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1. 发明授权

US08685458B2 Pharmaceutical compositions of dextran polymer derivatives 有权
标题翻译：葡聚糖聚合物衍生物的药物组合物
公开(公告)号：US08685458B2
公开(公告)日：2014-04-01
申请号：US13254802
申请日：2010-03-03
申请人： Warren K. Miller , David T. Vodak , Daniel E. Dobry , David K. Lyon , Dwayne T. Friesen , Michael M. Morgen , Corey J. Bloom , Daniel T. Smithey
发明人： Warren K. Miller , David T. Vodak , Daniel E. Dobry , David K. Lyon , Dwayne T. Friesen , Michael M. Morgen , Corey J. Bloom , Daniel T. Smithey
IPC分类号： A61P11/00 , A61K9/14 , A61K31/721 , B82Y5/00
CPC分类号： A61K47/36 , A61K9/0019 , A61K9/0048 , A61K9/0075 , A61K9/0095 , A61K9/10 , A61K9/1652 , A61K9/19 , A61K9/5161 , A61K31/57
摘要： Pharmaceutical compositions are provided comprising an active agent and a dextran polymer derivative. The compositions include from 0.01 to 99 wt % of an active agent and from 1 to 99.99 wt % of a dextran polymer derivative. The dextran polymer derivative is selected from dextran acetate, dextran propionate, dextran succinate, dextran acetate propionate, dextran acetate succinate, dextran propionate succinate, dextran acetate propionate succinate, and mixtures thereof.
摘要翻译：提供包含活性剂和葡聚糖聚合物衍生物的药物组合物。组合物包含0.01至99重量％的活性剂和1至99.99重量％的葡聚糖聚合物衍生物。葡聚糖聚合物衍生物选自葡聚糖乙酸酯，葡聚糖丙酸酯，葡聚糖琥珀酸酯，乙酸葡聚糖丙酸酯，醋酸葡聚糖琥珀酸酯，琥珀酸葡聚糖葡聚糖，琥珀酸葡聚糖乙酸酯及其混合物。

2. 发明申请

US20120003282A1 PHARMACEUTICAL COMPOSITIONS OF DEXTRAN POLYMER DERIVATIVES 有权
标题翻译： DEXTRAN聚合物衍生物的药物组合物
公开(公告)号：US20120003282A1
公开(公告)日：2012-01-05
申请号：US13254802
申请日：2010-03-03
申请人： Warren K. Miller , David T. Vodak , Daniel E. Dobry , David K. Lyon , Dwayne T. Friesen , Michael M. Morgen , Corey J. Bloom , Daniel t. Smithey
发明人： Warren K. Miller , David T. Vodak , Daniel E. Dobry , David K. Lyon , Dwayne T. Friesen , Michael M. Morgen , Corey J. Bloom , Daniel t. Smithey
IPC分类号： A61K9/14 , A61K31/216 , A61K31/428 , A61P7/00 , A61P9/10 , A61P9/12 , A61P25/00 , A61K31/56 , A61P29/00 , B82Y5/00
CPC分类号： A61K47/36 , A61K9/0019 , A61K9/0048 , A61K9/0075 , A61K9/0095 , A61K9/10 , A61K9/1652 , A61K9/19 , A61K9/5161 , A61K31/57
摘要： Pharmaceutical compositions are provided comprising an active agent and a dextran polymer derivative. The compositions include from 0.01 to 99 wt % of an active agent and from 1 to 99.99 wt % of a dextran polymer derivative. The dextran polymer derivative is selected from dextran acetate, dextran propionate, dextran succinate, dextran acetate propionate, dextran acetate succinate, dextran propionate succinate, dextran acetate propionate succinate, and mixtures thereof.
摘要翻译：提供包含活性剂和葡聚糖聚合物衍生物的药物组合物。组合物包含0.01至99重量％的活性剂和1至99.99重量％的葡聚糖聚合物衍生物。葡聚糖聚合物衍生物选自葡聚糖乙酸酯，葡聚糖丙酸酯，葡聚糖琥珀酸酯，乙酸葡聚糖丙酸酯，醋酸葡聚糖琥珀酸酯，琥珀酸葡聚糖葡聚糖，琥珀酸葡聚糖乙酸酯及其混合物。

