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1. 发明申请

US20120065696A1 Method and System for Characterizing Supraventricular Rhythm during Cardiac Pacing 有权
标题翻译：心脏起搏过程中表现室性节律的方法与系统
公开(公告)号：US20120065696A1
公开(公告)日：2012-03-15
申请号：US13159686
申请日：2011-06-14
申请人： Joseph Bocek , Jaeho Kim , Anthony S. Harrington , Lorenzo A. DiCarlo , Harley G. White , Phillip D. Foshee , David L. Perschbacher
发明人： Joseph Bocek , Jaeho Kim , Anthony S. Harrington , Lorenzo A. DiCarlo , Harley G. White , Phillip D. Foshee , David L. Perschbacher
IPC分类号： A61N1/365
CPC分类号： A61N1/3622
摘要： A method and system for generating a characterization of one beat of a patient's supraventricular rhythm (SVR) involves performing such characterization while the heart is being paced. During SVR characterization, various pacing parameters are modified and the patient's supraventricular rhythm is characterized while the pacing parameters are modified. The SVR characterization process is effective in single and multiple chamber pacing modes.
摘要翻译：用于产生患者室上性节律（SVR）的一搏的表征的方法和系统涉及在心脏起搏时进行这种表征。在SVR表征期间，修改了各种起搏参数，并对患者的室上节律进行了表征，同时对起搏参数进行了修改。 SVR表征过程在单腔和多腔起搏模式中有效。

2. 发明授权

US08583231B2 Method and system for characterizing supraventricular rhythm during cardiac pacing 有权
公开(公告)号：US08583231B2
公开(公告)日：2013-11-12
申请号：US13159686
申请日：2011-06-14
申请人： Joseph Bocek , Jaeho Kim , Anthony S. Harrington , Lorenzo A. DiCarlo , Harley G. White , Phillip D. Foshee , David L. Perschbacher
发明人： Joseph Bocek , Jaeho Kim , Anthony S. Harrington , Lorenzo A. DiCarlo , Harley G. White , Phillip D. Foshee , David L. Perschbacher
IPC分类号： A61N1/00
CPC分类号： A61N1/3622
摘要： A method and system for generating a characterization of one beat of a patient's supraventricular rhythm (SVR) involves performing such characterization while the heart is being paced. During SVR characterization, various pacing parameters are modified and the patient's supraventricular rhythm is characterized while the pacing parameters are modified. The SVR characterization process is effective in single and multiple chamber pacing modes.

3. 发明授权

US5797399A Method and apparatus for identifying and correctly responding to abnormal heart activity 失效
标题翻译：用于识别和正确应对异常心脏活动的方法和装置
公开(公告)号：US5797399A
公开(公告)日：1998-08-25
申请号：US639859
申请日：1996-04-19
申请人： Milton M. Morris , Janice M. Jenkins , Lorenzo A. DiCarlo
发明人： Milton M. Morris , Janice M. Jenkins , Lorenzo A. DiCarlo
IPC分类号： A61B5/046 , A61N1/39 , A61B5/0402
CPC分类号： A61B5/7264 , A61B5/046 , A61N1/3956 , Y10S128/92
摘要： A pattern recognition system for use in an implantable cardioverter defibrillator that is capable of responding correctively to abnormal activity of the heart efficiently and specifically. The system of the present invention first establishes a template standard defining a median or other statistical measure of central tendency representing the point above which or below which actual sample values would be remarkable. Against the median are compared sampled values within a window having a pre-programmed length. For each cycle, a comparison is made between the template median and every value sampled within this pre-programmed window. Each cycle is then individually diagnosed such that if a selected value is above a particular pre-established threshold or below a particular pre-established threshold it will be classified as abnormal. A plurality of specific cycles must be classified abnormal in order for a final diagnosis to be made that the individual is experiencing arrhythmia. The system of the present invention is also capable of differentiating between types of abnormal and can classify the abnormal as being either ventricular tachycardia and ventricular fibrillation.
摘要翻译：一种用于植入式心律转复除颤器中的模式识别系统，其能够有效且具体地对心脏的异常活动进行正确的响应。本发明的系统首先建立了模板标准，其定义了中心趋势的中位趋势或其他统计量度，该中心倾向表示高于该点或低于哪个实际样本值是显着的点。对于中值，在具有预编程长度的窗口内比较采样值。对于每个周期，在模板中位数和在此预编程窗口中采样的每个值之间进行比较。然后单独诊断每个周期，使得如果所选择的值高于特定的预先建立的阈值或低于特定的预先建立的阈值，则将被分类为异常。必须将多个特定周期分类为异常，以便进行最终诊断以证明个体正在经历心律失常。本发明的系统还能够区分异常的类型，并且可以将异常分类为室性心动过速和心室颤动。

