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1. 发明申请

US20050075461A1 Moldings of flurorubbers and process for their production 失效
标题翻译：氟橡胶的成型及其生产工艺
公开(公告)号：US20050075461A1
公开(公告)日：2005-04-07
申请号：US10486388
申请日：2002-09-30
申请人： Kazuki Morimoto , Naoya Kuzawa , Hitoshi Ogura , Takumi Arisawa , Takeshi Kuboyama , Kinro Hashimoto , Hitoshi Yamada , Masayuki Saito , Tetsuya Miwa
发明人： Kazuki Morimoto , Naoya Kuzawa , Hitoshi Ogura , Takumi Arisawa , Takeshi Kuboyama , Kinro Hashimoto , Hitoshi Yamada , Masayuki Saito , Tetsuya Miwa
IPC分类号： C08F6/00 , C08F6/02 , C08F8/00 , C08J3/24
CPC分类号： C08K5/0025 , C08F6/00 , C08F6/02 , C08F8/00 , C08J3/24 , C08J2327/12 , C08K5/14 , C08L27/18 , C08F214/18 , C08L27/12
摘要： Moldings of fluoro rubbers produced by crosslinking a tetrafluoroethylene/propylene copolymer or a tetrafluoroethylene/propylene/vinylidene fluoride copolymer, which have metal contents of 1.5% by mass or below in terms of metal elements and are suitable for use applications necessitating clean environment, for example, manufacturing or carrier equipment for semiconductors, manufacturing equipment, carriers, or storage containers for food, or medical supplies.
摘要翻译：通过将金属含量以金属元素计为1.5质量％以下且适用于需要清洁环境的用途的四氟乙烯/丙烯共聚物或四氟乙烯/丙烯/偏二氟乙烯共聚物交联而得到的氟橡胶的成形品，用于半导体，制造设备，运输工具或食品储存容器或医疗用品的制造或运输设备。

2. 发明授权

US07173094B2 Moldings of fluororubbers and process for their production 失效
标题翻译：氟橡胶的成型及其生产工艺
公开(公告)号：US07173094B2
公开(公告)日：2007-02-06
申请号：US10486388
申请日：2002-09-20
申请人： Kazuki Morimoto , Naoya Kuzawa , Hitoshi Ogura , Takumi Arisawa , Takeshi Kuboyama , Kinro Hashimoto , Hitoshi Yamada , Masayuki Saito , Tetsuya Miwa
发明人： Kazuki Morimoto , Naoya Kuzawa , Hitoshi Ogura , Takumi Arisawa , Takeshi Kuboyama , Kinro Hashimoto , Hitoshi Yamada , Masayuki Saito , Tetsuya Miwa
IPC分类号： C08L27/18 , D01F6/12 , B05D7/02 , C08F8/00 , C08L27/00 , C08J11/04
CPC分类号： C08K5/0025 , C08F6/00 , C08F6/02 , C08F8/00 , C08J3/24 , C08J2327/12 , C08K5/14 , C08L27/18 , C08F214/18 , C08L27/12
摘要： Moldings of fluoro rubbers produced by crosslinking a tetrafluoroethylene/propylene copolymer or a tetrafluoroethylene/propylene/vinylidene fluoride copolymer, which have metal contents of 1.5% by mass or below in terms of metal elements and are suitable for use applications necessitating clean environment, for example, manufacturing or carrier equipment for semiconductors, manufacturing equipment, carriers, or storage containers for food, or medical supplies.
摘要翻译：通过将金属含量以金属元素计为1.5质量％以下的四氟乙烯/丙烯共聚物或四氟乙烯/丙烯/偏二氟乙烯共聚物交联而制造的氟橡胶的成形品，适用于需要清洁环境的用途，例如，用于半导体，制造设备，运输工具或食品储存容器或医疗用品的制造或运输设备。

