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1. 发明授权

US08344135B2 Heterocyclic compound and use thereof 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US08344135B2
公开(公告)日：2013-01-01
申请号：US12675663
申请日：2008-08-28
申请人： Masaaki Hirose , Masanori Okaniwa , Yoko Hayashi , Terufumi Takagi
发明人： Masaaki Hirose , Masanori Okaniwa , Yoko Hayashi , Terufumi Takagi
IPC分类号： C07D345/00
CPC分类号： C07D471/04 , C07D513/04
摘要： The present invention provides a heterocyclic compound having a strong Raf inhibitory activity, which is represented by the following formula wherein each substituent is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有强Raf抑制活性的杂环化合物，其由下式表示，其中各取代基如本说明书中所定义，或其盐。

2. 发明申请

US20100249119A1 HETEROCYCLIC COMPOUND AND USE THEREOF 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US20100249119A1
公开(公告)日：2010-09-30
申请号：US12675663
申请日：2008-08-28
申请人： Masaaki Hirose , Masanori Okaniwa , Yoko Hayashi , Terufumi Takagi
发明人： Masaaki Hirose , Masanori Okaniwa , Yoko Hayashi , Terufumi Takagi
IPC分类号： A61K31/496 , C07D513/04 , A61K31/437 , A61K31/5377 , A61K31/541 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04 , C07D513/04
摘要： The present invention provides a heterocyclic compound having a strong Raf inhibitory activity, which is represented by the following formula wherein each substituent is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有强Raf抑制活性的杂环化合物，其由下式表示，其中各取代基如本说明书中所定义，或其盐。

3. 发明授权

US08497274B2 Heterocyclic compound and use thereof 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US08497274B2
公开(公告)日：2013-07-30
申请号：US13347302
申请日：2012-01-10
申请人： Masanori Okaniwa , Terufumi Takagi , Masaaki Hirose
发明人： Masanori Okaniwa , Terufumi Takagi , Masaaki Hirose
IPC分类号： C07D277/82 , C07D417/00
CPC分类号： C07D277/82 , C07D417/12
摘要： Provided is a fused heterocycle derivative showing a strong Raf inhibitory activity.A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：提供显示出强的Raf抑制活性的稠合杂环衍生物。由下式表示的化合物，其中每个符号如本说明书中所定义，或其盐。

4. 发明授权

US08143258B2 Benzothiazole compounds useful for Raf inhibition 有权
标题翻译：可用于Raf抑制的苯并噻唑化合物
公开(公告)号：US08143258B2
公开(公告)日：2012-03-27
申请号：US12628697
申请日：2009-12-01
申请人： Masanori Okaniwa , Terufumi Takagi , Masaaki Hirose
发明人： Masanori Okaniwa , Terufumi Takagi , Masaaki Hirose
IPC分类号： C07D277/82 , C07D417/00
CPC分类号： C07D277/82 , C07D417/12
摘要： Provided is a fused heterocycle derivative showing a strong Raf inhibitory activity.A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：提供显示出强的Raf抑制活性的稠合杂环衍生物。由下式表示的化合物，其中每个符号如本说明书中所定义，或其盐。

5. 发明申请

US20080139639A1 Proton Pump Inhibitors 有权
标题翻译：质子泵抑制剂
公开(公告)号：US20080139639A1
公开(公告)日：2008-06-12
申请号：US11664346
申请日：2005-09-30
申请人： Masahiro Kajino , Atsushi Hasuoka , Naoki Tarui , Terufumi Takagi
发明人： Masahiro Kajino , Atsushi Hasuoka , Naoki Tarui , Terufumi Takagi
IPC分类号： A61K31/40 , C07D207/48 , A61P1/04
CPC分类号： C07D207/48 , A61K31/4025 , A61K31/41 , A61K31/4439 , A61K31/501 , A61K31/506 , C07D207/335 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/12 , C07D487/04
摘要： A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R2, R3 and R4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R5 and R6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.
摘要翻译：一种质子泵抑制剂，其含有式（I）表示的化合物，其中X和Y相同或不同，并且各自是主链中具有1至20个碳原子的键或间隔基，R 1 >是任选取代的烃基或任选取代的杂环基，R 2，R 3和R 4相同或不同，并且各自任选取代的苯并[b]噻吩基，任选取代的呋喃基，任意取代的吡啶基，任意取代的吡唑基，任意取代的嘧啶基，酰基，卤素原子，氰基或硝基，R 5和R 6相同或不同，各自为氢原子或任选地取代烃基，其具有优异的质子泵作用，并显示出抗溃疡活性等转化为体内的质子泵抑制剂或其盐。或其前药。

