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1. 发明专利

FR2628106B1 未知
公开(公告)号：FR2628106B1
公开(公告)日：1993-06-04
申请号：FR8902771
申请日：1989-03-03
申请人： NITROKEMIA IPARTELEPEK , MAGYAR TUDOMANYOS AKADEMIA
发明人： BEZENYEI GABOR , NEMETH SANDOR , SIMANDI LASZLO , BELAK MARIA , SZABO MARIA , DUKAI JOZSEF , NAGY LAJOS , TOEMOERDI ELEMER , SOEPTEI CSABA , DIOSZEGINE ERZSEBET EICHHARDT
IPC分类号： C07D251/16 , B01J27/13 , B01J31/16 , C07B61/00 , C07C311/60 , C07D213/75 , C07D239/42 , C07D251/18 , C07D251/22 , C07D251/46 , C07D333/34 , C07D521/00 , C07C143/833 , C07D251/14
摘要： The invention relates to a process for preparing sulphonyl-ureas of the general formula (I) (I) wherein Ar1 represents a phenyl, naphthyl or thienyl group, the derivatives thereof substituted by C1-4 alkyl, C1-4 haloalkyl, (halo)alkoxycarbonyl, (halo)alkyloxy, nitro, cyano groups as well as by halogen atoms, Ar2 represents a phenyl, pyridyl, pirimidinyl or triazinyl group and the derivatives thereof substituted by C1-4 (halo)alkyl, C1-4 (halo)alkyloxy, amino, O-acyl, O-arylsulphonyl, O-(substituted carbamoyl) groups as well as by halogen atoms. According to the invention N-halogen aryl sulphonamidate is reacted in the presence of a carbonylating catalyst, carbon monoxide and an aromatic amine, optionally in the presence of a phase transfer catalyst, or N-halogen aryl sulphonamidate is reacted with carbon monoxide in the presence of a carbonylating catalyst, and optionally in the presence of a phase transfer catalyst, then the obtained reaction mixture is further reacted with an aromatic amine or an N-halogen-arylamine-alkali metal salt is reacted with aryl-sulphonamid in the presence of a carbonylating catalyst, carbon monoxide and optionally in the presence of a phase transfer catalyst or an amine, amine dihalogenid, aryl sulphonamid are reacted in the presence of a carbonylating catalyst and carbon monoxide and the obtained reaction mixture is worked up in a known manner. The thus prepared sulphonyl-ureas are biologically active compounds, which are used in the pharmaceutical industry and for regulating plant growth.

2. 发明专利

GB2216519B PROCESS FOR PREPARING N-SULPHONYL-UREAS 未知
公开(公告)号：GB2216519B
公开(公告)日：1991-12-11
申请号：GB8904946
申请日：1989-03-03
申请人： NITROKEMIA IPARTELEPEK , MAGYAR TUDOMANYOS AKADEMIA
发明人： BESENYEI GABOR , NEMETH SANDOR , SIMANDI LASZLO , BELAK MARIA , SZABO MARIA , DUKAI JOZSEF , NAGY LAJOS , TOEMOERDI ELEMER , SOEPTEI CSABA , EICHHARDT DIOSZEGINE ERZSEBET
IPC分类号： C07D251/16 , B01J27/13 , B01J31/16 , C07B61/00 , C07C311/60 , C07D213/75 , C07D239/42 , C07D251/18 , C07D251/22 , C07D251/46 , C07D333/34 , C07D521/00
摘要： The invention relates to a process for preparing sulphonyl-ureas of the general formula (I) (I) wherein Ar1 represents a phenyl, naphthyl or thienyl group, the derivatives thereof substituted by C1-4 alkyl, C1-4 haloalkyl, (halo)alkoxycarbonyl, (halo)alkyloxy, nitro, cyano groups as well as by halogen atoms, Ar2 represents a phenyl, pyridyl, pirimidinyl or triazinyl group and the derivatives thereof substituted by C1-4 (halo)alkyl, C1-4 (halo)alkyloxy, amino, O-acyl, O-arylsulphonyl, O-(substituted carbamoyl) groups as well as by halogen atoms. According to the invention N-halogen aryl sulphonamidate is reacted in the presence of a carbonylating catalyst, carbon monoxide and an aromatic amine, optionally in the presence of a phase transfer catalyst, or N-halogen aryl sulphonamidate is reacted with carbon monoxide in the presence of a carbonylating catalyst, and optionally in the presence of a phase transfer catalyst, then the obtained reaction mixture is further reacted with an aromatic amine or an N-halogen-arylamine-alkali metal salt is reacted with aryl-sulphonamid in the presence of a carbonylating catalyst, carbon monoxide and optionally in the presence of a phase transfer catalyst or an amine, amine dihalogenid, aryl sulphonamid are reacted in the presence of a carbonylating catalyst and carbon monoxide and the obtained reaction mixture is worked up in a known manner. The thus prepared sulphonyl-ureas are biologically active compounds, which are used in the pharmaceutical industry and for regulating plant growth.

