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1. 发明申请

WO0066225A8 CONTRACEPTIVE COMPOSITIONS CONTAINING CYCLIC CARBAMATES AND AMIDE DERIVATIVES 审中-公开
标题翻译：含有环状碳酸酯和酰胺衍生物的合成组合物
公开(公告)号：WO0066225A8
公开(公告)日：2002-05-30
申请号：PCT/US0011846
申请日：2000-05-01
申请人： AMERICAN HOME PROD , LIGAND PHARM INC , GRUBB GARY S , ZHI LIN , JONES TODD K , SANTILLI ARTHUR A , TEGLEY CHRISTOPHER M , VIET ANDREW Q , ZHANG PUWEN , FENSOME ANDREW , WROBEL JAY E , EDWARDS JAMES P
发明人： GRUBB GARY S , ZHI LIN , JONES TODD K , SANTILLI ARTHUR A , TEGLEY CHRISTOPHER M , VIET ANDREW Q , ZHANG PUWEN , FENSOME ANDREW , WROBEL JAY E , EDWARDS JAMES P
IPC分类号： C07D498/04 , A61K31/40 , A61K31/445 , A61K31/535 , A61K31/5365 , A61K31/56 , A61K45/06 , A61P15/18 , A61K31/565 , A61K31/57
CPC分类号： A61K31/56 , A61K31/40 , A61K31/445 , A61K31/535 , A61K31/565 , A61K45/06 , A61K2300/00
摘要： This invention relates to cyclic combination therapies and regimens utilizing, in combination with progestins, estrogens, or both, substituted indoline derivative compounds which are antagonists of the progesterone receptor having general structure (I) wherein A and B are independent substituents selected from S, CH or N; provided that when A is S, B is CH or N; and when B is S, A is CH or N; and A and B cannot both be CH; and when A and B both equal N, one N may be optionally substituted with a C1 to C6 alkyl group; R1 and R2 are independent substituents selected from the group of H, C1 to C6 alkyl, substituted C1 to C6 alkyl, C2 to C6 alkenyl, substituted C2 to C6 alkenyl, C2 to C6 alkynyl, substituted C2 to C6 alkynyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, substituted aryl, heterocyclic, substituted heterocyclic, COR , or NR COR ; or R and R are fused to form optionally substituted 3 to 8 membered spirocyclic alkyl, alkenyl or heterocyclic ring, the heterocyclic ring containing one to three heteroatoms selected from the group of O, S and N; or pharmaceutically useful salts thereof. These methods of treatment may be used for contraception or for the treatment and/or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or minimization of side effects or cyclic menstrual bleeding. Additional uses of the invention include stimulation of food intake.
摘要翻译：本发明涉及利用与孕激素，雌激素或两者作为孕酮受体的拮抗剂的代用药物，其具有一般结构（I）的循环组合疗法和方案，其中A和B是选自S，CH 或N; 条件是当A为S时，B为CH或N; 当B为S时，A为CH或N; A和B不能同时为CH; 并且当A和B均等于N时，一个N可以任选地被C 1至C 6烷基取代; R1和R2是选自H，C1至C6烷基，取代C1至C6烷基，C2至C6烯基，取代C2至C6烯基，C2至C6炔基，取代C2至C6炔基，C3至C8环烷基的独立取代基取代的C 3至C 8环烷基，芳基，取代的芳基，杂环基，取代的杂环基，COR A或NR C CORA; 或R 1和R 2稠合形成任选取代的3至8元螺环烷基，烯基或杂环，所述杂环含有一至三个选自O，S和N的杂原子; 或其药学上有用的盐。这些治疗方法可用于避孕或治疗和/或预防继发性闭经，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症; 多囊卵巢综合征，子宫内膜，卵巢，乳腺，结肠，前列腺的癌和腺癌，或副作用最小化或周期性月经出血。本发明的额外用途包括刺激食物摄取。