6. 发明申请

US20110288040A1 ARYL- OR HETEROARYL-SULFONYL COMPOUNDS AS ACID SECRETION INHIBITORS 有权
标题翻译：作为酸分泌抑制剂的ARYL-或HETEROARYL-SULFONYL化合物
公开(公告)号：US20110288040A1
公开(公告)日：2011-11-24
申请号：US13204093
申请日：2011-08-05
申请人： Atsushi Hasuoka , Terufumi Takagi , Masahiro Kajino , Haruyuki Nishida
发明人： Atsushi Hasuoka , Terufumi Takagi , Masahiro Kajino , Haruyuki Nishida
IPC分类号： A61K31/7048 , A61K31/417 , A61K31/4439 , A61K31/4178 , A61P31/04 , A61K31/426 , A61K31/43 , A61P1/04 , A61P35/00 , A61P7/04 , A61K31/40 , A61K31/415
CPC分类号： C07D207/36 , A61K31/40 , A61K31/415 , A61K31/417 , A61K31/4178 , A61K31/426 , A61K31/4439 , C07D231/12 , C07D233/64 , C07D233/84 , C07D277/36 , C07D401/12 , C07D409/12
摘要： The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like.A proton pump inhibitor containing a compound represented by the formula (I) wherein ring A is a saturated or unsaturated 5- or 6-membered ring group optionally having, as a ring-constituting atom besides carbon atom, 1 to 4 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, ring-constituting atoms X1 and X2 are each a carbon atom or a nitrogen atom, a ring-constituting atom X3 is a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom, R1 is an optionally substituted aryl group or an optionally substituted heteroaryl group, R2 is an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted heteroaryl group, R3 is an aminomethyl group optionally substituted by 1 or 2 lower alkyl groups, which is a substituent on a ring-constituting atom other than X1, X2 and X3, and ring A optionally further has substituent(s) selected from a lower alkyl group, a halogen atom, a cyano group and an oxo group, or a salt thereof or a prodrug thereof.
摘要翻译：本发明提供具有优异的酸分泌抑制作用，抗溃疡活性等的化合物。含有式（I）表示的化合物的质子泵抑制剂，其中环A是饱和或不饱和的5-或6-元环基，任选具有除碳原子之外的环构成原子，含有1-4个选自氮原子，氧原子和硫原子，构成环的原子X1和X2各自为碳原子或氮原子，构成环的原子X3为碳原子，氮原子，氧原子或硫原子原子，R 1是任选取代的芳基或任选取代的杂芳基，R 2是任选取代的烷基，任选取代的芳基或任选取代的杂芳基，R 3是任选被1或2个低级烷基取代的氨基甲基其是除X1，X2和X3以外的环构成原子上的取代基，环A任选地还具有选自低级烷基，卤素原子，氰基和氧代基的取代基，或盐在那里 f或其前药。

7. 发明申请

US20110028476A1 PROTON PUMP INHIBITORS 审中-公开
标题翻译： PROTON PUMP抑制剂
公开(公告)号：US20110028476A1
公开(公告)日：2011-02-03
申请号：US12873971
申请日：2010-09-01
申请人： Masahiro Kajino , Atsushi Hasuoka , Naoki Tarui , Terufumi Takagi
发明人： Masahiro Kajino , Atsushi Hasuoka , Naoki Tarui , Terufumi Takagi
IPC分类号： A61K31/5377 , C07D207/48 , A61K31/40 , C07D409/12 , A61K31/4025 , C07D403/12 , A61K31/506 , C07D401/12 , A61K31/4439 , C07D405/12 , C07D417/12 , A61K31/428 , A61K31/4178 , C07D403/04 , A61K31/4155 , C07D487/04 , A61K31/519 , A61K31/501 , C07D413/12 , A61P1/00
CPC分类号： C07D207/48 , A61K31/4025 , A61K31/41 , A61K31/4439 , A61K31/501 , A61K31/506 , C07D207/335 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/12 , C07D487/04
摘要： A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R2, R3 and R4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R5 and R6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.
摘要翻译：一种含有式（I）表示的化合物的质子泵抑制剂，其中X和Y相同或不同，并且各自是主链中的键或具有1至20个碳原子的间隔基，R 1是任选取代的烃基或任选取代的杂环基，R 2，R 3和R 4相同或不同，各自为氢原子，任选取代的烃基，任选取代的噻吩基，任选取代的苯并[b]噻吩基，任选取代的呋喃基，任选取代的吡啶基，任选取代的吡唑基，任选取代的嘧啶基，酰基，卤素原子，氰基或硝基，R 5和R 6相同或不同，各自为氢原子或任选取代的烃基，其具有优异的质子泵作用，并且在体内转化为质子泵抑制剂之后显示出抗溃疡活性等，或其中的盐的。或其前药。