3. 发明专利

HUT51249A PROCESS FOR PRODUCTION OF N-/ARYL-SULPHONIL/-CARBAMIDES 未知
公开(公告)号：HUT51249A
公开(公告)日：1990-04-28
申请号：HU388888
申请日：1988-07-22
申请人： MTA KOEZPONTI KEMIAI KUTATO IN , NITROKEMIA IPARTELEPEK
发明人： BESENYEI GABOR , NEMETH SANDOR , SIMANDI LASZLO , BELAK MARIA , DUKAI JOZSEF , NAGY LAJOS , TOEMOERDI ELEMER , SOEPTEI CSABA
IPC分类号： A01N20060101 , C07C303/36 , C07D20060101

4. 发明专利

HUT51248A PROCESS FOR PRODUCTION OF N-/ARYL-SULPHONIL/-CARBAMIDE ACID ESTHERS AND N-/ARYL-SULPHONIL/-THIO-CARBAMIDE ACID-S-ESTERS 未知
公开(公告)号：HUT51248A
公开(公告)日：1990-04-28
申请号：HU388788
申请日：1988-07-22
申请人： MTA KOEZPONTI KEMIAI KUTATO IN , NITROKEMIA IPARTELEPEK
发明人： BESENYEI GABOR , NEMETH SANDOR , SIMANDI LASZLO , BELAK MARIA , DUKAI JOZSEF , NAGY LAJOS , TOEMOERDI ELEMER , SOEPTEI CSABA
IPC分类号： C07C303/36
摘要： In a new process for the prodn. of arylsulphony isocyanate derivs. of formula Ar-SO2-NM-Y (I), an N-halo-arylsulphonamidate of formula Ar-SO2-NH-CX=O (II) is reacted with carbon monoxide and ( simultaneously or subsequently) with an alcohol or thiol of formula HZR (III) or with carbon monoxide and an amine of formula HNR2R3 (IV) in a solvent at -20 to -130 deg.C under a carbon monoxide atmosphere with an initial pressure of 0.3-10 MPa for 0.5-24 hrs and subsequently working up the reaction mixture in a conventional manner, the reactions being carried out (A) in the presence of 0.01-10 wt.% (based on II) of a carbonylation catalyst which is a homogeneous, heterogeneous or immobilised homogeneous palladium complex (added to the reaction mixture or formed insditu in situ) in which the coordinative binding is through carbon, nitrogen, oxygen, phosphorus, sulphur and/or halogen atoms or a palladium complex with a group VII metal and (B) in the optional presence of 0.1-10 wt.% (based on (II)) of a phase-transfer catalyst: (where Ar is phenyl, naphtyl or thienyl op. substd. by 1-4C alkyl, 1-4C alkyl, 1-4C haloalkyl, haloalkoxy, NO2, CN or halogen; X is a residue -ZR1 or -NR2R3 or together with H forms a direct bond; Z is O or S; R1 is 1-8C alkyl, allyl, propargyl, 1-4C haloalkyl, cyclohexyl, benzyl or op. substd. phenyl; R2 and R3 are H, 1-4C alkyl, allyl, cyclohexyl, alkoxycarbonyl, arylsulphonyl, 2-4C acyl or opt. substd. benzoyl (R2 and R3 not both being H) or R2+R3 is a 4-6C alpha, omega-alkylene chain which may be interrupted by oxygen; Y is Cl or Br; and M is Na, K, or a quaternary ammonium or quaternary phosphonium ion).

