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1. 发明申请

WO2009089022A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS 审中-公开
标题翻译： N-烷氧基酰胺作为成像剂
公开(公告)号：WO2009089022A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/000096
申请日：2009-01-08
申请人： LANTHEUS MEDICAL IMAGING, INC. , CESATI, Richard, R. , HARRIS, Thomas, D. , ROBINSON, Simon, P. , LOOBY, Richard, J. , CHEESMAN, Edward, H. , YALAMANCHILI, Padmaja , CASEBIER, David, S.
发明人： CESATI, Richard, R. , HARRIS, Thomas, D. , ROBINSON, Simon, P. , LOOBY, Richard, J. , CHEESMAN, Edward, H. , YALAMANCHILI, Padmaja , CASEBIER, David, S.
IPC分类号： A61K49/10 , C07C271/22 , C07D257/02
CPC分类号： C07D257/02 , A61K49/103 , A61K49/106 , A61K51/04 , C07C53/18 , C07C259/06 , C07C259/14 , C07C271/22 , C07C2601/14 , C07D209/20 , C07D213/56 , C07D403/12
摘要： The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.
摘要翻译：本公开涉及化合物，诊断剂和相关方法。在某些情况下，提供了治疗患者的方法。更具体地，本公开提供了用于检测和/或成像和/或监测富含弹性蛋白的组织的化合物，诊断剂和试剂盒。此外，本公开提供了检测和/或成像和/或监测冠状动脉斑块，颈动脉斑块，髂骨/股骨斑块，主动脉斑块，肾动脉斑块，任何动脉血管的斑块，动脉瘤，血管炎，其他疾病的存在的方法的动脉壁，和/或韧带，子宫，肺或皮肤的损伤或结构变化，如总血管壁面积，内腔大小和外动脉周长的变化所示。

2. 发明申请

WO2011005322A3 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS 审中-公开
公开(公告)号：WO2011005322A3
公开(公告)日：2011-01-13
申请号：PCT/US2010/001926
申请日：2010-07-08
申请人： LANTHEUS MEDICAL IMAGING, INC. , CESATI, Richard, R. , HARRIS, Thomas, D. , ROBINSON, Simon, P. , LOOBY, Richard, J. , CHEESMAN, Edward, H. , YALAMANCHILI, Padmaja , CASEBIER, David, S.
发明人： CESATI, Richard, R. , HARRIS, Thomas, D. , ROBINSON, Simon, P. , LOOBY, Richard, J. , CHEESMAN, Edward, H. , YALAMANCHILI, Padmaja , CASEBIER, David, S.
IPC分类号： C07C271/22 , C07D257/02 , A61K49/10
摘要： The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

3. 发明公开

EP2240206A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS 有权
标题翻译： N-ALKOXYAMIDKONJUGATE ALS BILDGEBUNGSMITTEL
公开(公告)号：EP2240206A1
公开(公告)日：2010-10-20
申请号：EP09700768.6
申请日：2009-01-08
申请人： Lantheus Medical Imaging, Inc.
发明人： CESATI, Richard, R. , HARRIS, Thomas, D. , ROBINSON, Simon, P. , LOOBY, Richard, J. , CHEESMAN, Edward, H. , YALAMANCHILI, Padmaja , CASEBIER, David, S.
IPC分类号： A61K49/10 , C07C271/22 , C07D257/02
CPC分类号： C07D257/02 , A61K49/103 , A61K49/106 , A61K51/04 , C07C53/18 , C07C259/06 , C07C259/14 , C07C271/22 , C07C2601/14 , C07D209/20 , C07D213/56 , C07D403/12
摘要： The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.
摘要翻译：本公开涉及化合物，诊断剂和相关方法。在某些情况下，提供了治疗患者的方法。更具体地，本公开提供了用于检测和/或成像和/或监测富含弹性蛋白的组织的化合物，诊断剂和试剂盒。此外，本公开提供了检测和/或成像和/或监测冠状动脉斑块，颈动脉斑块，髂骨/股骨斑块，主动脉斑块，肾动脉斑块，任何动脉血管的斑块，动脉瘤，血管炎，其他疾病的存在的方法的动脉壁，和/或韧带，子宫，肺或皮肤的损伤或结构变化，如总血管壁面积，内腔大小和外动脉周长的变化所示。