2. 发明申请

WO0066564A8 BENZIMIDAZOLONES AND ANALOGUES AND THEIR USE AS PROGESTERONE RECEPTOR LIGANDS 审中-公开
标题翻译：苯并咪唑和类似物及其作为孕酮受体配体使用
公开(公告)号：WO0066564A8
公开(公告)日：2001-08-02
申请号：PCT/US0011824
申请日：2000-05-01
申请人： AMERICAN HOME PROD , LIGAND PHARM INC , ZHANG PUWEN , BENDER REINHOLD H W , ZHI LIN , JONES TODD K , TEGLEY CHRISTOPHER M , WROBEL JAY E , EDWARDS JAMES P
发明人： ZHANG PUWEN , BENDER REINHOLD H W , ZHI LIN , JONES TODD K , TEGLEY CHRISTOPHER M , WROBEL JAY E , EDWARDS JAMES P
IPC分类号： A61K31/136 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/498 , A61K31/4985 , A61K31/5415 , A61P5/00 , A61P5/24 , A61P13/08 , A61P15/00 , A61P35/00 , A61P43/00 , C07C215/76 , C07C229/18 , C07D235/26 , C07D235/28 , C07D241/44 , C07D263/58 , C07D277/68 , C07D279/16 , C07D409/04 , C07D487/04 , A61K31/429
CPC分类号： C07D263/58 , C07C215/76 , C07C229/18 , C07D235/26 , C07D235/28 , C07D241/44 , C07D277/68 , C07D279/16 , C07D409/04 , C07D487/04
摘要： The present invention provides compounds and pharmaceutical formulations useful as progesterone receptor agonists and antagonists and having general formula (a): wherein A is O, S, or NR ; B is a bond between A and C=Q, or the moiety CR R ; R , R , R are independently selected from H or optionally substituted C1 to C6 alkyl, C2 to C6 alkenyl, C2 to C6 alkynyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, or heteorcyclic groups, or cyclic alkyl constructed by fusing R and R to from a 5 to 7 membered ring; R is selected from H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C6 alkenyl, substituded C1 to C6 alkenyl, alkynyl, substituted alkynyl, -COH, or optionally substituted -CO(C1 to C3 alkyl), -CO(aryl), -CO(C1 to C3 alkoxy), or -CO(C1 toC3 aminoalkyl) groups; R is selected from H, halogen, CN, NO2, or optionally substituted C1 to C6 alkyl, C1 to C6 alkoxy, or C1 to C6 aminoalkyl groups; R is selected from a trisubstituted benzene ring; or a 5- or 6- membered heteroaromatic ring containing 1 or 2 substituents; Q is O, S, NR , or CR R ; or a pharmaceutically acceptable salt thereof. The invention also includes methods of contraception and methods of treating or preventing maladies associated with the progesterone receptor.
摘要翻译：本发明提供可用作孕酮受体激动剂和拮抗剂并具有通式（a）的化合物和药物制剂：其中A是O，S或NR 4; B是A和C = Q之间的键，或部分CR 5 R 6; R 4，R 5，R 6独立地选自H或任选取代的C 1 -C 6烷基，C 2至C 6烯基，C 2至C 6炔基，C 3至C 8环烷基，取代的C 3至C 8环烷基，芳基，或杂环基团，或通过将R 4和R 5与5至7元环稠合而构成的环状烷基; R 1选自H，OH，NH 2，C 1至C 6烷基，取代的C 1 -C 6烷基，C 3至C 6烯基，取代的C 1至C 6烯基，炔基，取代的炔基，-COH或任选取代的-CO 至C 3烷基），-CO（芳基），-CO（C 1至C 3烷氧基）或-CO（C 1至C 3氨基烷基） R 2选自H，卤素，CN，NO 2或任选取代的C 1至C 6烷基，C 1至C 6烷氧基或C 1至C 6氨基烷基; R 3选自三取代苯环; 或含有1或2个取代基的5-或6-元杂芳族环; Q是O，S，NR 8或CR 9 R 10; 或其药学上可接受的盐。本发明还包括避孕方法和治疗或预防与孕酮受体相关的疾病的方法。