5. 发明专利

HUT51246A PROCESS FOR PRODUCTION OF ARYL-SULPHONIL-IZOZYANATES 未知
公开(公告)号：HUT51246A
公开(公告)日：1990-04-28
申请号：HU311588
申请日：1988-06-17
申请人： MTA KOEZPONTI KEMIAI KUTATO IN , NITROKEMIA IPARTELEPEK
发明人： BESENYEI GABOR , NEMETH SANDOR , SIMANDI LASZLO , BELAK MARIA , DUKAI JOZSEF , NAGY LAJOS , TOEMOERDI ELEMER , SOEPTEI CSABA
IPC分类号： C07C263/00 , C07C311/65
摘要： In a new process for the prodn. of arylsulphony isocyanate derivs. of formula Ar-SO2-NM-Y (I), an N-halo-arylsulphonamidate of formula Ar-SO2-NH-CX=O (II) is reacted with carbon monoxide and ( simultaneously or subsequently) with an alcohol or thiol of formula HZR (III) or with carbon monoxide and an amine of formula HNR2R3 (IV) in a solvent at -20 to -130 deg.C under a carbon monoxide atmosphere with an initial pressure of 0.3-10 MPa for 0.5-24 hrs and subsequently working up the reaction mixture in a conventional manner, the reactions being carried out (A) in the presence of 0.01-10 wt.% (based on II) of a carbonylation catalyst which is a homogeneous, heterogeneous or immobilised homogeneous palladium complex (added to the reaction mixture or formed insditu in situ) in which the coordinative binding is through carbon, nitrogen, oxygen, phosphorus, sulphur and/or halogen atoms or a palladium complex with a group VII metal and (B) in the optional presence of 0.1-10 wt.% (based on (II)) of a phase-transfer catalyst: (where Ar is phenyl, naphtyl or thienyl op. substd. by 1-4C alkyl, 1-4C alkyl, 1-4C haloalkyl, haloalkoxy, NO2, CN or halogen; X is a residue -ZR1 or -NR2R3 or together with H forms a direct bond; Z is O or S; R1 is 1-8C alkyl, allyl, propargyl, 1-4C haloalkyl, cyclohexyl, benzyl or op. substd. phenyl; R2 and R3 are H, 1-4C alkyl, allyl, cyclohexyl, alkoxycarbonyl, arylsulphonyl, 2-4C acyl or opt. substd. benzoyl (R2 and R3 not both being H) or R2+R3 is a 4-6C alpha, omega-alkylene chain which may be interrupted by oxygen; Y is Cl or Br; and M is Na, K, or a quaternary ammonium or quaternary phosphonium ion).

6. 发明专利

DE3919747A1 未知
公开(公告)号：DE3919747A1
公开(公告)日：1989-12-21
申请号：DE3919747
申请日：1989-06-16
申请人： MAGYAR TUDOMANYOS AKADEMIA , NITROKEMIA IPARTELEPEK
发明人： BESENYEI GABOR , NEMETH SANDOR , SIMANDI LASZLO , BELAK MARIA , DUKAI JOZSEF , NAGY LAJOS , TOEMOERDI ELEMER , SOEPTEI CSABA , DIOSZEGINE ERZSEBET EICHHARDT
IPC分类号： C07D333/34 , A01N47/34 , A01N47/40 , B01J31/16 , C07B61/00 , C07C311/53 , C07C311/57 , C07C311/65
摘要： The invention relates to a process for preparing arylsulphonyl isocyanates of the general formula (I) (I) and addition derivatives thereof-where in the formula the meaning of the substituents are as follows: Ar represents optionally substituted aryl, naphthyl- or thienyl group, and HX is a chemical bond or X ZR1 stands for a group where Z is oxygen or sulphur, R1 is saturated or unsaturated alkyl, benzyl, cyclohexyl or substituted phenyl group or X is an NR2R3 group wherein R2R3 is hydrogen, alkyl, unsubstituted alkyl, aryl, substituted aryl, aroyl or acyl group, and the essence of the process is that an N-halogen sulphonamidate is carbonylated in the presence of a carbonylating catalyst, in the presence or absence of alcohol, (thio) alcohol or amine reactants and the carbonylated compound obtained is reacted subsequently with the reactants.

