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1. 发明申请

US20080114409A1 HEART STIMULATOR 失效
标题翻译：心脏刺激器
公开(公告)号：US20080114409A1
公开(公告)日：2008-05-15
申请号：US11560099
申请日：2006-11-15
申请人： Jie Lian , Christopher S. de Voir , Garth Garner , Hannes Kraetschmer , Dirk Mussig
发明人： Jie Lian , Christopher S. de Voir , Garth Garner , Hannes Kraetschmer , Dirk Mussig
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/3688
摘要： Heart stimulator that stimulates at least a heart's right atrium and ventricle in an atrium asynchronous stimulation mode with an overdrive stimulation rate. Interposes one resynchronization cycle after a sensed atrial event to regain AV synchrony during otherwise asynchronous stimulation mode. Allows for pacing mode that can pace the atrium with an overdrive stimulation rate in dual-chamber asynchronous mode while maintaining the AV synchrony and is called DDI(R)+. In DDI(R)+, pacemaker performs an atrial asynchronous (V synchronous) pacing mode such as DDI or DDI(R). The overdrive stimulation rate (OSR) is either a fixed rate (programmed by the external device) that is thought to be above the underlying intrinsic atrial rate, or is dynamically adjusted according to the measured atrial cycle length to be slightly above intrinsic atrial rate. The overdrive stimulation rate may be based on an intrinsic atrial rate or on hemodynamic need. DDI(R)+ timing may be ventricle-based.
摘要翻译：心脏刺激器，可以刺激至少一个心脏异位刺激模式的心脏和心室，具有超速刺激速率。在感应到的心房事件之后插入一个再同步循环，以在其他异步刺激模式下重新获得AV同步。允许起搏模式，可以在双室异步模式下以过驱动刺激速率调节心房，同时保持AV同步，称为DDI（R）+。在DDI（R）+中，起搏器执行心房异步（V同步）起搏模式，如DDI或DDI（R）。超速刺激速率（OSR）是被认为高于潜在固有心房率的固定比率（由外部设备编程），或根据测量的心房周期长度动态调整为略高于固有心房率。超速刺激速率可以基于固有心房率或血液动力学需要。 DDI（R）+时间可能是基于心室的。

2. 发明申请

US20080065161A1 METHOD AND APPARATUS FOR GENERATING A COMPOSITE FARFIELD ELECTROGRAM 有权
标题翻译：用于生成复合农田电极的方法和装置
公开(公告)号：US20080065161A1
公开(公告)日：2008-03-13
申请号：US11848824
申请日：2007-08-31
申请人： Jie Lian , Garth Garner , Hannes Kraetschmer , Dirk Mussig
发明人： Jie Lian , Garth Garner , Hannes Kraetschmer , Dirk Mussig
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61N1/368
摘要： Uses dual-chamber (RA-RV), three-chamber (BiA-RV, or RA-BiV), or four-chamber (BiA-BiV) implantable cardiac device including pacemakers, defibrillators and cardioverters, which stimulate cardiac tissue electrically to control the patient's heart rhythm to create a far-field intra-atrial electrogram (AEGM) and a far-field intra-ventricular electrogram (VEGM) that are independently filtered, scaled, and then summed to form a composite far-field electrogram.
摘要翻译：使用双室（RA-RV），三室（BiA-RV或RA-BiV）或四室（BiA-BiV）植入式心脏装置，包括起搏器，除颤器和心律转换器，其电刺激心脏组织以控制患者的心律以创建远场心房电图（AEGM）和远场心室电图（VEGM），其被独立过滤，缩放，然后相加以形成复合远场电描记图。