3. 发明申请

WO0066165A8 CONTRACEPTIVE COMPOSITIONS CONTAINING QUINAZOLINONE AND BENZOXAZINE DERIVATIVES 审中-公开
标题翻译：含有喹唑啉酮和苯并恶唑衍生物的合成组合物
公开(公告)号：WO0066165A8
公开(公告)日：2001-11-22
申请号：PCT/US0011644
申请日：2000-05-01
申请人： AMERICAN HOME PROD , LIGAND PHARM INC , GRUBB GARY S , ZHI LIN , JONES TODD K , TEGLEY CHRISTOPHER M , ZHANG PUWEN , FENSOME ANDREW , TEREFENKO EUGENE A , WROBEL JAY E , EDWARDS JAMES P
发明人： GRUBB GARY S , ZHI LIN , JONES TODD K , TEGLEY CHRISTOPHER M , ZHANG PUWEN , FENSOME ANDREW , TEREFENKO EUGENE A , WROBEL JAY E , EDWARDS JAMES P
IPC分类号： C07D239/80 , A61K31/4704 , A61K31/517 , A61K31/536 , A61K31/565 , A61K31/567 , A61K31/57 , A61K45/06 , A61P15/18 , A61P35/00 , C07D215/22 , C07D265/16
CPC分类号： A61K31/565 , A61K31/57 , A61K45/06 , A61K2300/00
摘要： This invention relates to cyclic combination therapies utilizing, in combination with progestins, estrogens, or both, compounds which are progesterone receptor antagonists of general structure: (I) wherein: R and R are H, COR , or NR COR , alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or heterocyclic; or R and R fuse to form 3 to 8 membered spirocyclic alkyl, alkenyl or heterocyclic rings; R is H or optionally substituted alkyl, aryl, alkoxy, or aminoalkyl groups; R is H or alkyl; R is H, OH, NH2, COR or alkyl, alkenyl, or alkynyl; R is H, alkyl, aryl, alkoxy, or aminoalkyl; R is H, halogen, CN, NO2, alkyl, alkynyl, alkoxy, amino or aminoalkyl; R is benzen or 5- or 6-membered heterocyclic ring; R is H or alkyl; G1 is O, NR7, or CR7R8; G2 is CO or CR7R8; provided that when G1 is O, G2 is CR7R8, and G1 and G2 cannot both be CR7R8; R7 and R8 are H or an optionally substituted alkyl, aryl, or heterocyclic moiety; or pharmaceutically acceptable salt thereof. These methods may be used for contraception or treatment and/or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or minimization of side effects or cyclic menstrual bleeding. Additional uses of the invention include stimulation of food intake.
摘要翻译：本发明涉及利用与孕激素，雌激素或两者结合的孕酮受体拮抗剂组合的循环组合疗法，其通式结构如下：（I）其中：R 1和R 2为H，COR A 或NR C COR A，烷基，烯基，炔基，环烷基，芳基或杂环; 或R 1和R 2融合形成3至8元螺环烷基，烯基或杂环; R AA是H或任选取代的烷基，芳基，烷氧基或氨基烷基; R B是H或烷基; R 3是H，OH，NH 2，COR C或烷基，烯基或炔基; R C是H，烷基，芳基，烷氧基或氨基烷基; R 4是H，卤素，CN，NO 2，烷基，炔基，烷氧基，氨基或氨基烷基; R 5是苯或5-或6-元杂环; R 6是H或烷基; G1是O，NR7或CR7R8; G2为CO或CR7R8; 条件是当G1为O时，G2为CR7R8，G1和G2不能为CR7R8; R 7和R 8是H或任选取代的烷基，芳基或杂环部分; 或其药学上可接受的盐。这些方法可用于避孕或治疗和/或预防继发性闭经，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症; 多囊卵巢综合征，子宫内膜，卵巢，乳腺，结肠，前列腺的癌和腺癌，或副作用最小化或周期性月经出血。本发明的额外用途包括刺激食物摄取。

