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1. 发明申请

US20120082667A1 Antibodies That Specifically Bind To A Beta Oligomers And Use Thereof 有权
标题翻译：特异性结合β-低聚物及其用途的抗体
公开(公告)号：US20120082667A1
公开(公告)日：2012-04-05
申请号：US13264671
申请日：2010-04-16
申请人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii , Naofumi Takamatsu
发明人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii , Naofumi Takamatsu
IPC分类号： A61K39/395 , A61P25/00 , A61P25/28 , C07K16/18 , G01N33/566
CPC分类号： C07K16/18 , C07K2317/33 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译：本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。

2. 发明申请

US20080247090A1 Head Holding Member, Disk Device With the Head Holding Member, And Head Holding Method In The Disk Device 失效
标题翻译：主管会员，磁盘设备总监，
公开(公告)号：US20080247090A1
公开(公告)日：2008-10-09
申请号：US10575456
申请日：2005-06-21
申请人： Yoshihiro Ueno , Makoto Umeda
发明人： Yoshihiro Ueno , Makoto Umeda
IPC分类号： G11B5/48
CPC分类号： G11B21/22 , G11B5/4826 , G11B5/4833 , G11B21/12
摘要： The present invention provides a head holding member and a head holding method of a head actuator having a very high impact resisting property by a simple construction, and a disk device using the head holding member and the head holding method. Concretely, a head support arm has a leaf spring portion for pressing the head support arm against a lamp portion (14), and is constructed so as to be rotated around a line perpendicular to a plane formed by a center line of the longitudinal direction of the head support arm and the axis of a rotating shaft. The head holding member is constructed by forming a load side wall face (14d), a tab portion upper wall face (14g) and a tab portion holding plane (14e) in the lamp portion (14). The load side wall face (14d) prevents tab portion (8a) from being moved from an escaping position to the direction of recording medium (4) and tab portion (8a) abuts on load side wall face (14d). Tab portion upper wall face (14g) prevents tab portion (8a) from being moved in the upward direction. Tab portion holding plane (14e) holds tab portion (8a) in the escaping position. Thus, the head holding member resists an impact applied at a stopping time, and a stable operation can be performed at a power turning-on time.
摘要翻译：本发明提供一种通过简单的结构具有非常高的耐冲击性的头致动器的头保持构件和头保持方法，以及使用头保持构件和头保持方法的盘装置。具体而言，头部支撑臂具有用于将头部支撑臂压靠在灯具部分（14）上的片簧部分，并且被构造成围绕垂直于由纵向方向的中心线形成的平面的线旋转头部支撑臂和旋转轴的轴线。头部保持构件通过在灯部分（14）中形成负载侧壁面（14d），突出部分上壁面（14g）和突出部保持面（14e）而构成。负载侧壁面（14d）防止突片部分（8a）从逸出位置移动到记录介质（4）的方向，并且突片部分（8a）抵靠负载侧壁面（14d）。突片部分上壁面（14g）防止舌片部分（8a）沿向上的方向移动。突片部分保持平面（14e）将突出部分（8a）保持在逃逸位置。因此，头部保持构件抵抗在停止时间施加的冲击，并且可以在通电时进行稳定的操作。

3. 发明授权

US07417521B2 Battery pack 有权
标题翻译：电池组
公开(公告)号：US07417521B2
公开(公告)日：2008-08-26
申请号：US11837408
申请日：2007-08-10
申请人： Shuhei Marukawa , Makoto Umeda , Masahiro Misu , Kunio Kanamaru
发明人： Shuhei Marukawa , Makoto Umeda , Masahiro Misu , Kunio Kanamaru
IPC分类号： H02J7/00
CPC分类号： H01H50/305
摘要： Noise generated by driving a relay provided on a battery pack is suppressed. A negative relay is fixed onto top of a bottom face and an inner side surface of a lower case of the battery pack via multiple mounting points formed on an L-shaped fixture. The center of gravity of the negative relay is located within a polygon having the mounting points as vertices.
摘要翻译：通过驱动设置在电池组上的继电器产生的噪声被抑制。负极继电器通过形成在L形夹具上的多个安装点固定在电池组的下壳体的底面和内侧表面的顶部上。负极继电器的重心位于具有安装点作为顶点的多边形内。

