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1. 发明授权

US08927207B2 miRNAs as therapeutic targets in cancer 有权
标题翻译： miRNA作为癌症治疗靶点
公开(公告)号：US08927207B2
公开(公告)日：2015-01-06
申请号：US12996249
申请日：2009-06-05
申请人： Jingfang Ju , Bo Song , Yuan Wang
发明人： Jingfang Ju , Bo Song , Yuan Wang
IPC分类号： C12Q1/68 , C12N15/113
CPC分类号： C12N15/1137 , A61K31/7088 , A61K45/06 , C12N15/113 , C12N15/1135 , C12N2310/113 , C12N2310/14 , C12N2320/31 , C12Q1/6886 , C12Q2600/136 , C12Q2600/178
摘要： MicroRNAs (miRNAs) are a class of non-coding small RNA molecules that regulate gene expression at the post-transcriptional level by interacting with 3′ untranslated regions (UTRs) of their target mRNAs. The invention relates to the application of miR-192 and miR-215. Both of these miRNAs impact cellular proliferation through the p53-miRNA circuit, and interact with dihydrofolate reductase (DHFR) and thymidylate synthase (TS). Particularly, upregulation of these miRNAs reduces cellular proliferation. The invention relates to this discovery. For example, inhibiting miR-192 and/or miR-215 sensitizes a neoplasm or a subject with a neoplasm to chemotherapeutic agents. Furthermore, measuring the levels of miR-192 and/or miR-215 provides one with information regarding whether the neoplasm or subject will respond to chemotherapeutic agents. Accordingly, the invention relates to composition and methods relating to the identification, characterization and modulation of the expression of miR-192 and miR-215.
摘要翻译：微RNA（miRNA）是一类非编码小RNA分子，通过与其靶mRNA的3'非翻译区（UTR）相互作用，在转录后水平调节基因表达。本发明涉及miR-192和miR-215的应用。这两种miRNA通过p53-miRNA电路影响细胞增殖，并与二氢叶酸还原酶（DHFR）和胸苷酸合酶（TS）相互作用。特别地，这些miRNA的上调减少细胞增殖。本发明涉及这一发现。例如，抑制miR-192和/或miR-215使肿瘤或具有肿瘤的受试者对化学治疗剂敏感。此外，测量miR-192和/或miR-215的水平提供了关于肿瘤或受试者是否将对化学治疗剂作出反应的信息。因此，本发明涉及与miR-192和miR-215的表达的鉴定，表征和调节相关的组合物和方法。

2. 发明申请

US20120087992A1 miRNAS AS THERAPEUTIC TARGETS IN CANCER 审中-公开
标题翻译： miRNA作为癌症中的治疗目标
公开(公告)号：US20120087992A1
公开(公告)日：2012-04-12
申请号：US13257836
申请日：2010-03-22
申请人： Jingfang Ju , Yuan Wang , Bo Song
发明人： Jingfang Ju , Yuan Wang , Bo Song
IPC分类号： A61K31/7088 , A61K33/24 , A61N5/00 , C07H21/02 , C12Q1/68 , C12N5/00 , A61K31/704
CPC分类号： C12Q1/6886 , A61K31/7088 , A61K45/06 , C12Q1/6809 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , A61K2300/00 , C12Q2525/207
摘要： Methods for modulating expression of a component of a cell, comprising contacting the cell with a nucleic acid comprising an miR-140 nucleic acid sequence in an amount sufficient to modulate the cellular component are provided. Overexpression of miR-140 inhibits cell proliferation in both U-2 OS (wt-p53) and HCT 116 (wt-p53) cell lines. Cells transfected with miR-140 are more resistant to chemotherapeutic agent methotrexate, mi-140 expression is related to HDAC4 protein expression. The claimed methods reduce the protein expression level of HDAC4 without degrading the target mRNA.
摘要翻译：提供了调节细胞成分表达的方法，包括使细胞与含有足以调节细胞成分的量的miR-140核酸序列的核酸接触。 miR-140的过表达抑制U-2 OS（wt-p53）和HCT 116（wt-p53）细胞系中的细胞增殖。用miR-140转染的细胞对化学治疗剂甲氨蝶呤更具抗性，mi-140表达与HDAC4蛋白表达有关。所要求的方法降低HDAC4的蛋白质表达水平，而不降解靶mRNA。

