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1. 发明申请

US20090214629A1 GENE TRANSFER METHOD 审中-公开
标题翻译：基因转移方法
公开(公告)号：US20090214629A1
公开(公告)日：2009-08-27
申请号：US11915474
申请日：2005-05-26
申请人： Kazuo Maruyama , Tomoko Takizawa , Kosuke Hagisawa , Toshihiko Nishioka , Hironobu Yanagie
发明人： Kazuo Maruyama , Tomoko Takizawa , Kosuke Hagisawa , Toshihiko Nishioka , Hironobu Yanagie
IPC分类号： A61K9/127 , C12N15/87 , A61K31/7088
CPC分类号： C12N15/88 , A61K9/0009 , A61K9/127 , A61K9/1272 , A61K41/0028 , A61K47/42 , A61K48/00 , A61K48/0008 , A61N7/00
摘要： A method for efficiently transferring a gene to a target cell is provided. A method of transferring a gene to a target cell, including adding or administering a positively charged complex (A) composed of the gene and a cationic substance and gas-filled microparticles (B) to a target cell-containing composition or a living body and then exposing the target cell-containing composition or the living body to a low-frequency ultrasound.
摘要翻译：提供了将基因有效转移到靶细胞的方法。将基因转移到靶细胞的方法，包括将由该基因构成的带正电荷的复合物（A）和阳离子性物质和充气微粒（B）添加或给予含靶细胞的组合物或活体，然后将含靶细胞的组合物或活体暴露于低频超声波。

2. 发明授权

US5870659A Color image forming apparatus and method using plural photosensitive drums 失效
标题翻译：彩色图像形成装置和使用多个感光鼓的方法
公开(公告)号：US5870659A
公开(公告)日：1999-02-09
申请号：US922484
申请日：1997-09-03
申请人： Kazuo Maruyama , Koji Masuda , Tsutomu Sugimoto
发明人： Kazuo Maruyama , Koji Masuda , Tsutomu Sugimoto
IPC分类号： G03G15/00 , G03G15/01
CPC分类号： G03G15/0194
摘要： In an image forming apparatus, three or more (four in this case) cylindrical photosensitive members 1 to 4 on which latent images are formed and developed through use of toner to thereby produce toner images, are arranged so as to share a tangential line in common, and a cylindrical intermediate transfer member 51 is provided. Alternatively, a first unit containing one or more image carriers is positioned next to a first transfer member and a second unit containing one or more image carriers is positioned next to a second transfer member such that there is reflectional symmetry between the first and second units and the transfer members.
摘要翻译：在图像形成装置中，通过使用调色剂形成和显影潜像从而产生调色剂图像的三个或更多个（在这种情况下为四个）圆柱形感光构件1至4被布置成共享切向线，并且设置有圆筒状的中间转印部件51。或者，包含一个或多个图像载体的第一单元位于第一转印构件的旁边，并且包含一个或多个图像载体的第二单元位于第二转印构件的旁边，使得在第一和第二单元之间存在反射对称，转移成员。