3. 发明申请

US20090221758A1 PERFLUOROELASTOMER COMPOSITION AND MOLDED ARTICLE HEREOF 有权
标题翻译：全氟聚合物组合物及其成型品
公开(公告)号：US20090221758A1
公开(公告)日：2009-09-03
申请号：US12393401
申请日：2009-02-26
申请人： Tomoya Shimizu , Naoya Kuzawa , Takeshi Kuboyama , Hideyuki Shishitani
发明人： Tomoya Shimizu , Naoya Kuzawa , Takeshi Kuboyama , Hideyuki Shishitani
IPC分类号： C08F214/18
CPC分类号： C08K5/092 , C08F8/00 , C08F2800/10 , C08K5/16 , C08F214/262 , C08L27/12
摘要： The present invention provides a perfluoroelastomer composition comprising: a perfluoroelastomer having a nitrogen-containing curing site; and a catalyst mixture comprising: a tertiary amine; and an organic dicarboxylic acid represented by general formula (1) or (2) in an amount of 0.4 to 2 mol per mol of the tertiary amine: HOOC—COOH (1) HOOC-A-COOH (2) wherein A in formula (2) is an alkyl group having 1 to 10 carbon atoms or a phenyl group, which may be partially or fully fluorinated. Also disclosed is a perfluoroelastomer molded article obtained from the composition.
摘要翻译：本发明提供一种全氟弹性体组合物，其包含：具有含氮固化位点的全氟弹性体; 和催化剂混合物，其包含：叔胺; 和由通式（1）或（2）表示的有机二羧酸的量相对于每摩尔叔胺为0.4〜2摩尔：<η在线式描述=“在线式”末端=“铅 “？> HOOC-COOH（1）<？in-line-formula description =”In-line Formulas“end =”tail“？> <？in-line-formula description =”In-line Formulas“end =”lead “○”HOOC-A-COOH（2）<？in-line-formula description =“In-line formula”end =“tail”？>式（2）中的A是具有1-10个碳原子的烷基或苯基，其可以是部分或完全氟化的。还公开了由该组合物获得的全氟弹性体成型体。

4. 发明申请

US20080131644A1 Fluororubber molded article, and rubber material and O-ring using the same 审中-公开
标题翻译：氟橡胶成型品，橡胶材料和使用其的O型圈
公开(公告)号：US20080131644A1
公开(公告)日：2008-06-05
申请号：US11987665
申请日：2007-12-03
申请人： Takeshi Kuboyama , Naoya Kuzawa
发明人： Takeshi Kuboyama , Naoya Kuzawa
IPC分类号： B32B1/00 , C08F14/18
CPC分类号： C08F214/18 , C08J7/123 , C08J2327/16 , Y10T428/215
摘要： The present invention provides a fluororubber molded article having a fluorinated surface, wherein the fluorinated surface has a ratio of the number of oxygen atoms to the number of fluorine atoms of 0.11 or less, and a ratio of the number of C—H bonds to the number of C—F2 bonds is 1.0 or less, and wherein the fluororubber molded article shows a leak amount 3 minutes after initiation of a helium leak test of 1.0×10−12 Pa·m3/sec or less.
摘要翻译：本发明提供一种具有氟化表面的氟橡胶成型体，其中氟化表面的氧原子数与氟原子数的比例为0.11以下，CH键数与 CF 2 O 2键为1.0以下，其中氟橡胶成型体在开始氦气泄漏试验后3分钟显示出1.0×10 -6 Pa·m 2， SUP> 3 / sec以下。

