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1. 发明申请

WO2021084051A1 SYSTEMS AND METHODS FOR COLOR MAPPINGS OF CONTRAST IMAGES 审中-公开
公开(公告)号：WO2021084051A1
公开(公告)日：2021-05-06
申请号：PCT/EP2020/080477
申请日：2020-10-29
申请人： KONINKLIJKE PHILIPS N.V.
发明人： WANG, Shiying , ERRICO, Claudia , SHI, William, Tao , LOUPAS, Thanasis , POWERS, Jeffry, Earl , SHEERAN, Paul , TREMBLAY-DARVEAU, Charles
IPC分类号： A61B8/08 , A61B8/00
摘要： Systems and methods for time-varying two-dimensional (2D) color maps for visualizing images or sequences of images are disclosed. The 2D color map may include brightness values of a hue corresponding to different intensities that changes over time. In some 2D color maps, the hue used for the intensity scale may change over time while the brightness of a pixel may not. In some 2D color maps, both the hue and the brightness may change relative to intensity over time.

2. 发明申请

WO2019211175A1 SHEAR WAVE AMPLITUDE RECONSTRUCTION FOR TISSUE ELASTICITY MONITORING AND DISPLAY 审中-公开
公开(公告)号：WO2019211175A1
公开(公告)日：2019-11-07
申请号：PCT/EP2019/060681
申请日：2019-04-25
申请人： KONINKLIJKE PHILIPS N.V.
发明人： MERAL, Faik, Can , SETHURAMAN, Shriram , SHI, William, Tao , KRUECKER, Jochen
IPC分类号： A61B8/08 , G01S7/52 , A61B8/00 , G16H30/40
摘要： The present disclosure describes ultrasound systems and methods configured to determine the elasticity of a target tissue. Systems can include an ultrasound transducer configured to acquire echoes responsive to ultrasound pulses transmitted toward the tissue, which may include a region of increased stiffness. Systems can also include a beamformer configured to control the transducer to transmit a push pulse into the tissue, thereby generating a shear wave in the region of increased stiffness. The beamformer can be configured to control the transducer to emit tracking pulses adjacent to the push pulse. Systems can further include a processor configured to determine a displacement amplitude of the shear wave and based on the amplitude, generate a qualitative tissue elasticity map of the tissue. The processor can combine the qualitative map with a quantitative map of the same tissue, and based on the combination, determine a boundary of the region of increased stiffness.

3. 发明申请

WO2018060502A1 ULTRASOUND THERMOMETRY SYSTEM WITH MOTION COMPENSATION AND METHOD OF OPERATION THEREOF 审中-公开
标题翻译：具有运动补偿的超声波温度测量系统及其操作方法
公开(公告)号：WO2018060502A1
公开(公告)日：2018-04-05
申请号：PCT/EP2017/074909
申请日：2017-09-29
申请人： KONINKLIJKE PHILIPS N.V.
发明人： KRUECKER, Jochen , YAN, Pingkun , SHI, William, Tao , MERAL, Faik, Can , SETHURAMAN, Shriram
IPC分类号： A61B8/00 , A61N7/00
摘要： An ultrasound thermometry system (100) includes a controller (110) configured to obtain ultrasound information (USI) of a region-of-interest (ROI); generate first and second sets of data frames based upon the USI of the ROI, each of the first and second sets of data frames includes data frames with first and second zones which are substantially mutually exclusive to each other; determine motion fields in the first and second zones in each of the data frames; form a model which correlates the motion fields between the first and second zones within the frames; estimate motion fields due to a physiological component within the first zone of a current data frame selected from the second set of data frames in accordance with motion fields in the second zone of the current data frame and the model; and update the current data frame by correcting the first zone of the current data frame in accordance with a difference between the determined motion and the estimated motion fields in the first zone.
摘要翻译：超声测温系统（100）包括控制器（110），其被配置为获得感兴趣区域（ROI）的超声信息（USI）;以及控制器基于ROI的USI生成第一和第二组数据帧，第一和第二组数据帧中的每一个包括具有彼此基本互斥的第一和第二区域的数据帧; 确定每个数据帧中的第一和第二区域中的运动场; 形成使帧内的第一和第二区域之间的运动场相关的模型; 根据当前数据帧的第二区域和模型中的运动场，估计由于第二组数据帧中的当前数据帧的第一区域内的生理成分引起的运动场; 并且通过根据所确定的运动和第一区域中的所估计的运动场之间的差异来校正当前数据帧的第一区域来更新当前数据帧。