7. 发明专利

ES2010631A6 PROCEDIMIENTO DE PREPARAR N-SULFONIL-UREAS. 未知
公开(公告)号：ES2010631A6
公开(公告)日：1989-11-16
申请号：ES8901091
申请日：1989-03-03
申请人： NITROKEMIA IPARTELEPEK , MAGYAR TUDOMANYOS AKADEMIA
发明人： BENSENYEI GABOR , NEMETH SANDOR , SIMANDI LASZLO , BELAK MARIA , SZABO MARIA , DUKAI JOZSEF , NAGY LAJOS , TOMORDI ELEMER , SOPTEI CSABA , EICHHARDT DIOSZEGINE ERZSEBET
IPC分类号： C07D251/16 , B01J27/13 , B01J31/16 , C07B61/00 , C07C311/60 , C07D213/75 , C07D239/42 , C07D251/18 , C07D251/22 , C07D251/46 , C07D333/34 , C07D521/00 , C07C127/19 , C07C126/00 , C07D211/00 , C07D251/00 , C07D253/00
摘要： PROCEDIMIENTO DE PREPARAR N-SULFONIL-UREAS DE LA FORMULA GENERAL (I) EN QUE H-HALOGEN-ARILSULFONAMIDATOS SE TRANSFORMAN EN PRESENCIA DE UN CATALIZADOR DE CARBONIZACION, MONOXIDO DE CARBONO Y UNA AMINA AROMATICA Y, EN SU CASO, EN PRESENCIA DE UN CATALIZADOR DE TRANSFERENCIA DE FASE; O N-HALOGEN-ARILSULFONAMIDATOS SE TRANSFORMAN CON MONOXIDO DE CARBONO EN PRESENCIA DE UN CATALIZADOR DE CARBONIZACION Y, EN SU CASO, DE UN CATALIZADOR DE TRANSFERENCIA DE FASE Y LA MEZCLA DE REACCION OBTENIDA SE TRANSFORMA CON UNA AMINA AROMATICA; O SAL METALICA ALCALINA DE N-HALOGEN-ARILAMINA SE TRANSFORMA EN PRESENCIA DE UN CATALIZADOR DE CARBONIZACION, MONOXIDO DE CARBONO Y UNA ARILSULFONAMIDA Y, EN SU CASO, EN PRESENCIA DE UN CATALIZADOR DE TRANSFERENCIA DE FASE; OTRAS VARIANTES DEL PROCEDIMIENTO SE INDICAN EN LA DESCRIPCION. LAS SULFONILUREAS PREPARADAS SON BIOLOGICAMENTE ACTIVAS Y TIENEN APLICACION EN LA INDUSTRIA FARMACEUTICA Y EN LA REGULARIZACION DEL CRECIMIENTO DE PLANTAS.

8. 发明专利

PT89901A 未知
公开(公告)号：PT89901A
公开(公告)日：1989-11-10
申请号：PT8990189
申请日：1989-03-03
申请人： NITROKEMIA IPARTELEPEK , MAGYAR TUDOM AKAD KOZPONTI KEM
发明人： SPOTEI CSABA , SZABO MARIA , NAGY LAJOS , BESENYEI GABOR , NEMETH SANDOR , SIMANDI LASZLO , BELAK MARIA , DUKAI JOZSEF , TOMORDI ELEMER , DIOSZEGINE ERZSEBET EICHHARDT
IPC分类号： B01J27/13 , B01J31/16 , C07B61/00 , C07C311/60 , C07D213/75 , C07D251/16 , C07D239/42 , C07D251/18 , C07D251/22 , C07D251/46 , C07D333/34 , C07D521/00 , C07C157/00 , C07D333/00 , C07D213/00 , C07D239/00 , C07D251/00
摘要： The invention relates to a process for preparing sulphonyl-ureas of the general formula (I) (I) wherein Ar1 represents a phenyl, naphthyl or thienyl group, the derivatives thereof substituted by C1-4 alkyl, C1-4 haloalkyl, (halo)alkoxycarbonyl, (halo)alkyloxy, nitro, cyano groups as well as by halogen atoms, Ar2 represents a phenyl, pyridyl, pirimidinyl or triazinyl group and the derivatives thereof substituted by C1-4 (halo)alkyl, C1-4 (halo)alkyloxy, amino, O-acyl, O-arylsulphonyl, O-(substituted carbamoyl) groups as well as by halogen atoms. According to the invention N-halogen aryl sulphonamidate is reacted in the presence of a carbonylating catalyst, carbon monoxide and an aromatic amine, optionally in the presence of a phase transfer catalyst, or N-halogen aryl sulphonamidate is reacted with carbon monoxide in the presence of a carbonylating catalyst, and optionally in the presence of a phase transfer catalyst, then the obtained reaction mixture is further reacted with an aromatic amine or an N-halogen-arylamine-alkali metal salt is reacted with aryl-sulphonamid in the presence of a carbonylating catalyst, carbon monoxide and optionally in the presence of a phase transfer catalyst or an amine, amine dihalogenid, aryl sulphonamid are reacted in the presence of a carbonylating catalyst and carbon monoxide and the obtained reaction mixture is worked up in a known manner. The thus prepared sulphonyl-ureas are biologically active compounds, which are used in the pharmaceutical industry and for regulating plant growth.