5. 发明申请

US20060292373A1 Elastomer molded article, rubber material and O-ring using same 审中-公开
标题翻译：弹性体成型体，橡胶材料和使用其的O形环
公开(公告)号：US20060292373A1
公开(公告)日：2006-12-28
申请号：US11475030
申请日：2006-06-27
申请人： Takeshi Kuboyama , Naoya Kuzawa
发明人： Takeshi Kuboyama , Naoya Kuzawa
IPC分类号： B32B9/04
CPC分类号： C08J7/047 , C08J2427/00 , Y10T428/31504
摘要： A film of a fluorine-type resin having a thickness of 500 μm or less is formed on a surface of an elastomer molded article by a vacuum deposition method. The resultant elastomer molded article having the film of the fluorine-type resin has a sticking force to a metal of 100 N or less in an environment of from 200° C. to 300° C. and has a weight reduction ratio of 1.0% by weight or less by irradiation of a mixed plasma containing oxygen and carbon tetrafluoride.
摘要翻译：通过真空蒸镀法在弹性体成形体的表面上形成厚度为500μm以下的氟类树脂的膜。具有氟类树脂的膜的所得弹性体成型体在200℃〜300℃的环境中对金属具有100N以下的粘附力，并且重量减少率为1.0％重量以下，通过照射含有氧和四氟化碳的混合等离子体。

6. 发明申请

US20060047075A1 Fluoro-rubber composite, rubber material using the same, and a method of manufacturing a fluoro-rubber molded product 审中-公开
标题翻译：氟橡胶复合材料，使用其的橡胶材料以及氟橡胶成型体的制造方法
公开(公告)号：US20060047075A1
公开(公告)日：2006-03-02
申请号：US11212625
申请日：2005-08-29
申请人： Tomoya Shimizu , Takeshi Kuboyama , Naoya Kuzawa , Hiroshi Saito
发明人： Tomoya Shimizu , Takeshi Kuboyama , Naoya Kuzawa , Hiroshi Saito
IPC分类号： C08L27/12
CPC分类号： C08L27/16 , C08L27/18 , C08L2205/03 , C08L2666/04
摘要： In order to provide a fluoro-rubber composite which hardly reduces a clean degree of a manufacturing environment and in which any of cracks is hardly generated, a rubber material using the same, and a method of manufacturing a fluoro-rubber molded product, a fluoro rubber is mixed with a tetrafluoroethylene/propylene system copolymer or a tetrafluoroethylene/propylene/vinylidenefluoride system copolymer, and a fluorine thermoplastic resin, and the resulting mixture is compounded with a peroxide cross-linking agent, and a co-cross-linking agent, and if necessary, any other suitable filler or the like, thereby obtaining a fluoro-rubber composite, and cross-linking is performed for the resulting fluoro-rubber composite, thereby obtaining a fluoro-rubber molded product. A cross-linking method, for example, is such that a predetermined amount of fluoro-rubber composite is filled in a mold having a desired shape, and primary cross-linking is performed for the fluoro-rubber composite through a heat process, and if necessary, secondary cross-linking may be performed for the fluoro-rubber composite in an oven at 150 to 250° C. for 1 to 32 hours. The fluoro-rubber molded product can have an arbitrary shape such as a sheet-like shape, a rod-like shape, a ring-like shape, or any of various complicated block-like shapes in correspondence to its application.
摘要翻译：为了提供几乎不降低制造环境的清洁程度并且难以产生任何裂纹的氟橡胶复合材料，使用该氟橡胶复合材料的橡胶材料，以及氟橡胶模塑制品的制造方法，氟橡胶与四氟乙烯/丙烯体系共聚物或四氟乙烯/丙烯/偏二氟乙烯系共聚物和氟热塑性树脂混合，将所得混合物与过氧化物交联剂和共交联剂，以及如果需要，可以使用任何其它合适的填料等，从而获得氟橡胶复合物，并对所得氟橡胶复合物进行交联，由此得到氟橡胶模制产品。例如，交联方法是将预定量的氟橡胶复合材料填充到具有所需形状的模具中，并且通过热处理对氟橡胶复合材料进行一次交联，如果可以在150-250℃的烘箱中对氟橡胶复合材料进行必要的二次交联1至32小时。氟橡胶成型体可以具有任意形状，例如片状，棒状，环状，或与其应用相对应的各种复杂的块状形状。