4. 发明授权

US5857977A Method and apparatus for separation of ventricular tachycardia from ventricular fibrillation for implantable cardioverter defibrillators 失效
标题翻译：用于分离室性心动过速与心室颤动的方法和装置，用于可植入的心律转复除颤器
公开(公告)号：US5857977A
公开(公告)日：1999-01-12
申请号：US694189
申请日：1996-08-08
申请人： Stephanie A. Caswell , Janice M. Jenkins , Lorenzo A. DiCarlo
发明人： Stephanie A. Caswell , Janice M. Jenkins , Lorenzo A. DiCarlo
IPC分类号： A61N1/39 , A61B5/046
CPC分类号： A61N1/3956
摘要： A method and appartus for differentiating between ventricular tachycardia and ventricular fibrillation includes a pair of electrodes located on a single catheter which, in conjunction with an implantable cardioverter device, utilize two channel ventricular algorithms for ventricular tachycardia and ventricular fibrillation separation. Two closely spaced unipolar electrograms demonstrate similar morphology and consistency during rhythms with broad coherent activation (such as sinus rhythm and ventricular tachycardia). Conversely, for incoherent rhythms (ventricular fibrillation and polymorphic ventricular tachycardia), activation between the electrodes proved to be dissimilar and inconsistent. The cross-correlation of the two depolarizations measures similarity between electrogram morphology, and interquartile range measures consistency in a passage. The method and apparatus of the present invention is able to address the limitation of existing algorithms and provide accurate separation of ventricular fibrillation from other rhythms.
摘要翻译：用于区分室性心动过速和心室颤动的方法和系统包括位于单个导管上的一对电极，其与可植入式心律转复器装置一起利用用于室性心动过速和心室颤动分离的两个通道心室算法。两个紧密间隔的单极电图在具有广泛相干激活（如窦性心律和室性心动过速）的节律中表现出类似的形态和一致性。相反，对于非相干节律（心室颤动和多形性室性心动过速），电极之间的激活被证明是不同的和不一致的。两个去极化的互相关性测量电描记图形态之间的相似性，并且四分位数范围测量通道中的一致性。本发明的方法和装置能够解决现有算法的局限性，并提供心室颤动与其他节律的精确分离。

5. 发明授权

US5000189A Method and system for monitoring electrocardiographic signals and detecting a pathological cardiac arrhythmia such as ventricular tachycardia 失效
标题翻译：用于监测心电图信号和检测病理性心律失常如心室性心动过速的方法和系统
公开(公告)号：US5000189A
公开(公告)日：1991-03-19
申请号：US437079
申请日：1989-11-15
申请人： Robert D. Throne , Janice M. Jenkins , Lorenzo A. DiCarlo
发明人： Robert D. Throne , Janice M. Jenkins , Lorenzo A. DiCarlo
IPC分类号： A61B5/0452 , A61N1/362 , G06F17/00
CPC分类号： A61B5/04525 , A61B5/7239 , A61N1/3621
摘要： A method and system are provided for monitoring electrocardiographic signals and detecting a pathological cardiac arrhythmia, such as ventricular tachycardia wherein the zero crossings of the first derivative of a reference template (i.e. reference waveform) are utilized to separate or partition both the template and each subsequent electrocardiographic signal being monitored into first and second sets of identifiable partitions. Each zero crossing is a boundary between adjacent partitions. Initially, the reference template is generated by acquiring a first set of wavefrom data representing a known good electrocardiographic signal. Identifiable partitions of the first set of data are then matched with corresponding identifiable partitions of the second set of data to obtain a performance measure signal. In one embodiment, the area beneath the derivative in each partition of the analyzed waveform is computed and compared (i.e. matched) to the corresponding area of the template. Preferably, a plurality of electrocardiographic signals are analyzed by utilizing the template and a plurality of performance measure signals are obtained. Finally, a therapy signal is provided as a function of the plurality of performance measure signals in the event of a pathologica cardiac arrhythmia, such as ventricular tachycardia.
摘要翻译：提供了一种方法和系统，用于监测心电图信号并检测病理性心律失常，例如室性心动过速，其中参考模板的一阶导数（即参考波形）的过零点用于分离或分隔模板和每个随后的监测心电图信号到第一组和第二组可识别分区。每个过零点是相邻分区之间的边界。最初，通过获取表示已知良好的心电图信号的第一组波形数据来生成参考模板。然后将第一组数据的可识别分区与第二组数据的相应的可识别分区进行匹配以获得性能测量信号。在一个实施例中，计算分析波形的每个分区中的导数下面的区域，并将其与模板的相应区域进行比较（即匹配）。优选地，通过利用模板来分析多个心电图信号，并且获得多个性能测量信号。最后，在发生病态心律失常（例如室性心动过速）的情况下，提供治疗信号作为多个性能测量信号的函数。

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