4. 发明申请

WO2017097853A1 INTERLEAVED BEAM PATTERN FOR SONOTHROMBOLYSIS AND OTHER VASCULAR ACOUSTIC RESONATOR MEDIATED THERAPIES 审中-公开
标题翻译： SONOTHROMBOLYSIS与其他血管声学谐振器介入治疗的交错波束模式
公开(公告)号：WO2017097853A1
公开(公告)日：2017-06-15
申请号：PCT/EP2016/080127
申请日：2016-12-07
申请人： KONINKLIJKE PHILIPS N.V. , BRACCO SUISSE SA
发明人： DIANIS, Scott, William , POWERS, Jeffry, Earl , SEIP, Ralf , SHI, William, Tao , BOHREN, Yannick , GAUD, Emmanuel, Jean-Marie , HYVELIN, Jean-Marc, Paul, Robert
IPC分类号： A61N7/02 , A61B17/22 , A61N7/00
CPC分类号： A61N7/02 , A61B17/22004 , A61B2017/22008 , A61N2007/0039 , A61N2007/0078 , A61N2007/0082 , A61N2007/0095 , A61N2007/027
摘要： A therapeutic ultrasound system transmits a staggered or interleaved pattern of therapy beams for use in sonothrombolysis and other Vascular Acoustic Resonators (VAR) mediated therapy. The inventive technique minimizes VAR, e.g. microbubble, destruction due to adjacent beams, ensures uniform sonication of the targeted region by filling in the spaces between the beams in subsequent passes, and further provides a means for bubble replenishment to maximize the clot lysis from ultrasound. The technique is also applicable to diagnostic ultrasound, VAR mediated drug delivery and blood brain barrier opening.
摘要翻译：治疗超声系统传输治疗束的交错或交错模式，用于声导溶栓和其他血管声学谐振器（VAR）介导的治疗。本发明技术使VAR例如最小化。由于相邻光束的破坏，通过在随后的通道中填充光束之间的空间来确保目标区域的均匀超声处理，并进一步提供用于补充泡沫的装置，以使来自超声波的血块溶解最大化。该技术也适用于超声诊断，VAR介导的药物输送和血脑屏障开放。

5. 发明申请

WO2021099629A1 SYSTEMS AND METHODS FOR FINDING HEPATO-RENAL INDICES 审中-公开
公开(公告)号：WO2021099629A1
公开(公告)日：2021-05-27
申请号：PCT/EP2020/082998
申请日：2020-11-22
申请人： KONINKLIJKE PHILIPS N.V.
发明人： HUANG, Sheng-Wen , XIE, Hua , NGUYEN, Man, M , SHAMDASANI, Vijay, Thakur , SHI, William, Tao
IPC分类号： A61B8/00 , A61B8/08
摘要： Systems and methods for calculating hepato-renal index (HRI) values from radiofrequency (RF) data are disclosed herein. The RF data may include fundamental frequency components, harmonic frequency components, or a combination thereof. Signal intensities within regions of interest may be calculated from the RF data. The signal intensities may be averaged to arrive at an average signal intensity value for each region of interest. In some examples, some of the highest and/or lowest signal intensity values may be removed prior to averaging. The ratio of the average signal intensities from the different regions of interest may be then be taken to arrive at the HRI values.

