专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP3094325A4 HETEROARYLS AND USES THEREOF 无效转让
标题翻译：杂技团队VERWENDUNGEN DAVON
公开(公告)号：EP3094325A4
公开(公告)日：2017-08-09
申请号：EP15737173
申请日：2015-01-13
申请人： MILLENNIUM PHARM INC
发明人： BHARATHAN INDU T , BLACKBURN CHRIS , CIAVARRI JEFFREY P , CHOUITAR JOUHARA , CULLIS COURTNEY A , D'AMORE NATALIE , FLEMING PAUL E , GIGSTAD KENNETH M , GIPSON KRISTA E , GIRARD MARIO , HU YONGBO , LEE JANICE , LI GANG , REZAEI MANSOUREH , SINTCHAK MICHAEL D , SOUCY FRANCOIS , STROUD STEPHEN G , VOS TRICIA J , WONG TZU-TSHIN , XU HE , XU TIANLIN , YE YINGCHUN
IPC分类号： A61K31/44 , A61P35/00 , C07D213/22 , C07D401/04
CPC分类号： C07D513/04 , A61K31/437 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/549 , A61K45/06 , C07D401/04 , C07D401/14 , C07D417/14 , C07D471/04 , A61K2300/00
摘要： The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译：其中X，R 1，R 2，R 3，R 4，R 5，L 1，L 2，m和n如说明书中所述。这类化合物是VPS34的抑制剂，因此可用于治疗增殖性，炎症或心血管疾病。

2. 发明公开

EP2814791A4 PYRAZOLOPYRIMIDINYL INHIBITORS OF UBIQUITIN-ACTIVATING ENZYME 审中-公开
标题翻译：泛维菌素酶的吡唑并嘧啶脒类化合物
公开(公告)号：EP2814791A4
公开(公告)日：2015-08-19
申请号：EP13748707
申请日：2013-02-14
申请人： MILLENNIUM PHARM INC
发明人： AFROZE ROUSHAN , BHARATHAN INDU T , CIAVARRI JEFFREY P , FLEMING PAUL E , GAULIN JEFFREY L , GIRARD MARIO , LANGSTON STEVEN P , SOUCY FRANCOIS R , WONG TZU-TSHIN , YE YINGCHUN
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I : or a pharmaceutically acceptable salt thereof, wherein Y is and W, Z, X Y , R Y1 , R Y2 and R Y3 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.

3. 发明专利

NZ628969A Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme 未知
公开(公告)号：NZ628969A
公开(公告)日：2017-03-31
申请号：NZ62896913
申请日：2013-02-14
申请人： MILLENNIUM PHARM INC
发明人： AFROZE ROUSHAN , BHARATHAN INDU T , CIAVARRI JEFFREY P , FLEMING PAUL E , GAULIN JEFFREY L , GIRARD MARIO , LANGSTON STEVEN P , SOUCY FRANCOIS R , WONG TZU-TSHIN , YE YINGCHUN
IPC分类号： C07B45/04 , A61K31/4162 , A61K31/519 , A61P35/00 , C07D487/04 , C07H5/04
摘要： Disclosed are { 2,3-dihydroxy-4-[(2-aryl-pyrazolo[1,5-a]pyrimidin-7-yl)amino]cyclopentyl} methyl sulfamate derivatives as represented by the general formula (I) as the depicted single stereochemical isomer, or as an enantiomeric, racemic, or disatereomeric mixture of the depicted single stereochemical isomer; and pharmaceutically acceptable salts of any of the foregoing, wherein: W is -N(R*3)-; Y is pyrazolo[1,5-a]pyrimidin-7-yl substituted in positions 2 with the group Z; wherein Z is an optionally substituted aryl, an optionally substituted fused aryl: or an optionally substituted heteroaryl; and wherein the remaining substituents are as defined herein. Representative compounds include (2,3-dihydroxy-4-(2-(3-(trifluoromethylthio)phenyl)pyrazolo[1,5-a]pyrimidin-7-ylamino)cyclopentyl)methyl sulfamate as either a racemate or single enantiomer (s.e.), ((1R,2R,3S,4R)-2,3-dihydroxy-4-(2-phenylpyrazolo[1,5-a]pyrimidin-7-ylamino)cyclopentyl)methyl sulfamate, ((1R,2R,3S,4R)-2,3-dihydroxy-4-{ [2-(1-naphthyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino} cyclopentyl)methyl sulfamate, ((1R,2R,3S,4R)-4-(2-(3,3-dimethyl-2,3-dihydrobenzofuran-7-yl)pyrazolo[1,5-a]pyrimidin-7-ylamino)-2,3-dihydroxycyclopentyl)methyl sulfamate, ((1R,2R,3S,4R)-4-(5-chloro-2-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidin-7-ylamino)-2,3-dihydroxycyclopentyl)methyl sulfamate and ((1R,2R,3S,4R)-4-(2-(dibenzo[b,d]furan-4-yl)pyrazolo[1,5-a]pyrimidin-7-ylamino)-2,3-dihydroxycyclopentyl)methyl sulfamate. Also disclosed is a pharmaceutical composition comprising, a compound as defined above and a pharmaceutically acceptable carrier, for use in treating lung cancer, ovarian cancer, colon cancer, breast cancer, or lymphoma.