4. 发明申请

WO0066164A8 CONTRACEPTIVE COMPOSITIONS CONTAINING ANTIPROGESTINIC AND PROGESTINIC 审中-公开
标题翻译：含有抗菌素和抗生素的合成组合物
公开(公告)号：WO0066164A8
公开(公告)日：2001-05-03
申请号：PCT/US0011643
申请日：2000-05-01
申请人： AMERICAN HOME PROD , LIGAND PHARM INC , GRUBB GARY S , ZHI LIN , JONES TODD K , MARSCHKE KEITH B , TEGLEY CHRISTOPHER M , ZHANG PUWEN , TEREFENKO EUGENE A , FENSOME ANDREW , WROBEL JAY E , EDWARDS JAMES P , FLETCHER HORACE A
发明人： GRUBB GARY S , ZHI LIN , JONES TODD K , MARSCHKE KEITH B , TEGLEY CHRISTOPHER M , ZHANG PUWEN , TEREFENKO EUGENE A , FENSOME ANDREW , WROBEL JAY E , EDWARDS JAMES P , FLETCHER HORACE A
IPC分类号： A61K31/567 , A61K20060101 , A61K31/535 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/565 , A61K31/57 , A61K45/06 , A61P20060101 , A61P15/18
CPC分类号： A61K45/06 , A61K31/565 , A61K31/57 , A61K31/535 , A61K2300/00
摘要： This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having general structure (I): wherein R and R may be single substituents or fused to form spirocyclic or hetero-spirocyclic rings; R is H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C6 alkenyl, substituted C1 to C6 alkenyl, alkynyl, or substituted alkynyl, COR ; R is H, C1 to C3 alkyl, substituted C1 to C3 alkyl, aryl, substituted aryl, C1 to C3 alkoxy, substituted C1 to C3 alkoxy, C1 to C3 aminoalkyl, or substituted C1 to C3 aminoalkyl; R is H, halogen, CN, NO2, C1 to C6 alkyl, substituted C1 to C6 alkyl, alkynyl, or substituted alkynyl, C1 to C6 alkoxy, substituted C1 to C6 alkoxy, amino, C1 to C6 aminoalkyl, or substituted C1 to C6 aminoalkyl; and R is selected from a trisubstituted benzene ring of a five or six membered ring with 1, 2, or 3 heteroatoms from the group including O, S, SO, SO2 or NR and containing one or two independent substituents from the group including H, halogen, CN, NO2 , amino, and C1 to C3 alkyl, C1 to C3 alkoxy, C1 to C3 aminoalkyl, COR , or NR COR ; or pharmaceutically acceptable salt thereof. These methods of treatment may be used for contraception or for the treatment and/or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endormetrium, ovary, breast, colon, prostate, or minimization of side effects or cyclic menstrual bleeding. Additional uses of the invention inlcude stimulation of food intake.
摘要翻译：本发明涉及使用具有通式结构（I）的孕酮受体的拮抗剂的取代的二氢吲哚衍生物化合物的环状组合疗法和方案：其中R 1和R 2可以是单个取代基或稠合形成螺环或异 - 螺环; R 3是H，OH，NH 2，C 1至C 6烷基，取代的C 1 -C 6烷基，C 3至C 6烯基，取代的C 1至C 6烯基，炔基或取代的炔基。 R C是H，C 1至C 3烷基，取代的C 1至C 3烷基，芳基，取代的芳基，C 1至C 3的烷氧基，取代的C 1至C 3的烷氧基，C 1至C 3的氨基烷基或取代的C 1至C 3氨基烷基; R 4是H，卤素，CN，NO 2，C 1至C 6烷基，取代的C 1 -C 6烷基，炔基或取代的炔基，C 1至C 6烷氧基，取代的C 1至C 6烷氧基，氨基，C 1至C 6氨基烷基或取代 C1至C6氨基烷基; R 5选自具有1,2或3个杂原子的五元或六元环的三取代苯环，所述杂原子包括O，S，SO，SO 2或NR 6，并含有一个或两个独立的取代基包括H，卤素，CN，NO 2，氨基和C 1至C 3烷基，C 1至C 3烷氧基，C 1至C 3氨基烷基，COR F或NR G COR F; 或其药学上可接受的盐。这些治疗方法可用于避孕或治疗和/或预防继发性闭经，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症; 多囊卵巢综合征，宫内膜，卵巢，乳腺，结肠，前列腺的癌和腺癌，或副作用或周期性月经出血的最小化。本发明的另外用途包括刺激食物摄取。