6. 发明申请

WO2020141229A1 CONTRAST IMAGING 审中-公开
公开(公告)号：WO2020141229A1
公开(公告)日：2020-07-09
申请号：PCT/EP2020/050113
申请日：2020-01-06
申请人： KONINKLIJKE PHILIPS N.V.
发明人： SHI, William, Tao , XIE, Hua , WANG, Shiying , TREMBLAY-DARVEAU, Charles , SHEERAN, Paul , SHAMDASANI, Vijay, Thakur
IPC分类号： A61B8/08 , A61B8/00 , G01S7/52
摘要： The present disclosure describes ultrasound systems configured to perform microbubble-based contrast imaging with enhanced sensitivity. The systems can enhance echo signals derived from microbubbles while suppressing echo signals derived from tissue by detecting phase shifts exhibited by microbubbles in resonance. To detect the phase shifts, and thereby distinguish between microbubble-based signals and tissue-based signals, the systems can transmit a series of ultrasound pulses into a target region in accordance with a predefined sequence. The sequence can include an initiation pulse configured to stimulate microbubbles into nonlinear oscillation, a detection pulse configured to detect the nonlinear oscillation, and a summation pulse formed by transmitting an initiation pulse and detection pulse with a small time delay therebetween. A signal processor included in the system can determine phase shifts exhibited by the signals generated in response to the series of pulses and mask non-microbubble-based signals based on the magnitude of the detected phase shifts.

7. 发明申请

WO2019219485A1 SYNTHETIC TRANSMIT FOCUSING ULTRASOUND SYSTEM WITH SPEED OF SOUND MAPPING 审中-公开
公开(公告)号：WO2019219485A1
公开(公告)日：2019-11-21
申请号：PCT/EP2019/061883
申请日：2019-05-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： ROBERT, Jean-Luc, Francois-Marie , HUANG, Sheng-Wen , VIGNON, Francois, Guy, Gerard, Marie , SHIN, Jun, Seob , KIM, Seungsoo , XIE, Hua , NGUYEN, Man- , MERAL, Faik, Can , SHI, William, Tao , AMADOR CARRASCAL, Carolina
IPC分类号： G01S7/52 , G01S15/89 , A61B8/00 , A61B8/08
摘要： In an ultrasound imaging system which produces synthetically transmit focused images, the multiline signals used to form image scanlines are analyzed for speed of sound variation, and a map 60 of this variation is generated. In a preferred implementation, the phase discrepancy of the received multilines caused by speed of sound variation in the medium is estimated in the angular spectrum domain for the receive angular spectrum. Once the phase is estimated for all locations in an image, the differential phase between two points at the same lateral location, but different depth, is computed. This differential phase is proportional to the local speed of sound between the two points. A color-coded two- or three-dimensional map 60 is produced from these speed of sound estimates and presented to the user.

8. 发明申请

WO2017211757A1 USING REFLECTED SHEAR WAVES FOR MONITORING LESION GROWTH IN THERMAL ABLATIONS 审中-公开
标题翻译：反射剪切波用于监测热剥落中的裂隙增长
公开(公告)号：WO2017211757A1
公开(公告)日：2017-12-14
申请号：PCT/EP2017/063598
申请日：2017-06-05
申请人： KONINKLIJKE PHILIPS N.V.
发明人： MERAL, Faik, Can , SETHURAMAN, Shriram , YAN, Pingkun , SHI, William, Tao , KRUECKER, Jochen
IPC分类号： A61B8/08
摘要： A system for boundary identification includes a memory (42) to store shear wave displacements through a medium as a displacement field including a spatial component and a temporal component. A directional filter (206, 208) filters the displacement field to provide a directional displacement field. A signal processing device (26) is coupled to the memory to execute a boundary estimator (214) to estimate a tissue boundary in a displayed image based upon a history of the directional displacement field accumulated over time.
摘要翻译：用于边界识别的系统包括存储器（42），用于存储通过介质的剪切波位移作为包括空间分量和时间分量的位移场。方向滤波器（206,208）对位移场进行滤波以提供方向位移场。信号处理设备（26）耦合到存储器以执行边界估计器（214），以基于随时间累积的定向位移场的历史来估计显示图像中的组织边界。