4. 发明专利

DOP2016000173A HETEROARILOS Y USOS DE ESTOS 未知
公开(公告)号：DOP2016000173A
公开(公告)日：2016-12-15
申请号：DO2016000173
申请日：2016-07-12
申请人： MILLENNIUM PHARM INC
发明人： FLEMING PAUL E , HU YONGBO , XU TIANLIN , STROUD STEPHEN G , CIAVARRI JEFFREY P , BHARATHAN INDU T , BLACKBURN CHRIS , CHOUITAR JOUHARA , CULLIS COURTNEY A , AMORE NATALIE D , GIGSTAD KENNETH M , GIPSON KRISTA E , GIRAD MARIO , LEE JANICE , LI GANG , RAZAEI MANSOUREH , SINTCHAK MICHAEL D , SOUCY FRANCOIS , VOS TRICIA J , XU HE , YE YINGCHUN , WONG TZU-TSHIN
IPC分类号： A61K31/44 , C07D213/22 , C07D401/04
摘要： LA PRESENTE INVENCIÓN PROPORCIONA UN COMPUESTO DE LA FÓRMULA I: I Y SALES FARMACÉUTICAMENTE ACEPTABLES DE ESTE, DONDE X, R1, R2, R3, R4, R5, L1, L2, M Y N SON COMO SE DESCRIBIÓ EN LA MEMORIA DESCRIPTIVA.DICHOS COMPUESTOS SON INHIBIDORES DE VPS34 Y, POR LO TANTO, SON ÚTILES PARA TRATAR TRASTORNOS PROLIFERATIVOS, INFLAMATORIOS O CARDIOVASCULARES.

