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1. 发明申请

US20050136048A1 Assay buffer, compositions containing the same, and methods of using the same 有权
标题翻译：测定缓冲液，含有该组合物的组合物及其使用方法
公开(公告)号：US20050136048A1
公开(公告)日：2005-06-23
申请号：US11054672
申请日：2005-02-09
申请人： Michael Tsionsky , Eli Glezer , Selen Altunata , George Sigal , Jonathan Leland , Mark Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
发明人： Michael Tsionsky , Eli Glezer , Selen Altunata , George Sigal , Jonathan Leland , Mark Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
IPC分类号： G01N33/53 , C12Q1/42 , C12Q1/48 , G01N21/76 , G01N33/531 , G01N33/543 , G01N33/58 , G01N33/68 , A61K39/395
CPC分类号： G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
摘要： Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.
摘要翻译：组合物，试剂，试剂盒，系统，系统组分和用于进行测定的方法。更具体地说，本发明涉及使用新颖的试剂组合来提供改进的测定性能。

2. 发明申请

US20050136497A1 Assay buffer, compositions containing the same, and methods of using the same 有权
公开(公告)号：US20050136497A1
公开(公告)日：2005-06-23
申请号：US11055472
申请日：2005-02-09
申请人： Michael Tsionsky , Eli Glezer , Selen Altunata , George Sigal , Jonathan Leland , Mark Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
发明人： Michael Tsionsky , Eli Glezer , Selen Altunata , George Sigal , Jonathan Leland , Mark Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
IPC分类号： G01N33/53 , C12Q1/42 , C12Q1/48 , G01N21/76 , G01N33/531 , G01N33/543 , G01N33/58 , G01N33/68 , G01N33/537
CPC分类号： G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
摘要： Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.

3. 发明申请

US20060019319A1 Methods and apparatuses for conducting assays 有权
公开(公告)号：US20060019319A1
公开(公告)日：2006-01-26
申请号：US11145528
申请日：2005-06-03
申请人： Mark Billadeau , Jeff Debad , Eli Glezer , Jonathan Leland , Charles Wijayawardhana
发明人： Mark Billadeau , Jeff Debad , Eli Glezer , Jonathan Leland , Charles Wijayawardhana
IPC分类号： G01N33/567
CPC分类号： G01N33/543 , G01N33/523 , G01N33/54366 , Y10T436/106664 , Y10T436/117497 , Y10T436/25125 , Y10T436/25375
摘要： Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.

4. 发明申请

US20060160246A1 Graphitic nanotubes in luminescence assays 有权
公开(公告)号：US20060160246A1
公开(公告)日：2006-07-20
申请号：US11385277
申请日：2006-03-20
申请人： Richard Massey , Mark Martin , Liwen Dong , Ming Lu , Alan Fischer , Fabian Jameison , Pam Liang , Robert Hoch , Jonathan Leland
发明人： Richard Massey , Mark Martin , Liwen Dong , Ming Lu , Alan Fischer , Fabian Jameison , Pam Liang , Robert Hoch , Jonathan Leland
IPC分类号： G01N33/543 , C12M1/34
CPC分类号： C01B31/0213 , B82Y30/00 , B82Y40/00 , C01B32/152 , C01B32/174 , C01B2202/34 , C01B2202/36 , C07K17/06 , D01F9/12 , D01F11/14 , G01N21/69 , G01N21/76 , G01N33/54373 , G01N33/5438 , G01N33/582 , G01N2030/8863 , G11C13/025 , H01M4/60 , Y10S435/968 , Y10S436/805 , Y10S436/806 , Y10S977/737 , Y10S977/742
摘要： Graphitic nanotubes, which include tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.