8. 发明授权

US08048909B2 Proton pump inhibitors 有权
标题翻译：质子泵抑制剂
公开(公告)号：US08048909B2
公开(公告)日：2011-11-01
申请号：US11664346
申请日：2005-09-30
申请人： Masahiro Kajino , Atsushi Hasuoka , Terufumi Takagi
发明人： Masahiro Kajino , Atsushi Hasuoka , Terufumi Takagi
IPC分类号： A61K31/40 , C07D207/48 , A61P1/04
CPC分类号： C07D207/48 , A61K31/4025 , A61K31/41 , A61K31/4439 , A61K31/501 , A61K31/506 , C07D207/335 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/12 , C07D487/04
摘要： A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R2, R3 and R4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R5 and R6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof, or a prodrug thereof is provided.
摘要翻译：一种含有式（I）表示的化合物的质子泵抑制剂，其中X和Y相同或不同，并且各自是主链中的键或具有1至20个碳原子的间隔基，R 1是任选取代的烃基或任选取代的杂环基，R 2，R 3和R 4相同或不同，各自为氢原子，任选取代的烃基，任选取代的噻吩基，任选取代的苯并[b]噻吩基，任选取代的呋喃基，任选取代的吡啶基，任选取代的吡唑基，任选取代的嘧啶基，酰基，卤素原子，氰基或硝基，R 5和R 6相同或不同，各自为氢原子或任选取代的烃基，其具有优异的质子泵作用，并且在体内转化为质子泵抑制剂之后显示出抗溃疡活性等，或其中的盐或其前药。

9. 发明授权

US08686010B2 Aryl- or heteroaryl-sulfonyl compounds as acid secretion inhibitors 有权
标题翻译：芳基或杂芳基磺酰基化合物作为酸分泌抑制剂
公开(公告)号：US08686010B2
公开(公告)日：2014-04-01
申请号：US13204093
申请日：2011-08-05
申请人： Atsushi Hasuoka , Terufumi Takagi , Haruyuki Nishida
发明人： Atsushi Hasuoka , Terufumi Takagi , Haruyuki Nishida
IPC分类号： A61K31/426 , A61K31/417 , A61K31/40
CPC分类号： C07D207/36 , A61K31/40 , A61K31/415 , A61K31/417 , A61K31/4178 , A61K31/426 , A61K31/4439 , C07D231/12 , C07D233/64 , C07D233/84 , C07D277/36 , C07D401/12 , C07D409/12
摘要： The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like.A proton pump inhibitor containing a compound represented by the formula (I) wherein ring A is a saturated or unsaturated 5- or 6-membered ring group optionally having, as a ring-constituting atom besides carbon atom, 1 to 4 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, ring-constituting atoms X1 and X2 are each a carbon atom or a nitrogen atom, a ring-constituting atom X3 is a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom, R1 is an optionally substituted aryl group or an optionally substituted heteroaryl group, R2 is an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted heteroaryl group, R3 is an aminomethyl group optionally substituted by 1 or 2 lower alkyl groups, which is a substituent on a ring-constituting atom other than X1, X2 and X3, and ring A optionally further has substituent(s) selected from a lower alkyl group, a halogen atom, a cyano group and an oxo group, or a salt thereof or a prodrug thereof.
摘要翻译：本发明提供具有优异的酸分泌抑制作用，抗溃疡活性等的化合物。含有式（I）表示的化合物的质子泵抑制剂，其中环A是饱和或不饱和的5-或6-元环基，任选具有除碳原子之外的环构成原子，含有1-4个选自氮原子，氧原子和硫原子，构成环的原子X1和X2各自为碳原子或氮原子，构成环的原子X3为碳原子，氮原子，氧原子或硫原子原子，R 1是任选取代的芳基或任选取代的杂芳基，R 2是任选取代的烷基，任选取代的芳基或任选取代的杂芳基，R 3是任选被1或2个低级烷基取代的氨基甲基其是除X1，X2和X3以外的环构成原子上的取代基，环A任选地还具有选自低级烷基，卤素原子，氰基和氧代基的取代基，或盐在那里 f或其前药。

10. 发明授权

US07994205B2 Aryl-or heteroaryl-sulfonyl compounds as acid secretion inhibitors 有权
标题翻译：芳基或杂芳基磺酰基化合物作为酸分泌抑制剂
公开(公告)号：US07994205B2
公开(公告)日：2011-08-09
申请号：US12225851
申请日：2007-03-30
申请人： Atsushi Hasuoka , Terufumi Takagi , Haruyuki Nishida
发明人： Atsushi Hasuoka , Terufumi Takagi , Haruyuki Nishida
IPC分类号： A01N43/50
CPC分类号： C07D207/36 , A61K31/40 , A61K31/415 , A61K31/417 , A61K31/4178 , A61K31/426 , A61K31/4439 , C07D231/12 , C07D233/64 , C07D233/84 , C07D277/36 , C07D401/12 , C07D409/12
摘要： The present invention provides an aryl- or heteroaryl compound represented by the formula (Ia) or (Ib) wherein each symbol is as defined in the specification, or a salt thereof, or a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier. The compound has superior acid secretion inhibitory action, an antiulcer activity and the like.
摘要翻译：本发明提供由式（Ia）或（Ib）表示的芳基或杂芳基化合物，其中每个符号如说明书中所定义，或其盐，或包含该化合物和药学上可接受的载体的药物组合物。该化合物具有优异的酸分泌抑制作用，抗溃疡活性等。

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