3. 发明授权

US09060938B2 Pharmaceutical compositions of active agents and cationic dextran polymer derivatives 有权
标题翻译：活性剂和阳离子葡聚糖聚合物衍生物的药物组合物
公开(公告)号：US09060938B2
公开(公告)日：2015-06-23
申请号：US13468997
申请日：2012-05-10
申请人： Warren K. Miller , Michael M. Morgen , Corey J. Bloom
发明人： Warren K. Miller , Michael M. Morgen , Corey J. Bloom
IPC分类号： A61K31/721 , A61K9/14 , A61K9/72 , A61K9/16 , A61K9/00 , A61K31/4422 , C08B37/02 , C08L5/02
CPC分类号： A61K9/1652 , A61K9/0075 , A61K31/4422 , C08B37/0021 , C08L5/02
摘要： Solid dry powder compositions comprising active agents and dextran polymer derivatives comprising an ester-linked amine-containing substituent and an alkyl ester substituent are disclosed, as are methods for making such compositions.
摘要翻译：公开了包含活性剂和包含酯连接的含胺取代基和烷基酯取代基的葡聚糖聚合物衍生物的固体干粉组合物，以及制备这种组合物的方法。

4. 发明申请

US20120289469A1 METHODS AND COMPOSITIONS FOR MAINTAINING ACTIVE AGENTS IN INTRA-ARTICULAR SPACES 有权
标题翻译：维持空间中活性剂的方法和组合
公开(公告)号：US20120289469A1
公开(公告)日：2012-11-15
申请号：US13468965
申请日：2012-05-10
申请人： Michael M. Morgen , Warren K. Miller
发明人： Michael M. Morgen , Warren K. Miller
IPC分类号： A61K47/36 , A61P19/02 , A61K38/06 , A61K31/721 , A61K47/32 , B82Y5/00
CPC分类号： A61K9/1652 , A61K9/0075 , A61K31/4422 , C08B37/0021 , C08L5/02
摘要： Methods and compositions for maintaining an active agent in an intra-articular space are disclosed. Methods of delivering the compositions to an intra-articular space and methods of making the compositions also are disclosed. The compositions comprise an active agent and a polymer comprising at least one cationic group. A fluid including the composition may be injected into an intra-articular space in a human or animal whereby the composition associates with endogenous material in the intra-articular space. In some embodiments, the fluid further comprises a poorly aqueous soluble polymer.
摘要翻译：公开了在关节内空间中维持活性剂的方法和组合物。将组合物递送至关节间隙的方法以及制备组合物的方法也被公开。组合物包含活性剂和包含至少一个阳离子基团的聚合物。包括组合物的流体可以注射到人或动物的关节内空间中，由此该组合物与关节内空间内的内源物质相关联。在一些实施方案中，流体还包含水溶性差的聚合物。

5. 发明申请

US20120283427A1 CATIONIC DEXTRAN POLYMER DERIVATIVES 有权
标题翻译：阳离子衍生聚合物衍生物
公开(公告)号：US20120283427A1
公开(公告)日：2012-11-08
申请号：US13471266
申请日：2012-05-14
申请人： Warren K. Miller , Michael M. Morgen , Corey J. Bloom
发明人： Warren K. Miller , Michael M. Morgen , Corey J. Bloom
IPC分类号： C08B37/02
CPC分类号： C08B37/0021
摘要： Cationic dextran polymer derivatives including an ester-linked amine-containing substituent and an alkyl ester substituent and methods for making such dextran polymer derivatives are disclosed.
摘要翻译：公开了包含酯连接的含胺取代基和烷基酯取代基的阳离子葡聚糖聚合物衍生物和制备这种葡聚糖聚合物衍生物的方法。

