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1. 发明申请

US20100188666A1 METHOD FOR BEAM CALIBRATION AND USAGE OF A CALIBRATION BODY 有权
标题翻译：光束校准方法和校准体的使用
公开(公告)号：US20100188666A1
公开(公告)日：2010-07-29
申请号：US11813334
申请日：2006-01-05
申请人： Matthias Brunner , Ralf Schmid , Bernhard Mueller , Axel Wenzel
发明人： Matthias Brunner , Ralf Schmid , Bernhard Mueller , Axel Wenzel
IPC分类号： G01B11/14
CPC分类号： G09G3/006 , G01R31/305 , G01R31/308 , G01R35/005 , H01J2237/2826
摘要： The invention relates to a method of calibration of the beam position of a corpuscular beam. A calibration body with structures is used, wherein the structures have a structure period Ps in the plain section and within each structure there is a position L intended for the measurement. For the calibration, at least one detection signal each at structures in the plain section of the calibration body is generated, wherein the corpuscular beam is deflected with deflectors on beam target positions L1 with the beam target period P1, which is larger than half of the structure period Ps, whereby a basic calibration is used for the control of the deflectors, and wherein the beam target deflections intentionally deviate either in the beam target period P1 from the structure period Ps and/or in the beam target position L1 from the position L.
摘要翻译：本发明涉及一种校准红细胞束的束位置的方法。使用具有结构的校准体，其中结构在平坦部分中具有结构周期Ps，并且在每个结构内具有用于测量的位置L. 对于校准，生成校准体的平坦部分中的结构处的至少一个检测信号，其中，粒子束在束目标位置L1上被偏转器偏转，其中光束目标周期P1大于结构周期Ps，由此基准校准用于偏转器的控制，并且其中光束目标偏转有意地在光束目标周期P1中与结构周期Ps和/或光束目标位置L1从位置L 。

2. 发明授权

US08009299B2 Method for beam calibration and usage of a calibration body 有权
标题翻译：用于光束校准和使用校准体的方法
公开(公告)号：US08009299B2
公开(公告)日：2011-08-30
申请号：US11813334
申请日：2006-01-05
申请人： Matthias Brunner , Ralf Schmid , Bernhard Mueller , Axel Wenzel
发明人： Matthias Brunner , Ralf Schmid , Bernhard Mueller , Axel Wenzel
IPC分类号： G01B11/14
CPC分类号： G09G3/006 , G01R31/305 , G01R31/308 , G01R35/005 , H01J2237/2826
摘要： The invention relates to a method of calibration of the beam position of a corpuscular beam. A calibration body with structures is used, wherein the structures have a structure period PS in the plain section and within each structure there is a position L intended for the measurement. For the calibration, at least one detection signal each at structures in the plain section of the calibration body is generated, wherein the corpuscular beam is deflected with deflectors on beam target positions L1 with the beam target period P1, which is larger than half of the structure period PS, whereby a basic calibration is used for the control of the deflectors, and wherein the beam target deflections deviate either in the beam target period P1 from the structure period PS and/or in the beam target position L1 from the position L.
摘要翻译：本发明涉及一种校准红细胞束的束位置的方法。使用具有结构的校准体，其中结构在平坦部分中具有结构周期PS，并且在每个结构内具有用于测量的位置L. 对于校准，生成校准体的平坦部分中的结构处的至少一个检测信号，其中，粒子束在束目标位置L1上被偏转器偏转，其中光束目标周期P1大于结构周期PS，由此使用基准校准来控制偏转器，并且其中光束目标偏转在光束目标周期P1中与结构周期PS和/或从位置L的光束目标位置L1偏离。