3. 发明申请

US20110166201A1 MIRNAS AS THERAPEUTIC TARGETS IN CANCER 有权
标题翻译： MIRNAS作为癌症中的治疗目标
公开(公告)号：US20110166201A1
公开(公告)日：2011-07-07
申请号：US12996249
申请日：2009-06-05
申请人： Jingfang Ju , Bo Song , Yuan Wang
发明人： Jingfang Ju , Bo Song , Yuan Wang
IPC分类号： A61K31/7052 , C12N5/00 , C12Q1/68 , C07H21/00 , A61P35/00
CPC分类号： C12N15/1137 , A61K31/7088 , A61K45/06 , C12N15/113 , C12N15/1135 , C12N2310/113 , C12N2310/14 , C12N2320/31 , C12Q1/6886 , C12Q2600/136 , C12Q2600/178
摘要： MicroRNAs (miRNAs) are a class of non-coding small RNA molecules that regulate gene expression at the post-transcriptional level by interacting with 3′ untranslated regions (UTRs) of their target mRNAs. The invention relates to the application of miR-192 and miR-215. Both of these miRNAs impact cellular proliferation through the p53-miRNA circuit, and interact with dihydrofolate reductase (DHFR) and thymidylate synthase (TS). Particularly, upregulation of these miRNAs reduces cellular proliferation. The invention relates to this discovery. For example, inhibiting miR-192 and/or miR-215 sensitizes a neoplasm or a subject with a neoplasm to chemotherapeutic agents. Furthermore, measuring the levels of miR-192 and/or miR-215 provides one with information regarding whether the neoplasm or subject will respond to chemotherapeutic agents. Accordingly, the invention relates to composition and methods relating to the identification, characterization and modulation of the expression of miR-192 and miR-215.
摘要翻译：微RNA（miRNA）是一类非编码小RNA分子，通过与其靶mRNA的3'非翻译区（UTR）相互作用，在转录后水平调节基因表达。本发明涉及miR-192和miR-215的应用。这两种miRNA通过p53-miRNA电路影响细胞增殖，并与二氢叶酸还原酶（DHFR）和胸苷酸合酶（TS）相互作用。特别地，这些miRNA的上调减少细胞增殖。本发明涉及这一发现。例如，抑制miR-192和/或miR-215使肿瘤或具有肿瘤的受试者对化学治疗剂敏感。此外，测量miR-192和/或miR-215的水平提供了关于肿瘤或受试者是否将对化学治疗剂作出反应的信息。因此，本发明涉及与miR-192和miR-215的表达的鉴定，表征和调节相关的组合物和方法。

4. 发明授权

US10883799B1 Metasurface skin cloak 有权
公开(公告)号：US10883799B1
公开(公告)日：2021-01-05
申请号：US14999918
申请日：2016-12-13
申请人： Xingjie Ni , Yuan Wang , Xiang Zhang
发明人： Xingjie Ni , Yuan Wang , Xiang Zhang
IPC分类号： H01Q15/02 , F41H3/02 , H01Q17/00
摘要： This disclosure provides systems, methods, and devices related to a metasurface skin cloak. In one aspect, a metasurface skin cloak includes a dielectric layer and a plurality of blocks disposed on the dielectric layer. The dielectric layer is disposed over a surface including a feature on the surface. Each block of the plurality of blocks has a shape that is symmetric about two perpendicular axes. The metasurface skin can render the feature on the surface not optically detectable.

5. 发明申请

US20180280968A1 NANOPORE DEVICES FOR SENSING BIOMOLECULES 审中-公开
公开(公告)号：US20180280968A1
公开(公告)日：2018-10-04
申请号：US15945717
申请日：2018-04-04
申请人： Quan Qing , Yuan Wang , Joshua Sadar
发明人： Quan Qing , Yuan Wang , Joshua Sadar
IPC分类号： B01L3/00 , C12Q1/6869 , G01N27/327
摘要： The present disclosure provides chips, devices and methods for sequencing a biomolecule. The biomolecule may be DNA, RNA. a protein, or a peptide. The chip comprises a substrate; a first and second fluid chamber; fluid channels connecting the first and second fluid chamber; a first and second electrode disposed on opposing sides of the central fluid channel and having a nanogap therebetween, wherein the width of the nanogap is modulated by confined electrochemical deposition; and a passivation layer disposed on top of the first and second electrodes and the fluid channel.

