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    • 7. 发明授权
    • Medical devices having adherent polymeric layers with depth-dependent properties
    • 具有与深度相关性质的贴壁聚合物层的医疗装置
    • US07919137B2
    • 2011-04-05
    • US11983952
    • 2007-11-13
    • Derek SutermeisterJay RassatJames Anderson
    • Derek SutermeisterJay RassatJames Anderson
    • A61L33/00C08J7/18
    • A61L31/10A61L31/14Y10T428/31678
    • According to one aspect of the invention, a method of forming a medical device is provided, which includes: (a) contacting a substrate with a solution that contains (i) one or more types of polymers, (ii) a solvent that contains one or more types of solvent species, and (iii) one or more optional agents, for example, one or more therapeutic agents, among others; and (b) removing the solvent from the solution, thereby forming a polymeric layer on the substrate. The composition of the solution is changed over the course of forming the polymeric layer. In another aspect of the invention, a medical device is provided, which includes a substrate and a polymeric layer over the substrate. The polymeric layer contains a copolymer that contains differing first and second monomers. The lower surface of the polymeric layer contacting the substrate has a surface concentration of the first monomer relative to the second monomer that is higher than that of the upper surface of the polymeric layer opposite the substrate.
    • 根据本发明的一个方面,提供了一种形成医疗装置的方法,其包括:(a)使基底与含有(i)一种或多种聚合物的溶液接触,(ii)含有一种 或更多类型的溶剂物质,和(iii)一种或多种任选的试剂,例如一种或多种治疗剂等; 和(b)从溶液中除去溶剂,由此在基材上形成聚合物层。 在形成聚合物层的过程中改变溶液的组成。 在本发明的另一方面,提供了一种医疗装置,其包括衬底和在衬底上的聚合物层。 聚合物层含有含有不同的第一和第二单体的共聚物。 与基材接触的聚合物层的下表面具有相对于第二单体的第一单体的表面浓度高于与基材相对的聚合物层的上表面的表面浓度。
    • 8. 发明申请
    • Medical devices having adherent polymeric layers with depth-dependent properties
    • 具有与深度相关性质的贴壁聚合物层的医疗装置
    • US20080113083A1
    • 2008-05-15
    • US11983952
    • 2007-11-13
    • Derek SutermeisterJay RassatJames Anderson
    • Derek SutermeisterJay RassatJames Anderson
    • A61L33/00A61F2/01A61F2/24A61N1/00A61F2/82
    • A61L31/10A61L31/14Y10T428/31678
    • According to one aspect of the invention, a method of forming a medical device is provided, which includes: (a) contacting a substrate with a solution that contains (i) one or more types of polymers, (ii) a solvent that contains one or more types of solvent species, and (iii) one or more optional agents, for example, one or more therapeutic agents, among others; and (b) removing the solvent from the solution, thereby forming a polymeric layer on the substrate. The composition of the solution is changed over the course of forming the polymeric layer. In another aspect of the invention, a medical device is provided, which includes a substrate and a polymeric layer over the substrate. The polymeric layer contains a copolymer that contains differing first and second monomers. The lower surface of the polymeric layer contacting the substrate has a surface concentration of the first monomer relative to the second monomer that is higher than that of the upper surface of the polymeric layer opposite the substrate.
    • 根据本发明的一个方面,提供了一种形成医疗装置的方法,其包括:(a)使基底与包含(i)一种或多种聚合物的溶液接触,(ii)含有一种 或更多类型的溶剂物质,和(iii)一种或多种任选的试剂,例如一种或多种治疗剂等; 和(b)从溶液中除去溶剂,由此在基材上形成聚合物层。 在形成聚合物层的过程中改变溶液的组成。 在本发明的另一方面,提供了一种医疗装置,其包括衬底和在衬底上的聚合物层。 聚合物层含有含有不同的第一和第二单体的共聚物。 接触基材的聚合物层的下表面具有相对于第二单体的第一单体的表面浓度高于与基材相对的聚合物层的上表面的表面浓度。
    • 9. 发明申请
    • MEDICAL DEVICES HAVING ADHERENT POLYMERIC LAYERS WITH DEPTH-DEPENDENT PROPERTIES
    • 具有深度依赖性的附加聚合物层的医疗装置
    • US20110150965A1
    • 2011-06-23
    • US13036894
    • 2011-02-28
    • Derek SutermeisterJay RassatJames Anderson
    • Derek SutermeisterJay RassatJames Anderson
    • A61F2/00A61F2/01B32B15/08C08F299/00
    • A61L31/10A61L31/14Y10T428/31678
    • According to one aspect of the invention, a method of forming a medical device is provided, which includes: (a) contacting a substrate with a solution that contains (i) one or more types of polymers, (ii) a solvent that contains one or more types of solvent species, and (iii) one or more optional agents, for example, one or more therapeutic agents, among others; and (b) removing the solvent from the solution, thereby forming a polymeric layer on the substrate. The composition of the solution is changed over the course of forming the polymeric layer. In another aspect of the invention, a medical device is provided, which includes a substrate and a polymeric layer over the substrate. The polymeric layer contains a copolymer that contains differing first and second monomers. The lower surface of the polymeric layer contacting the substrate has a surface concentration of the first monomer relative to the second monomer that is higher than that of the upper surface of the polymeric layer opposite the substrate.
    • 根据本发明的一个方面,提供了一种形成医疗装置的方法,其包括:(a)使基底与含有(i)一种或多种聚合物的溶液接触,(ii)含有一种 或更多类型的溶剂物质,和(iii)一种或多种任选的试剂,例如一种或多种治疗剂等; 和(b)从溶液中除去溶剂,由此在基材上形成聚合物层。 在形成聚合物层的过程中改变溶液的组成。 在本发明的另一方面,提供了一种医疗装置,其包括衬底和在衬底上的聚合物层。 聚合物层含有含有不同的第一和第二单体的共聚物。 与基材接触的聚合物层的下表面具有相对于第二单体的第一单体的表面浓度高于与基材相对的聚合物层的上表面的表面浓度。