3. 发明申请

US20050187585A1 Adaptive ventricular rate smoothing during atrial fibrillation 有权
标题翻译：心房颤动期间自适应心率平滑
公开(公告)号：US20050187585A1
公开(公告)日：2005-08-25
申请号：US11063240
申请日：2005-02-22
申请人： Dirk Mussig , Volker Lang , Jie Lian
发明人： Dirk Mussig , Volker Lang , Jie Lian
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3622 , A61N1/365
摘要： An implantable cardiac device is provided for adaptive ventricular rate smoothing during atrial fibrillation (AF). When AF is detected, the operation of the device is switched to non-atrial synchronized pacing mode such as DDI, DDIR, VDI, VDIR, VVI, or VVIR. The ventricular escape interval (VEI) is beat-by-beat modulated around a physiological interval zone (PIZ), which is determined by the pre-arrhythmia ventricular rate or the output of rate responsive sensor. The VEI remains unchanged if the preceding ventricular event is sensed and its RR interval is within the PIZ. Otherwise, the VEI is decreased asymptotically toward a lower interval threshold if the preceding RR interval is longer than the upper limit of the PIZ, or the VEI is increased asymptotically toward an upper interval threshold if the preceding RR interval is shorter than the upper limit of the PIZ. The step of incrementing or decrementing the VEI is adaptive to the absolute difference value between the preceding RR interval and the asymptotic interval threshold to ensure fast recovery of deviant RR interval toward the PIZ and to reduce the amount of high rate ventricular paces after a ventricular sense with very short coupling interval.
摘要翻译：提供可植入的心脏装置，用于心房颤动（AF）期间的适应性心室率平滑。当检测到AF时，设备的操作切换到非心率同步起搏模式，如DDI，DDIR，VDI，VDIR，VVI或VVIR。心室逃逸间隔（VEI）围绕生理间隔区（PIZ）进行逐搏调制，其由心律失常心室率或速率响应传感器的输出决定。如果检测到先前的心室事件并且其RR间期在PIZ内，则VEI保持不变。否则，如果前一个RR间隔长于PIZ的上限，则VEI会逐渐减小到较低的间隔阈值，或者如果前一个RR间隔比上一个RR间隔的上限更短，VEI会渐近地向上限间隔增加 PIZ。增加或减少VEI的步骤适应于前面的RR间隔和渐近间隔阈值之间的绝对差值，以确保偏离RR间隔向PIZ的快速恢复，并减少心室感觉后的高速率心室起搏量具有非常短的耦合间隔。

4. 发明授权

US07532929B2 Adaptive ventricular rate smoothing during atrial fibrillation 有权
标题翻译：心房颤动期间自适应心率平滑
公开(公告)号：US07532929B2
公开(公告)日：2009-05-12
申请号：US11063240
申请日：2005-02-22
申请人： Dirk Mussig , Volker Lang , Jie Lian
发明人： Dirk Mussig , Volker Lang , Jie Lian
IPC分类号： A61N1/08
CPC分类号： A61N1/3622 , A61N1/365
摘要： An implantable cardiac device is provided for adaptive ventricular rate smoothing during atrial fibrillation (AF). When AF is detected, the operation of the device is switched to non-atrial synchronized pacing mode such as DDI, DDIR, VDI, VDIR, VVI, or VVIR. The ventricular escape interval (VEI) is beat-by-beat modulated around a physiological interval zone (PIZ), which is determined by the pre-arrhythmia ventricular rate or the output of rate responsive sensor. The VEI remains unchanged if the preceding ventricular event is sensed and its RR interval is within the PIZ. Otherwise, the VEI is decreased asymptotically toward a lower interval threshold if the preceding RR interval is longer than the upper limit of the PIZ, or the VEI is increased asymptotically toward an upper interval threshold if the preceding RR interval is shorter than the upper limit of the PIZ. The step of incrementing or decrementing the VEI is adaptive to the absolute difference value between the preceding RR interval and the asymptotic interval threshold to ensure fast recovery of deviant RR interval toward the PIZ and to reduce the amount of high rate ventricular paces after a ventricular sense with very short coupling interval.
摘要翻译：提供可植入的心脏装置，用于心房颤动（AF）期间的适应性心室率平滑。当检测到AF时，设备的操作切换到非心率同步起搏模式，如DDI，DDIR，VDI，VDIR，VVI或VVIR。心室逃逸间隔（VEI）围绕生理间隔区（PIZ）进行逐搏调制，其由心律失常心室率或速率响应传感器的输出决定。如果检测到先前的心室事件并且其RR间期在PIZ内，则VEI保持不变。否则，如果前一个RR间隔长于PIZ的上限，则VEI会逐渐减小到较低的间隔阈值，或者如果前一个RR间隔比上一个RR间隔的上限更短，VEI会渐近地向上限间隔增加 PIZ。增加或减少VEI的步骤适应于前面的RR间隔和渐近间隔阈值之间的绝对差值，以确保偏离RR间隔向PIZ的快速恢复，并减少心室感觉后的高速率心室起搏量具有非常短的耦合间隔。