5. 发明专利

PE20142244A1 INHIBIDORES DE PIRAZOLOPIRIMIDINILO DE ENZIMA ACTIVADORA DE UBIQUITINA 未知
公开(公告)号：PE20142244A1
公开(公告)日：2015-01-07
申请号：PE2014001278
申请日：2013-02-14
申请人： MILLENNIUM PHARM INC
发明人： AFROZE ROUSHAN , BHARATHAN INDU T , CIAVARRI JEFFREY P , FLEMING PAUL E , GAULIN JEFFREY L , GIRARD MARIO , LANGSTON STEVEN P , SOUCY FRANCOIS R , WONG TZU-TSHIN , YE YINGCHUN
IPC分类号： C07B45/04
摘要： SE REFIERE A UN COMPUESTO DE FORMULA I O UNA SAL FARMACEUTICAMENTE ACEPTABLE, DONDE: W ES -N(R*3)-; R*3 ES H, ALQUILO C1-C3; Y ES UN COMPUESTO DE FORMULA II, DONDE: RY1, RY2 Y RY3 SON H, HALO, ALIFATICO C1-C3, ENTRE OTROS; Z ES ARILO OPCIONALMENTE SUSTITUIDO, ARILO FUSIONADO, HETEROARILO, ENTRE OTROS; SON COMPUESTOS PREFERIDOS: (RAC)-REL-SULFAMATO DE ((1R,2R,3S,4R)-2,3-DIHIDROXI-4-(2-FENILPIRAZOLO[1,5-A]PIRIMIDIN-7-ILAMINO)CICLOPENTIL)METILO; (RAC)-REL-SULFAMATO DE ((1R,2R,3S,4R)-4-(2-(BIFENIL-3-IL)PIRAZOLO[1,5-A]PIRIMIDIN-7-ILAMINO)-2,3-DIHIDROXICICLOPENTIL)METILO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE LA ENZIMA ACTIVADORA DE UBIQUITINA (UAE). UTIL EN EL TRATAMIENTO DEL CANCER.

6. 发明专利

SG11201404757WA PYRAZOLOPYRIMIDINYL INHIBITORS OF UBIQUITIN-ACTIVATING ENZYME 未知
公开(公告)号：SG11201404757WA
公开(公告)日：2014-09-26
申请号：SG11201404757W
申请日：2013-02-14
申请人： MILLENNIUM PHARM INC
发明人： AFROZE ROUSHAN , BHARATHAN INDU T , CIAVARRI JEFFREY P , FLEMING PAUL E , GAULIN JEFFREY L , GIRARD MARIO , LANGSTON STEVEN P , SOUCY FRANCOIS R , WONG TZU-TSHIN , YE YINGCHUN
IPC分类号： C07B45/04
摘要： Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formulaor a pharmaceutically acceptable salt thereof, wherein Y isand W, Z, X, R, Rand Rare defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.

7. 发明专利

UY34629A Inhibidores de pirazolopirimidinilo de enzima activadora de ubicuitina 未知
公开(公告)号：UY34629A
公开(公告)日：2013-09-02
申请号：UY34629
申请日：2013-02-15
申请人： MILLENNIUM PHARM INC
发明人： ROUSHAN AFROZE , BHARATHAN INDU T , CIAVARRI JEFFREY P , FLEMING PAUL E , GAULIN JEFFREY L , MARIO GIRARD , LANGSTON STEVEN P , SOUCY FRANCOIS R , WONG TZU-TSHIN , YINGCHUN YE
IPC分类号： A61K31/343 , A61K31/381 , A61K31/403 , A61K31/404 , A61K31/4155 , A61K31/422 , A61K31/427 , A61K31/4427 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P35/00 , C07C307/02 , C07D209/04 , C07D209/82 , C07D213/16 , C07D215/04 , C07D217/04 , C07D231/12 , C07D241/12 , C07D263/32 , C07D277/22 , C07D295/033 , C07D307/78 , C07D307/91 , C07D333/10 , C07D333/52 , C07D487/04
摘要： Se divulgan entidades químicas que inhiben la enzima activadora de ubicuitina (UAE), cada una de las cuales es un compuesto de Fórmula I o una sal farmacéuticamente aceptable del mismo, en donde Y es y W, Z, XY, RY1, RY2 y RY3 se definen en la presente; composiciones farmacéuticas que comprenden las entidades químicas; y métodos para usar las entidades químicas. Estas entidades químicas son útiles para tratar trastornos, particularmente trastornos de proliferación celular, incluidos cánceres.