3. 发明申请

US20130101605A1 MODULATORS AND MODULATION OF THE INTERACTION BETWEEN RGM AND NEOGENIN 审中-公开
标题翻译： RGM和NEOGENIN之间的相互作用的调节剂和调节
公开(公告)号：US20130101605A1
公开(公告)日：2013-04-25
申请号：US13547109
申请日：2012-07-12
申请人： Stephen Strittmatter , Bernhard Mueller
发明人： Stephen Strittmatter , Bernhard Mueller
IPC分类号： G01N33/68 , C07K16/28 , G01N33/53 , C07K14/705
CPC分类号： G01N33/68 , A61K2039/505 , C07K14/475 , C07K14/705 , C07K14/71 , C07K16/28 , G01N33/53 , G01N33/566 , G01N2500/00 , G01N2500/02 , G01N2500/10 , Y10S530/839
摘要： This invention relates to drug screening using mammalian repulsive guidance molecules and mammalian Neogenin. In addition, the invention provides for methods of preventing, alleviating or treating various disorders of the nervous system, angiogenic disorders or disorders of the cardio-vascular system and malignancies of different etiology by disrupting the interaction between RGM and Neogenin.
摘要翻译：本发明涉及使用哺乳动物排斥指导分子和哺乳动物Neogenin的药物筛选。此外，本发明提供了通过破坏RGM和Neogenin之间的相互作用来预防，减轻或治疗各种神经系统疾病，血管生成障碍或心血管系统病症和不同病因恶性肿瘤的方法。

4. 发明授权

US07771952B2 Modulators and modulation of the interaction between RGM and Neogenin 有权
标题翻译： RGM和Neogenin之间的相互作用的调节剂和调节
公开(公告)号：US07771952B2
公开(公告)日：2010-08-10
申请号：US10519132
申请日：2003-06-26
申请人： Stephen Strittmatter , Bernhard Mueller , Lutz Deitinghoff
发明人： Stephen Strittmatter , Bernhard Mueller , Lutz Deitinghoff
IPC分类号： G01N33/53 , C07K14/00 , C07K16/00 , A61K35/30
CPC分类号： G01N33/68 , A61K2039/505 , C07K14/475 , C07K14/705 , C07K14/71 , C07K16/28 , G01N33/53 , G01N33/566 , G01N2500/00 , G01N2500/02 , G01N2500/10 , Y10S530/839
摘要： This invention relates to drug screening using mammalian repulsive guidance molecules and mammalian Neogenin. In addition, the invention provides for methods of preventing, alleviating or treating various disorders of the nervous system, angiogenic disorders or disorders of the cardio-vascular system and malignancies of different etiology by disrupting the interaction between RGM and Neogenin.
摘要翻译：本发明涉及使用哺乳动物排斥指导分子和哺乳动物Neogenin的药物筛选。此外，本发明提供了通过破坏RGM和Neogenin之间的相互作用来预防，减轻或治疗各种神经系统疾病，血管生成障碍或心血管系统病症和不同病因恶性肿瘤的方法。

5. 发明申请

US20100001442A1 Method and Installation for the Dry Transformation of a Material Structure of Semifinished Products 有权
标题翻译：半成品材料结构干变换方法与安装
公开(公告)号：US20100001442A1
公开(公告)日：2010-01-07
申请号：US12083278
申请日：2006-09-25
申请人： Bernhard Mueller
发明人： Bernhard Mueller
IPC分类号： C21D1/62 , C21D1/00
CPC分类号： C21D1/20 , C21D1/613 , C21D1/62 , C21D1/767 , C21D9/00 , C21D2211/002
摘要： An installation for the dry transformation of a material structure of semifinished products, particularly for dry bainitization, includes a quenching chamber and heating and/or cooling mechanism for setting the temperature prevailing on the inside of the quenching chamber, wherein the heating and/or cooling mechanism is developed as heating or cooling mechanism of a wall that borders on an inner chamber of the quenching chamber.
摘要翻译：用于干燥转化半成品的材料结构的装置，特别是用于干燥贝氏体化的装置包括用于设定在淬火室内部的温度的淬火室和加热和/或冷却机构，其中加热和/或冷却机构被开发为与淬火室的内室接合的壁的加热或冷却机构。