4. 发明申请

US20080068116A1 BATTERY PACK 有权
标题翻译：电池组
公开(公告)号：US20080068116A1
公开(公告)日：2008-03-20
申请号：US11837408
申请日：2007-08-10
申请人： Shuhei Marukawa , Makoto Umeda , Masahiro Misu , Kunio Kanamaru
发明人： Shuhei Marukawa , Makoto Umeda , Masahiro Misu , Kunio Kanamaru
IPC分类号： H01H50/04
CPC分类号： H01H50/305
摘要： Noise generated by driving a relay provided on a battery pack is suppressed. A negative relay is fixed onto top of a bottom face and an inner side surface of a lower case of the battery pack via multiple mounting points formed on an L-shaped fixture. The center of gravity of the negative relay is located within a polygon having the mounting points as vertices.
摘要翻译：通过驱动设置在电池组上的继电器产生的噪声被抑制。负极继电器通过形成在L形夹具上的多个安装点固定在电池组的下壳体的底面和内侧表面的顶部上。负极继电器的重心位于具有安装点作为顶点的多边形内。

5. 发明授权

US06230333B1 Life jacket with cushioning air-bag 失效
标题翻译：救生衣与缓冲气囊
公开(公告)号：US06230333B1
公开(公告)日：2001-05-15
申请号：US09359725
申请日：1999-07-23
申请人： Makoto Umeda
发明人： Makoto Umeda
IPC分类号： A41D1300
CPC分类号： A41D13/0125 , A41D13/018 , A41D2600/102 , Y10S2/03
摘要： A life jacket with a cushioning air-bag comprises a jacket body (1), which includes a continuous torso air-bag portion (7) having a chest air-bag portion (2), a back air-bag portion (3), and a side air-bag portion (4), and further includes a neck air-bag portion (5) and a waist air-bag portion (6). The jacket body is provided with a gas generator (8) having a gas cartridge. Each of the air-bag portions (2, 3, 4, 5 and 6) has a dual structure composed of an outer bag (9) and an inner bag (10), which bags (9 and 10) are made of synthetic resin such as urethane or vinyl chloride. The gas generator (8) is connected to the outer bag (9) and inner bag (10) of each of the air bag portions (2, 3, 4, 5 and 6).
摘要翻译：具有缓冲气囊的救生衣包括护套主体（1），其包括具有胸部气囊部分（2）的连续躯干气囊部分（7），后气囊部分（3），和侧气囊部分（4），还包括颈部安全气囊部分（5）和腰部安全气囊部分（6）。护套主体设置有具有气体盒的气体发生器（8）。每个气囊部分（2,3,4,5和6）具有由外袋（9）和内袋（10）组成的双重结构，所述袋（9和10）由合成树脂制成例如聚氨酯或氯乙烯。气体发生器（8）连接到每个气囊部分（2,3,4,5和6）的外袋（9）和内袋（10）。

6. 发明授权

US6123227A Gas generating apparatus for emergency refuge implements 失效
标题翻译：用于紧急避难工具的气体发生装置
公开(公告)号：US6123227A
公开(公告)日：2000-09-26
申请号：US233069
申请日：1999-01-19
申请人： Makoto Umeda
发明人： Makoto Umeda
IPC分类号： B63C9/18 , B60C23/16 , B63B7/08 , B63C9/105 , B63C9/19 , B63C9/22 , F15D20060101 , F17C7/00 , F17C13/06 , B67B7/24
CPC分类号： B63C9/24
摘要： A gas generating apparatus for emergency refuge implements includes a gas generator body, a gas cartridge arrange in the gas generator body, a firing pin disposed opposite to the gas cartridge in the gas generator body, and a slider disposed slidably in the gas generator body. A movable ball-shaped pin is inserted through an opening formed in the gas generator body into an arcuate recess formed in the slider to maintain the slider at a standstill position. A pulling rope with a knob is connected to the movable ball-shaped pin to release the movable ball-shaped pin from the arcuate recess of the slider. A spring always presses the slider. When the movable ball-shaped pin is released from the arcuate recess of the slider, the firing pin and the gas cartridge are impacted to each other by moving the slider due to the pressure of the spring, thus to discharge the gas from the gas cartridge.
摘要翻译：一种应急避难器具的气体发生装置包括气体发生器本体，配置在气体发生器主体中的气体卡座，与气体发生器主体中的气体盒相对设置的撞针，以及滑动地设置在气体发生器主体中的滑块。可移动的球形销通过形成在气体发生器主体中的开口插入形成在滑块中的弓形凹部，以将滑块保持在停止位置。具有旋钮的拉绳连接到可移动的球形销，以从滑块的弓形凹部释放可移动的球形销。弹簧总是按下滑块。当可移动的球形销从滑动件的弓形凹部释放时，由于弹簧的压力使滑块移动，撞击销和气体盒彼此撞击，从而将气体从气体盒排出。