6. 发明授权

US09533710B2 Twelve-cornered strengthening member 有权
标题翻译：十二角加固件
公开(公告)号：US09533710B2
公开(公告)日：2017-01-03
申请号：US12891801
申请日：2010-09-27
申请人： James Chih Cheng , Raj Jayachandran , Ching-Hung Chuang , Yiping Xie , Yuan Wang , Tau Tyan , Leonard Anthony Shaner , Yu-Kan Hu
发明人： James Chih Cheng , Raj Jayachandran , Ching-Hung Chuang , Yiping Xie , Yuan Wang , Tau Tyan , Leonard Anthony Shaner , Yu-Kan Hu
IPC分类号： G06G7/48 , B62D21/15 , F16F7/12
CPC分类号： B62D25/08 , B60Y2304/00 , B62D21/152 , B62D65/00 , F16F7/128 , Y02T10/82
摘要： A method for optimizing a twelve-cornered strengthening member comprises: modeling a vehicle assembly including a strengthening member having a twelve-cornered cross section; parameterizing a geometry of the strengthening member with a plurality of control parameters; defining a design of experiment using the plurality of control parameters; modeling a vehicle using the vehicle assembly; simulating a frontal impact event with the vehicle; generating a response surface based on the frontal impact event; and determining a set of optimized control parameters for the strengthening member based on the response surface.
摘要翻译：一种用于优化十二角加固构件的方法包括：对包括具有十二角横截面的加强构件的车辆组件进行建模; 用多个控制参数对加固构件的几何形状进行参数化; 使用所述多个控制参数来定义实验设计; 使用车辆组件对车辆进行建模; 模拟与车辆的正面碰撞事件; 基于正面碰撞事件产生响应面; 以及基于所述响应面确定所述加强构件的优化控制参数的集合。

7. 发明申请

US20150192767A1 MULTIPLANE OPTICAL MICROSCOPE 有权
标题翻译：多平面光学显微镜
公开(公告)号：US20150192767A1
公开(公告)日：2015-07-09
申请号：US14591760
申请日：2015-01-07
申请人： Tongcang Li , Sadao Ota , Jeongmin Kim , Yuan Wang , Xiang Zhang
发明人： Tongcang Li , Sadao Ota , Jeongmin Kim , Yuan Wang , Xiang Zhang
IPC分类号： G02B21/18 , H04N5/30 , G02B21/06 , G02B21/04 , G02B21/36
CPC分类号： G02B21/18 , G02B21/06 , G02B21/16 , G02B21/361 , G02B21/367
摘要： This disclosure provides systems, methods, and apparatus related to optical microscopy. In one aspect, an apparatus includes a sample holder, a first objective lens, a plurality of optical components, a second objective lens, and a mirror. The apparatus may directly image a cross-section of a sample oblique to or parallel to the optical axis of the first objective lens, without scanning.
摘要翻译：本公开提供了与光学显微镜相关的系统，方法和装置。一方面，一种装置包括样本保持器，第一物镜，多个光学部件，第二物镜和反射镜。该装置可以直接对样品的横截面进行图像，而不扫描而倾斜或平行于第一物镜的光轴。