5. 发明申请

US20080057559A1 Rate measurements of biomolecular reactions using electrochemiluminescence 审中-公开
标题翻译：使用电化学发光测量生物分子反应的速率
公开(公告)号：US20080057559A1
公开(公告)日：2008-03-06
申请号：US11785511
申请日：2007-04-18
申请人： Laurette Nacamulli , Jonathan Leland , Stephanie Hayes
发明人： Laurette Nacamulli , Jonathan Leland , Stephanie Hayes
IPC分类号： C12N9/00 , G01N31/00
CPC分类号： C12Q1/00 , G01N33/557 , G01N33/582
摘要： The rate of a biomolecular reaction, such as an enzymatic reaction or an affinity binding reaction, is measured using electrochemiluminescence (“ECL”). The reaction is conducted in an electrochemical cell with a mixture of reagents including a luminophore which will relate the concentration of a reactant, a reaction partner or the reaction product of a reaction partner to the ECL intensity. The reaction partner is a reagent which reacts with the reactant and which participates with the luminophore (or its reaction product participates with the luminophore) to cause the emission of ECL. The ECL intensity is modulated with a series of electrical pulses which are applied to the mixture of reagents at a preselected potential and for preselected intervals of time and duration. The ECL intensity is measured at the same intervals to provide a timed series of values (P). The same experiment is repeated except that the modulation is conducted after the reaction has gone to completion to obtain a timed series of values (C). The same experiment is repeated a third time in the absence of the reaction partner to obtain a times series of values (B). The results are normalized (N) using the following formula: N = P - B C - B ( I ) to obtain a series of values N which can be used to plot the time course (concentration vs. time) of the reaction.
摘要翻译：使用电化学发光（“ECL”）测量生物分子反应的速率，例如酶反应或亲和结合反应。反应在具有包含发光体的试剂混合物的电化学电池中进行，其将反应物的浓度，反应配对物或反应物的反应产物与ECL强度相关联。反应伴侣是与反应物反应并与发光体（或其反应产物与发光体一起参与）引起ECL的发射的试剂。 ECL强度用一系列电脉冲进行调制，这些电脉冲以预先选择的电位和预选的时间和持续时间间隔施加到试剂的混合物。以相同的间隔测量ECL强度以提供定时的一系列值（P）。重复相同的实验，除了在反应完成之后进行调制以获得定时系列值（C）。在没有反应配偶体的情况下，第三次重复相同的实验以获得值（B）的时间序列。使用以下公式对结果进行归一化（N）： $\begin{matrix} MI> N PC-B（I）的值N可用于绘制反应的时间过程（浓度对时间）。 \end{matrix}$

6. 发明申请

US20070031283A1 Assay cartridges and methods for point of care instruments 审中-公开
标题翻译：用于点护理仪器的分析盒和方法
公开(公告)号：US20070031283A1
公开(公告)日：2007-02-08
申请号：US11473535
申请日：2006-06-23
申请人： Charles Davis , John Liljestrand , Jonathan Leland , Martin Blankfard , Jonathan Miller
发明人： Charles Davis , John Liljestrand , Jonathan Leland , Martin Blankfard , Jonathan Miller
IPC分类号： G01N31/22
CPC分类号： G01N33/582 , A61B5/14546 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150251 , A61B5/150358 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150786 , A61B5/150793 , A61B5/150862 , A61B5/15087 , A61B5/150893 , A61B5/15107 , A61B5/15117 , A61B5/15142 , A61B5/157 , A61B5/411 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L3/502776 , B01L7/00 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2300/022 , B01L2300/0627 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/1805 , B01L2300/1861 , B01L2300/1877 , B01L2400/0406 , B01L2400/0442 , B01L2400/046 , B01L2400/0481 , B01L2400/0487 , B01L2400/0633 , B01L2400/0677 , B01L2400/0683 , B01L2400/0688 , G01N21/6428 , G01N21/648 , G01N21/8483 , G01N33/5002 , G01N33/5302 , G01N33/54326 , G01N33/54346 , G01N33/54386 , G01N35/0098 , G01N2035/00108
摘要： Devices and methods are provided for performing a test to detect and/or quantify the presence of an analyte of interest within a sample using a portable instrument.
摘要翻译：提供了装置和方法，用于使用便携式仪器进行测试以检测和/或定量样品内感兴趣的分析物的存在。

7. 发明申请

US20070116600A1 Detection device and methods associated therewith 审中-公开
标题翻译：与之相关的检测装置和方法
公开(公告)号：US20070116600A1
公开(公告)日：2007-05-24
申请号：US11474099
申请日：2006-06-23
申请人： Manish Kochar , Charles Davis , Jonathan Leland , Richard Manteuffel , Richard Cook
发明人： Manish Kochar , Charles Davis , Jonathan Leland , Richard Manteuffel , Richard Cook
IPC分类号： G01N33/00
CPC分类号： G01N21/76 , B01L3/5082 , B01L2200/025 , B01L2300/0858 , G01N33/54326 , G01N33/5438 , G01N35/00 , G01N2035/0436 , G01N2035/0493 , G01N2035/1025
摘要： Detection devices and methods associated therewith are provided. In some embodiments, the detection system can be adapted to measure one or more analytes of interest possibly present in a sample through the use of binding reactions.
摘要翻译：提供与其相关联的检测装置和方法。在一些实施方案中，检测系统可以适于通过使用结合反应来测量样品中可能存在的一种或多种感兴趣的分析物。

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