7. 发明授权

US08722780B2 Perfluoroelastomer composition and molded article hereof 有权
标题翻译：全氟弹性体组合物及其成型品
公开(公告)号：US08722780B2
公开(公告)日：2014-05-13
申请号：US12393401
申请日：2009-02-26
申请人： Tomoya Shimizu , Naoya Kuzawa , Takeshi Kuboyama , Hideyuki Shishitani
发明人： Tomoya Shimizu , Naoya Kuzawa , Takeshi Kuboyama , Hideyuki Shishitani
IPC分类号： C08K5/092 , C08F14/26
CPC分类号： C08K5/092 , C08F8/00 , C08F2800/10 , C08K5/16 , C08F214/262 , C08L27/12
摘要： The present invention provides a perfluoroelastomer composition comprising: a perfluoroelastomer having a nitrogen-containing curing site; and a catalyst mixture comprising: a tertiary amine; and an organic dicarboxylic acid represented by general formula (1) or (2) in an amount of 0.4 to 2 mol per mol of the tertiary amine: HOOC—COOH (1) HOOC-A-COOH (2) wherein A in formula (2) is an alkyl group having 1 to 10 carbon atoms or a phenyl group, which may be partially or fully fluorinated. Also disclosed is a perfluoroelastomer molded article obtained from the composition.
摘要翻译：本发明提供一种全氟弹性体组合物，其包含：具有含氮固化位点的全氟弹性体; 和催化剂混合物，其包含：叔胺; 和由通式（1）或（2）表示的有机二羧酸的量相对于每摩尔叔胺HOOC-COOH（1）HOOC-A-COOH（2）为0.4〜2摩尔，其中式（1） 2）是具有1至10个碳原子的烷基或可以部分或完全氟化的苯基。还公开了由该组合物获得的全氟弹性体成型体。

8. 发明申请

US20090036586A1 HALOGEN GAS-RESISTANT PERFLUORO ELASTOMER MOLDED ARTICLE AND SEALING MATERIAL 审中-公开
标题翻译：耐高温全氟弹性体成型制品和密封材料
公开(公告)号：US20090036586A1
公开(公告)日：2009-02-05
申请号：US12181709
申请日：2008-07-29
申请人： Hideyuki Shishitani , Naoya Kuzawa , Takeshi Kuboyama
发明人： Hideyuki Shishitani , Naoya Kuzawa , Takeshi Kuboyama
IPC分类号： C08L27/14 , C08K3/30
CPC分类号： C08K5/18 , C08L27/12
摘要： The present invention provides a halogen gas-resistant perfluoro elastomer molded article obtained by molding and crosslinking a composition comprising: (A) 100 parts by mass of a perfluoro elastomer comprising copolymerization units comprising (A1) a perfluoro olefin; (A2) a perfluorovinyl ether; and (A3) a curing site monomer selected from the group consisting of an olefin fluoride having a nitrile group, a vinyl fluoride ether having a nitrile group and a mixture thereof, the curing site monomer (A3) being contained in an amount of 1.0 to 8.0 mol %; and (B) 0.1 to 10 parts by mass of a specific crosslinking agent represented by the following formula (a).
摘要翻译：本发明提供一种通过模塑和交联组合物获得的耐卤素气体全氟弹性体模塑制品，其包含：（A）100质量份包含（A1）全氟烯烃的共聚单元的全氟弹性体; （A2）全氟乙烯基醚; 和（A3）选自具有腈基的烯烃氟化物，具有腈基的氟乙烯醚及其混合物的固化部位单体，所述固化部位单体（A3）的含量为1.0〜 8.0摩尔％和（B）0.1〜10质量份由下式（a）表示的特定交联剂。