3. 发明授权

US5614935A Ink transfer medium for toner, ink transfer process and re-inking process for the same 失效
标题翻译：用于调色剂的墨水转印介质，墨水转印过程和再次上墨过程相同
公开(公告)号：US5614935A
公开(公告)日：1997-03-25
申请号：US447212
申请日：1995-05-22
申请人： Kenji Ogi , Hiroshi Takayama , Yasuo Yamamoto , Kazuo Maruyama , Eiichi Akutsu
发明人： Kenji Ogi , Hiroshi Takayama , Yasuo Yamamoto , Kazuo Maruyama , Eiichi Akutsu
IPC分类号： B41J2/325 , B41J31/00 , B41J31/14 , B41M5/30 , B41M5/392 , G03G15/34 , B41J2/315
CPC分类号： B41J2/325 , G03G15/344 , Y10S428/913 , Y10S428/914 , Y10T428/24802 , Y10T428/24901 , Y10T428/25 , Y10T428/254 , Y10T428/31504 , Y10T428/31786
摘要： An ink transfer medium for toner is disclosed, comprising the following layers, in this order: a heat-generating resistive layer heated by input of electrical signal, a conductive layer, and an ink release layer having a toner layer on it, an adhesion from 0.2 g/mm to 40 g/mm as measured by the 90.degree. peeling off method and consisting of a viscoelastomer having a critical surface tension of 35 dyne/cm or less. It can be re-inked by attaching toner to the portions of the ink transfer medium from which the ink has been removed, using toner held in a toner holding means.An ink transfer process for toner is also disclosed, wherein an ink transfer medium having toner layer formed on the above described ink release layer is used and the toner layer contacts the recording medium under pressure, while a recording head contacts the anisotropic conductive layer of the ink transfer medium, so that an electrical signal is input and then toner fused by heat generated by the heat-generating resistive layer is transferred to the recording medium.
摘要翻译：公开了一种用于调色剂的油墨转印介质，包括以下层：通过电信号输入加热的发热电阻层，导电层和在其上具有调色剂层的油墨释放层， 0.2g / mm至40g / mm，通过90°剥离法测量，并由粘弹性体组成，其临界表面张力为35达因/厘米或更小。通过使用保持在调色剂保持装置中的调色剂将调色剂附着到已经从中除去油墨的油墨转印介质的部分上，可以再次进行再墨。还公开了一种用于调色剂的油墨转印方法，其中使用在上述油墨释放层上形成有调色剂层的油墨转印介质，并且调色剂层在压力下与记录介质接触，而记录头接触到油墨转印介质，从而输入电信号，然后通过发热电阻层产生的热量将调色剂转印到记录介质上。

4. 发明授权

US5466654A Erasable display medium 失效
标题翻译：可擦除显示介质
公开(公告)号：US5466654A
公开(公告)日：1995-11-14
申请号：US284999
申请日：1994-08-03
申请人： Eiichi Akutsu , Hiroh Soga , Shigehito Ando , Susumu Hirakata , Kazuo Maruyama
发明人： Eiichi Akutsu , Hiroh Soga , Shigehito Ando , Susumu Hirakata , Kazuo Maruyama
IPC分类号： B41M5/40 , B41M5/42
CPC分类号： B41M5/42 , B41M5/426
摘要： A display medium is disclosed, comprising at least the following layers, in this order: a heating resistive layer, a conductive layer, a background layer and an erasable thermochromic layer, and comprising a heating resistive layer which may comprise at least two layers. The display medium may also comprise a contact resistance reducing layer on the heating resistive layer and a protective layer on the erasable thermochromic layer.
摘要翻译：公开了显示介质，其至少包括以下层：依次包括加热电阻层，导电层，背景层和可擦除热致变色层，并且包括可包括至少两层的加热电阻层。显示介质还可以包括加热电阻层上的接触电阻降低层和可擦除热变色层上的保护层。