6. 发明授权

US09084727B2 Methods and compositions for maintaining active agents in intra-articular spaces 有权
标题翻译：维持活动剂在关节间隙中的方法和组合物
公开(公告)号：US09084727B2
公开(公告)日：2015-07-21
申请号：US13468965
申请日：2012-05-10
申请人： Michael M. Morgen , Warren K. Miller
发明人： Michael M. Morgen , Warren K. Miller
IPC分类号： C08B37/02 , A61K31/721 , A61K9/16 , A61K9/00 , A61K31/4422 , C08L5/02
CPC分类号： A61K9/1652 , A61K9/0075 , A61K31/4422 , C08B37/0021 , C08L5/02
摘要： Methods and compositions for maintaining an active agent in an intra-articular space are disclosed. Methods of delivering the compositions to an intra-articular space and methods of making the compositions also are disclosed. The compositions comprise an active agent and a polymer comprising at least one cationic group. A fluid including the composition may be injected into an intra-articular space in a human or animal whereby the composition associates with endogenous material in the intra-articular space. In some embodiments, the fluid further comprises a poorly aqueous soluble polymer.
摘要翻译：公开了在关节内空间中维持活性剂的方法和组合物。将组合物递送至关节间隙的方法以及制备组合物的方法也被公开。组合物包含活性剂和包含至少一个阳离子基团的聚合物。包括组合物的流体可以注射到人或动物的关节内空间中，由此该组合物与关节内空间内的内源物质相关联。在一些实施方案中，流体还包含水溶性差的聚合物。

7. 发明授权

US08735570B2 Cationic dextran polymer derivatives 有权
标题翻译：阳离子葡聚糖聚合物衍生物
公开(公告)号：US08735570B2
公开(公告)日：2014-05-27
申请号：US13471266
申请日：2012-05-14
申请人： Warren K. Miller , Michael M. Morgen , Corey J. Bloom
发明人： Warren K. Miller , Michael M. Morgen , Corey J. Bloom
IPC分类号： C08B37/02 , A61K31/721
CPC分类号： C08B37/0021
摘要： Cationic dextran polymer derivatives including an ester-linked amine-containing substituent and an alkyl ester substituent and methods for making such dextran polymer derivatives are disclosed.
摘要翻译：公开了包含酯连接的含胺取代基和烷基酯取代基的阳离子葡聚糖聚合物衍生物和制备这种葡聚糖聚合物衍生物的方法。

8. 发明申请

US20120288491A1 PHARMACEUTICAL COMPOSITIONS OF ACTIVE AGENTS AND CATIONIC DEXTRAN POLYMER DERIVATIVES 有权
标题翻译：活性剂和阳离子衍生物聚合物衍生物的药物组合物
公开(公告)号：US20120288491A1
公开(公告)日：2012-11-15
申请号：US13468997
申请日：2012-05-10
申请人： Warren K. Miller , Michael M. Morgen , Corey J. Bloom
发明人： Warren K. Miller , Michael M. Morgen , Corey J. Bloom
IPC分类号： A61K47/36 , A61K31/7088 , A61K39/395 , A61K39/00 , A61K31/4418 , A61K38/00
CPC分类号： A61K9/1652 , A61K9/0075 , A61K31/4422 , C08B37/0021 , C08L5/02
摘要： Solid dry powder compositions comprising active agents and dextran polymer derivatives comprising an ester-linked amine-containing substituent and an alkyl ester substituent are disclosed, as are methods for making such compositions.
摘要翻译：公开了包含活性剂和包含酯连接的含胺取代基和烷基酯取代基的葡聚糖聚合物衍生物的固体干粉组合物，以及制备这种组合物的方法。

