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1. 发明授权

US07583996B2 Atrial overdrive pacing in non-atrial tracking mode while maintaining AV synchrony 失效
标题翻译：心房超速起搏在非心房跟踪模式同时保持AV同步
公开(公告)号：US07583996B2
公开(公告)日：2009-09-01
申请号：US11560099
申请日：2006-11-15
申请人： Jie Lian , Christopher S. de Voir , Garth Garner , Hannes Kraetschmer , Dirk Müssig
发明人： Jie Lian , Christopher S. de Voir , Garth Garner , Hannes Kraetschmer , Dirk Müssig
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/3688
摘要： Heart stimulator that stimulates at least a heart's right atrium and ventricle in an atrium asynchronous stimulation mode with an overdrive stimulation rate. Interposes one resynchronization cycle after a sensed atrial event to regain AV synchrony during otherwise asynchronous stimulation mode. Allows for pacing mode that can pace the atrium with an overdrive stimulation rate in dual-chamber asynchronous mode while maintaining the AV synchrony and is called DDI(R)+. In DDI(R)+, pacemaker performs an atrial asynchronous (V synchronous) pacing mode such as DDI or DDI(R). The overdrive stimulation rate (OSR) is either a fixed rate (programmed by the external device) that is thought to be above the underlying intrinsic atrial rate, or is dynamically adjusted according to the measured atrial cycle length to be slightly above intrinsic atrial rate. The overdrive stimulation rate may be based on an intrinsic atrial rate or on hemodynamic need. DDI(R)+ timing may be ventricle-based.
摘要翻译：心脏刺激器，可以刺激至少一个心脏异位刺激模式的心脏和心室，具有超速刺激速率。在感应到的心房事件之后插入一个再同步循环，以在其他异步刺激模式下重新获得AV同步。允许起搏模式，可以在双室异步模式下以过驱动刺激速率调节心房，同时保持AV同步，称为DDI（R）+。在DDI（R）+中，起搏器执行心房异步（V同步）起搏模式，如DDI或DDI（R）。超速刺激速率（OSR）是被认为高于潜在固有心房率的固定比率（由外部设备编程），或根据测量的心房周期长度动态调整为略高于固有心房率。超速刺激速率可以基于固有心房率或血液动力学需要。 DDI（R）+时间可能是基于心室的。

2. 发明授权

US08060198B2 Method and apparatus for generating a composite farfield electrogram 有权
标题翻译：用于生成复合远场电描记图的方法和装置
公开(公告)号：US08060198B2
公开(公告)日：2011-11-15
申请号：US11848824
申请日：2007-08-31
申请人： Jie Lian , Garth Garner , Hannes Kraetschmer , Dirk Müssig
发明人： Jie Lian , Garth Garner , Hannes Kraetschmer , Dirk Müssig
IPC分类号： A61N1/362 , A61B5/0456
CPC分类号： A61N1/3622 , A61N1/368
摘要： Method and apparatus that uses dual-chamber (RA-RV), three-chamber (BiA-RV, or RA-BiV), or four-chamber (BiA-BiV) implantable cardiac devices including pacemakers, defibrillators and cardioverters, which stimulate cardiac tissue electrically to control the patient's heart rhythm. The method and apparatus are further configured to create a far-field intra-atrial electrogram (AEGM) and a far-field intra-ventricular electrogram (VEGM) that are independently filtered, scaled, and then summed to form a composite far-field electrogram.
摘要翻译：使用双室（RA-RV），三室（BiA-RV或RA-BiV）或四室（BiA-BiV）可植入心脏装置的方法和装置，包括起搏器，除颤器和心律转换器，其刺激心脏组织电气以控制患者的心律。所述方法和装置还被配置为创建远场心房电描记图（AEGM）和远场心室电描记图（VEGM），所述远场心室电描记图被独立地过滤，缩放，然后相加以形成复合远场电描记图。