7. 发明授权

US08279543B2 Lens drive unit, lens barrel and imaging apparatus 失效
标题翻译：镜头驱动单元，镜筒和成像设备
公开(公告)号：US08279543B2
公开(公告)日：2012-10-02
申请号：US12979433
申请日：2010-12-28
申请人： Makoto Umeda , Kenichi Miyamori
发明人： Makoto Umeda , Kenichi Miyamori
IPC分类号： G02B7/02 , G02B15/14
CPC分类号： G03B17/04 , G03B5/02
摘要： A lens drive unit includes a movable member with lenses; and a guide portion configured to movably guide the movable member back and forth along a predetermined direction and rotatably guide the movable member about a predetermined rotational axis in a plane perpendicular to an optical axis of the lens. A distance r between the gravity center of the movable member and the rotational axis satisfies the following expression (A): r≦√{square root over (0.2J/M)} (A).
摘要翻译：透镜驱动单元包括具有透镜的可移动部件; 以及引导部，其构造成沿着预定方向可动地引导所述可动构件并且在垂直于所述透镜的光轴的平面中围绕预定旋转轴线可旋转地引导所述可动构件。可移动部件的重心与旋转轴之间的距离r满足以下表达式（A）：r＆nlE;√{平方根超过（0.2J / M）}（A）。

8. 发明申请

US20120156193A1 Antibodies That Specifically Bind to A Beta Oligomers and Use Thereof 有权
标题翻译：特异性结合β-低聚物及其用途的抗体
公开(公告)号：US20120156193A1
公开(公告)日：2012-06-21
申请号：US13389228
申请日：2010-08-05
申请人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
发明人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
IPC分类号： A61K39/395 , A61P25/28 , G01N33/566 , C07K16/18
CPC分类号： C07K16/18 , C07K2317/56 , C07K2317/565 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the anti-bodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译：本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。证明抗体可用作阿尔茨海默氏病的诊断/治疗单克隆抗体。

9. 发明授权

US06950274B2 Disk storage apparatus and disk storage apparatus control method 失效
标题翻译：磁盘存储装置和磁盘存储装置的控制方法
公开(公告)号：US06950274B2
公开(公告)日：2005-09-27
申请号：US10305366
申请日：2002-11-27
申请人： Toshio Inaji , Hiroshi Kohso , Keizo Miyata , Makoto Umeda
发明人： Toshio Inaji , Hiroshi Kohso , Keizo Miyata , Makoto Umeda
IPC分类号： G11B5/55 , G11B5/596 , G11B21/10
CPC分类号： G11B5/5582 , G11B5/59694 , G11B21/106
摘要： A disk storage apparatus includes: an actuator positioning a head with respect to a disk; a drive device driving the actuator; a voltage detection device detecting a voltage signal induced in driving the actuator; a disturbance estimation unit estimating the magnitude of load disturbance exerted on the head from a drive signal and the voltage signal, and outputting a disturbance estimation signal; a filter unit cutting off a high frequency component of the disturbance estimation signal, and outputting a filter signal; a position detection unit producing a position error signal corresponding to a current position of the head; a position control unit producing a position control signal based on the position error signal; and a correction unit outputting the drive signal based on the filter signal and the position control signal, and the apparatus controls stable positioning of the head against a resistance value fluctuation of a drive coil of the actuator and a resistance value change.
摘要翻译：磁盘存储装置包括：致动器相对于盘定位头部; 驱动致动器的驱动装置; 电压检测装置，检测在驱动致动器时感应的电压信号; 干扰估计单元，从驱动信号和所述电压信号估计施加在所述磁头上的负载扰动的大小，并输出干扰估计信号; 滤波单元，切断干扰估计信号的高频分量，输出滤波信号; 位置检测单元，产生与头部的当前位置对应的位置误差信号; 位置控制单元，基于位置误差信号产生位置控制信号; 以及校正单元，其基于滤波器信号和位置控制信号输出驱动信号，并且该装置控制头部抵抗致动器的驱动线圈的电阻值波动和电阻值变化的稳定定位。

10. 发明授权

US09090679B2 Antibodies that specifically bind to A beta oligomers and use thereof 有权
标题翻译：特异性结合Aβ寡聚体的抗体及其用途
公开(公告)号：US09090679B2
公开(公告)日：2015-07-28
申请号：US13264671
申请日：2010-04-16
申请人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii , Naofumi Takamatsu
发明人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii , Naofumi Takamatsu
IPC分类号： C07K16/00 , C07K16/18 , G01N33/68
CPC分类号： C07K16/18 , C07K2317/33 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译：本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。

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