9. 发明授权

US09408914B2 Cationic lipid 有权
标题翻译：阳离子脂质
公开(公告)号：US09408914B2
公开(公告)日：2016-08-09
申请号：US13643342
申请日：2011-04-28
申请人： Takeshi Kuboyama , Tomohiro Era , Tomoyuki Naoi
发明人： Takeshi Kuboyama , Tomohiro Era , Tomoyuki Naoi
IPC分类号： A61K47/16 , A61K47/18 , A61K47/22 , C07C217/08 , C07D211/58 , C07C219/06 , C07C237/22 , C07D491/056 , C07C217/28 , C07C219/08 , C07D207/08 , C07D207/12 , A61K9/00 , A61K9/127 , C12N15/113
CPC分类号： C07D401/04 , A61K9/0019 , A61K9/1272 , A61K47/16 , A61K47/18 , A61K47/186 , A61K47/22 , C07C217/08 , C07C217/28 , C07C217/40 , C07C219/06 , C07C219/08 , C07C237/06 , C07C237/22 , C07C271/22 , C07D207/08 , C07D207/12 , C07D211/58 , C07D491/056 , C12N15/113 , C12N2310/14 , C12N2320/30 , C12N2310/321 , C12N2310/3521
摘要： The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I)(wherein: R1 and R2 are, the same or different, alkenyl, etc, andX1 and X2 are hydrogen atoms, or are combined together to form a single bond or alkylene, andX3 is absent or is alkyl, etc,Y is absent or anion,a and b are, the same or different, 0 to 3, andL3 is a single bond, etc,R3 is alkyl, etc,L1 and L2 are —O—, —CO—O— or —O—CO—),a composition comprising the cationic lipid and a nucleic acid, anda method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.
摘要翻译：本发明提供一种阳离子脂质，其允许将核酸容易地引入由式（I）表示的细胞中（其中：R 1和R 2是相同或不同的烯基等，并且X 1和X 2是氢原子，或组合在一起形成单键或亚烷基，并且X3不存在或为烷基等，Y不存在或阴离子，a和b相同或不同，0至3，L3为单键等，R3是烷基等，L1和L2是-O-，-CO-O-或-O-CO-），包含阳离子脂质和核酸的组合物，以及将核酸引入细胞的方法通过使用包含阳离子脂质和核酸的组合物等。

10. 发明申请

US20120101266A1 18F-LABELED AZIDE COMPOUND, REAGENT FOR 18F-LABELING AND METHOD FOR 18F-LABELING OF ALKYNE COMPOUND USING SAME 失效
标题翻译： 18F标记的AZIDE化合物，18F标记试剂和使用其的18K标记的烷基化合物的方法
公开(公告)号：US20120101266A1
公开(公告)日：2012-04-26
申请号：US13320421
申请日：2010-05-14
申请人： Yasuyoshi Watanabe , Masaaki Suzuki , Hisashi Doi , Takeshi Kuboyama , Satoshi Obika , Takeshi Imanichi
发明人： Yasuyoshi Watanabe , Masaaki Suzuki , Hisashi Doi , Takeshi Kuboyama , Satoshi Obika , Takeshi Imanichi
IPC分类号： C07H1/00 , C07D249/06 , C07D249/04
CPC分类号： A61K51/0453 , A61K51/0491 , C07B59/005 , C07B2200/05 , C07C247/16 , C07D249/06
摘要： [OBJECT]The present invention provides an 18F-labeled azide compound usable in the Huisgen reaction which enables 18F-labeling although only a small quantity of alkyne compound is available as a counterpart substrate, more specifically the 18F-labeled azide compound enabling the PET to be applied to peptides or oligonucleotides and enabling the 18F-labeling of any sites of oligonucleotide other than the 5′ end or 3′ end thereof, a reagent for 18F-labeling, and a method for 18F-labeling of an alkyne compound using the same.[SOLVING MEANS]An 18F-labeled azide compound according to the present invention is expressed by the following structural formula 1.[SELECTED DRAWING] None
摘要翻译：本发明提供了可用于Huisgen反应的18F标记的叠氮化合物，其能够进行18F标记，尽管只有少量的炔化合物可用作对应的底物，更具体地说，18F-标记的叠氮化合物使PET能够应用于肽或寡核苷酸，并且使得除了5'末端或3'末端以外的寡核苷酸的任何位点的18F标记，用于18F标记的试剂和使用其的18E-标记的炔化合物的方法。 [解决方案]根据本发明的18F标记的叠氮化合物由以下结构式1表示。[选择的图]无

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