9. 发明专利

FR2632952B1 未知
公开(公告)号：FR2632952B1
公开(公告)日：1991-04-12
申请号：FR8908010
申请日：1989-06-16
申请人： NITROKEMIA IPARTELEPEK , MAGYAR TUDOMANYOS AKADEMIA
发明人： BENSENYEI GABOR , NEMETH SANDOR , SIMANDI LASZLO , BELAK MARIA , DUKAI JOZSEF , NAGY LAJOS , TOMORDI ELEMER , SOPTEI CSABA , DIOSZEGINE ERZSEBET EICHHARDT
IPC分类号： C07D333/34 , A01N47/34 , A01N47/40 , B01J31/16 , C07B61/00 , C07C311/53 , C07C311/57 , C07C311/65 , C07C143/828 , C07C143/83 , C07C143/833
摘要： The invention relates to a process for preparing arylsulphonyl isocyanates of the general formula (I) (I) and addition derivatives thereof-where in the formula the meaning of the substituents are as follows: Ar represents optionally substituted aryl, naphthyl- or thienyl group, and HX is a chemical bond or X ZR1 stands for a group where Z is oxygen or sulphur, R1 is saturated or unsaturated alkyl, benzyl, cyclohexyl or substituted phenyl group or X is an NR2R3 group wherein R2R3 is hydrogen, alkyl, unsubstituted alkyl, aryl, substituted aryl, aroyl or acyl group, and the essence of the process is that an N-halogen sulphonamidate is carbonylated in the presence of a carbonylating catalyst, in the presence or absence of alcohol, (thio) alcohol or amine reactants and the carbonylated compound obtained is reacted subsequently with the reactants.

10. 发明专利

HU202487B PROCESS FOR PRODUCING N-SULFONYLUREAS 未知
公开(公告)号：HU202487B
公开(公告)日：1991-03-28
申请号：HU106288
申请日：1988-03-04
申请人： MTA KOEZPONTI KEMIAI KUTATO IN , NITROKEMIA IPARTELEPEK
发明人： BESENYEI GABOR , NEMETH SANDOR , SIMANDI LASZLO , BELAK MARIA , SZABO MARIA , DUKAI JOZSEF , NAGY LAJOS , TOEMOERDI ELEMER , SOEPTEI CSABA , DIOSZEGINE EICHARDT ERZSEBET
IPC分类号： B01J27/13 , B01J31/16 , C07D251/16 , C07B61/00 , C07C311/60 , C07D213/75 , C07D239/42 , C07D251/18 , C07D251/22 , C07D251/46 , C07D333/34 , C07D521/00 , C07C311/57
摘要： The invention relates to a process for preparing sulphonyl-ureas of the general formula (I) (I) wherein Ar1 represents a phenyl, naphthyl or thienyl group, the derivatives thereof substituted by C1-4 alkyl, C1-4 haloalkyl, (halo)alkoxycarbonyl, (halo)alkyloxy, nitro, cyano groups as well as by halogen atoms, Ar2 represents a phenyl, pyridyl, pirimidinyl or triazinyl group and the derivatives thereof substituted by C1-4 (halo)alkyl, C1-4 (halo)alkyloxy, amino, O-acyl, O-arylsulphonyl, O-(substituted carbamoyl) groups as well as by halogen atoms. According to the invention N-halogen aryl sulphonamidate is reacted in the presence of a carbonylating catalyst, carbon monoxide and an aromatic amine, optionally in the presence of a phase transfer catalyst, or N-halogen aryl sulphonamidate is reacted with carbon monoxide in the presence of a carbonylating catalyst, and optionally in the presence of a phase transfer catalyst, then the obtained reaction mixture is further reacted with an aromatic amine or an N-halogen-arylamine-alkali metal salt is reacted with aryl-sulphonamid in the presence of a carbonylating catalyst, carbon monoxide and optionally in the presence of a phase transfer catalyst or an amine, amine dihalogenid, aryl sulphonamid are reacted in the presence of a carbonylating catalyst and carbon monoxide and the obtained reaction mixture is worked up in a known manner. The thus prepared sulphonyl-ureas are biologically active compounds, which are used in the pharmaceutical industry and for regulating plant growth.

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