6. 发明授权

US09109026B2 Dual variable domain immunoglobulins and uses thereof 有权
公开(公告)号：US09109026B2
公开(公告)日：2015-08-18
申请号：US12477668
申请日：2009-06-03
申请人： Tariq Ghayur , Alfred Hahn , Bernhard Mueller
发明人： Tariq Ghayur , Alfred Hahn , Bernhard Mueller
IPC分类号： C07K16/00 , C12P21/08 , C07H21/04 , C12P21/04 , C12N5/16 , C12N1/20 , C12N15/00 , A61K39/395 , A61K39/40 , C07K16/22 , C07K16/18 , C07K16/24 , C07K16/28 , C07K1/00
CPC分类号： C07K16/2869 , A61K39/3955 , A61K45/06 , A61K47/6843 , A61K47/6845 , A61K47/6849 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/248 , C07K16/28 , C07K16/2803 , C07K16/2863 , C07K16/2887 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/525 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

7. 发明申请

US20120118344A1 HEAT EXCHANGER AND METHOD FOR CONVERTING THERMAL ENERGY OF A FLUID INTO ELECTRICAL POWER 审中-公开
标题翻译：热交换器和将流体转化为电力的热能的方法
公开(公告)号：US20120118344A1
公开(公告)日：2012-05-17
申请号：US13318997
申请日：2010-05-12
申请人： Peter Schluck , Bernhard Mueller , Miroslaw Brzoza
发明人： Peter Schluck , Bernhard Mueller , Miroslaw Brzoza
IPC分类号： H01L35/30
CPC分类号： H01L35/30 , F01N5/025 , Y02T10/16
摘要： A heat exchanger for converting thermal energy of a fluid, e.g., exhaust gas of an internal combustion engine, into electrical power, has a flow channel for conveying a hot fluid, and at least one thermoelectric module for generating electrical power is thermally connected to the flow channel. The flow channel is manufactured from a ceramic material. Thermal expansion effects of the flow channel is reduced by the ceramic material of the flow channel so that the design complexity for converting thermal energy into electrical power is reduced.
摘要翻译：用于将流体（例如内燃机的废气）的热能转换为电力的热交换器具有用于输送热流体的流动通道，并且用于产生电力的至少一个热电模块热连接到流通道。流动通道由陶瓷材料制成。通过流动通道的陶瓷材料减少了流动通道的热膨胀效应，从而降低了将热能转换成电力的设计复杂性。

8. 发明申请

US20120067467A1 QUENCHING DEVICE AND QUENCHING METHOD 审中-公开
标题翻译：淬火装置和淬火方法
公开(公告)号：US20120067467A1
公开(公告)日：2012-03-22
申请号：US13144232
申请日：2009-12-02
申请人： Bernhard Mueller , Michael Loercher
发明人： Bernhard Mueller , Michael Loercher
IPC分类号： C21D1/62 , C21D1/18
CPC分类号： C21D1/767 , C21D1/613
摘要： A quenching device is described that includes at least one chamber that can be filled with quenching gas and that has a blower wheel for circulating quenching gas, in particular a quenching chamber and/or a flow channel, a drive motor, situated outside the chamber, for driving the blower being allocated to the blower wheel. The drive motor is coupled to the blower wheel so as to transmit torque via a coupling that operates in contactless fashion. Also described is a related quenching method.
摘要翻译：描述了一种淬火装置，其包括可以填充有淬火气体的至少一个室，并且具有用于循环淬火气体的鼓风机叶轮，特别是淬火室和/或流动通道，位于室外的驱动马达，用于驱动被分配给鼓风机轮的鼓风机。驱动马达联接到鼓风机叶轮，以通过以非接触方式操作的联轴器传递扭矩。还描述了相关的淬火方法。