4. 发明公开

EP2451776A2 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS 有权
标题翻译： N-二ALKOXYAMIDKONJUGATE用作成像剂
公开(公告)号：EP2451776A2
公开(公告)日：2012-05-16
申请号：EP10797455.2
申请日：2010-07-08
申请人： Lantheus Medical Imaging, Inc.
发明人： CESATI, Richard, R. , HARRIS, Thomas, D. , ROBINSON, Simon, P. , LOOBY, Richard, J. , CHEESMAN, Edward, H. , YALAMANCHILI, Padmaja , CASEBIER, David, S.
IPC分类号： C07C271/22 , C07D257/02 , A61K49/10
CPC分类号： A61K51/0497 , A61K49/085 , A61K49/10 , A61K51/0406 , C07C259/06 , C07C271/22 , C07D257/02
摘要： The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

5. 发明申请

WO2018195355A1 TOPICAL DELIVERY OF NUCLEIC ACID COMPOUNDS 审中-公开
公开(公告)号：WO2018195355A1
公开(公告)日：2018-10-25
申请号：PCT/US2018/028436
申请日：2018-04-19
申请人： RXI PHARMACEUTICALS CORPORATION , LOOBY, Richard, J.
发明人： LOOBY, Richard, J. , MAXWELL, Melissa
IPC分类号： A61K8/35 , A61K8/37 , A61K8/49 , A61K9/06 , A61K31/12 , A61K31/122 , A61K31/22
摘要： In some aspects, the disclosure relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal applications.

6. 发明申请

WO2011106703A3 CXCR4 RECEPTOR COMPOUNDS 审中-公开
标题翻译： CXCR4受体化合物
公开(公告)号：WO2011106703A3
公开(公告)日：2011-09-01
申请号：PCT/US2011/026322
申请日：2011-02-25
申请人： ANCHOR THERAPEUTICS, INC. , LOOBY, Richard, J. , TCHERNYCHEV, Boris
发明人： LOOBY, Richard, J. , TCHERNYCHEV, Boris
IPC分类号： A61K38/16
摘要： The invention relates generally to compounds which are allosteric modulators {e.g., positive and negative allosteric modulators, and allosteric agonists) of the G protein coupled receptor for stromal derived factor 1 (SDF-I), also known as the CXCR4 receptor. The CXCR4 receptor compounds are derived from the intracellular loops and domains of the CXCR4 receptor. The invention also relates to the use of these CXCR4 receptor compounds and pharmaceutical compositions comprising the CXCR4 receptor compounds in the treatment of diseases and conditions associated with CXCR4 modulation such as bone marrow transplantation, chemosensitization, cancer, metastatic disease ( e.g. , cancer), auto-immune disease ( e.g ., rheumatoid arthritis), fibrosis disease ( e.g ., pulmonary), AIDS infection, cardiovascular disease, uveitis, inflammatory diseases, celiac disease HIV infection and stem cell-based regenerative medicine.
摘要翻译：本发明一般涉及用于基质衍生因子1（SDF-1）的G蛋白偶联受体的变构调节剂（例如，正向和负向变构调节剂和变构激动剂）的化合物，也是已知的作为CXCR4受体。 CXCR4受体化合物来源于CXCR4受体的细胞内环和结构域。本发明还涉及这些CXCR4受体化合物和包含CXCR4受体化合物的药物组合物在治疗与CXCR4调节相关的疾病和病症例如骨髓移植，化学增敏作用，癌症，转移性疾病（例如，癌症），自身免疫疾病（例如类风湿性关节炎），纤维化疾病（例如肺癌），AIDS感染，心血管疾病，葡萄膜炎，炎症疾病，腹腔疾病HIV感染和基于干细胞的再生医学。

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