5. 发明申请

US20140155813A1 THERAPEUTIC MUSCULAR DYSTROPHY DRUG HAVING BUBBLE LIPOSOME LOADED WITH MORPHOLINO AS ACTIVE INGREDIENT 有权
标题翻译：具有作为活性成分的以摩尔作为负载的泡沫脂多糖的治疗性肌肉DYSTROPHY药物
公开(公告)号：US20140155813A1
公开(公告)日：2014-06-05
申请号：US14116316
申请日：2012-04-25
申请人： Yoichi Negishi , Yoko Takahashi , Kazuo Maruyama , Yukihiko Aramaki
发明人： Yoichi Negishi , Yoko Takahashi , Kazuo Maruyama , Yukihiko Aramaki
IPC分类号： A61K47/48 , A61K41/00
CPC分类号： A61K47/48815 , A61K9/0019 , A61K9/1271 , A61K41/0028 , A61K47/24 , A61K47/6911 , C12N15/113 , C12N15/88 , C12N2310/11 , C12N2310/3233 , C12N2310/3515 , C12N2320/32 , C12N2320/33
摘要： To provide a technology for introducing a PMO with remarkably enhanced cell permeability, leading to significantly enhanced introduction efficiency to thereby provide a therapeutic drug that dramatically ameliorates a medical condition of DMD. Also provided is a therapeutic drug for Duchenne muscular dystrophy, including as an active ingredient a Bubble liposome having a specific morpholino oligomer (PMO) bound to a surface thereof, in which the PMO is introduced into a muscle fiber (muscle cell) of a muscle tissue with high efficiency by administration of the therapeutic drug into the muscle tissue or into a blood vessel followed by ultrasound irradiation to the muscle tissue transcutaneously.
摘要翻译：为了提供引入具有显着增强的细胞渗透性的PMO的技术，导致显着提高的引入效率，从而提供显着改善DMD的医学状况的治疗药物。还提供了杜烯肌营养不良的治疗药物，其包括作为活性成分的具有与其表面结合的特异性吗啉代低聚物（PMO）的泡沫脂质体，其中将PMO引入肌肉的肌肉纤维（肌肉细胞）通过将治疗药物施用到肌肉组织中或进入血管，然后经皮超声照射到肌肉组织，从而高效地进行组织。

6. 发明申请

US20090067766A1 Sliding Bearing 有权
标题翻译：滑动轴承
公开(公告)号：US20090067766A1
公开(公告)日：2009-03-12
申请号：US12224656
申请日：2007-03-27
申请人： Kazuo Maruyama , Takeshi Yanase , Kunio Maki , Jun-ichi Kobayashi
发明人： Kazuo Maruyama , Takeshi Yanase , Kunio Maki , Jun-ichi Kobayashi
IPC分类号： F16C33/02
CPC分类号： F16C33/1065 , F16C17/026
摘要： A sliding bearing comprises a shaft hole for rotatably supporting a shaft that is inserted thereinto, an inner circumferential surface on which the shaft slides, and plural linearly oblique grooves. The grooves extend in a direction crossing a circumferential direction of the sliding bearing and are formed on the inner circumferential surface at intervals, and the grooves are provided with a lubricant. The oblique grooves have an oblique angle in a range of 10° to 60° with respect to a direction perpendicular to the circumferential direction and have a width B in a range of 0.5 to 5 mm in the circumferential direction. The adjacent grooves have a land with a surface as a sliding surface therebetween, and the sliding surface has a width A in a range of 1 to 7 mm in the circumferential direction. A ratio A/B of the width A of the sliding surface of the land to the width B of the groove is in a range of 0.5 to 5.0.
摘要翻译：滑动轴承包括用于可旋转地支撑插入其中的轴的轴孔，轴滑动的内周面和多个线性倾斜槽。这些槽沿着与滑动轴承的圆周方向交叉的方向延伸，并且在内周面上间隔地形成，并且槽设置有润滑剂。斜槽相对于与圆周方向垂直的方向具有10°至60°的倾斜角度，并且在圆周方向上具有在0.5至5mm的范围内的宽度B. 相邻的槽具有在其间具有滑动面的表面的平台，并且滑动面的宽度A在圆周方向上在1至7mm的范围内。槽脊的滑动面的宽度A与槽的宽度B的比A / B在0.5〜5.0的范围内。