8. 发明授权

US08635249B2 Federation of multi-level master data management systems 失效
标题翻译：多级主数据管理系统联合会
公开(公告)号：US08635249B2
公开(公告)日：2014-01-21
申请号：US13117370
申请日：2011-05-27
申请人： Rangachari Anand , Stacy F. Hobson , Juhnyoung Lee , Xuan Liu , Yuan Wang , Jeaha Yang
发明人： Rangachari Anand , Stacy F. Hobson , Juhnyoung Lee , Xuan Liu , Yuan Wang , Jeaha Yang
IPC分类号： G06F17/30
CPC分类号： G06F17/30286 , G06F17/30566
摘要： Federating multiple-level master data management systems may include a first set of master data management nodes having one or more common characteristics. A first group master data management node may be assigned to centrally manage the first set of master data management nodes, the first group master data management node maintaining master data management functionalities at a group level and providing a single logical view of master data to the first set of master data management nodes. Each master data management node in the first set has data access link with the first group master data management node based on implementation style of said each master data management node.
摘要翻译：联合多级主数据管理系统可以包括具有一个或多个共同特征的第一组主数据管理节点。可以分配第一组主数据管理节点以集中管理第一组主数据管理节点，第一组主数据管理节点维护组级别的主数据管理功能，并将主数据的单个逻辑视图提供给第一组主数据管理节点主数据管理节点集。基于所述每个主数据管理节点的实现风格，第一组中的每个主数据管理节点与第一组主数据管理节点具有数据访问链路。

9. 发明申请

US20130046100A1 S-5-SUBSTITUENT-N-2'-(THIOPHENE-2-YL)ETHYL-TETRALIN-2-AMINE OR CHIRAL ACID SALTS THEREOF AND USE FOR PREPARING ROTIGOTINE 有权
标题翻译： S-5-替代N-2' - （噻吩-2-基）乙基 - 四环素-2-胺或其酸性酸盐及其制备ROTIGOTINE的用途
公开(公告)号：US20130046100A1
公开(公告)日：2013-02-21
申请号：US13394614
申请日：2010-09-07
申请人： Xungui He , Jianping Guo , Yanling Wang , Wensheng Tang , Xingzhong Zhang , Xuezhang Wang , Yuan Wang
发明人： Xungui He , Jianping Guo , Yanling Wang , Wensheng Tang , Xingzhong Zhang , Xuezhang Wang , Yuan Wang
IPC分类号： C07D333/20 , C07D333/22
CPC分类号： C07D333/20 , C07B57/00
摘要： The chiral compound S-5-substituted-N-2′-(thienyl-2-yl-)ethyl-tetralin-2-amine or its chiral acid salts and preparation method thereof are disclosed, and the method for preparing Rotigotine by using the chiral compound is also disclosed. Racemic 5-substituted-N-2′-(thien-2-yl-)ethyl-tetralin-2-amine (compound 1) is resolved by using a conventional chiral acid to obtain an optically pure chiral acid salt of S-5-substituted-N-2′-(thien-2-yl-)ethyl-tetralin-2-amine, which is then dissociated to obtain S-5-substituted-N-2′-(thien-2-yl-)ethyl-tetralin-2-amine (compound 2). The compound 2 or chiral acid salt thereof is alkylated and deprotected to produce rotigotine (compound 5).
摘要翻译：公开了手性化合物S-5-取代-N-2' - （噻吩基-2-基） - 乙基 - 四氢化萘-2-胺或其手性酸盐及其制备方法，还公开了手性化合物。通过使用常规的手性酸来拆分外消旋的5-取代的N-2' - （噻吩-2-基）乙基 - 四氢化萘-2-胺（化合物1），得到光学纯的手性酸S-5- 取代的N-2' - （噻吩-2-基）乙基 - 四氢化萘-2-胺，然后将其解离得到S-5-取代的N-2' - （噻吩-2-基）四氢化萘-2-胺（化合物2）。将化合物2或其手性酸式盐进行烷基化和脱保护，得到罗替戈汀（化合物5）。

10. 发明授权

US08334388B2 Palonosetron salts and processes for preparation and purification thereof 有权
标题翻译：帕洛诺司琼盐及其制备和纯化方法
公开(公告)号：US08334388B2
公开(公告)日：2012-12-18
申请号：US12601744
申请日：2008-05-28
申请人： Tang Wensheng , Zhang Xingzhong , He Xungui , Yuan Wang , Joseph Kaspi
发明人： Tang Wensheng , Zhang Xingzhong , He Xungui , Yuan Wang , Joseph Kaspi
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： Provided are novel salts of 2-(1-azabicyclo-[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one, methods of using such salts, and processes for producing such salts.
摘要翻译：提供了2-（1-氮杂双环 - [2.2.2]辛-3-基）-2,3,3a，4,5,6-六氢-1H-苯并[de]异喹啉-1-酮的新型盐，使用这些盐的方法，以及这些盐的制造方法。

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