9. 发明申请

WO2014136016A1 CONSISTENT SEQUENTIAL ULTRASOUND ACQUISITIONS FOR INTRA-CRANIAL MONITORING 审中-公开
标题翻译：一致的顺序超声波收集用于进行内部监测
公开(公告)号：WO2014136016A1
公开(公告)日：2014-09-12
申请号：PCT/IB2014/059232
申请日：2014-02-25
申请人： KONINKLIJKE PHILIPS N.V.
发明人： RAJU, Balasundar, Iyyavu , SHI, William, Tao , VIGNON, Francois, Guy, Gerard, Marie
IPC分类号： A61B8/00 , A61B5/00 , A61B19/00
CPC分类号： A61B8/54 , A61B5/6842 , A61B8/0808 , A61B8/14 , A61B8/42 , A61B8/4245 , A61B8/46 , A61B8/5223 , A61B2090/395
摘要： A medical imaging probe (102) for contact with an imaging subject includes an indicium placement apparatus for, while the probe is in contact, selectively performing an instance of marking the subject so as to record a position of the probe. The device may further include a feedback module for determining whether an orientation, with respect to a the mark, that currently exists for a medical imaging probe of the device meets a criterion of proximity to a predetermined orientation. Responsive to the determination that the criterion is met, a quantitative evaluation may be made automatically and without need for user intervention, via live imaging via the probe, of a lesion that was, prior to the determination, specifically identified for the evaluation. Change, such as growth (116), in the lesion, like a brain lesion, may thereby be tracked over consistent sequential imaging acquisitions, such as through ultrasound.
摘要翻译：用于与成像对象接触的医学成像探针（102）包括：标记放置装置，用于在探针接触时，选择性地执行标记对象的实例，以记录探针的位置。该装置还可以包括反馈模块，用于确定当前是否存在用于该装置的医学成像探针的相对于标记的取向是否满足接近预定取向的标准。响应于确定该标准的确定，可以自动进行定量评估，并且不需要通过探针的实时成像来进行在确定之前被确定为评估的病变的用户干预。因此，可以通过诸如通过超声波的一致的顺序成像采集来跟踪病变（例如脑损伤）中的生长（116）的变化。

10. 发明申请

WO2023274763A1 ULTRASONIC QUANTIFICATION OF ACOUSTIC ATTENUATION COEFFICIENT IN THE PRESENCE OF ELEVATION APERTURE BLOCKAGE 审中-公开
公开(公告)号：WO2023274763A1
公开(公告)日：2023-01-05
申请号：PCT/EP2022/066678
申请日：2022-06-20
申请人： KONINKLIJKE PHILIPS N.V.
发明人： XIE, Hua , NGUYEN, Man , ROBERT, Jean-Luc, Francois-Marie , SHI, William, Tao , ERRICO, Claudia
IPC分类号： G01S7/52 , G01S15/89 , A61B8/08 , A61B8/488 , A61B8/5207 , A61B8/523 , A61B8/5253 , A61B8/5269 , G01S15/8915 , G01S7/52036 , G01S7/5205
摘要： An ultrasonic diagnostic imaging system and method produce attenuation coefficient maps of a region of interest in an ultrasound image. In order to detect the presence of elevation aperture blockage, the system estimates attenuation coefficients by two different methods. The estimates produced by the two different methods are combined to produce a metric, which is evaluated as a function of depth. If the metric satisfies one or more criteria of measurement bias, elevation aperture blockage is identified and an alert of the blockage is produced for the user.

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