7. 发明授权

US07014367B2 Oil-impregnated sintered sliding bearing 有权
标题翻译：浸油烧结滑动轴承
公开(公告)号：US07014367B2
公开(公告)日：2006-03-21
申请号：US10500980
申请日：2003-01-20
申请人： Motohiro Miyasaka , Kazuo Maruyama , Michiharu Mogami , Junichi Kobayashi , Hideki Akita , Osamu Gokita
发明人： Motohiro Miyasaka , Kazuo Maruyama , Michiharu Mogami , Junichi Kobayashi , Hideki Akita , Osamu Gokita
IPC分类号： F16C33/02 , H01F3/02 , H01F3/04 , H01F3/06
CPC分类号： F16C33/104 , F16C33/1065 , F16C33/12 , F16C2204/60 , F16C2240/40 , Y10S384/902 , Y10T428/12021 , Y10T428/12153
摘要： An oil-impregnated sintered sliding bearing formed of a porous iron-based sintered alloy with quenched structure and receiving a high surface pressure capable of reducing the number of finishing steps by cutting and grinding and providing a bearing performance equivalent to or higher than that of conventional bearings, wherein a plurality of ridge-and-groove lines having a height difference of 2 to 12.5 μm and extending in circumferential direction are axially arranged in parallel with each other by boring the bearing surface thereof to form a wavy surface in axial direction, and the portion thereof deeper by 10 to 60 μm from the outer layer of the bearing surface is formed dense to seal surface pores so as to reduce the pores opening to the outer surface to 1 to 10 percent by area, whereby the bearing can be used at a surface pressure of 6 kgf/mm2 (58.5 MPa) or higher and a sliding speed of 2 to 5 cm/s.
摘要翻译：一种浸油烧结滑动轴承，由具有淬火结构的多孔铁基烧结合金形成，并具有能够通过切割和研磨减少精加工步骤的数量的高表面压力，并提供与常规相当或更高的轴承性能轴承，其中通过对其轴承表面进行钻孔而在轴向方向上彼此平行地布置具有2至12.5μm的高差为2至12.5μm并沿圆周方向延伸的多个脊沟槽线，以在轴向方向上形成波浪形表面，并且从支承面的外层更深10〜60μm的部分形成为致密的，以密封表面孔，以便将通过外表面打开的孔减少到1至10％的面积，由此轴承可以用于表面压力为6kgf / mm 2（58.5MPa）以上，滑动速度为2〜5cm / s。

8. 发明授权

US06589700B2 Image carrier and apparatus and method for recording image using image carrier 有权
公开(公告)号：US06589700B2
公开(公告)日：2003-07-08
申请号：US09951487
申请日：2001-09-14
申请人： Yasuyuki Tsutsumi , Shigeki Nishimura , Kazuya Yamanoi , Tadashi Kiyama , Kazuo Maruyama
发明人： Yasuyuki Tsutsumi , Shigeki Nishimura , Kazuya Yamanoi , Tadashi Kiyama , Kazuo Maruyama
IPC分类号： G03G5147
CPC分类号： G03G5/14773 , G03G5/14704 , G03G5/14708 , G03G5/14791 , G03G5/14795
摘要： In an image recording apparatus, the surface of an image carrier is formed of a material having a high affinity to particulates the particle size of which is smaller than toner and the surfaces of which have been treated to be hydrophobic, so that a layer of the particulates treated to be hydrophobic is retained on the surface of the image carrier.