5. 发明申请

WO0066590A3 TETRACYCLIC PROGESTERONE RECEPTOR MODULATOR COMPOUNDS AND METHODS 审中-公开
标题翻译：四环类孕酮受体调节剂化合物和方法
公开(公告)号：WO0066590A3
公开(公告)日：2001-02-08
申请号：PCT/US0011750
申请日：2000-05-01
申请人： LIGAND PHARM INC , AMERICAN HOME PROD , ZHI LIN , JONES TODD K , MARSCHKE KEITH B , TEGLEY CHRISTOPHER M , FENSOME ANDREW , ZHANG PUWEN , WROBEL JAY E , EDWARDS JAMES P
发明人： ZHI LIN , JONES TODD K , MARSCHKE KEITH B , TEGLEY CHRISTOPHER M , FENSOME ANDREW , ZHANG PUWEN , WROBEL JAY E , EDWARDS JAMES P
IPC分类号： A61P5/32 , A61P35/00 , C07D498/04 , A61K31/5383
CPC分类号： C07D498/04
摘要： Nonsteroidal compounds that are high affinity, high selectivity modulators for progesterone receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring progesterone receptor agonist, partial agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the progesterone receptor modulator compounds.
摘要翻译：公开了用于孕酮受体的高亲和力，高选择性调节剂的非甾体化合物。还公开了掺入这种化合物的药物组合物，使用所公开的化合物的方法和用于治疗需要孕酮受体激动剂，部分激动剂或拮抗剂治疗的患者的组合物，可用于制备化合物的中间体和用于制备孕酮受体调节剂化合物的方法。

6. 发明专利

EA005034B1 ПРОИЗВОДНЫЕ ТИООКСИНДОЛА 未知
公开(公告)号：EA005034B1
公开(公告)日：2004-10-28
申请号：EA200101180
申请日：2000-05-01
申请人： AMERICAN HOME PROD , LIGAND PHARM INC
发明人： FENSOME ANDREW , ZHANG PUWEN , KOKO MARCI C , ZHI LIN , JONES TODD K , TEGLEY CHRISTOPHER M , MELENSKI EDWARD G , EDWARDS JAMES P , WROBEL JAY E
IPC分类号： C07D409/10 , A61K31/404 , A61P1/00 , A61P5/34 , A61P7/00 , A61P7/04 , A61P13/08 , A61P15/00 , A61P35/00 , A61P43/00 , C07D209/08 , C07D209/30 , C07D209/40 , C07D209/96 , A61P5/36
摘要： Настоящееизобретениевключаетсоединенияобщейформулы (1) или (2), имеющиеуказанныезаместители, илиихфармацевтическиприемлемаясоль, которыеявляютсяагонистамирецепторапрогестерона, атакжеспособихполученияи ихприменениедляпроведенияконтрацепцииилилеченияпрогестеронзависимыхкарциноми аденокарцином.

7. 发明专利

AT275973T 未知
公开(公告)号：AT275973T
公开(公告)日：2004-10-15
申请号：AT00928611
申请日：2000-05-01
申请人： WYETH CORP , LIGAND PHARM INC
发明人： GRUBB GARY S , ZHI LIN , JONES TODD K , TEGLEY CHRISTOPHER M , EDWARDS JAMES P , FLETCHER HORACE A , WROBEL JAY E , FENSOME ANDREW , ZHANG PUWEN , TEREFENKO EUGENE A
IPC分类号： A61K31/567 , A61K20060101 , A61K31/535 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/565 , A61K31/57 , A61K45/06 , A61P20060101 , A61P15/18

