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1. 发明申请

WO2009060403A3 CEST MRI CONTRAST AGENTS BASED ON NON-SPHERICAL PARTICLES 审中-公开
标题翻译：基于非球形颗粒的CEST MRI对比剂
公开(公告)号：WO2009060403A3
公开(公告)日：2009-12-17
申请号：PCT/IB2008054630
申请日：2008-11-06
申请人： KONINKL PHILIPS ELECTRONICS NV , LANGEREIS SANDER , BURDINSKI DIRK , BEVERS EDOUARD M , HACKENG TILMAN M , PIKKEMAAT JEROEN A
发明人： LANGEREIS SANDER , BURDINSKI DIRK , BEVERS EDOUARD M , HACKENG TILMAN M , PIKKEMAAT JEROEN A
IPC分类号： A61K49/18
CPC分类号： A61K49/1896
摘要： In magnetic resonance imaging (MRI) based on chemical exchange-dependent saturation transfer (CEST), a carrier for CEST contrast agents is provided which comprises a paramagnetic chemical shift reagent and a source of protons with which the chemical shift reagent can interact, so as to provide chemically shifted protons. It is desired for a CEST contrast agent to be non-spherical, so as to allow a bulk magnetic susceptibility effect of the poolofprotons within the agent to contribute to the CEST effect. Intrinsically non-spherical carriers are provided on the basis of erythrocyte ghosts.
摘要翻译：在基于化学交换依赖性饱和转移（CEST）的磁共振成像（MRI）中，提供了一种用于CEST造影剂的载体，其包括顺磁性化学位移试剂和化学位移试剂可与之交互的质子源，因此以提供化学转移的质子。期望CEST造影剂是非球形的，以便允许试剂内的poolofproton的体积磁化率作用有助于CEST效应。本质上非球形载体是基于红细胞重影提供的。

2. 发明申请

WO2008047293A2 STAMPER AND METHOD OF MANUFACTURING A STAMPER 审中-公开
标题翻译：印模和制造冲模的方法
公开(公告)号：WO2008047293A2
公开(公告)日：2008-04-24
申请号：PCT/IB2007054180
申请日：2007-10-15
申请人： KONINKL PHILIPS ELECTRONICS NV , BOS MATTHEUS I , BURDINSKI DIRK , VAN DER LEE ALEXANDER M , SALMINK MILAN , IMMINK ALBERT H J
发明人： BOS MATTHEUS I , BURDINSKI DIRK , VAN DER LEE ALEXANDER M , SALMINK MILAN , IMMINK ALBERT H J
IPC分类号： G11B7/26 , B29C33/58 , B29C33/60
CPC分类号： G11B7/263 , B29C33/60 , B29C45/2632
摘要： The present invention relates to a stamper (10) for optical disc manufacturing, having a stamper substrate (12), a substrate surface (14) comprising Ni and/or NiO, and a self-assembled monolayer (16) at least partly covering the substrate surface. The present invention further relates to manufacturing methods for stampers (10) and optical discs (22).
摘要翻译：本发明涉及一种用于光盘制造的压模（10），其具有压模基板（12），包含Ni和/或NiO的基板表面（14）以及至少部分地覆盖该基板表面的自组装单层衬底表面。本发明还涉及用于压模（10）和光盘（22）的制造方法。

3. 发明申请

WO2005096078A8 METHOD OF PRODUCING A FIBRE WITH LATERAL ELECTRIC FIELDS 审中-公开
标题翻译：生产具有侧向电场的纤维的方法
公开(公告)号：WO2005096078A8
公开(公告)日：2005-12-01
申请号：PCT/IB2005051011
申请日：2005-03-24
申请人： KONINKL PHILIPS ELECTRONICS NV , WILDERBEEK JOHANNES T A , BURDINSKI DIRK , DEN TOONDER JACOB M J , KRANS JAN M , VAN BRUGGEN MICHEL P B
发明人： WILDERBEEK JOHANNES T A , BURDINSKI DIRK , DEN TOONDER JACOB M J , KRANS JAN M , VAN BRUGGEN MICHEL P B
IPC分类号： D02G3/34 , D03D15/00 , G02F1/01 , G02F1/13 , G02F1/1334
CPC分类号： G02F1/01 , B82Y30/00 , G02F1/1334 , G02F2201/124
摘要： A method of producing a fibre or filament (10) by forming a substrate (11) in the form of an elongate core having a core axis. Coating the substrate directly, or indirectly, with a substance (13) having at least one electrically modulatable optical characteristic and associating with the substrate and/or substance, an electrical stimulation means (12) adapted to produce an electric field extending in a direction substantially parallel to the core axis or in a direction extending substantially circumferentially about the core axis, wherein the electric field electrically induces a change in the optical characteristic of the substance, thereby changing the visual appearance of the fibre or filament.
摘要翻译：通过形成具有芯轴的细长芯形式的基底（11）来生产纤维或细丝（10）的方法。用具有至少一个可电可调光学特征并与衬底和/或物质相关联的物质（13）直接或间接地涂覆衬底，电刺激装置（12），其适于产生沿基本上平行于芯轴或在围绕芯轴基本上周向延伸的方向上，其中电场电导致物质的光学特性的变化，从而改变纤维或细丝的视觉外观。