9. 发明授权

US5912101A Toner for forming an image, image forming method and heat-fixing method 失效
标题翻译：用于形成图像的调色剂，成像方法和热定影方法
公开(公告)号：US5912101A
公开(公告)日：1999-06-15
申请号：US55317
申请日：1998-04-06
申请人： Yuki Karaki , Hiroshi Yusa , Takashige Kasuya , Kazuo Maruyama , Masao Takano
发明人： Yuki Karaki , Hiroshi Yusa , Takashige Kasuya , Kazuo Maruyama , Masao Takano
IPC分类号： G03G9/08 , G03G9/087 , G03G9/097 , G03G13/22
CPC分类号： G03G9/08782 , G03G9/0819 , G03G9/0827 , G03G9/08795 , G03G9/08704 , G03G9/09725
摘要： A toner for forming an image has toner particles containing at least a colorant, a binder resin and a wax. The toner has (i) a circularity distribution in which the toner has an average circularity of 0.900 to less than 0.965, contains 20 to 60% by number of particles with a circularity of less than 0.95 and has a mode circularity of 0.90 or more; and (ii) a particle size distribution in which the toner has a circle-equivalent average diameter of 2.0 to 10.0 .mu.m and has at least one peak of frequency by number in the region of a circle-equivalent diameter of 0.6 to 3.0 .mu.m and at least one peak of frequency by number in the region of a circle-equivalent diameter of from more than 3.0 .mu.m to 10.0 .mu.m. The wax has an endothermic main peak as measured by DSC of 60 to 120.degree. C. The binder resin contains THF soluble matter and 0 to 5.0% by weight of THF insoluble matter. The THF soluble matter having a molecular-weight distribution as measured by GPC in which the THF soluble matter has a content (M1) of 5% or less of a component with a molecular weight of less than 50,000, a content (M2) of 20 to 45% of a component with a molecular weight of 50,000 to 500,000, and a content (M3) of 2 to 25% of a component with a molecular weight exceeding 500,000 and the following condition (1) is satisfied:M1.gtoreq.M2>M3 (1)
摘要翻译：用于形成图像的调色剂具有至少含有着色剂，粘合剂树脂和蜡的调色剂颗粒。调色剂具有（i）其中调色剂的平均圆形度为0.900至小于0.965的圆形度分布，包含20至60个数量的圆形度小于0.95的颗粒，并且具有0.90以上的模式圆形度; 和（ii）调色剂的圆当量平均直径为2.0〜10.0μm的粒径分布，并且在圆当量直径为0.6〜3.0μm的区域中具有至少一个频数峰值并且在圆当量直径为3.0μm以上10.0μm以上的区域中，至少存在一个数量以上的峰。蜡具有通过DSC测量的吸热主峰为60至120℃。粘合剂树脂含有THF可溶物质和0至5.0重量％的THF不溶物质。通过GPC测定的THF可溶物质，其中THF可溶物质的分子量小于50,000的成分的含量（M1）为5％以下，含量（M2）为20 至45％的分子量为50,000至500,000的组分，并且分子量超过500,000的组分的含量（M3）为2至25％，满足以下条件（1）：M1> = M2 > M3（1）

10. 发明授权

US5471233A Ink jet recording apparatus 失效
标题翻译：喷墨记录装置
公开(公告)号：US5471233A
公开(公告)日：1995-11-28
申请号：US347166
申请日：1994-11-23
申请人： Toru Okamoto , Kazuo Maruyama
发明人： Toru Okamoto , Kazuo Maruyama
IPC分类号： B41J2/01 , B41J2/005 , B41J2/06
CPC分类号： B41J2/005 , B41J2/01 , B41J2/06
摘要： A recording apparatus is disclosed comprising a recording head adapted to hold fusible ink, a transfer member facing the recording head without contacting it, heating means for heating the transfer member to a predetermined temperature, pressure applying means facing the transfer member in such a way that a recording medium can pass therebetween and cooperating with the transfer member for applying pressure to the recording medium, and voltage applying means for applying a voltage between the recording head and the transfer member, the recording head supplying the fusible ink in a molten state to the transfer member, the predetermined temperature being higher than the softening point of the ink and lower than the melting point of the ink, and the transfer member comprising materials having a surface energy approximately equal to the value of the critical surface tension of the ink and smaller than the surface energy of the recording medium.
摘要翻译：公开了一种记录装置，包括：适于容纳可熔油墨的记录头;不与其接触的面向记录头的转印件;用于将转印件加热至预定温度的加热装置;面对转印件的加压装置，记录介质可以在其间通过并与转印构件配合以向记录介质施加压力;以及电压施加装置，用于在记录头和转印构件之间施加电压，记录头将熔融状态的熔融态提供给所述预定温度高于所述油墨的软化点且低于所述油墨的熔点，并且所述转印部件包括表面能大致等于所述油墨的临界表面张力的值的材料和更小的比记录介质的表面能量高。

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