8. 发明专利

CA2864672A1 PYRAZOLOPYRIMIDINYL INHIBITORS OF UBIQUITIN-ACTIVATING ENZYME 未知
公开(公告)号：CA2864672A1
公开(公告)日：2013-08-22
申请号：CA2864672
申请日：2013-02-14
申请人： MILLENNIUM PHARM INC
发明人： AFROZE ROUSHAN , BHARATHAN INDU T , CIAVARRI JEFFREY P , FLEMING PAUL E , GAULIN JEFFREY L , GIRARD MARIO , LANGSTON STEVEN P , SOUCY FRANCOIS R , WONG TZU-TSHIN , YE YINGCHUN
IPC分类号： C07B45/04
摘要： Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula (/): or a pharmaceutically acceptable salt thereof, wherein Y is Formula (II) and W, Z, XY, RY1, RY2 and RY3 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particulariy cell proliferation disorders, including cancers.

9. 发明专利

EA035020B1 ПИРАЗОЛОПИРИМИДИНИЛОВЫЕ ИНГИБИТОРЫ УБИКВИТИН-АКТИВИРУЮЩЕГО ФЕРМЕНТА 未知
公开(公告)号：EA035020B1
公开(公告)日：2020-04-17
申请号：EA201400831
申请日：2013-02-14
申请人： MILLENNIUM PHARM INC
发明人： AFROZE ROUSHAN , BHARATHAN INDU T , CIAVARRI JEFFREY P , FLEMING PAUL E , GAULIN JEFFREY L , GIRARD MARIO , LANGSTON STEVEN P , SOUCY FRANCOIS R , WONG TZU-TSHIN , YE YINGCHUN
IPC分类号： C07B45/04
摘要： Соединение, котороеингибируетубиквитин-активирующийфермент (UAE), представляющеесобой (рац)-(2,3-дигидрокси-4-(2-(3-(трифторметилтио)фенил)пиразоло[1,5-a]пиримидин-7-иламино)циклопентил)метилсульфаматилиодинизегоэнантиомеров ((1R,2R,3S,4R)-2,3-дигидрокси-4-(2-(3-(трифторметилтио)фенил)пиразоло[1,5-a]пиримидин-7-иламино)циклопентил)метилсульфаматили ((1S,2S,3R,4S)-2,3-дигидрокси-4-(2-(3-(трифторметилтио)фенил)пиразоло[1,5-a]пиримидин-7-иламино)циклопентил)метилсульфаматследующихструктур:илиегофармацевтическиприемлемаясоль. Этисоединенияполезныдлялечениянарушений, вчастностинарушенийпролиферацииклеток, включаявидырака.

10. 发明专利

EA032458B1 ГЕТЕРОАРИЛЫ И ИХ ПРИМЕНЕНИЕ 未知
公开(公告)号：EA032458B1
公开(公告)日：2019-05-31
申请号：EA201691421
申请日：2015-01-13
申请人： MILLENNIUM PHARM INC
发明人： BHARATHAN INDU T , BLACKBURN CHRIS , CIAVARRI JEFFREY P , CHOUITAR JOUHARA , CULLIS COURTNEY A , D'AMORE NATALIE , FLEMING PAUL E , GIGSTAD KENNETH M , GIPSON KRISTA E , GIRARD MARIO , HU YONGBO , LEE JANICE , LI GANG , REZAEI MANSOUREH , SINTCHAK MICHAEL D , SOUCY FRANCOIS , STROUD STEPHEN G , VOS TRICIA J , WONG TZU-TSHIN , XU HE , XU TIANLIN , YE YINGCHUN
IPC分类号： A61K31/44 , C07D213/22 , C07D401/04
摘要： Вданномизобретениипредложеносоединениеформулы Iиегофармацевтическиприемлемыесоли, где X, R, R, R, R, R, L, L, m и n представленыв описании. Такиесоединенияпредставляютсобойингибиторы VPS34 ипоэтомумогутбытьпригодныдлялеченияпролиферативных, воспалительныхилисердечно-сосудистыхзаболеваний.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式