4. 发明申请

WO2009072079A3 POLYMERIC DRUG CARRIER FOR IMAGE-GUIDED DELIVERY 审中-公开
标题翻译：用于图像导向的聚合物药物载体
公开(公告)号：WO2009072079A3
公开(公告)日：2009-12-30
申请号：PCT/IB2008055098
申请日：2008-12-04
申请人： KONINKL PHILIPS ELECTRONICS NV , LANGEREIS SANDER , GRUELL HOLGER , MESSAGER LEA L P , PIKKEMAAT JEROEN A , BURDINSKI DIRK
发明人： LANGEREIS SANDER , GRUELL HOLGER , MESSAGER LEA L P , PIKKEMAAT JEROEN A , BURDINSKI DIRK
IPC分类号： A61K41/00 , A61K9/00 , A61K9/127 , A61K49/00 , A61K49/18
CPC分类号： A61K41/0028 , A61K9/1273 , A61K49/1812
摘要： Described are Chemical Exchange-dependent Saturation Transfer (CEST) contrast agents for Magnetic Resonance Imaging (MRI) comprising a polymersome provided with a paramagnetic agent. The polymersome preferably comprises a polymeric shell enclosing a cavity, wherein the cavity comprises a pool of proton analytes, and wherein the shell allows diffusion of the proton analytes. The polymersome-based CEST MRI contrast agents are suitable as drug carriers useful in MRI-guided drug release.
摘要翻译：描述了包含具有顺磁性试剂的聚合物的磁共振成像（MRI）的化学交换依赖性饱和转移（CEST）造影剂。聚合物组件优选包括封闭空腔的聚合物壳体，其中空腔包括质子分析物池，并且其中壳体允许质子分析物的扩散。基于聚合物体的CEST MRI造影剂适用于可用于MRI引导药物释放的药物载体。

5. 发明申请

WO2006003592A3 SOFT LITHOGRAPHIC STAMP WITH A CHEMICALLY PATTERNED SURFACE 审中-公开
标题翻译：具有化学表面的软光刻印
公开(公告)号：WO2006003592A3
公开(公告)日：2007-12-27
申请号：PCT/IB2005052111
申请日：2005-06-27
申请人： KONINKL PHILIPS ELECTRONICS NV , DECRE MICHEL M J , BLEES MARTIN , VAN EERD PATRICK P J , SCHROEDERS RICHARD J M , BURDINSKI DIRK , SHARPE RUBEN B A , HUSKENS JURRIAAN
发明人： DECRE MICHEL M J , BLEES MARTIN , VAN EERD PATRICK P J , SCHROEDERS RICHARD J M , BURDINSKI DIRK , SHARPE RUBEN B A , HUSKENS JURRIAAN
IPC分类号： G03F7/00 , H05K3/12
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , H05K3/0002 , H05K3/1275 , H05K2203/0108 , H05K2203/1173
摘要： The present invention provides a soft lithographic stamp (30) and a method for the manufacturing of such a stamp (30). A stamp (30) according to the present invention comprises blocking regions (37) and printing regions (38). The blocking regions (37) are formed of a material which is different from the material the printing regions (38) are formed of and which exhibits a reduced permeability, diffusivity or absorbing or adsorbing capability to the printing compound, such that it prevents or significantly reduces chemical or physical transport or transfer of the printing compound from the blocking regions to a substrate that has to be patterned or printed. In that way, when impregnating the stamp (30) with a printing compound, the printing compound only diffuses into the printing regions (38) and hence, the printing compound is only transferred from the printing regions (38) to the substrate to be patterned and substantially no diffusion of printing compound via air voids (33) between protruding elements (32) will occur.
摘要翻译：本发明提供了一种软光刻印模（30）及其制造方法。根据本发明的印模（30）包括阻挡区域（37）和印刷区域（38）。阻挡区域（37）由不同于印刷区域（38）的材料形成的材料形成，并且其对印刷化合物的渗透性，扩散性或吸收或吸附能力降低，从而防止或显着地减少化学或物理运输或将印刷化合物从阻挡区转移到必须被图案化或印刷的基底上。以这种方式，当用印刷化合物浸渍印模（30）时，印刷化合物仅扩散到印刷区域（38）中，因此印刷化合物仅从印刷区域（38）转移到待图案化的基材并且基本上不会在突出元件（32）之间通过空气（33）扩散印刷化合物。