3. 发明授权

US08868181B2 Implantable electrostimulator 有权
标题翻译：植入式电刺激仪
公开(公告)号：US08868181B2
公开(公告)日：2014-10-21
申请号：US11383232
申请日：2006-05-15
申请人： Volker Lang , Jie Lian , Dirk Müssig
发明人： Volker Lang , Jie Lian , Dirk Müssig
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/3682
摘要： An implantable cardiac electrostimulator includes an atrial sensing channel generating an atrial sense event signal upon detection of atrial activity, a ventricular sensing channel generating a ventricular sense event signal upon detection of ventricular activity, a VES detector detecting ventricular extrasystoles, atrial and ventricular stimulation pulse generators, and a stimulation control unit. The stimulation control unit determines scheduled delivery times of atrial stimulation pulses (T(A)) and/or ventricular stimulation pulses (T(V)), and triggers delivery if no atrial sense event signal arises before the end of an atrial escape interval (VAI) timing out at T(A), or if no ventricular sense event signal arises before the end of a ventricular escape interval (VEI) timing out at T(V). T(A) and T(V) depend upon detection of a ventricular extrasystole, and proper atrioventricular synchrony is maintained by setting a physiologically adequate A-V-delay between T(A) and T(V).
摘要翻译：可植入心脏电刺激器包括在检测到心房活动时产生心房感觉事件信号的心房感知通道，在检测到心室活动时产生心室感测事件信号的心室感测通道，检测心室收缩期，心房和心室刺激脉冲发生器的VES检测器，以及刺激控制单元。刺激控制单元确定心房刺激脉冲（T（A））和/或心室刺激脉冲（T（V））的调度递送时间，并且如果在心房逸出间隔结束之前没有出现心房感觉事件信号，则触发递送 VAI）在T（A）处超时，或者如果在T（V）之前的心室逃逸间隔（VEI）终止之前没有出现心室感觉事件信号。 T（A）和T（V）取决于心室收缩期的检测，通过在T（A）和T（V）之间设置生理上足够的A-V延迟来维持适当的房室同步。

4. 发明授权

US07616993B2 Heart stimulator using a Bezier function to define AV-delay values 失效
标题翻译：心脏刺激器使用贝塞尔函数定义AV延迟值
公开(公告)号：US07616993B2
公开(公告)日：2009-11-10
申请号：US11563296
申请日：2006-11-27
申请人： Dirk Müssig , Kurt Swenson
发明人： Dirk Müssig , Kurt Swenson
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/37247
摘要： A heart stimulator provides for a more appropriate yet simple setting of the AV-delay. The heart stimulator comprises a stimulation pulse generator adapted to generate electric stimulation pulses and connected to a ventricular stimulation electrode for delivering electric stimulation pulses. A sensing stage connected to an electrode for picking up electric potentials inside a ventricle is adapted to sense an excitation or a contraction of a heart chamber. A memory is adapted to store parameters defining a Bezier function determining the relationship between AV-delay values and heart rate and a control unit connected to said memory, said sensing stage and to said stimulation pulse generator, is adapted to determine an actual AV-delay based on an actual intrinsic heart rate or an actual stimulation rate and a non-linear smoothing interpolation between said parameters stored in said memory.
摘要翻译：心脏刺激器提供更适合但简单的AV延迟设置。心脏刺激器包括适于产生电刺激脉冲并连接到心室刺激电极以传送电刺激脉冲的刺激脉冲发生器。连接到用于拾取心室内的电位的电极的感测级适于感测心室的激发或收缩。存储器适于存储定义确定AV延迟值和心率之间的关系的贝塞尔函数的参数以及连接到所述存储器，所述感测级和所述刺激脉冲发生器的控制单元适于确定实际的AV延迟基于在所述存储器中存储的所述参数之间的实际固有心率或实际刺激速率和非线性平滑插值。

5. 发明授权

US06428218B1 Method and device for splicing optical conductors 失效
标题翻译：用于拼接光导体的方法和装置
公开(公告)号：US06428218B1
公开(公告)日：2002-08-06
申请号：US09647163
申请日：2000-09-26
申请人： Dirk Müssig
发明人： Dirk Müssig
IPC分类号： G02B6255
CPC分类号： G01J5/0003 , G01J2005/0077 , G01N21/67 , G02B6/2551
摘要： In a process of splicing optical fibers, a temperature distribution during the splicing of the waveguides at a constant discharge current will depend on ambient parameters, which include temperature, air pressure and air humidity, and these parameters also influence the quality of the splice being produced. The discharge current is regulated by measuring the actual intensity distribution of the thermionic emissions of the waveguide during the splicing operation and by comparing this intensity distribution with a stored reference intensity distribution. The device includes a sensor which is used for measuring the intensity distribution and for adjusting the ends of the waveguides relative to each other.
摘要翻译：在接合光纤的过程中，波导在恒定放电电流下的拼接期间的温度分布将取决于包括温度，空气压力和空气湿度在内的环境参数，并且这些参数也影响所生产的接头的质量。通过在拼接操作期间测量波导的热离子发射的实际强度分布并通过将该强度分布与存储的参考强度分布进行比较来调节放电电流。该装置包括用于测量强度分布并且用于相对于彼此调节波导的端部的传感器。

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