8. 发明专利

AU766801B2 Cyclothiocarbamate derivatives as progesterone receptor modulators 未知
公开(公告)号：AU766801B2
公开(公告)日：2003-10-23
申请号：AU4811900
申请日：2000-05-01
申请人： WYETH CORP , LIGAND PHARM INC
发明人： ZHANG PUWEN , FENSOME ANDREW , TEREFENKO EUGENE A , ZHI LIN , JONES TODD K , TEGLEY CHRISTOPHER M , COLLINS MARK A , WROBEL JAY E , EDWARDS JAMES P
IPC分类号： A61K31/535 , A61K31/5355 , A61P15/00 , A61P15/18 , A61P35/00 , A61P43/00 , C07D265/18 , C07D413/04 , A61K31/536
摘要： PROBLEM TO BE SOLVED: To provide novel cyclothiocarbamate derivatives which are agonists of the progesterone receptor.SOLUTION: This invention relates to compounds expressed by the following formula, wherein R is a substituent. The derivatives are useful for: birth control; and treating and preventing progesterone-related disorder.

9. 发明专利

BG106080A CYCLOTHIOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS 未知
公开(公告)号：BG106080A
公开(公告)日：2002-05-31
申请号：BG10608001
申请日：2001-11-02
申请人： AMERICAN HOME PROD , LIGAND PHARM INC
发明人： ZHANG PUWEN , FENSOME ANDREW , TEFERENKO EUGENE A , WROBEL JAY E , EDWARDS JAMES P , JONES TODD K , TEGLEY CHRISTOPHER M , ZHI LIN , COLLINS MARK A
IPC分类号： A61K31/535 , A61K31/5355 , A61P15/00 , A61P15/18 , A61P35/00 , A61P43/00 , C07D265/18 , C07D413/04 , A61K31/536
摘要： The present invention provides compounds which are agonists of the progesterone receptor and have structures or wherein R1 and R2 are independent substituents selected from the group of H, optionally substituted C1 to C6 alkyl, alkenyl, alkynyl, or alkynyl groups C3 to C8 cycloalkyl, aryl, substituted aryl, or heterocyclic groups, or CORA or NRBCORA; or R1 and R2 are fused to form an optionally substituted 3 to 8 membered Spiro alkyl or alkenyl ring, or a Spiro cyclic ring containing one to three heteroatoms selected from O, S and N; RA is selected from H, amino, or optionally substituted C1 to C3 alkyl, aryl, C1 to C3 alkoxy, or C1 to C3 aminoalkyl groups; RB is H, C1 to C3 alkyl, or substituted C1 to C3 alkyl; R3 is H, OH, NH2 CORC, or optionally substituted C1 to C6 alkyl, C3 to C6 alkenyl, or alkynyl groups; RC is selected from H or optionally substituted C1 to C3 alkyl, aryl, C1 to C3 alkoxy, or C1 to C3 aminoalkyl groups; Q1 is S, NR7, or CR8R9, R5 is an optionally trisubstituted benzene ring or an optionally substituted five or six membered heterocyclic ring with 1, 2 or 3 ring heteroatoms selected from the group of O, S, SO, SO2 or NR6; or a pharmaceutically acceptable salt thereof. As well as methods of using these compounds for contraception and the treatment of progesterone-related maladies. 13 claims

10. 发明专利

BG106078A THIO-OXINDOLE DERIVATIVES 未知
公开(公告)号：BG106078A
公开(公告)日：2002-05-31
申请号：BG10607801
申请日：2001-11-02
申请人： AMERICAN HOME PROD , LIGAND PHARM INC
发明人： FENSOME ANDREW , ZHANG PUWEN , KOKO MARCI C , WROBEL JAY E , EDWARDS JAMES P , JONES TODD K , TEGLEY CHRISTOPHER M , ZHI LIN , MELENSKI EDWARD G
IPC分类号： C07D409/10 , A61K31/404 , A61P1/00 , A61P5/34 , A61P7/00 , A61P7/04 , A61P13/08 , A61P15/00 , A61P35/00 , A61P43/00 , C07D209/08 , C07D209/30 , C07D209/40 , C07D209/96 , A61P5/36
摘要： The invention relates to compounds which are agonists of the progesterone receptor, which have the general structures or wherein their substituents have the meanings listed in the description, or a pharmaceutically acceptable salt thereof, as well as methods of using these compounds to induce contraception or treat progesterone-related carcinomas and adenocacinomas. 18 claims

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