6. 发明申请

WO2005057255A2 COLLIMATOR 审中-公开
公开(公告)号：WO2005057255A2
公开(公告)日：2005-06-23
申请号：PCT/IB2004052708
申请日：2004-12-08
申请人： KONINKL PHILIPS ELECTRONICS NV , HIKMET RIFAT A M , VAN BOMMEL TIES , VAN DE WITTE PETER , WIMBERGER-FRIEDL REINHOLD , BURDINSKI DIRK
发明人： HIKMET RIFAT A M , VAN BOMMEL TIES , VAN DE WITTE PETER , WIMBERGER-FRIEDL REINHOLD , BURDINSKI DIRK
IPC分类号： F21V11/08 , G02B5/00 , G02B5/20 , G02B27/30 , G21K1/02
CPC分类号： B82Y30/00 , G02B5/005 , G02B5/206 , G02B27/30 , G21K1/025
摘要： A collimator panel comprises: a solid panel having a first face for receiving uncollimated radiation and a second opposite face for providing collimated radiation; and a plurality of elongate particles disposed in the panel and orientated to provide the collimating function. A method of manufacturing a collimator panel comprises the steps of: suspending a plurality of elongate particles in a liquid; applying an electric or magnetic field to the suspension to orientate the particles; and solidifying the liquid to fix the orientation of the particles, thereby forming a collimator panel. A method of manufacturing the elongate particles is also provided.
摘要翻译：准直器面板包括：具有用于接收未预激射辐射的第一面的实心面板和用于提供准直辐射的第二相对面; 以及设置在面板中并且定向以提供准直功能的多个细长颗粒。制造准直器面板的方法包括以下步骤：将多个细长颗粒悬浮在液体中; 对悬浮液施加电场或磁场以使颗粒定向; 并固化液体以固定颗粒的取向，由此形成准直板。还提供了制造细长颗粒的方法。

7. 发明申请

WO2010119389A3 PRETARGETING KIT, METHOD AND AGENTS USED THEREIN 审中-公开
标题翻译： PRETARGETING KIT，方法和其中使用的药剂
公开(公告)号：WO2010119389A3
公开(公告)日：2010-12-29
申请号：PCT/IB2010051565
申请日：2010-04-12
申请人： KONINKL PHILIPS ELECTRONICS NV , ROBILLARD MARC S , ROSSIN RAFFAELLA , LUB JOHAN , RENART VERKERK PASCAL , BURDINSKI DIRK
发明人： ROBILLARD MARC S , ROSSIN RAFFAELLA , LUB JOHAN , RENART VERKERK PASCAL , BURDINSKI DIRK
IPC分类号： A61K47/48 , A61K51/04
CPC分类号： A61K51/0495 , A61K47/6897 , B82Y5/00
摘要： Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels- Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other a cyclooctene or cyclooctyne.
摘要翻译：描述了用于靶向医疗成像和/或治疗的预靶向方法和相关试剂盒，其中使用了对彼此表现出生物正交反应性的非生物反应性化学基团。本发明涉及使用[4 + 2]逆电子需求（逆向）Diels-Alder化学提供预靶向探针和效应探针之间的耦合。为此目的，这些探针中的一个包含缺电子四嗪或其他合适的二烯，另一个包含环辛烯或环辛炔。

8. 发明申请

WO2009069051A3 NON-SPHERICAL CONTRAST AGENTS FOR CEST MRI BASED ON BULK MAGNETIC SUSCEPTIBILITY EFFECT 审中-公开
标题翻译：基于散体磁敏感度效应的非球面造影剂
公开(公告)号：WO2009069051A3
公开(公告)日：2009-11-05
申请号：PCT/IB2008054894
申请日：2008-11-21
申请人： KONINKL PHILIPS ELECTRONICS NV , BURDINSKI DIRK , LANGEREIS SANDER , PIKKEMAAT JEROEN A
发明人： BURDINSKI DIRK , LANGEREIS SANDER , PIKKEMAAT JEROEN A
IPC分类号： A61K49/18
CPC分类号： A61K49/1812 , A61K49/1815
摘要： In magnetic resonance imaging (MRI) based on chemical exchange-dependent saturation transfer (CEST), a novel carrier for CEST contrast agents is provided. The carrier is non-spherical and comprises a semipermeable shell, wherein the shell comprises a paramagnetic compound. The shell encloses a cavitycomprising an MR analyte, wherein the semipermeable shell allows diffusion of the MR analyte. The CEST effect is based on the 5 bulk magnetic susceptibility effect caused by the anisotropy of the carrier. This leads to a versatile carrier that does not require interaction of the analyte with a paramgnetic chemical shift reagent.
摘要翻译：在基于化学交换依赖性饱和转移（CEST）的磁共振成像（MRI）中，提供了用于CEST造影剂的新型载体。载体是非球形的并且包含半透壳，其中壳包含顺磁性化合物。壳包围包含MR分析物的空腔，其中半透性壳允许MR分析物扩散。 CEST效应基于由载体的各向异性引起的5体磁化率效应。这导致不需要分析物与磁性化学位移试剂相互作用的多功能载体。