5. 发明申请

US20070265670A1 IMPLANTABLE ELECTROSTIMULATOR 有权
标题翻译：可植入电解质
公开(公告)号：US20070265670A1
公开(公告)日：2007-11-15
申请号：US11383232
申请日：2006-05-15
申请人： Volker Lang , Jie Lian , Dirk Mussig
发明人： Volker Lang , Jie Lian , Dirk Mussig
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61N1/3682
摘要： An implantable cardiac electrostimulator comprising an atrial sensing channel for processing intracardiac electrogram signals and for detecting signals corresponding to atrial activity and for generating an atrial sense event signal upon detection of a signal corresponding to atrial activity, a ventricular sensing channel for processing intracardiac electrogram signals and for detecting signals corresponding to ventricular activity and for generating a ventricular sense event signal upon detection of a signal corresponding to ventricular activity, a VES detector being operatively connected to said atrial and ventricular sensing channel and being adapted to detect ventricular extrasystoles an atrial stimulation pulse generator a ventricular stimulation pulse generator a stimulation control unit being operatively connected to said atrial stimulation pulse generator and said ventricular stimulation pulse generator. The stimulation control unit is adapted to determine a scheduled time of delivery of an atrial stimulation pulse (T(A)) and a scheduled time of delivery of ventricular stimulation pulse (T(V)). The stimulation control unit is further adapted to trigger said atrial stimulation pulse generator or said ventricular stimulation pulse generator at the scheduled point of time T(A) or T(V), respectively, if no atrial sense event signal is generated before time out of an atrial escape interval (VAI), said atrial escape interval timing out at T(A), or if no ventricular sense event signal is generated before time out of a ventricular escape interval (VEI), said ventricular escape interval timing out at T(V), respectively. T(A) und T(V) are determined depending upon detection of a ventricular extra systole while maintaining a proper atrioventricular synchrony by setting a physiologically adequate A-V-delay between T(A) and corresponding T(V).
摘要翻译：一种可植入心脏电刺激器，包括用于处理心内电描记信号的心房感测通道，并且用于检测对应于心房活动的信号，并且用于在检测到对应于心房活动的信号时产生心房感测事件信号;心室感测通道，用于处理心内电描记图信号;以及用于检测对应于心室活动的信号，并且在检测到对应于心室活动的信号时产生心室感测事件信号，VES检测器可操作地连接到所述心房和心室感测通道，并且适于检测心室收缩期心房刺激脉冲发生器心室刺激脉冲发生器，其可操作地连接到所述心房刺激脉冲发生器和所述心室刺激脉冲发生器的刺激控制单元。刺激控制单元适于确定预定的心房刺激脉冲（T（A））的输送时间和心室刺激脉冲（T（V））的预定运送时间。刺激控制单元还适于在预定的时间点T（A）或T（V））分别触发所述心房刺激脉冲发生器或所述心室刺激脉冲发生器，如果在超时之前没有产生心房感测事件信号心房逸出间隔（VAI），所述心房逃逸间隔在T（A）处超时，或者如果在心室逸出间隔（VEI）之前的时间之前没有产生心室感测事件信号，则所述心室逃逸间隔在T（ V）。通过在T（A）和相应的T（V）之间设置一个生理上足够的A-V延迟来维持室内额外心脏收缩，同时保持适当的房室同步来确定T（A）和T（V）。

6. 发明授权

US5718726A Method of attaching heparin to, and immobilizing it on, inorganic substrate surfaces of cardiovascular implants 失效
标题翻译：将肝素连接并固定在心血管植入物的无机底物表面上的方法
公开(公告)号：US5718726A
公开(公告)日：1998-02-17
申请号：US712471
申请日：1996-09-11
申请人： Michael Amon , Armin Bolz , Dirk Mussig
发明人： Michael Amon , Armin Bolz , Dirk Mussig
IPC分类号： A61F2/00 , A61L27/30 , A61L31/08 , A61L33/00 , A61F2/02 , A61F2/24
CPC分类号： A61L33/0023 , A61L27/306 , A61L31/088 , A61F2310/00742
摘要： A method of attaching heparin to, and immobilizing it on, inorganic substrate surfaces of cardiovascular implants such as cardiac valves or alloplastic vessel wall supports, comprising the following steps: activation of the inorganic substrate surface by etching, attachment, by exposure to ultraviolet light, of a photoactive benzophenone compound with an amino protective group as a spacer to the activated substrate surface, splitting off of the amino protective group by the aid of a non-aqueous piperidine solution, and covalent peptide-bonding of heparin to the free and reactive amino groups of the substrate surface by an aqueous heparin solution acting on the amino groups.
摘要翻译：将肝素附着在其上并将其固定在诸如心脏瓣膜或异体血管壁支架的心血管植入物的无机基底表面上的方法，包括以下步骤：通过暴露于紫外线的蚀刻，附着来激活无机基底表面，的具有氨基保护基的光活性二苯甲酮化合物作为活化底物表面的间隔基，借助于非水性哌啶溶液分离氨基保护基，并将肝素与游离和反应性氨基的共价肽键合通过作用在氨基上的肝素水溶液的底物表面的组。

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