect the focused imaging light; and an actuator system, configured to deform the elastomeric optical element to redirect the focused imaging light.
摘要翻译：成像探针可以包括壳体，其具有被配置为耦合到光缆的近端区域; 套管，其从所述壳体的远侧区域延伸; 光学引导件，部分地定位在壳体中并且部分地定位在套管中，被配置为在壳体的近侧区域中接收来自电缆的成像光，并且将成像光导向套管的远端; 光学聚焦元件，被配置为从所述光学引导件接收成像光，并且发射聚焦的成像光; 弹性体光学元件，被配置为从所述光学聚焦元件接收所聚焦的成像光，并且可变形以使所聚焦的成像光重定向; 以及致动器系统，其构造成使弹性体光学元件变形以重定向聚焦的成像光。

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