专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5749042A Bismuth generator method 失效
标题翻译：铋发生器方法
公开(公告)号：US5749042A
公开(公告)日：1998-05-05
申请号：US789973
申请日：1997-01-28
申请人： Lane Allan Bray , Jaquetta R. DesChane
发明人： Lane Allan Bray , Jaquetta R. DesChane
IPC分类号： G21G4/08 , B01D15/04 , B01D59/30 , B01J20/22 , B01J20/26 , B01J41/04 , B01J49/00 , C01G29/00 , C01G30/00 , C22B30/06
CPC分类号： C01G30/001 , C22B3/42 , C22B30/06 , Y02P10/234
摘要： A method for separating .sup.213 Bi from a solution of radionuclides wherein the solution contains a concentration of the chloride ions and hydrogen ions adjusted to allow the formation of a chloride complex. The solution is then brought into contact with an anion exchange resin, whereupon .sup.213 Bi is absorbed from the solution and adhered onto the anion exchange resin in the chloride complex. Other non-absorbing radionuclides such as .sup.225 Ra, .sup.225 Ac, and .sup.221 Fr, along with HCl are removed from the anion exchange resin with a scrub solution. The .sup.213 Bi is removed from the anion exchange resin by washing the anion exchange resin with a stripping solution free of chloride ions and with a reduced hydrogen ion concentration which breaks the chloride anionic complex, releasing the .sup.213 Bi as a cation. In a preferred embodiment of the present invention, the anion exchange resin is provided as a thin membrane, allowing for extremely rapid adherence and stripping of the .sup.213 Bi. A preferred stripping solution for purification of .sup.213 Bi for use in medical applications includes sodium acetate, pH 5.5. A protein conjugated with bifunctional chelating agents in vivo with the NaOAc, to receive the .sup.213 Bi as it is being released from the anion exchange resin.
摘要翻译：一种从放射性核素溶液中分离213Bi的方法，其中溶液含有氯离子和氢离子的浓度以调节以形成氯化物络合物。然后使溶液与阴离子交换树脂接触，于是溶液中吸收213Bi并附着到氯化物络合物中的阴离子交换树脂上。使用洗涤溶液从阴离子交换树脂中除去其它非吸收放射性核素如225Ra，225Ac和221Fr以及HCl。通过用不含氯离子的剥离溶液洗涤阴离子交换树脂，并且以降低的氢离子浓度破坏氯化物阴离子络合物，从而将213Bi从阴离子交换树脂中除去，释放213Bi作为阳离子。在本发明的一个优选实施方案中，阴离子交换树脂被提供为薄膜，允许极快速地粘附和剥离213Bi。纯化用于医疗应用的213Bi的优选的汽提溶液包括乙酸钠，pH5.5。与NaOAc一起体内与双功能螯合剂缀合的蛋白质，以便从阴离子交换树脂中释放出213Bi。

IPRDB

热门服务

关于我们

友情链接

联系方式