9. 发明授权

US5744980A Flexible, high-performance static RAM architecture for field-programmable gate arrays 失效
标题翻译：用于现场可编程门阵列的灵活高性能静态RAM架构
公开(公告)号：US5744980A
公开(公告)日：1998-04-28
申请号：US603597
申请日：1996-02-16
申请人： John E. McGowan , William C. Plants , Joel D. Landry , Sinan Kaptanoglu , Warren K. Miller
发明人： John E. McGowan , William C. Plants , Joel D. Landry , Sinan Kaptanoglu , Warren K. Miller
IPC分类号： H03K19/177
CPC分类号： H03K19/1776 , H03K19/17704
摘要： A field programmable gate array architecture comprises a plurality of horizontal and vertical routing channels each including a plurality of interconnect conductors. Some interconnect conductors are segmented by user-programmable interconnect elements, and some horizontal and vertical interconnect conductors are connectable by user-programmable interconnect elements located at selected intersections between them. An array of rows and columns of logic function modules each having at least one input and one output is superimposed on the routing channels. The inputs and outputs of the logic function modules are connectable to ones of the interconnect conductors in either or both of the horizontal and vertical routing channels. At least one column of random access memory blocks is disposed in the array. Each random access memory block spans a distance of more than one row of the array such that more than one horizontal routing channel passes therethrough and is connectable to adjacent logic function modules on either side thereof. Each of the random access memory blocks has address inputs, control inputs, data inputs, and data outputs. User-programmable interconnect elements are connected between the address inputs, control inputs, data inputs, and data outputs of the random access memory blocks and selected ones of the interconnect conductors in the horizontal routing channels passing therethrough. Programming circuitry is provided for programming selected ones of the user-programmable interconnect conductors to connect the inputs and outputs of the logic function modules to one another and to the address inputs, control inputs, data inputs, and data outputs of the random access memory blocks.
摘要翻译：现场可编程门阵列架构包括多个水平和垂直路由通道，每个路由通道包括多个互连导体。一些互连导体由用户可编程互连元件分段，并且一些水平和垂直互连导体可由位于它们之间的选定交叉处的用户可编程互连元件连接。每个具有至少一个输入和一个输出的逻辑功能模块的行和列阵列叠加在路由信道上。逻辑功能模块的输入和输出可连接到水平和垂直路由通道中的一个或两者中的互连导体中的一个。至少一列随机存取存储器块被布置在阵列中。每个随机存取存储器块跨越阵列的多于一行的距离，使得多于一个的水平路由信道通过其中并且可连接到其任一侧的相邻逻辑功能模块。每个随机存取存储块具有地址输入，控制输入，数据输入和数据输出。用户可编程互连元件连接在随机存取存储器块的地址输入，控制输入，数据输入和数据输出以及通过其中的水平路由通道中的选定的互连导体。提供了编程电路，用于编程用户可编程互连导体中的所选择的一个以将逻辑功能模块的输入和输出彼此连接，并将随机存取存储器块的地址输入，控制输入，数据输入和数据输出。

10. 发明授权

US5008099A Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor 失效
标题翻译：淀粉样变性和阿尔茨海默病诊断测定及其试剂
公开(公告)号：US5008099A
公开(公告)日：1991-04-16
申请号：US510461
申请日：1990-04-17
申请人： Steven C. Quay , Scott M. Rocklage , Warren K. Miller
发明人： Steven C. Quay , Scott M. Rocklage , Warren K. Miller
IPC分类号： A61K51/04 , C07C309/47 , C07C309/50 , C07D277/66 , C09B29/01 , C09B29/30 , C09B35/08 , C09B35/16 , C09B35/20 , C09B43/40 , G01N33/68
CPC分类号： G01N33/6896 , A61K51/0406 , C07C309/47 , C07C309/50 , C07D277/66 , C09B29/0003 , C09B29/0011 , C09B29/30 , C09B35/08 , C09B35/16 , C09B35/20 , C09B43/40 , A61K2123/00 , G01N2800/2821
摘要： The presence and location of amyloid deposits in an organ or body area of a patient is effected by intravenous administration of novel radioactive iodine-labeled amyloid binding compounds and preferably .sup.123 I-labeled compounds to the patient and sensing radiation emitted from the organ or body area. Novel non-radioactive iodine substituted amyloid binding compounds and amyloid binding compounds which are readily iodinated are further aspects or the invention.
摘要翻译：淀粉样蛋白沉积物在患者的器官或身体区域中的存在和位置通过向患者静脉内施用新的放射性碘标记的淀粉样蛋白结合化合物和优选123I标记的化合物来实现，并感测从器官或身体区域发射的辐射。容易碘化的新型非放射性碘取代的淀粉样蛋白结合化合物和淀粉样蛋白结合化合物是其它方面或本发明。

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