9. 发明申请

US20110226782A1 GAS TEMPERATURE MODERATION WITHIN COMPRESSED GAS VESSEL THROUGH HEAT EXCHANGER 审中-公开
标题翻译：通过热交换器在压缩气瓶内进行气体温度调节
公开(公告)号：US20110226782A1
公开(公告)日：2011-09-22
申请号：US12725874
申请日：2010-03-17
申请人： Bernhard Mueller , Holger Winkelmann
发明人： Bernhard Mueller , Holger Winkelmann
IPC分类号： B65D88/74
CPC分类号： H01M8/04208 , F17C1/00 , F17C2201/0119 , F17C2201/056 , F17C2201/058 , F17C2203/0604 , F17C2203/0619 , F17C2203/066 , F17C2203/0663 , F17C2205/0305 , F17C2205/0397 , F17C2221/011 , F17C2221/012 , F17C2223/0123 , F17C2223/036 , F17C2260/02 , F17C2260/023 , F17C2260/025 , F17C2270/0184 , Y02E60/321
摘要： A pressure vessel for storing fuel cell reactants is disclosed. The pressure vessel includes an inner shell formed from a moldable material and forming a cavity therein, and an outer shell formed about the inner shell. A heat transfer member is disposed within the vessel cavity. The heat transfer member is thermally coupled a suitable external thermal mass external the pressure vessel to minimize the effect of thermal energy on the vessel. The heat transfer member may be a metallic structure within the cavity, or may be integrated within the inner shell on an inner shell surface. The external thermal mass may further be thermally coupled to either an active or a passive external thermal handling system for controlling the temperature of the fluid within the vessel.
摘要翻译：公开了一种用于储存燃料电池反应物的压力容器。压力容器包括由可模制材料形成并在其中形成空腔的内壳和围绕内壳形成的外壳。传热构件设置在容器腔内。热传递构件将合适的外部热质量热耦合在压力容器外部以最小化热能对容器的影响。传热构件可以是空腔内的金属结构，或者可以在内壳表面内的内壳中集成。外部热质量还可以热耦合到主动或被动外部热处理系统，用于控制容器内的流体的温度。

10. 发明申请

US20100322948A1 Bone morphogenetic protein (BMP)-binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and use of same 审中-公开
标题翻译：排斥指导分子（RGM）蛋白家族的蛋白质的骨形态发生蛋白（BMP）结合结构域及其功能片段及其使用
公开(公告)号：US20100322948A1
公开(公告)日：2010-12-23
申请号：US12677054
申请日：2008-09-08
申请人： Bernhard Mueller , Gregor Schaffar , Axel Meyer , Martin Schmidt
发明人： Bernhard Mueller , Gregor Schaffar , Axel Meyer , Martin Schmidt
IPC分类号： A61K39/395 , C07K14/47 , C07K5/08 , C07K5/10 , C07K7/06 , C07K7/08 , C07K19/00 , C07K16/18 , A61K38/02 , A61P3/10 , A61P25/02 , A61P19/08 , A61P7/06 , A61P9/00 , A61P17/06 , A61P1/04 , A61P17/14
CPC分类号： C07K14/705 , C07K16/22
摘要： The present invention relates to the identification and use of bone morphogenetic protein (BMP)-binding domains of members of the repulsive guidance molecule (RGM) protein family, and polypeptide fragments and fusion proteins derived therefrom. The domains, i.e., peptide fragments and fusion proteins, according to the invention are suitable as agents for the active or passive immunization of individuals, or as diagnostic and therapeutic agents for use for diseases or medical conditions in whose origin or progression a member of the RGM family and a cellular receptor associated with this molecule, such as neogenin and/or BMP in particular, is involved. The invention further relates to monoclonal and polyclonal antibodies directed against the binding domains according to the invention, and against the polypeptides derived therefrom, and to methods for producing the polypeptides, fusion proteins, and antibodies according to the invention.
摘要翻译：本发明涉及排斥性指导分子（RGM）蛋白家族的成员的骨形态发生蛋白（BMP）结合结构域的鉴定和应用，以及从其衍生的多肽片段和融合蛋白质。根据本发明的结构域，即肽片段和融合蛋白，适合作为个体的主动或被动免疫的试剂，或作为用于疾病或医学病症的诊断和治疗剂，其来源或进展是涉及RGM家族和与该分子相关的细胞受体，例如特别是新生蛋白和/或BMP。本发明还涉及针对根据本发明的结合结构域和针对本发明的多肽的单克隆抗体和多克隆抗体，以及根据本发明的用于产生多肽，融合蛋白和抗体的方法。

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