9. 发明申请

WO2006061741A3 ETCHANT SOLUTIONS AND ADDITIVES THEREFOR 审中-公开
标题翻译：其他解决方案及其添加剂
公开(公告)号：WO2006061741A3
公开(公告)日：2008-01-17
申请号：PCT/IB2005053989
申请日：2005-11-30
申请人： KONINKL PHILIPS ELECTRONICS NV , BURDINSKI DIRK , BRANS HAROLD
发明人： BURDINSKI DIRK , BRANS HAROLD
IPC分类号： C23F1/02 , C23F1/26 , C23F1/30 , G03F7/00
CPC分类号： C23F1/30 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C23F1/02 , C23F1/26 , G03F7/0002
摘要： The present invention is concerned with etchant or etching solutions and additives therefor, a process of preparing the same, a process of patterning a substrate employing the same, a patterned substrate thus prepared in accordance with the present invention and an electronic device including such a patterned substrate. An etchant solution according to the present invention for patterned etching of at least one surface or surface coating of a substrate comprises nitric acid, a nitrite salt, a halogenated organic acid represented by the formula C(H)n(Hal)m[C(H)o(Hal)p]qC?2H, where Hal represents bromo, chloro, fluoro or iodo, where n is 0, 1, 2 or 3, and m is 0, 1, 2 or 3, with the proviso that m + n = 3; o is 0 or 1, p is 1 or 2, with the proviso that o + p = 2; q is 0 or 1, with the proviso that q + m = 1 , 2, 3 or 4; and balance water.
摘要翻译：本发明涉及蚀刻剂或其蚀刻溶液及其添加剂，其制备方法，使用该方法的基材图案化方法，根据本发明制备的图案化基材和包含这种图案化的电子器件基质。根据本发明的用于图案化蚀刻底物的至少一个表面或表面涂层的蚀刻剂溶液包括硝酸，亚硝酸盐，由式C（H）n（Hal）m [C（H） H）o（Hal）p] qC 2 H 2，其中Hal表示溴，氯，氟或碘，其中n为0,1,2或3，m为0,1,2或3，条件是m + n = 3; o为0或1，p为1或2，条件是o + p = 2; q为0或1，条件是q + m = 1,2,3或4; 并平衡水分。

10. 发明申请

WO2006067694A2 NANOFABRICATION BASED ON SAM GROWTH 审中-公开
标题翻译：基于SAM生长的南非
公开(公告)号：WO2006067694A2
公开(公告)日：2006-06-29
申请号：PCT/IB2005054250
申请日：2005-12-14
申请人： KONINKL PHILIPS ELECTRONICS NV , BURDINSKI DIRK , SHARPE RUBEN B A
发明人： BURDINSKI DIRK , SHARPE RUBEN B A
IPC分类号： G03F7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： The present invention relates to a process of nano fabrication based on nucleated SAM growth, to patterned substrates prepared thereby, to a nano wire or grid of nanowires prepared thereby and to electronic devices including the same. In particular, there is provided a process which comprises applying a first SAM- forming molecular species to a first surface region of the substrate surface, so as to provide a first SAM defining a scaffold pattern on the first surface region; and applying a second SAM-forming molecular species to at least a second surface region of said substrate surface which is not covered by the first SAM, whereby a second replica SAM comprising the second SAM-forming molecular species selectively forms on substrate surface adjacent to at least one edge of said first SAM.
摘要翻译：本发明涉及一种基于有核SAM生长的纳米制造方法，由其制备的图案化衬底，由其制备的纳米线或纳米线网格以及包括该纳米线的电子器件。特别地，提供了一种方法，其包括将第一SAM形成分子物质施加到衬底表面的第一表面区域，以便在第一表面区域上提供限定支架图案的第一SAM; 以及将第二SAM形成分子物质施加到所述基底表面的至少第二表面区域，所述第二表面区域未被所述第一SAM覆盖，由此包含所述第二SAM形成分子种类的第二副本SAM选择性地形成在邻近于所述第一SAM的至少一个边缘。

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